ARTHUR GUTIERREZ-HARTMANN, M.D.
Department of Medicine
University of Colorado Denver/Anschutz Medical Campus
P. O. Box 6511, Mail Stop 8106
Aurora, CO 80045
Phone: (303)-724-3921; Fax: (303)- 724-3920
E Mail: a.gutierrez-hartmann@UCHSC.edu
Web pages: http://www.uchsc.edu/molbio/gutierreza.htm
Education and Training:
U. of Texas at Austin, TX B.A. 1971 Chemistry
U. of Texas-Southwestern, Dallas, TX M.D. 1975 Medicine
U. of Texas-Southwestern, Dallas, TX Grad School 1977 Biochemistry
(Mentor: Ronald A. Butow, Ph.D.)
Stanford University Hospitals, Palo Alto, CA Residency 1977-80 Internal Medicine
Univ. of California, San Francisco, CA Res. Fellow 1980-83 Molecular Endo
(Mentor: John D. Baxter, M.D.)
Appointments & Research Experience:
2006-present Training faculty and Steering Committee member, Cancer Biology Graduate Program
2004-present Training faculty and Steering Committee member, Reproductive Biology Graduate
1996-present Professor, Departments of Medicine and of Biochemistry & Molecular Genetics,
University of Colorado Health Sciences Center at Fitzsimons, Aurora, CO.
1994-persent Director, Medical Scientist Training Program (NIH T32 GM 08497)
1994-2007 Program Director, Molecular & Structural Biology Program, Colorado Comprehensive
Cancer Center, University of Colorado Health Sciences Center, Aurora, CO.
1992-1996 Associate Professor, Departments of Medicine and of Biochemistry, Biophysics &
Genetics, University of Colorado Health Sciences Center, Denver, CO.
1985-present Founding Faculty Member, Interdepartmental Graduate Program in Molecular Biology,
University of Colorado Health Sciences Center at Fitzsimons, Aurora, CO.
1985-1995 Member, Molecular Biology and Hormones & Cancer Programs, Colorado Cancer
Center, University of Colorado Health Sciences Center, Denver, CO.
1985-present Member, MSTP Training Faculty, University of Colorado Health Sciences Center at
Fitzsimons, Aurora, CO.
1985-92 Assistant Professor, Departments of Medicine and of Biochemistry, Biophysics &
Genetics, University of Colorado Health Sciences Center, Denver, CO.
1983-85 Instructor, Metabolic Research Unit, Department of Medicine, University of California,
San Francisco, CA.
1980-83 Postdoctoral Research Fellow, Metabolic Research Unit, Department of Medicine,
University of California, San Francisco, CA. (Mentor: Dr. John D. Baxter).
Honors and Awards:
Alpha Epsilon Delta, Pre-Medical Honor Society (1969-71)
Spain-Leff Memorial Scholarship (1969-71)
Special Projects Grant, Biochemistry Research, University of Texas (1970)
AP Giannini-Bank of America Fellowship Award (1980-82)
NIH New Investigator Research Award (1983-86)
Faculty Development Award, University of California, San Francisco (1983)
Pew Scholars Award in the Biomedical Sciences (1986-90)
Associate Investigator of the Lucille P. Markey Program in Molecular Biology (1990-1996)
American Society for Clinical Investigation (elected to membership 1993)
Chancellor’s Award for Promoting and Supporting Diversity, 2002
The 2002 SACNAS Distinguished Scientist of the Year Award
University of Colorado President’s Award for Diversity, MST Program, 2002
American Cancer Society Council, 2004-2008
University of Colorado, Emerging Leaders Program, 2004-2005
University of Vermont MD/PhD Program Keynote Speaker, July, 2007
Cornell University-Rockefeller-Sloan Kettering Tri-Institutional MSTP Keynote Speaker, Sept, 2007
The 2008 AACR-Minorities in Cancer Research- Jane Cooke Wright Lectureship Award
The 2009 Endocrine Society Distinguished Educator Award
Tissue-specific, hormone-regulated, and oncogene-mediated mechanisms controlling gene expression
and cell-specific fates in pituitary cells. Ets transcription factors in epithelial cell branching
morphogenesis and epithelial (breast and GI) cancers.
Editorial Board: DNA and Cell Biology (1986-present); Endocrinology (1990-94); Molecular
Endocrinology (1995-2002); Journal Experimental Biology and Medicine (2000-present); Journal
of Biological Chemistry (2001-06); Journal of Endocrinology (2006-2010); Endocrine Reviews
(2006-08); Associate Editor, Molecular Endocrinology (2008-13).
Grant Reviewer: NSF Cellular Physiology Program (ad hoc, 1983); NSF Molecular & Cellular
Biosciences (ad hoc, 1991-92); NSF Neuroendocrinology (ad hoc, 1993); VA Merit Review
(1986-94); Colorado Heart Association (1986-88); NIH Biochemical Endocrinology Study Section
(ad hoc, 1989; Resident member, 1994-98); ACS Biochemistry & Endocrinology Study Section
(ad hoc, 1990 & 1992); Cancer League of Colorado, Chairperson (1990-92); NIH Endocrinology
Site Visit Study Section (1991); UCHSC Institutional Committees for ACS Awards (1991-94); for
Pew Scholar candidate selection (1995); for HHMI candidate selection (1996); MRC Canada
(1995); Cancer Research Campaign, Great Britain (1999); American Cancer Society, Tumor
Biochemistry & Endocrinology Study Section (1999-02); NIH NIGMS Biomedical Research
Training-A IRG (2000-04); HHMI Research Fellowships for Medical Students Program
(2001-2003). American Cancer Society Council (2004-08). NIH Molecular & Cellular
Endocrinology Study Section (2008-2011).
Manuscript Reviewer: DNA and Cell Biology; Molecular Endocrinology; Endocrinology;
Neuroendocrinology; Nucleic Acids Research; Biochemistry Biophysica Acta; Trends in Genetics;
Trends in Biochemistry; Molecular and Cellular Biology; Proceedings of the National Academy of
Sciences; Science; Journal of Biological Chemistry; Cell Growth & Differentiation.
Professional Societies/Activities: Endocrine Society; American Federation for Clinical Research;
Western Society for Clinical Research; AAAS; American Society for Clinical Investigation
(elected to membership 1993); American Association for Cancer Research; American Society for
Biochemistry and Molecular Biology; and FASEB. Co-Chair, 2004 Prolactin Gordon Conference
and Chair, 2006 Prolactin Gordon Conference. 2004 & 2006 AAMC GREAT Group National
Meetings, Organizing Committee. Association of MD/PhD Directors (1994-current; President,
2005-06). GREAT Group-MD/PhD Section President (2005-06). Steering Committee, AAMC
GREAT Group (2005-08). Chair, 2006 Prolactin Gordon Conference. ACS Council (2004-2008).
NIH Molecular & Cellular Endocrinology IRG (2007-2011).
School of Medicine: Steering Committee Member, Medical Scientist Training Program (1986-);
Chairman, Clinical Transition Committee, Medical Scientist Training Program (1988-); Steering
Committee Member, Interdepartmental Graduate Program in Molecular Biology (1987-94);
Student Advisor and Chairman, Student Advisory Committee, Interdepartmental Graduate
Program in Molecular Biology (1990-94); Institutional Transgenic Core Committee (1990-95);
Selection Committee Member, Dean's Distinguished Seminar Series (1990-96); Minority Initiative
Committee (1991-); Dean's Advisory Committee (1992-96); Selection Committee Member,
Molecular Biology/Biochemistry Full Professor Search Committee (1992); Organizer, Molecular
Genetics Course for Clinical Fellows (1992-95); Selection Committee Member, Biochemistry,
Biophysics & Genetics Chairperson Search Committee (1993 & 1994); Director, Medical Scientist
Training Program (1994-); Program Leader, Molecular & Structural Biology Program, Colorado
Cancer Center (1994-). Internal Selection Committee, Pew Scholars Award in Biomedicine (1995
& 97); Internal Selection Committee, Howard Hughes Medical Institute (1995 & 98); Vice-
president (1997-98) and Member (1997-), Board of Directors, Association of MD-PhD Training
Program Directors; Co-chair, Graduate School Reorganization Committee (1996); Chairman,
Graduate Core Curriculum Planning Committee (1996); Member, Analysis of Graduate Education
Funding Committee (2000-01); Member (1994-present) and Chair (2001-), Graduate School
Executive Council; Chair, SOM Dean’s Research Advisory Committee (2003-06).
1. Allison JP, Davidson L, Gutierrez-Hartmann A, Kitto GB. Insolubilization of L-asparaginase by
covalent attachment to nylon tubing. Biochem Biophys Res Comm 47:66, 1972.
2. Bennett WF, Gutierrez-Hartmann A, Butow RA. The role of mitochondrial-bound 80S
ribosomes in mitochondrial biogenesis. In: Interdisciplinary Conference on the Genetics and
Biogenesis of Mitochondria and Chloroplasts, North Holland Press, Amsterdam, 1977.
3. Pont A, Gutierrez-Hartmann A. Cushing's disease: Recurrence after a surgically-induced
remission. Arch Intern Med 139:938, 1979.
4. Eberhardt NL, Selby M, Cathala G, Karin M, Gutierrez-Hartmann A, Mellon SH, Lan NC,
Gardner DG, Baxter JD. The growth hormone gene family: Structure, evolution, expression and
regulation. In: Gene Regulation. UCLA Symposia on Molecular and Cellular Biology, Vol. 26,
BW O'Malley, Ed. Academic Press, New York, 1982.
5. Cathala G, Eberhardt NL, Lan NC, Gardner DG, Gutierrez-Hartmann A, Mellon SH, Karin M,
Baxter JD. Structure and expression of growth hormone-related genes. In: Perspectives on Genes
and the Molecular Biology of Cancer. DL Robberson GF Saunders, Eds. Raven Press, New York,
6. Gutierrez-Hartmann A, Lieberburg I, Gardner DG, Baxter JD, Cathala G. Transcription of two
classes of rat growth hormone-gene associated repetitive DNA: Differences in activity and effects
of tandem repeat structure. Nucleic Acids Res 12:7153, 1984.
7. Gutierrez-Hartmann A, Baxter JD. Stable accumulation of a rat truncated repeat transcript in
Xenopus oocytes. Proc Natl Acad Sci USA 83:3106, 1986.
8. Gutierrez-Hartmann A, Baxter JD. Differential ability of various plasmid DNAs to sequester
inhibitors of RNA polymerase III transcription. DNA 6:231, 1987.
9. Gutierrez-Hartmann A, Siddiqui S, Loukin S. Selective transcription and DNAse I protection of
the rat prolactin gene by GH3 pituitary cell-free extracts. Proc Natl Acad Sci USA 84:5211, 1987.
10. Mellon SH, Baxter JD, Gutierrez-Hartmann A. Cell-specific expression of transfected brain
identifier repetitive DNAs. Nucleic Acids Research 16:3963, 1988.
11. Gutierrez-Hartmann A. Basics of Transcription Control. In: Introduction to Endocrine
Investigation 1988: Techniques and Concepts, Serono Symposia, USA Press, 1988.
12. Keech CA, Gutierrez-Hartmann A. Analysis of rat prolactin promoter sequences that mediate
pituitary-specific and cAMP-regulated gene expression in vivo. Molecular Endo 3:832, 1989.
13. Alexander LM, Gordon DF, Wood WM, Ridgway EC, Gutierrez-Hartmann A. Identification of
thyrotroph-specific factors and cis-acting sequences of the murine thyrotropin ß-subunit gene.
Molecular Endo 3:1037, 1989.
14. Ocran KW, Sarapura VD, Wood WM, Gordon DF, Gutierrez-Hartmann A, Ridgway EC.
Identification of cis-acting promoter elements important for expression of the mouse glycoprotein
hormone α-subunit gene in thyrotropes. Molecular Endo 4:766, 1990.
15. Raynolds MV, Awald PD, Gordon DF, Gutierrez-Hartmann A, Rule DC, Wood WM, Eckel RH.
Lipoprotein lipase gene expression is regulated by isoproteronol and insulin through different
mechanisms. Molecular Endo 4:1416, 1990.
16. Alexander LM, Williamson DJ, Wood WM, Gordon DF, Ridgway EC, Gutierrez-Hartmann A.
Activation of the murine thyrotropin ß-subunit promoter by GH4 rat pituitary cell-free extracts.
Molecular Endo 4:1887, 1990.
17. Wood WM, Ocran KW, Kao MY, Gordon DF, Alexander LM, Gutierrez-Hartmann A, Ridgway
EC. Protein factors in thyrotropic tumor nuclear extracts bind to a region of the mouse thyrotropin
ß-subunit promoter essential for expression in thyrotropes. Molecular Endo 4:1897, 1990.
18. Gutierrez-Hartmann A. Pituitary-specific expression of the rat prolactin gene. In: Molecular and
Clinical Advances in Pituitary Disorders. S Melmed and RJ Robbins, Eds. Blackwell Scientific
Publications, Cambridge, Mass., 1991.
19. Keech CA, Gutierrez-Hartmann A. Insulin activation of the rat prolactin promoter. Mol Cell
Endo 78:55, 1991.
20. Harvey C, Jackson SM, Siddiqui SK, Gutierrez-Hartmann A. Structure-function analysis of the
rat prolactin promoter: Phasing requirements of proximal cell-specific elements. Molecular Endo
21. Reusch JE-B, Kleinschmidt-DeMasters BK, Lillehei K, Rappe D, Gutierrez-Hartmann A.
Preoperative diagnosis of lymphocytic hypophysitis (adenohypophysitis) unresponsive to short
course dexamthasone- a case report. Neurosurgery 30:268, 1992.
22. Jackson SM, Keech CA, Williamson DJ, Gutierrez-Hartmann A. The interaction of basal
positive and negative transcription elements controls the repression of the proximal rat prolactin
promoter in nonpituitary cells. Mol Cell Biol 12:2708, 1992.
23. Conrad KE, Gutierrez-Hartmann A. The ras and protein kinase A pathways are mutually
antagonistic in regulating rat prolactin promoter activity. Oncogene 7: 1279-1286, 1992.
24. Smith MF, Eidlen D, Brewer MT, Eisenberg SP, Arend W, Gutierrez-Hartmann A. The human
IL-1 receptor antagonist promoter: Cell type-specific activity and identification of regulatory
regions. J Immunol 149:2000, 1992.
25. Keech CA, Jackson SM, Siddiqui SK, Ocran KW, Gutierrez-Hartmann A. Cyclic AMP
activation of the rat prolactin promoter is restricted to the pituitary specific cell-type. Molecular
Endo 6:2059, 1992.
26. Kroll DJ, Sullivan DM, Gutierrez-Hartmann A, Hoeffler JP. Modification of DNA
topoisomerase II activity via direct interactions with CREB and related transcription factors.
Molecular Endo 7:305, 1993.
27. Kroll DJ, Abdel-Hafiz H A-M, Marcell T, Simpson S, Chen C-Y, Gutierrez-Hartmann A,
Lustbader JW, Hoeffler JP. A multifunctional prokaryotic expression system: Overproduction,
affinity purification, and selective detection. DNA and Cell Biol 12:441, 1993.
28. Oberwetter JM, Conrad KE, Gutierrez-Hartmann A. Ras and protein kinase C signaling
pathways are functionally antagonistic in GH4 neuroendocrine cells. Molecular Endo 7:915-923,
29. Jackson SM, Barnhart KM, Mellon PL, Gutierrez-Hartmann A, Hoeffler JP. The role of helix-
loop-helix proteins in gonadotropin gene expression. In: Glycoprotein Hormones: Structure,
function and clinical implications. JW Lustbader, JD Puett, and R Ruddon, Eds. Plenum
Publishing Corp., NY. 1993.
30. Jackson SM, Barnhart KM, Mellon PL, Gutierrez-Hartmann A, Hoeffler JP. Helix-loop-helix
proteins are present and differentially expressed in different cell types of the anterior pituitary. Mol
Cell Endo 796:167, 1993.
31. Conrad KE, Oberwetter JM, Vallaincourt R, Johnson GL, Gutierrez-Hartmann A. Identification
of the functional components of the ras signaling pathway regulating pituitary-specific gene
expression. Mol Cell Biol 14:1553-1565, 1994.
32. Pickett CA, Gutierrez-Hartmann A. Ras mediates Src but not EGF-Receptor tyrosine kinase
signaling pathways in GH4 neuroendocrine cells. Proc Natl Acad Sci USA 18:8612-8616, 1994.
33. Smith MF, Eidlen D, Arend W, Gutierrez-Hartmann A. LPS-induced expression of the human
IL-1 receptor antagonist gene is controlled by multiple promoter elements. J. Immunol 153:3584,
34. Steinmetz R, Gutierrez-Hartmann A, Bigsby RM, Ben-Jonathan N. Activation of the prolactin
promoter in transfected GH3 cells by posterior pituitary cells. Endocrinology 135:2737, 1994.
35. Gutierrez-Hartmann, A. Pit-1/GHF-1: A pituitary-specific transcription factor linking general
signaling pathways to cell-specific gene expression. (Minireview: Cover Article). Molecular Endo
36. Rajnarayan S, Chiono M, Alexander LM, Gutierrez-Hartmann A. Reconstitution of protein
kinase A regulation of the rat prolactin promoter in HeLa nonpituitary cells: Identification of both
GHF-1/Pit-1-dependent and -independent mechanisms. Molecular Endo 9:502, 1995.
37. Jackson SM, Gutierrez-Hartmann A, Hoeffler JP. Upstream stimulatory factor (USF), a basic-
helix-loop-helix-zipper protein, regulates the activity of the alpha-glycoprotein hormone subunit
gene in pituitary cells. Molecular Endo 9:278, 1995.
38. Bradford AP, Conrad KE, Wasylyk C, Wasylyk B, Gutierrez-Hartmann A. Functional
interaction of c-Ets-1 and GHF-1/Pit-1 mediates Ras activation of pituitary-specific gene
expression: Mapping of the essential c-Ets-1 domain. Mol Cell Biol 15:2849, 1995.
39. Pickett CA, Gutierrez-Hartmann A. EGF and Ras mediates mediate separate but antagonistic
signaling pathways in GH4 pituitary cells. Mol Cell Biol 15:6667, 1995.
40. Atkinson BL, Fantle KS, Ruegg P, Ryan M, Huffer WE, Gutierrez-Hartmann A. Elucidation of
homeodomain protein Cart-1 function during in vitro chondrogenesis of 10T1/2 micromass
cultures. Ann NY Acad Sci 785:206, 1996.
41. Gordon DF, Wagner J, Atkinson BL, Chiono M, Berry R, Sikela J, Gutierrez-Hartmann A.
Human Cart-1: Structural organization, chromosomal localization and functional analysis of a
cartilage-specific homeodomain cDNA. DNA & Cell Biol 15:531, 1996.
42. Farrow KN, Manning N, Schaufele F, Gutierrez-Hartmann A. The c-Jun δ-domain inhibits
neuroendocrine promoter activity in a DNA sequence- and pituitary-specific manner. J Biol Chem
43. Bradford AP, Conrad KE, Tran PH, Ostrowski MC, Gutierrez-Hartmann A. GHF-1/Pit-1
functions as a cell-specific integrator of Ras signaling by targeting the Ras pathway to a composite
Ets-1/GHF-1 response element. J Biol Chem 271:24639, 1996.
44. Diamond SE, Gutierrez-Hartmann, A. A 26 amino acid insertion domain defines a functional
transcription switch motif in Pit-1ß. J Biol Chem 271:28925, 1996.
45. Wasylyk C, Bradford AP, Gutierrez-Hartmann A, Wasylyk B. Conserved mechanisms of Ras
regulation of evolutionary related transcription factors, Ets-1 and Pointed P2. Oncogene
46. Bradford AP, Tran PH, Wasylyk C, Wasylyk B, Gutierrez-Hartmann A. Interaction of Ets-1 and
the POU-homeodomain protein GHF-1/Pit-1 reconstitutes pituitary-specific gene expression. Mol
Cell Biol 17:1065-1074, 1997.
47. Guthridge CJ, Eidlen D, Arend WP, Gutierrez-Hartmann A, Smith Jr MF. Lipopolysaccharide
and Raf-1 or MEK kinase regulate secretory IL-1 receptor antagonist gene expression by mutually
antagonistic mechanisms. Mol Cell Biol 17: 1118-1128, 1997.
48. Pickett CA, Gutierrez-Hartmann A. Molecular and Cellular Ontogeny of Distinct Pituitary Cell
Types. IN: Pituitary Diseases: Diagnosis and Treatment. ME Wierman, Ed. Humana Press,
Totowa, NY. 1997
49. Atkinson BL, Fantle KS, Benedict J, Huffer WE, Gutierrez-Hartmann A. A combination of
osteoinductive bone proteins differentiates mesenchymal C3H/10T1/2 cells specifically to the
cartilage lineage. J Cell Biochem 65:325-339, 1997.
50. Tentler JJ, Hadcock JR, Gutierrez-Hartmann A. Somatostatin acts by inhibiting cAMP/protein
kinase A pathway, CREB phosphorylation and CREB transcription potency. Molecular Endo
51. Jensen DR, Schlepfer IR, Morin CL, Pennington DS, Marcell T, Ammon SM, Gutierrez-
Hartmann A, Eckel RH. Prevention of diet-induced obesity in transgenic mice overexpressing
skeletal muscle lipoprotein lipase. Am J Physiol 273: R683-R689, 1997.
52. Schweppe RE, Frazer-Abel A, Gutierrez-Hartmann A, Bradford AP. Functional components of
FGF signal transduction in pituitary cells: Identification of FGF response elements in the prolactin
gene. J Biol Chem: 272:30852-30859, 1997.
53. Wasylyk B, Hagman, J, Gutierrez-Hartmann, A. ETS transcription factors: Nuclear effectors of
the Ras/MAPK signaling pathway. Trends in Bioch. Sci. 23: 213-216, 1998.
54. Diamond SE, Chiono M, Gutierrez-Hartmann A. Reconstitution of the protein kinase A response
of the rat prolactin promoter: Differential effects of distinct Pit-1 isoforms and functional
interaction with Oct-1. Molecular Endo 13:228-238, 1998.
55. Farrow KN, Gutierrez-Hartmann A. Transforming Growth Factor-ß1 inhibits rat prolactin
promoter activity in GH4 neuroendocrine cells. DNA & Cell Biol 18:863-873, 1999.
56. Bradford AP, Brodsky KS, Diamond SE, Kuhn LC, Liu Y, Gutierrez-Hartmann A. The Pit-1
homeodomain and ß-domain interact with Ets-1 and modulate synergistic activation of the rat
prolactin promoter. J. Biol. Chem. 275: 3100-3106, 2000.
57. Diamond SE, Gutierrez-Hartmann A. The Pit-1ß-domain dictates active repression and
alteration of histone acetylation of the proximal rat prolactin promoter. J. Biol. Chem. 275:
58. Bradford AP, Gutierrez-Hartmann A. Ets transcription factors: Nuclear integrators of signaling
pathways iregulating endocrine gene expression and carcinogenesis. IN: gene Engineering and
Molecular Models in Endocrinology. MA Shupnik, Ed. Humana Press, Totowa, NY, 2000.
59. Schweppe RE, Gutierrez-Hartmann A. Pituitary Ets-1 and GABP bind to the growth factor
regulatory sites of the rat prolactin promoter. Nucl. Acids Res. 29:1251-1260, 2001.
60. Dunkelburg JA, Gutierrez-Hartmann A. LZ-FYVE: A novel developmental stage-specific
leucine zipper, FYVE-finger protein. DNA & Cell Biology 20:403-412, 2001.
61. Duval DL, Gutierrez-Hartmann A. PRL-releasing peptide stimulation of PRL gene
transcription--enter AKT. Endocrinology 143:11-12, 2002.
62. Tentler JJ, Diamond SE, Gutierrez-Hartmann A. Pituitary hormone gene regulation. In: Genetics
in Endocrinology. JD Baxter, S Melmed and M New, Eds. (Modern Endocrinology). Lippincott
Williams & Wilkins, Philadelphia, PA. 2002. pp 565-584.
63. Augustijn KD*, Duvall DL*, Wechselberger R, Kaptein R, Gutierrez-Hartmann A, van der
Vliet, PC. Structural characterization of the Pit-1/Ets-1 interaction: Pit-1 phosphorylation regulates
Pit-1/Ets-1 binding. Proc. Natl. Acad. Sci. USA 99:12657-12662, 2002. (* dual first authors).
64. Pickett CA, Manning N, Akita Y, Gutierrez-Hartmann A. Role of specific protein kinase C
isozymes in mediating epidermal growth factor, thyrotropin-releasing hormone, and phorbol ester
regulation of the rat prolactin promoter in GH4/GH4C1 pituitary cells. Mol Endocrinol.
65. Tentler JJ, AP Bradford, RE Schweppe, Gutierrez-Hartmann A. Selective repression of prolactin
gene transcription by stable expression of dominant-negative Ets in GH4 rat pituitary cells.
Endocrine 20:3-12, 2003 (Invited submission to for issue dedicated to prolactin biology).
66. Eckel KL, J.T. Tentler, G.J. Cappetta, S.E. Diamond, Gutierrez-Hartmann A. The epithelial-
specific ETS transcription factor ESX/ESE-1/Elf-3 modulates breast cancer-associated gene
expression. DNA & Cell Biol. 22:79-94, 2003.
67. Schweppe RE, Melton AA, Eads M, Aveline L, Resing, K, Ahn NG, Gutierrez-Hartmann A.
Purification and mass spectrometric identification of GABP as the functional pituitary Ets factor
binding to the basal transcription element of the prolactin promoter. J. Biol. Chem.
68. Duval DL, Jean A, Gutierrez-Hartmann A. Ras signaling and transcriptional synergy at a
flexible Ets-1/Pit-1 composite element is defined by the assembly of selective activation domains.
J. Biol Chem. 278:18543-18552, 2003.
69. Schedin PJ, Eckel KL, McDaniel SM, Prescott JD, Brodsky KS, Tentler JJ, Gutierrez-Hartmann
A. ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A
mammary epithelial cells. Oncogene 23:1766-1779, 2004.
70. Coletta RD, Jedlicka P, Gutierrez-Hartmann A, Ford HL. Transcriptional control of the cell
cycle in mammary gland development and tumorigenesis. (Invited review). J Mamm Gland Biol
71. Prescott JD, Koto K, Singh M, Gutierrez-Hartmann A. The ETS transcription factor ESE-1
transforms MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Mol Cell Biol
72. Farrow KN, Bradford AP, Tentler JJ, Gutierrez-Hartmann A. Structural and functional analysis
of the differential effects of c-Jun and v-Jun on prolactin gene expression. Mol Endocrinol
73. Ferry AL, Locasto DM, Meszaros L, Bailey JC, Jonsen MD, Brodsky KS, Hoon CJ, Gutierrez-
Hartmann A, Diamond SE. Pit-1ß reduces transcription and CBP recruitment in a DNA context-
dependent manner. J Endocrinology 185:173-185, 2005.
74. Duval DL, Jonsen MD, Diamond SE, Murapa P, Jean A, Gutierrez-Hartmann A. Differential
utilization of transcription activation subdomains by distinct coactivators regulates Pit-1 basal and
Ras responsiveness. J Biol Chem 21: 172-185, 2006.
75. Gutierrez-Hartmann A, Duval DL, Bradford AP. ETS transcription factors in endocrine systems.
Trends Endocrinol Metab, 18(4): 150-158, 2007.
76. Jedlicka P, Gutierrez-Hartmann A. ETS transcription factors in intestinal morphogenesis and
disease. Histol Histopathol 23:1417-1424, 2008.
77. Jedlicka P, Sui, X, Sussell, L, Gutierrez-Hartmann A. Epithelial Ets transcription factors
regulate small intestinal crypt-villus homeostasis and tumorigenesis. Am J Path, in press.
78. Jonsen MD, Duval DL, Gutierrez-Hartmann A. The 26-amino acid ß-motif of the Pit-1ß
transcription factor is an independent repressor domain possessing protein and DNA context
dependent and independent activity. Mol Endocrinol, accepted.
79. Walker DM, Pozcobutt J, Gonzales MS, Horita H, Gutierrez-Hartmann A. ESE-1 is required to
maintain the transformed phenotype of MCF-7 and ZR-75 human mammary epithelial cells.
80. Jedlicka P, Sui, X, Gutierrez-Hartmann A. A dominant ETS repressor enhances gastrointestinal
tumorigenesis in APCmin mice. Submitted.
81. Prescott JD, Gonzales M, Gutierrez-Hartmann A. Nuclear Import and Export Sequences in the
Oncogenic ETS Protein ESE-1: ESE-1-Mediated Transformation of MCF-12A Human Mammary
Epithelial Cells Requires ESE-1 Nuclear Export. Submitted.
82. Siwanon J, Osmundson E, Duval DL, Branson-Smith K, Ott C, Moons DS, Ray D, Gutierrez-
Hartmann A, Kiyokawa H. G1-Regulatory cyclin D/Cdk4 negatively modulates the Ets-
dependent activity of the prolactin promoter. Submitted.
83. Duval DL, Jonsen MD, Jean A, Cuaron JJ, Jirawatnotai S, Kiyokawa H, Gutierrez-Hartmann A.
Biological functions of Pit-1ß: A pituitary specific transcription repressor that diminishes cell
cycle progression, proliferation and tumorigenic growth of GH4 somatolactotrope cells. In
84. Prescott JD, Jedlicka P, Duval DL, Tentler JJ, Gutierrez-Hartmann A. Molecular mechanisms
underlying ETS transcription factor-mediated transformation of human mammary epithelial cells.
IN: Progress in Nucleic Acid Research and Molecular Biology. Vol . K Moldave, Ed. Academic
Press, San Diego, CA. (Invited review).
85. Tentler JJ, Eckel K, Hadcock JR, Gutierrez-Hartmann A. Signaling via the type 2 somatostatin
receptor (sst2A) inhibits growth factor-stimulated MAP Kinase pathway in GH4 pituitary cells. In
86. Hahm JR, Gutierrez-Hartmann A. Redundant co-repressor proteins restrict the Ras response of
the rat prolactin promoter with HDAC3 and SMRTß providing dominant inhibition via differential
interaction with Pit-1 and Ets-1. In preparation.
87. Hahm JR, Gutierrez-Hartmann A. Interaction of TRAP220/MED220 with Pit-1 governs basal
but not Ras-induced rat prolactin promoter activity. In preparation.