CURRICULUM VITAE

                         ARTHUR GUTIERREZ-HARTMANN, M.D.
                                      Departmen...
Honors and Awards:
 Alpha Epsilon Delta, Pre-Medical Honor Society (1969-71)
 Spain-Leff Memorial Scholarship (1969-71)
 S...
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     and Chair, ...
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8.    Gutierr...
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25.   Kee...
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41.   Gordon...
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58.   Brad...
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74.   Duval...
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  1. 1. CURRICULUM VITAE ARTHUR GUTIERREZ-HARTMANN, M.D. Department of Medicine University of Colorado Denver/Anschutz Medical Campus P. O. Box 6511, Mail Stop 8106 Aurora, CO 80045 Phone: (303)-724-3921; Fax: (303)- 724-3920 E Mail: a.gutierrez-hartmann@UCHSC.edu Web pages: http://www.uchsc.edu/molbio/gutierreza.htm www.uchsc.edu/reproductive-sciences/faculty/gutierrez.htm http://www.uchsc.edu/sm/mstp Education and Training: U. of Texas at Austin, TX B.A. 1971 Chemistry U. of Texas-Southwestern, Dallas, TX M.D. 1975 Medicine U. of Texas-Southwestern, Dallas, TX Grad School 1977 Biochemistry (Mentor: Ronald A. Butow, Ph.D.) Stanford University Hospitals, Palo Alto, CA Residency 1977-80 Internal Medicine Univ. of California, San Francisco, CA Res. Fellow 1980-83 Molecular Endo (Mentor: John D. Baxter, M.D.) Appointments & Research Experience: 2006-present Training faculty and Steering Committee member, Cancer Biology Graduate Program 2004-present Training faculty and Steering Committee member, Reproductive Biology Graduate Program 1996-present Professor, Departments of Medicine and of Biochemistry & Molecular Genetics, University of Colorado Health Sciences Center at Fitzsimons, Aurora, CO. 1994-persent Director, Medical Scientist Training Program (NIH T32 GM 08497) 1994-2007 Program Director, Molecular & Structural Biology Program, Colorado Comprehensive Cancer Center, University of Colorado Health Sciences Center, Aurora, CO. 1992-1996 Associate Professor, Departments of Medicine and of Biochemistry, Biophysics & Genetics, University of Colorado Health Sciences Center, Denver, CO. 1985-present Founding Faculty Member, Interdepartmental Graduate Program in Molecular Biology, University of Colorado Health Sciences Center at Fitzsimons, Aurora, CO. 1985-1995 Member, Molecular Biology and Hormones & Cancer Programs, Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, CO. 1985-present Member, MSTP Training Faculty, University of Colorado Health Sciences Center at Fitzsimons, Aurora, CO. 1985-92 Assistant Professor, Departments of Medicine and of Biochemistry, Biophysics & Genetics, University of Colorado Health Sciences Center, Denver, CO. 1983-85 Instructor, Metabolic Research Unit, Department of Medicine, University of California, San Francisco, CA. 1980-83 Postdoctoral Research Fellow, Metabolic Research Unit, Department of Medicine, University of California, San Francisco, CA. (Mentor: Dr. John D. Baxter).
  2. 2. Honors and Awards: Alpha Epsilon Delta, Pre-Medical Honor Society (1969-71) Spain-Leff Memorial Scholarship (1969-71) Special Projects Grant, Biochemistry Research, University of Texas (1970) AP Giannini-Bank of America Fellowship Award (1980-82) NIH New Investigator Research Award (1983-86) Faculty Development Award, University of California, San Francisco (1983) Pew Scholars Award in the Biomedical Sciences (1986-90) Associate Investigator of the Lucille P. Markey Program in Molecular Biology (1990-1996) American Society for Clinical Investigation (elected to membership 1993) Chancellor’s Award for Promoting and Supporting Diversity, 2002 The 2002 SACNAS Distinguished Scientist of the Year Award University of Colorado President’s Award for Diversity, MST Program, 2002 American Cancer Society Council, 2004-2008 University of Colorado, Emerging Leaders Program, 2004-2005 University of Vermont MD/PhD Program Keynote Speaker, July, 2007 Cornell University-Rockefeller-Sloan Kettering Tri-Institutional MSTP Keynote Speaker, Sept, 2007 The 2008 AACR-Minorities in Cancer Research- Jane Cooke Wright Lectureship Award The 2009 Endocrine Society Distinguished Educator Award Research Interests: Tissue-specific, hormone-regulated, and oncogene-mediated mechanisms controlling gene expression and cell-specific fates in pituitary cells. Ets transcription factors in epithelial cell branching morphogenesis and epithelial (breast and GI) cancers. Professional Experience: Editorial Board: DNA and Cell Biology (1986-present); Endocrinology (1990-94); Molecular Endocrinology (1995-2002); Journal Experimental Biology and Medicine (2000-present); Journal of Biological Chemistry (2001-06); Journal of Endocrinology (2006-2010); Endocrine Reviews (2006-08); Associate Editor, Molecular Endocrinology (2008-13). Grant Reviewer: NSF Cellular Physiology Program (ad hoc, 1983); NSF Molecular & Cellular Biosciences (ad hoc, 1991-92); NSF Neuroendocrinology (ad hoc, 1993); VA Merit Review (1986-94); Colorado Heart Association (1986-88); NIH Biochemical Endocrinology Study Section (ad hoc, 1989; Resident member, 1994-98); ACS Biochemistry & Endocrinology Study Section (ad hoc, 1990 & 1992); Cancer League of Colorado, Chairperson (1990-92); NIH Endocrinology Site Visit Study Section (1991); UCHSC Institutional Committees for ACS Awards (1991-94); for Pew Scholar candidate selection (1995); for HHMI candidate selection (1996); MRC Canada (1995); Cancer Research Campaign, Great Britain (1999); American Cancer Society, Tumor Biochemistry & Endocrinology Study Section (1999-02); NIH NIGMS Biomedical Research Training-A IRG (2000-04); HHMI Research Fellowships for Medical Students Program (2001-2003). American Cancer Society Council (2004-08). NIH Molecular & Cellular Endocrinology Study Section (2008-2011). Manuscript Reviewer: DNA and Cell Biology; Molecular Endocrinology; Endocrinology; Neuroendocrinology; Nucleic Acids Research; Biochemistry Biophysica Acta; Trends in Genetics; Trends in Biochemistry; Molecular and Cellular Biology; Proceedings of the National Academy of Sciences; Science; Journal of Biological Chemistry; Cell Growth & Differentiation. Professional Societies/Activities: Endocrine Society; American Federation for Clinical Research; Western Society for Clinical Research; AAAS; American Society for Clinical Investigation (elected to membership 1993); American Association for Cancer Research; American Society for Biochemistry and Molecular Biology; and FASEB. Co-Chair, 2004 Prolactin Gordon Conference
  3. 3. AGH-CV Page 3 and Chair, 2006 Prolactin Gordon Conference. 2004 & 2006 AAMC GREAT Group National Meetings, Organizing Committee. Association of MD/PhD Directors (1994-current; President, 2005-06). GREAT Group-MD/PhD Section President (2005-06). Steering Committee, AAMC GREAT Group (2005-08). Chair, 2006 Prolactin Gordon Conference. ACS Council (2004-2008). NIH Molecular & Cellular Endocrinology IRG (2007-2011). School of Medicine: Steering Committee Member, Medical Scientist Training Program (1986-); Chairman, Clinical Transition Committee, Medical Scientist Training Program (1988-); Steering Committee Member, Interdepartmental Graduate Program in Molecular Biology (1987-94); Student Advisor and Chairman, Student Advisory Committee, Interdepartmental Graduate Program in Molecular Biology (1990-94); Institutional Transgenic Core Committee (1990-95); Selection Committee Member, Dean's Distinguished Seminar Series (1990-96); Minority Initiative Committee (1991-); Dean's Advisory Committee (1992-96); Selection Committee Member, Molecular Biology/Biochemistry Full Professor Search Committee (1992); Organizer, Molecular Genetics Course for Clinical Fellows (1992-95); Selection Committee Member, Biochemistry, Biophysics & Genetics Chairperson Search Committee (1993 & 1994); Director, Medical Scientist Training Program (1994-); Program Leader, Molecular & Structural Biology Program, Colorado Cancer Center (1994-). Internal Selection Committee, Pew Scholars Award in Biomedicine (1995 & 97); Internal Selection Committee, Howard Hughes Medical Institute (1995 & 98); Vice- president (1997-98) and Member (1997-), Board of Directors, Association of MD-PhD Training Program Directors; Co-chair, Graduate School Reorganization Committee (1996); Chairman, Graduate Core Curriculum Planning Committee (1996); Member, Analysis of Graduate Education Funding Committee (2000-01); Member (1994-present) and Chair (2001-), Graduate School Executive Council; Chair, SOM Dean’s Research Advisory Committee (2003-06). Publications: 1. Allison JP, Davidson L, Gutierrez-Hartmann A, Kitto GB. Insolubilization of L-asparaginase by covalent attachment to nylon tubing. Biochem Biophys Res Comm 47:66, 1972. 2. Bennett WF, Gutierrez-Hartmann A, Butow RA. The role of mitochondrial-bound 80S ribosomes in mitochondrial biogenesis. In: Interdisciplinary Conference on the Genetics and Biogenesis of Mitochondria and Chloroplasts, North Holland Press, Amsterdam, 1977. 3. Pont A, Gutierrez-Hartmann A. Cushing's disease: Recurrence after a surgically-induced remission. Arch Intern Med 139:938, 1979. 4. Eberhardt NL, Selby M, Cathala G, Karin M, Gutierrez-Hartmann A, Mellon SH, Lan NC, Gardner DG, Baxter JD. The growth hormone gene family: Structure, evolution, expression and regulation. In: Gene Regulation. UCLA Symposia on Molecular and Cellular Biology, Vol. 26, BW O'Malley, Ed. Academic Press, New York, 1982. 5. Cathala G, Eberhardt NL, Lan NC, Gardner DG, Gutierrez-Hartmann A, Mellon SH, Karin M, Baxter JD. Structure and expression of growth hormone-related genes. In: Perspectives on Genes and the Molecular Biology of Cancer. DL Robberson GF Saunders, Eds. Raven Press, New York, 1983. 6. Gutierrez-Hartmann A, Lieberburg I, Gardner DG, Baxter JD, Cathala G. Transcription of two classes of rat growth hormone-gene associated repetitive DNA: Differences in activity and effects of tandem repeat structure. Nucleic Acids Res 12:7153, 1984. 7. Gutierrez-Hartmann A, Baxter JD. Stable accumulation of a rat truncated repeat transcript in Xenopus oocytes. Proc Natl Acad Sci USA 83:3106, 1986.
  4. 4. AGH-CV Page 4 8. Gutierrez-Hartmann A, Baxter JD. Differential ability of various plasmid DNAs to sequester inhibitors of RNA polymerase III transcription. DNA 6:231, 1987. 9. Gutierrez-Hartmann A, Siddiqui S, Loukin S. Selective transcription and DNAse I protection of the rat prolactin gene by GH3 pituitary cell-free extracts. Proc Natl Acad Sci USA 84:5211, 1987. 10. Mellon SH, Baxter JD, Gutierrez-Hartmann A. Cell-specific expression of transfected brain identifier repetitive DNAs. Nucleic Acids Research 16:3963, 1988. 11. Gutierrez-Hartmann A. Basics of Transcription Control. In: Introduction to Endocrine Investigation 1988: Techniques and Concepts, Serono Symposia, USA Press, 1988. 12. Keech CA, Gutierrez-Hartmann A. Analysis of rat prolactin promoter sequences that mediate pituitary-specific and cAMP-regulated gene expression in vivo. Molecular Endo 3:832, 1989. 13. Alexander LM, Gordon DF, Wood WM, Ridgway EC, Gutierrez-Hartmann A. Identification of thyrotroph-specific factors and cis-acting sequences of the murine thyrotropin ß-subunit gene. Molecular Endo 3:1037, 1989. 14. Ocran KW, Sarapura VD, Wood WM, Gordon DF, Gutierrez-Hartmann A, Ridgway EC. Identification of cis-acting promoter elements important for expression of the mouse glycoprotein hormone α-subunit gene in thyrotropes. Molecular Endo 4:766, 1990. 15. Raynolds MV, Awald PD, Gordon DF, Gutierrez-Hartmann A, Rule DC, Wood WM, Eckel RH. Lipoprotein lipase gene expression is regulated by isoproteronol and insulin through different mechanisms. Molecular Endo 4:1416, 1990. 16. Alexander LM, Williamson DJ, Wood WM, Gordon DF, Ridgway EC, Gutierrez-Hartmann A. Activation of the murine thyrotropin ß-subunit promoter by GH4 rat pituitary cell-free extracts. Molecular Endo 4:1887, 1990. 17. Wood WM, Ocran KW, Kao MY, Gordon DF, Alexander LM, Gutierrez-Hartmann A, Ridgway EC. Protein factors in thyrotropic tumor nuclear extracts bind to a region of the mouse thyrotropin ß-subunit promoter essential for expression in thyrotropes. Molecular Endo 4:1897, 1990. 18. Gutierrez-Hartmann A. Pituitary-specific expression of the rat prolactin gene. In: Molecular and Clinical Advances in Pituitary Disorders. S Melmed and RJ Robbins, Eds. Blackwell Scientific Publications, Cambridge, Mass., 1991. 19. Keech CA, Gutierrez-Hartmann A. Insulin activation of the rat prolactin promoter. Mol Cell Endo 78:55, 1991. 20. Harvey C, Jackson SM, Siddiqui SK, Gutierrez-Hartmann A. Structure-function analysis of the rat prolactin promoter: Phasing requirements of proximal cell-specific elements. Molecular Endo 5:836, 1991. 21. Reusch JE-B, Kleinschmidt-DeMasters BK, Lillehei K, Rappe D, Gutierrez-Hartmann A. Preoperative diagnosis of lymphocytic hypophysitis (adenohypophysitis) unresponsive to short course dexamthasone- a case report. Neurosurgery 30:268, 1992. 22. Jackson SM, Keech CA, Williamson DJ, Gutierrez-Hartmann A. The interaction of basal positive and negative transcription elements controls the repression of the proximal rat prolactin promoter in nonpituitary cells. Mol Cell Biol 12:2708, 1992. 23. Conrad KE, Gutierrez-Hartmann A. The ras and protein kinase A pathways are mutually antagonistic in regulating rat prolactin promoter activity. Oncogene 7: 1279-1286, 1992. 24. Smith MF, Eidlen D, Brewer MT, Eisenberg SP, Arend W, Gutierrez-Hartmann A. The human IL-1 receptor antagonist promoter: Cell type-specific activity and identification of regulatory regions. J Immunol 149:2000, 1992.
  5. 5. AGH-CV Page 5 25. Keech CA, Jackson SM, Siddiqui SK, Ocran KW, Gutierrez-Hartmann A. Cyclic AMP activation of the rat prolactin promoter is restricted to the pituitary specific cell-type. Molecular Endo 6:2059, 1992. 26. Kroll DJ, Sullivan DM, Gutierrez-Hartmann A, Hoeffler JP. Modification of DNA topoisomerase II activity via direct interactions with CREB and related transcription factors. Molecular Endo 7:305, 1993. 27. Kroll DJ, Abdel-Hafiz H A-M, Marcell T, Simpson S, Chen C-Y, Gutierrez-Hartmann A, Lustbader JW, Hoeffler JP. A multifunctional prokaryotic expression system: Overproduction, affinity purification, and selective detection. DNA and Cell Biol 12:441, 1993. 28. Oberwetter JM, Conrad KE, Gutierrez-Hartmann A. Ras and protein kinase C signaling pathways are functionally antagonistic in GH4 neuroendocrine cells. Molecular Endo 7:915-923, 1993. 29. Jackson SM, Barnhart KM, Mellon PL, Gutierrez-Hartmann A, Hoeffler JP. The role of helix- loop-helix proteins in gonadotropin gene expression. In: Glycoprotein Hormones: Structure, function and clinical implications. JW Lustbader, JD Puett, and R Ruddon, Eds. Plenum Publishing Corp., NY. 1993. 30. Jackson SM, Barnhart KM, Mellon PL, Gutierrez-Hartmann A, Hoeffler JP. Helix-loop-helix proteins are present and differentially expressed in different cell types of the anterior pituitary. Mol Cell Endo 796:167, 1993. 31. Conrad KE, Oberwetter JM, Vallaincourt R, Johnson GL, Gutierrez-Hartmann A. Identification of the functional components of the ras signaling pathway regulating pituitary-specific gene expression. Mol Cell Biol 14:1553-1565, 1994. 32. Pickett CA, Gutierrez-Hartmann A. Ras mediates Src but not EGF-Receptor tyrosine kinase signaling pathways in GH4 neuroendocrine cells. Proc Natl Acad Sci USA 18:8612-8616, 1994. 33. Smith MF, Eidlen D, Arend W, Gutierrez-Hartmann A. LPS-induced expression of the human IL-1 receptor antagonist gene is controlled by multiple promoter elements. J. Immunol 153:3584, 1994. 34. Steinmetz R, Gutierrez-Hartmann A, Bigsby RM, Ben-Jonathan N. Activation of the prolactin promoter in transfected GH3 cells by posterior pituitary cells. Endocrinology 135:2737, 1994. 35. Gutierrez-Hartmann, A. Pit-1/GHF-1: A pituitary-specific transcription factor linking general signaling pathways to cell-specific gene expression. (Minireview: Cover Article). Molecular Endo 8:1447-1449, 1994. 36. Rajnarayan S, Chiono M, Alexander LM, Gutierrez-Hartmann A. Reconstitution of protein kinase A regulation of the rat prolactin promoter in HeLa nonpituitary cells: Identification of both GHF-1/Pit-1-dependent and -independent mechanisms. Molecular Endo 9:502, 1995. 37. Jackson SM, Gutierrez-Hartmann A, Hoeffler JP. Upstream stimulatory factor (USF), a basic- helix-loop-helix-zipper protein, regulates the activity of the alpha-glycoprotein hormone subunit gene in pituitary cells. Molecular Endo 9:278, 1995. 38. Bradford AP, Conrad KE, Wasylyk C, Wasylyk B, Gutierrez-Hartmann A. Functional interaction of c-Ets-1 and GHF-1/Pit-1 mediates Ras activation of pituitary-specific gene expression: Mapping of the essential c-Ets-1 domain. Mol Cell Biol 15:2849, 1995. 39. Pickett CA, Gutierrez-Hartmann A. EGF and Ras mediates mediate separate but antagonistic signaling pathways in GH4 pituitary cells. Mol Cell Biol 15:6667, 1995. 40. Atkinson BL, Fantle KS, Ruegg P, Ryan M, Huffer WE, Gutierrez-Hartmann A. Elucidation of homeodomain protein Cart-1 function during in vitro chondrogenesis of 10T1/2 micromass cultures. Ann NY Acad Sci 785:206, 1996.
  6. 6. AGH-CV Page 6 41. Gordon DF, Wagner J, Atkinson BL, Chiono M, Berry R, Sikela J, Gutierrez-Hartmann A. Human Cart-1: Structural organization, chromosomal localization and functional analysis of a cartilage-specific homeodomain cDNA. DNA & Cell Biol 15:531, 1996. 42. Farrow KN, Manning N, Schaufele F, Gutierrez-Hartmann A. The c-Jun δ-domain inhibits neuroendocrine promoter activity in a DNA sequence- and pituitary-specific manner. J Biol Chem 271:17139, 1996. 43. Bradford AP, Conrad KE, Tran PH, Ostrowski MC, Gutierrez-Hartmann A. GHF-1/Pit-1 functions as a cell-specific integrator of Ras signaling by targeting the Ras pathway to a composite Ets-1/GHF-1 response element. J Biol Chem 271:24639, 1996. 44. Diamond SE, Gutierrez-Hartmann, A. A 26 amino acid insertion domain defines a functional transcription switch motif in Pit-1ß. J Biol Chem 271:28925, 1996. 45. Wasylyk C, Bradford AP, Gutierrez-Hartmann A, Wasylyk B. Conserved mechanisms of Ras regulation of evolutionary related transcription factors, Ets-1 and Pointed P2. Oncogene 14:899-913, 1997. 46. Bradford AP, Tran PH, Wasylyk C, Wasylyk B, Gutierrez-Hartmann A. Interaction of Ets-1 and the POU-homeodomain protein GHF-1/Pit-1 reconstitutes pituitary-specific gene expression. Mol Cell Biol 17:1065-1074, 1997. 47. Guthridge CJ, Eidlen D, Arend WP, Gutierrez-Hartmann A, Smith Jr MF. Lipopolysaccharide and Raf-1 or MEK kinase regulate secretory IL-1 receptor antagonist gene expression by mutually antagonistic mechanisms. Mol Cell Biol 17: 1118-1128, 1997. 48. Pickett CA, Gutierrez-Hartmann A. Molecular and Cellular Ontogeny of Distinct Pituitary Cell Types. IN: Pituitary Diseases: Diagnosis and Treatment. ME Wierman, Ed. Humana Press, Totowa, NY. 1997 49. Atkinson BL, Fantle KS, Benedict J, Huffer WE, Gutierrez-Hartmann A. A combination of osteoinductive bone proteins differentiates mesenchymal C3H/10T1/2 cells specifically to the cartilage lineage. J Cell Biochem 65:325-339, 1997. 50. Tentler JJ, Hadcock JR, Gutierrez-Hartmann A. Somatostatin acts by inhibiting cAMP/protein kinase A pathway, CREB phosphorylation and CREB transcription potency. Molecular Endo 11:859-866, 1997. 51. Jensen DR, Schlepfer IR, Morin CL, Pennington DS, Marcell T, Ammon SM, Gutierrez- Hartmann A, Eckel RH. Prevention of diet-induced obesity in transgenic mice overexpressing skeletal muscle lipoprotein lipase. Am J Physiol 273: R683-R689, 1997. 52. Schweppe RE, Frazer-Abel A, Gutierrez-Hartmann A, Bradford AP. Functional components of FGF signal transduction in pituitary cells: Identification of FGF response elements in the prolactin gene. J Biol Chem: 272:30852-30859, 1997. 53. Wasylyk B, Hagman, J, Gutierrez-Hartmann, A. ETS transcription factors: Nuclear effectors of the Ras/MAPK signaling pathway. Trends in Bioch. Sci. 23: 213-216, 1998. 54. Diamond SE, Chiono M, Gutierrez-Hartmann A. Reconstitution of the protein kinase A response of the rat prolactin promoter: Differential effects of distinct Pit-1 isoforms and functional interaction with Oct-1. Molecular Endo 13:228-238, 1998. 55. Farrow KN, Gutierrez-Hartmann A. Transforming Growth Factor-ß1 inhibits rat prolactin promoter activity in GH4 neuroendocrine cells. DNA & Cell Biol 18:863-873, 1999. 56. Bradford AP, Brodsky KS, Diamond SE, Kuhn LC, Liu Y, Gutierrez-Hartmann A. The Pit-1 homeodomain and ß-domain interact with Ets-1 and modulate synergistic activation of the rat prolactin promoter. J. Biol. Chem. 275: 3100-3106, 2000. 57. Diamond SE, Gutierrez-Hartmann A. The Pit-1ß-domain dictates active repression and alteration of histone acetylation of the proximal rat prolactin promoter. J. Biol. Chem. 275: 30977-30986, 2000.
  7. 7. AGH-CV Page 7 58. Bradford AP, Gutierrez-Hartmann A. Ets transcription factors: Nuclear integrators of signaling pathways iregulating endocrine gene expression and carcinogenesis. IN: gene Engineering and Molecular Models in Endocrinology. MA Shupnik, Ed. Humana Press, Totowa, NY, 2000. 59. Schweppe RE, Gutierrez-Hartmann A. Pituitary Ets-1 and GABP bind to the growth factor regulatory sites of the rat prolactin promoter. Nucl. Acids Res. 29:1251-1260, 2001. 60. Dunkelburg JA, Gutierrez-Hartmann A. LZ-FYVE: A novel developmental stage-specific leucine zipper, FYVE-finger protein. DNA & Cell Biology 20:403-412, 2001. 61. Duval DL, Gutierrez-Hartmann A. PRL-releasing peptide stimulation of PRL gene transcription--enter AKT. Endocrinology 143:11-12, 2002. 62. Tentler JJ, Diamond SE, Gutierrez-Hartmann A. Pituitary hormone gene regulation. In: Genetics in Endocrinology. JD Baxter, S Melmed and M New, Eds. (Modern Endocrinology). Lippincott Williams & Wilkins, Philadelphia, PA. 2002. pp 565-584. 63. Augustijn KD*, Duvall DL*, Wechselberger R, Kaptein R, Gutierrez-Hartmann A, van der Vliet, PC. Structural characterization of the Pit-1/Ets-1 interaction: Pit-1 phosphorylation regulates Pit-1/Ets-1 binding. Proc. Natl. Acad. Sci. USA 99:12657-12662, 2002. (* dual first authors). 64. Pickett CA, Manning N, Akita Y, Gutierrez-Hartmann A. Role of specific protein kinase C isozymes in mediating epidermal growth factor, thyrotropin-releasing hormone, and phorbol ester regulation of the rat prolactin promoter in GH4/GH4C1 pituitary cells. Mol Endocrinol. 16:2840-2852, 2002. 65. Tentler JJ, AP Bradford, RE Schweppe, Gutierrez-Hartmann A. Selective repression of prolactin gene transcription by stable expression of dominant-negative Ets in GH4 rat pituitary cells. Endocrine 20:3-12, 2003 (Invited submission to for issue dedicated to prolactin biology). 66. Eckel KL, J.T. Tentler, G.J. Cappetta, S.E. Diamond, Gutierrez-Hartmann A. The epithelial- specific ETS transcription factor ESX/ESE-1/Elf-3 modulates breast cancer-associated gene expression. DNA & Cell Biol. 22:79-94, 2003. 67. Schweppe RE, Melton AA, Eads M, Aveline L, Resing, K, Ahn NG, Gutierrez-Hartmann A. Purification and mass spectrometric identification of GABP as the functional pituitary Ets factor binding to the basal transcription element of the prolactin promoter. J. Biol. Chem. 278:16863-16872, 2003. 68. Duval DL, Jean A, Gutierrez-Hartmann A. Ras signaling and transcriptional synergy at a flexible Ets-1/Pit-1 composite element is defined by the assembly of selective activation domains. J. Biol Chem. 278:18543-18552, 2003. 69. Schedin PJ, Eckel KL, McDaniel SM, Prescott JD, Brodsky KS, Tentler JJ, Gutierrez-Hartmann A. ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells. Oncogene 23:1766-1779, 2004. 70. Coletta RD, Jedlicka P, Gutierrez-Hartmann A, Ford HL. Transcriptional control of the cell cycle in mammary gland development and tumorigenesis. (Invited review). J Mamm Gland Biol 9:39-53, 2004. 71. Prescott JD, Koto K, Singh M, Gutierrez-Hartmann A. The ETS transcription factor ESE-1 transforms MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Mol Cell Biol 24:5548-5564, 2004. 72. Farrow KN, Bradford AP, Tentler JJ, Gutierrez-Hartmann A. Structural and functional analysis of the differential effects of c-Jun and v-Jun on prolactin gene expression. Mol Endocrinol 18:2479-2490, 2004. 73. Ferry AL, Locasto DM, Meszaros L, Bailey JC, Jonsen MD, Brodsky KS, Hoon CJ, Gutierrez- Hartmann A, Diamond SE. Pit-1ß reduces transcription and CBP recruitment in a DNA context- dependent manner. J Endocrinology 185:173-185, 2005.
  8. 8. AGH-CV Page 8 74. Duval DL, Jonsen MD, Diamond SE, Murapa P, Jean A, Gutierrez-Hartmann A. Differential utilization of transcription activation subdomains by distinct coactivators regulates Pit-1 basal and Ras responsiveness. J Biol Chem 21: 172-185, 2006. 75. Gutierrez-Hartmann A, Duval DL, Bradford AP. ETS transcription factors in endocrine systems. Trends Endocrinol Metab, 18(4): 150-158, 2007. 76. Jedlicka P, Gutierrez-Hartmann A. ETS transcription factors in intestinal morphogenesis and disease. Histol Histopathol 23:1417-1424, 2008. 77. Jedlicka P, Sui, X, Sussell, L, Gutierrez-Hartmann A. Epithelial Ets transcription factors regulate small intestinal crypt-villus homeostasis and tumorigenesis. Am J Path, in press. 78. Jonsen MD, Duval DL, Gutierrez-Hartmann A. The 26-amino acid ß-motif of the Pit-1ß transcription factor is an independent repressor domain possessing protein and DNA context dependent and independent activity. Mol Endocrinol, accepted. 79. Walker DM, Pozcobutt J, Gonzales MS, Horita H, Gutierrez-Hartmann A. ESE-1 is required to maintain the transformed phenotype of MCF-7 and ZR-75 human mammary epithelial cells. Submitted. 80. Jedlicka P, Sui, X, Gutierrez-Hartmann A. A dominant ETS repressor enhances gastrointestinal tumorigenesis in APCmin mice. Submitted. 81. Prescott JD, Gonzales M, Gutierrez-Hartmann A. Nuclear Import and Export Sequences in the Oncogenic ETS Protein ESE-1: ESE-1-Mediated Transformation of MCF-12A Human Mammary Epithelial Cells Requires ESE-1 Nuclear Export. Submitted. 82. Siwanon J, Osmundson E, Duval DL, Branson-Smith K, Ott C, Moons DS, Ray D, Gutierrez- Hartmann A, Kiyokawa H. G1-Regulatory cyclin D/Cdk4 negatively modulates the Ets- dependent activity of the prolactin promoter. Submitted. 83. Duval DL, Jonsen MD, Jean A, Cuaron JJ, Jirawatnotai S, Kiyokawa H, Gutierrez-Hartmann A. Biological functions of Pit-1ß: A pituitary specific transcription repressor that diminishes cell cycle progression, proliferation and tumorigenic growth of GH4 somatolactotrope cells. In preparation. 84. Prescott JD, Jedlicka P, Duval DL, Tentler JJ, Gutierrez-Hartmann A. Molecular mechanisms underlying ETS transcription factor-mediated transformation of human mammary epithelial cells. IN: Progress in Nucleic Acid Research and Molecular Biology. Vol . K Moldave, Ed. Academic Press, San Diego, CA. (Invited review). 85. Tentler JJ, Eckel K, Hadcock JR, Gutierrez-Hartmann A. Signaling via the type 2 somatostatin receptor (sst2A) inhibits growth factor-stimulated MAP Kinase pathway in GH4 pituitary cells. In preparation. 86. Hahm JR, Gutierrez-Hartmann A. Redundant co-repressor proteins restrict the Ras response of the rat prolactin promoter with HDAC3 and SMRTß providing dominant inhibition via differential interaction with Pit-1 and Ets-1. In preparation. 87. Hahm JR, Gutierrez-Hartmann A. Interaction of TRAP220/MED220 with Pit-1 governs basal but not Ras-induced rat prolactin promoter activity. In preparation.

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