ENDOCRINOLOGY (Web Course)
BIO 198/ SUMMER SESSION (Term 1) 2005
INSTRUCTOR: Amy Wisniewski, Ph.D.
Visiting Assistant Professor of Biology
Olin Hall, Room 328
TEXTS: 1. Basic & Clinical Endocrinology, 7th Ed., McGraw Hill
CLASS TIME: June 6 – July 8, 2005 (on-line)
OFFICE HOURS: I will check my email every M,W,F from 9 am - 5 pm. I will also hold traditional
office hours in Olin 328 every Monday from 9 – 11 am.
GRADING: Midterm (50%) and Final Exam (50%). Exams are time limited. You are allotted 24
hours to complete each exam.
To understand the evolution, physiology and molecular mechanisms underlying the human endocrine system.
Both normal and pathophysiologic development and expression will be considered. A lifespan approach, from
fetal development through geriatric endocrinology, will be employed. Finally, current topics such as hormone
replacement therapy (HRT), sharp increases in the prevalence of diabetes in industrialized nations, the
interface of toxicology and endocrinology, and the improper use of anabolic steroids will be considered.
How this Web Course is Designed to Work
Lecture notes are available on Black Board. It is your responsibility to keep up with the daily textbook
readings. DO NOT FALL BEHIND IN YOUR READING! It will overwhelm you if you allow this to happen.
Use the Black Board notes provided to help you with the assigned readings. If you have questions about the
content of the readings, email me or visit me in my office. Because I cannot proctor you during your exams, I
will test you in such a way that assumes you have access to your textbook and Black Board notes (i.e., exams
are open-book). As such, questions will be “thought questions” that may require you to search additional
information on other sites such as PubMed, as opposed to rote memorization of the material provided.
Mon 06/06: Evolution of the Endocrine System, Classes of Hormones, Actions of Hormones
(pp. 2-4 The Endocrine System, pp. 6-8 Mechanisms of Hormone Action, pp. 8-10
Classes of Hormone Action, pp. 17-19 Evolution of the Endocrine System and pp.
21-23 Actions of Hormones)
Tues 06/07: Hormone Synthesis, Release and Action
(pp. 38-40 Compartmentalization of Eukaryotic Cells and Overview of Hormone
Biosynthesis, p. 50 Endocytosis and Recycling, pp. 51-54 Hormone Export Not
Mediated by Vesicles, pp. 62-65 Receptors, pp. 75-76 Nuclear Receptors)
Weds 06/08: Disorders of the Endocrine System & Techniques for Studying Endocrinology
(pp. 24-28 Disorders of the Endocrine System, pp. 28-34 Approach to the Patient with
Thurs 06/09: Hypothalamus and Pituitary Gland
(pp. 107-108 Anatomy and Embryology, p. 108 Blood Supply, pp. 108-111 Pituitary
Development and Histology, pp. 111-115 Hypothalamic Hormones, pp. 115-116
Posterior Pituitary Hormones, pp. 119-129 Anterior Pituitary Hormones)
Fri 06/10: Growth Patterns and Growth Hormone
(pp. 176-186 Normal Growth, pp. 187-193 Measurement of Growth, pp. 194-208, 211,
212 Disorders of Growth)
Mon 06/13: Growth Patterns and Thyroid Hormones
(pp. 216-227 Anatomy and Physiology of the Thyroid Gland, pp. 232-237 Control of
Thyroid Function, pp. 251-255, 261-264, 275-277 Thyroid Disorders)
Tues 06/14: Adrenal Glands and Glucocorticoids
(pp. 363-364 Adrenal Anatomy, pp. 364-366 Biosynthesis of Cortisol, pp. 367-371
Regulation of Secretion of Cortisol, pp. 384-390 Addison’s Disease, pp. 395, 400-402
Weds 06/15: Endocrinology of Stress and Hypertension
(pp. 414-418 Hypertension of Adrenal Origin, pp. 424-425 Cushing’s Syndrome, pp.
428-435 Hypertension of Renal Origin)
Thurs 06/16: Male Hypothalamic-Pituitary-Gonadal (HPG) Axis
(pp. 478-480 Anatomy of Testis, pp. 480-484 HPG Axis, pp. 488-490 Drugs to Treat
Hypogonadism, pp. 491-493 Klinefelter’s Syndrome, pp. 494-496 Cryptorchidism, pp.
Fri 06/17: Review for Midterm. I will post answers to any questions that you send to me
covering the previous 9 lectures on Black Board for everyone to review. You must
send your questions no later than 5 p.m. today if you expect to have them answered.
Mon 06/20: Midterm exam (50%) available at 9 a.m. today and due tomorrow (06/21) at 9
Tues 06/21: Abnormalities in Male Sex Differentiation, Environmental Endocrine Disruption
(Wisniewski et al., 2003 available on Black Board; pp. 569-576 Differentiation of
testis, internal sex ducts and external genitalia, pp. 593-597 Androgen receptor
Weds 06/22: Female Hypothalamic-Pituitary-Gonadal (HPG) Axis
(pp. 511-512 Anatomy of ovary, p. 514 Ovarian steroidogenesis, pp. 514-522 HPG
Axis, pp. 522-528 Amenorrhea, pp. 539-542 Menopause, pp. 547-559 Contraception)
Thurs 06/23: Abnormalities in Female Sex Differentiation, Congenital Adrenal Hyperplasia
(Migeon and Wisniewski, 2003 available on Black Board; pp. 366-367 Synthesis of
adrenal androgens, p. 380 Adrenal androgens, p. 408 Hirsutism and virilism, pp.
584-587 Congenital adrenal hyperplasia due to 21-OH deficiency)
Fri 06/24: Pubertal Development: Hormonal and Genomic Influences and Abuse of
(pp. 608-613 Physiology of puberty, pp. 613-617 Endocrine changes at puberty, pp.
617-625 Delayed puberty, pp.628-635 Precocious puberty)
Mon 06/27: Pancreatic Hormones and Diabetes
(pp. 658-660 Anatomy of the pancreas, pp. 660-666 Insulin, pp. 666-668 Glucagon, p.
669 Type 1 diabetes, pp. 672-675 Type 2 diabetes)
Tues 06/28: Gastrointestinal Endocrinology and Obesity
(pp. 794-795 Definitions and diagnosis, pp. 795-798 Health consequences, pp.
798-801 Macronutrients and energy balance, pp. 803-803 Body fat stores, p. 808
Thyroid, p. 809 Leptin, p. 810 Androgens and GH)
Weds 06/29: Geriatric Endocrinology
(pp. 842-846 Thyroid function, pp. 847-848 Diabetes mellitus, pp. 850-851
Osteoporosis, pp. 859-861 Glucocorticoids, pp. 861-862 HPG axis in men)
Thurs 06/30: Endocrinology and HIV/AIDS
(pp. 893-895 Thyroid disorders, pp. 895-897 Adrenal disorders, p. 897 Bone
disorders, pp. 897-898 Gonadal disorders, p. 898 Pituitary disorders, pp. 898-899
Fri 07/01: Circadian and Seasonal Endocrinology (no additional reading)
Mon 07/04: No class, 4th of July
Tues 07/05: Bone Metabolism and Osteoporosis
(pp. 330-334 Bone Anatomy and Remodeling, pp. 295-296 Calcium Metabolism, pp.
296-302 PTH, pp. 302-304 Calcitonin, pp. 304-308 Vitamin D, pp. 335-343
Weds 07/06: Review for Final. I will post answers to any questions that you send to me covering
the previous 10 lectures on Black Board for everyone to review. You must send your
questions no later than 5 p.m. today if you expect to have them answered.
Thurs 07/07: Final exam available at 9 a.m.
Fri 07/08: Final exam due today at 9 a.m.
A = 90 - 100%
B = 80 - 89%
C = 70 - 79%
D = 60 - 69%
Academic integrity is expected in this class. Please familiarize yourself with Drake University’s policy on
academic integrity provided in the handbook for the College of Arts and Sciences. The penalty for cheating on
an exam includes receiving a “0” score and a formal report to the Office of Dean of Arts and Sciences.
Disability Services Statement
If you have a disability and require special accommodations for this course, I am happy to discuss those needs
with you. Accommodations are coordinated through Student Disability Services. Please contact Chrystal
Stanley, Director of Student Disability Services at x1835 or email@example.com for further information.