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Editorial Boards

  1. 1. CURRICULUM VITAE Date Prepared: August 2006 Name: Anthony Neil Hollenberg, M.D., FRCP(C) Office Address: Division of Endocrinology Beth Israel Deaconess Medical Center Boston, MA 02215 Home Address: 50 Victoria Circle Newton, MA 02159 E:Mail thollenb@caregroup.harvard.edu Fax: 617-667-2927 Place of Birth: Montreal, Quebec, Canada Education: 1983 A.B. (cum laude) Harvard College, Cambridge, MA Biochemical Sciences 1986 M.D. University of Calgary, Faculty of Medicine, Calgary, Alberta Postdoctoral Training: Internship and Residencies: 1986-1987 Intern in Medicine, Beth Israel Hospital, Boston, MA 1987-1989 Resident in Medicine, Beth Israel Hospital, Boston, MA 1990-1991 Chief Medical Resident, Beth Israel Hospital, Boston, MA Fellowships: 1989-1990 Clinical and Research Fellow in Endocrinology, Massachusetts General Hospital, Boston, MA 1991-1993 Clinical and Research Fellow in Endocrinology, Massachusetts General Hospital, Boston, MA Licensure and Certification: 1988 Board of Registration, Commonwealth of Massachusetts 1989 Diplomat, American Board of Internal Medicine 1990 Fellow, Royal College of Physicians and Surgeons (Canada) 1993 Diplomat in Endocrinology, Diabetes and Metabolism Academic Appointments: 1993 Instructor in Medicine, Harvard Medical School 1996- Assistant Professor of Medicine, Harvard Medical School 2003- Associate Professor of Medicine, Harvard Medical School 1
  2. 2. Hospital Appointments: 1992-1993 Assistant in Medicine, Massachusetts General Hospital 1993 Physician, Beth Israel Deaconess Medical Center Major Administrative Responsibilities: 1994-2000 Director, Internal Medicine Training Program-Beth Israel Hospital and Beth Israel Deaconess Medical Center 2000- Chief, Thyroid Unit 2000- 2005 Director Clinical Endocrinology – Beth Israel Deaconess Medical Center 2001.2004Co-Director BIDMC Endocrinology Fellowship Training Program 2004- Director, Clinical Investigator Training Program, HMS and HST 2005- Director Strategic Research Planning and Development BIDMC Major Committee Assignments: 2000.2004Chairperson, Education Committee, American Thyroid Association 2004.2006Member, Endocrinology Panel, Canadian Institutes for Health Research 2005- Member, NIH GCRC Study Section and PPG Study Section Professional Societies: 1993- Endocrine Society 1994- American Thyroid Association –2001-04 Chair, Education Committee 2004- American Diabetes Association Editorial Boards 2003- Endocrinology Member Awards and Honors: 1983 Harvard Scholar 1983-1986 Nat Christie Foundation Medical Entrance Award 1985 Joseph Albert Award for Elective Study 1999.2003 Fellowship, Medical Research Council of Canada 1999.2000 Milton Award, Harvard University 2000 Isadore Rosenberg Lectureship, Metrowest Medical Center 2000 Van Meter Award, American Thyroid Associatio 2004 Jack Oppenheimer Lecturer - Division of Endocrinology, University of Minnesota 2004 - Haines Lecturer, Division of Endocrinology, Diabetes, Nutrition and Metabolism, Mayo Clinic 2
  3. 3. Research Funding Information: Past: 1991-1993 Medical Research Council of Canada Research Fellowship 1994-1995 Boots Pharmaceuticals, PI Dominant Negative Activity of Mutant Thyroid Hormone Receptors on Genes Negatively Regulated by Thyroid Hormone. 1996-1998 National Institutes of Health- DK 46200 PI Functional Antagonism Between C/EBPα and PPARγ on the Leptin Promoter. 1995-2000 National Institutes of Health KO8-DK02354 PI Thyrotropin-releasing Hormone: A Study of Gene Expression. 1999-2000 National Institutes of Health R03 PI Thyrotropin-releasing Hormone: A Study of Gene Expression. 2000-2003 National Institutes of Health R21-DK57658 PI Regulation of Hypothalamic Gene Expression by Leptin and Thyroid Hormone 2002-2004 Hershey Fund for Prostate Cancer Research PI Regulation of Androgen Receptor Action by Nuclear CoRepressors 2002.2004 Thyroid Research Advisory Council Abbott Pharmaceuticals PI Regulation of TRH by Leptin Current: 2005-2009 National Institutes of Health R01 DK56123 PI CoRepressor Regulation of Nuclear Receptor Action 2003-2007 Takeda Pharmaceuticals Program Project in PI Metabolic Disease 2003-2006 American Diabetes Association Research Award PI Transcriptional Targets of Leptin Action 2005.2007 American Diabetes Association- Richard and Susan PI Smith Family Foundation Pinnacle Program Project Award Transcriptional Regulation of Arcuate Nucleus Function 2004-2007 Department of Defense Research Award Co-PI 3
  4. 4. The Role of CoRepressors in Prostate Cancer 2005-2009 Merck and Pfizer The Cliniccal Investigator Training Program PI C. Report of Current Research Activites 1. The Role of NCoR in NR Signaling Principal Investigator 2. The Regulation of Hypothalamic Gene Expression Principal Investigator D. Report of Teaching. Local contributions 1999-2004 HMS Endocrine Pathophysiology Lecturer 150 Harvard Medical Students 10 hours of preparation and contact time. 1999-present Harvard Science and Technology Endocrinology Lecturer 60 HST students 20 hours of preparation and contact time. 1999-present HMS Core II Thyroid Course 60 Harvard Medical Students 20 hours of preparation and contact time. Continuing Medical Education 1998-present Thyroid Disease-An UpDate: Beth Israel Deaconess Medical Center Review Course in Medicine. Lecturer 15 hours of contact and preparation. 2000-present PriMed in Los Angeles and Boston, two hours of lectures on Thyroid Disease. Lecturer 20 hours of contact and preparation time. . 2005 Harvard Medical International, Tokyo Japan Lecturer-New Developments in Endocrinology 30 hours of prepration 4
  5. 5. Advisory and Supervisory Responsibilities 1995- Attending in Medicine BIDMC. 40 hours year 1995- Attending in Endocrinology. 60 hours year. 1995-2005 Preceptor, Endocrine Clinic, 160 hours per year. E. Report on Clinical Activities I currently spend two weeks per year attending on the Internal Medicine service and 2 weeks per year as the consult attending in Endocrinology. Advisees and Trainees 1997.1999 Tsuyoshi Monden MD, Ph.D. Asst Professor Gunma Univ. School of Medicine. 1997.2000 Ronald Cohen MD Asst Professor Univ. of Chicago 1999-2000 Brian Kim MD Instructor, BWH 2000.2002 Marisol Lopez Ph.D. 2002- 05 Feifan Guo Ph.D. Research Assistant Professor Pennsylvania State University 2002-present Inna Astapova Ph.D post-doctoral fellow 2003-present Michelle Sugrue Ph.D. post-doctoral fellow 2003-05 Alison Cohen MD Endocrine Fellow 2003-05 Larissa Lee AB Harvard Medical School (HST) 2005-present Franck Chiappini V.MD, Ph.D. 2005-present Preeti Ramadoss Ph.D. Regional, national or international contributions 5
  6. 6. 1998 Endocrine Grand Rounds, Northwestern University School of Medicine 1999 Endocrine Grand Rounds, University of Chicago 1999 Plenary Lecture, American Thyroid Association 2000 Van Meter Lecture, International Thyroid Congress, Kyoto Japan 2001 Plenary Lecture, Endocrine Society Annual Meeting 2001 Invited Lecture. Fourth International Workshop on Resistance to Thyroid Hormone, Verbania Italy 2001 Endocrine Grand Rounds, University of Rochester School of Medicine 2002 Endocrine Grand Rounds, University of Chicago 2002 Invited lecture, International Congress on Obesity, Sao Paulo Brazil 2002 Plenary Lecture, American Thyroid Association Annual Meeting 2003 Invited lecture, German Endocrine Society, Cologne Germany 2003 Invited lecture, Sao Paulo Endocrine Society, Sao Paulo Brazil 2003 Guest Speaker, Endocrine Research Day, University of Toronto 2003 Guest Speaker, McGill University Thyroid Club, Montreal, Quebec 2003 Invited Speaker Transcription Research Group, National Institutes of Health 2004 Endocrine Grand Rounds, Brown Medical School 2004 Jack Oppenheimer Lecture, University of Minnesota 2004 Samuel F. Haines Lecturer, Mayo Clinic, Rochester MN 2005 Invited Short talk, Keystone Symposia Diabetes and Obesity, Keystone CO 2005 Invited lecture, International Thyroid Congress, Buenos Aires, Argentina 2006 Invited Lecturer, American Thyroid Association Meeting, Phoenix AZ Bibliography Original Articles: 1. Jameson JL, Chin WW, Hollenberg AN, Chang AS, Habener JF. The gene encoding the beta subunit of rat luteinizing hormone - analysis of gene structure and evolution of nucleotide sequence. J. Biol Chem 1984; 259-15474-80 2. Hollenberg AN, Arnold A. A novel biochemical presentation of primary hyperpara- thyroidism. Am J Med 1991; 91;547-548 3. Bauer-Dantoin A, Hollenberg AN, Jameson JL. Dynamic regulation of GnRH receptor mRNA levels in the anterior pituitary gland during the rat estrous cycle. Endocrinology 1993; 133; 1911-1914 4. Hollenberg AN, Pestell RG, Albanese C, Boers ME, Jameson JL. Multiple Promoter Elements in the Human Chorionic Gonadotropin β-subunit genes distinguish their expression from the luteinizing hormone β gene. Mol and Cell Endo, 1994; 106;111-119 5. Pestell RG, Hollenberg AN, Albanese C, Jameson JL. Distinct domains of c-jun are involved in repression of the human chorionic gonadotropin α and β genes. J Biol Chem , 1994; 269;31090-6 6. Flynn TR, Hollenberg AN, Cohen O, Menke JB, Usala SJ, Tollin S, Hegarty MK, 6
  7. 7. Wondisford FE. A Novel c-terminal Domain in the Thyroid Hormone Receptor Selectively Mediates Thyroid Hormone Inhibition. J Biol Chem, 1994; 269;52;32713-32716 7. Hollenberg AN, Monden T, Flynn TR, Boers M-E, Cohen O, Wondisford FE. The Human Thyrotropin-Releasing Hormone Gene Is Regulated by Thyroid Hormone through Two Distinct Classes of Negative Thyroid Hormone Response Elements. Mol Endocrinol, 1995; 9;5; 540-550 8. Hollenberg AN, Monden T, Wondisford FE. Ligand-Independent and Dependent Function of Thyroid Hormone Receptor Isoforms Depend Upon Their Distinct Amino- Termini. J Biol Chem, 1995; 270:14274-14280 9. Medeiros-Neto G, Herodotou DT, Rajan S, Kommareddi S, Lacerda L, Sandrini R, Boguszewski MCS, Hollenberg AN, Radovick S, Wondisford, FE. A Circulating, Biologically Inactive Thyrotropin Caused by a Mutation in the Beta Subunit Gene. J Clin Invest, 1996; 97:5,1250-1256 10. Hollenberg AN, Monden T, Madura JP, Lee K, Wondisford FE. Function of Nuclear Corepressor Protein on Thyroid Hormone Response Elements is Regulated by the Receptor A/B Domain. J Biol Chem, 1996; 271: 28516-28520 11. Hollenberg AN, Susulic VS, Madura JP, Zhang B, Moller DE, Tontonoz P, Sarraf P, Spiegelman BM, Lowell BB. Functional Antagonism Between C/EBPα and PPARγ on the Leptin Promoter. J Biol Chem 1997; 272: 5283-5290 12. Safer J, Langlois M-F, Cohen RM, Monden T, John-Hope D, Madura JP, Hollenberg AN, Wondisford FE. Isoform Variable Action Among Thyroid Hormone Receptor Mutants Provides Insight Into Pituitary Resistance to Thyroid Hormone. Mol Endocrinol 1997; 11: 16-26 13. Werman A., Hollenberg AN, Solanes G., Bjoerbaek C., Vidal-Puig T., Flier JS. Evidence For a Ligand-independent Activation Domain in the N-terminus of PPARγ2: Differential Activity of PPARγ1and PPARγ2 Isoforms and Influence of Insulin. J Biol Chem 1997; 272: 20230-20235 14. Langlois MF, Safer JS, Monden T, Hollenberg AN, Wondisford FE. The Thyroid Hormone Receptor Beta 2 Isoform Plays a Unique Role in Negative Regulation by Thyroid Hormone. J Biol Chem 1997; 272: 24927-24933 15. Monden T., Wondisford FE, Hollenberg AN. Isolation and Characterization of a Novel Thyroid Hormone Receptor Coactivating Protein. J Biol Chem 1997; 272: 29834-29841 16. Cohen RN, Wondisford FE, Hollenberg AN. Two Separate NCoR Interaction Domains Mediate Corepressor Action on Thyroid Hormone Response Elements. Mol Endocrinol 1998; 12:1567-1581 7
  8. 8. 17. Safer J, Cohen RN, Hollenberg AN, Wondisford FE. Defective Release of CoRepressor by Hinge Mutants of the Thyroid Hormone Receptor Found in Patients with Resistance to Thyroid Hormone. J Biol Chem 1998; 273: 30175-30180 18. Monden T, Kishi M, Hosoya T, Satoh T, Wondisford FE, Hollenberg AN, Yamada M, Mori M. p120 Acts as a Specific Coactivator for 9-cis Retinoic Acid Receptor (RXR) on Peroxisome-Proliferator Activated Receptor-γ/RXR Heterodimers. Mol Endocrinol 1999; 13: 1704-1717 19. Oberste-Berghaus C, Zanger K, Hashimoto K, Cohen RN, Hollenberg AN, Wondisford FE. Thyroid Hormone Independent Interaction Between the Thyroid Hormone Receptor- β2 Amino-Terminus and Coactivators. J Biol Chem 2000; 275:1787-1792 20. Cohen RN, Putney A, Wondisford FE, Hollenberg AN. The Nuclear Corepressors Recognize Distinct Nuclear Receptor Complexes. Mol Endocrinol 2000; 14: 900-914 21. Nillni EA, Bartnick AR, Harris M, Hollenberg AN, Bjorbaek C, Flier JS. Leptin regulates TRH biosynthesis: evidence for direct and indirect pathways. J Biol Chem 2000; 275:36124-36133 22. Hashimoto K, Zanger K, Cohen RN, Hollenberg AN, Wondisford FE. CBP Mediates Regulation of Thyrotropin Subunit Genes Through Distinct Domains. J Biol Chem 2000; 275:33365-72 23. Harris M, Aschkenasi C, Elias C, Chandrankunnel A, Nillni E, Bjorbaek C, Elmquist JK, Flier JS, Hollenberg AN. Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. J Clin Invest 2001: 107:111-120 24. Li AW, Morash B, Hollenberg AN, Ur E, Wilkinson M, Murphy PR. Transcriptional regulation of the leptin gene promoter in rat GH3 pituitary and C6 glioma cells. Mol Cell Endo 2001: 176: 57-65 25. Cohen RN, Kim B, Chorev M, Wondisford FE, Hollenberg AN. The specificity of interactions between nuclear hormone receptors corepressors and corepressors is mediated by distinct amino acid sequences within the interaction domains. Mol Endocrinol 2001: 15: 1049-1061 26. Cheng S, Brozstek S, Hollenberg AN, Balk SP. Inhibition of the Dihydrotestosterone- Activated Androgen Receptor by Nuclear Receptor Corepressor. Mol Endocrinol 2002: 16: 1492-1501 27. Yamamoto H, Lee CE, Kishi T. Marcus JN, Williams TD, Overton JM, Lopez ME, Hollenberg AN, Baggio LB, Drucker DJ, Emquist JE. Central glucagon like peptide-1: A novel regulator of sympathetic outflow. J Clin Invest. 2002 Jul;110(1):43-52 8
  9. 9. 28. Makowski A, Brzostek S, Cohen RN, Hollenberg AN: Determination of nuclear corepressor interactions with the thyroid hormone receptor. Mol Endocrinol 2003: 17; 273-286. 29. Shibusawa N, Hollenberg AN, Wondisford FE. Thyroid hormone receptor DNA binding is required for both positive and negative gene regulation. J Biol Chem. 2003: 278; 732-738 30. Yohrling GJ IV, Farrell LA, Hollenberg AN, Cha JH-J. Mutant huntington increases nuclear corepressor function and enhances ligand- dependent nuclear hormone receptor activation. Mol Cell Neurosci 2003: 23; 28-38. 31. Yamamoto H, Kishi T, Lee CE, Choi BJ, Fang H, Hollenberg AN, Drucker DJ, Elmquist JK. Glucagon-like Peptide-I Responsive Catecholamine Neurons in the Area Postrema Link Peripheral Glucagon-Like Peptide_I with Central Autonomic Control Sites. Journal of Neuroscience 2003: 23; 2939-46 32. Munzberg H, Huo L, Nillni E, Hollenberg AN, Bjorbaek C. Role of signal transducer and activator of hypothalamic proopiomelnacortin gene expression by leptin. Endocrinology 2003: 144; 2121-31. 33. Shattuck TM, Kim, TS, Costa J, Yandell DW, Imanishi Y, Palinisamy N, Gaz RD, Shoback D, Clark OH, Monchik JM, Wierman ME, Hollenberg AN, Tojo K, Chaganti RSK, Arnold A. Mutational analysis of RB and BRCA2 as candidate tumor suppression genes in parathyroid carcinoma. Clinical Endocrinology (Oxf) 2003: 59; 180-189 34. Meng X, Yang Y-F, Cao X, Govindan MV, Shuen M, Hollenberg AN, Mymryk JS, Walfish PG. Cellular context of co-regulator and adaptor protein regulates human adenovirus E1A dependent gene activation by the thyroid hormone receptors Molecular Endocrinology 2003: 17; 1095-1105 35. Monden T, Yamada M, Ishii S, Hosoya T, Satoh T, Wondisford FE, Hollenberg AN, Mori M. Leucine at codon 428 in the ninth heptad of thyroid receptor beta1 is necessary for interactions with the transcriptional cofactors and functions regardless of dimer formations. Thyroid 2003: 13; 427-435. 36. Costa J, Shattuck TM, Imanishi Y, Palanisamy N, Gaz RD, Shoback D, Clark OH, Monchik JM, Wierman ME, Hollenberg A, Tojo K, Chaganti RSK, Arnold A. Mutational analyses of connexin 26 , connexin 30 and connexin 46 as candidate tumor suppressor genes in parathyroid carcinoma. J Endocr Genet 2003; 3:57-62 9
  10. 10. 37. Valli-Jaakola K, Lipsanen-Nyman M, Oksanen L, Hollenberg AN, Kontula K, Bjorbaek C, Schalin-Jantti C. Identification and characterization of melanocortin-4 receptor gene mutations in morbidly obese finnish children and adults. J Clin Endocrinol Metab. 2004 Feb;89(2):940-5. 38. Guo F, Bakal K, Minokoshi Y, Hollenberg AN. Leptin Signaling Targets the Thyrotropin-Releasing Hormone Gene Promoter In Vivo. Endocrinology. 2004;145(5):2221-7 39. Bachman ES, Hampton TG, Dhillon H, Amende I, Wang J, Morgan JP, Hollenberg AN. The Metabolic and Cardiovascular Effects of Hyperthyroidism are Largely Independent of Beta-Adrenergic Stimulation. Endocrinology. 2004; 145(6):2767-2774 40. Tzameli I, Fang H, Ollero M, Shi H, Hamm JK, Kievit P, Hollenberg AN, Flier JS. Regulated production of a PPAR-gamma ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes. J Biol Chem. 2004 Aug 20;279(34):36093-102. Epub 2004 Jun 9. 41. Masiello D, Chen SY, Xu Y, Verhoeven MC, Choi E, Hollenberg AN, Balk SP. Recruitment of{beta}-CATENIN by Wild Type or Mutant Androgen Receptors Correlates With Ligand Stimulated Growth of Prostate Cancer Cells. Mol Endocrinol. 2004 Oct;18(10):2388-401. Epub 2004 Jul 15. 42. Hodgson MC, Astapova I, Cheng S, Lee LJ, Verhoeven MC, Choi E, Balk SP, Hollenberg AN. The androgen receptor recruits nuclear receptor corepressor (N- CoR) in the presence of mifepristone via its amino and carboxy terminii revealing a novel molecular mechanism for androgen receptor antagonists. J. Biol Chem. 2005 Feb 25;280(8):6511-9. 43. Kishi T, Aschkenasi CJ, Choi BJ, Lopez ME, Lee CE, Liu H, Hollenberg AN, Friedman JM, Elmquist JK. Neuropeptide Y Y1 receptor mRNA in rodent brain: Distribution and colocalization with melanocortin-4 receptor. J Comp Neurol. 2005 Feb 14;482(3):217-43. 44. Blumberg JM, Tzameli I, Astapova I, Lam FS, Flier JS, Hollenberg AN. Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells. J Biol Chem. 2006 2006 Apr 21;281(16):11205-13. Chapters/Reviews 1. Jameson JL, Hollenberg AN. Recent Advances in Studies of the Molecular Basis of Endocrine Disease. Horm Met Res 1992; 24: 201-209 10
  11. 11. 2. Jameson JL, Hollenberg AN. Regulation of Chorionic Gonadotropin Gene Expression. Endocrine Reviews 1993, 1193; 14: 203-221 3. Hollenberg AN. Thyroid Hormone Receptor Isoforms, Nuclear CoRepressors and Coactivators: New Insights into Thyroid Hormone Action. Curr Concepts in Endo and Metab 1998 4. Flier JS, Hollenberg AN. ADD 1 major new insight into the mechanism of insulin action. Proc Natl Acad Sci 1999; 96:14191-14192 5. Flier JS, Harris M, Hollenberg AN. Leptin, Nutrition, and The Thyroid: The Why, The Wherefore, and The Wiring. J Clin Invest 2000;105: 859-861 6. Hollenberg AN. Negative Regulation by Thyroid Hormone. Hot Thyroidology 2002. 7. Bjorbaek C, Hollenberg AN, Leptin and Melancortin Signaling in the Hypothalamus. Vitamins and Hormones 2002: 65; 281-311 8. Lechan RM, Hollenberg AN.Thyrotropin-Releasing Hormone (TRH): Gene, Synthesis, Structure, Cell Processing and Biology. Encyclopedia of Hormones In press 9. Lopez ME, Hollenberg AN. Regulation of TRH Gene Expression by Hypothalamic Signaling Pathways Important in Energy Expenditure. Progress in Obesity Research in press 10. Hollenberg AN, Regulation of Thyrotropin Secretion, Werner and Ingbar- The Thyroid edited by Lewis Braverman and Robert Utiger. 2005 Edition. 11. Hollenberg AN and Jameson JL. Thyroid Hormone Action. DeGroot and Jameson Textbook of Endocrinology, 2005 Edition 11
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