Annual Report
                           Division of Endocrinology
                  University of Pittsburgh School of Me...
Pennsylvania. Remarkably, this is the largest diabetes registry of unselected patients in the US.
(Medicare, the VA and Ka...
Faculty Honors and Recognition.


Amico:          Best Doctors in America 2004-2005

DeRubertis:     Top Ranked Clinical T...
Annual Report
                                  Division of Endocrinology
                                          2004-2...
Invited Lectures/ Sessions:

         U of North Carolina School of Medicine Sept 2004
       ‘”Anxiety-related behavior a...
PENDING

7) 1RO1 MH074850 (Pedersen)                            07/01/05 – 06/30/10              20%
“Oxytocin & Nurture: ...
3.    Light KC, Grewen KM, Amico JA More frequent partner hugs and higher oxytocin
      levels are linked to lower blood ...
Annual Report of Educational Activities
                                   Department of Internal Medicine
               ...
-Doctoral Thesis Committees
                                              (4 students SOP and 1 student SOM)

            ...
Annual Report
                                         Division of Endocrinology
                                         ...
Grants/Awards/Contracts:

Active                                                                         Direct Costs
1.  ...
In press or submitted:

  1.   Horwitz MJ, Tedesco MB, Sereika SM, Syed MA, Garcia-Ocaña A, Bisello A, Hollis BW, Rosen
  ...
Annual Report of Educational Activities
                                Department of Internal Medicine
                  ...
Annual Report
                                        Division of Endocrinology
                                          ...
Grants/Awards/Contracts:

Active Grant Support:                                                             Direct Costs

...
Annual Report of Educational Activities
                                Department of Internal Medicine
                  ...
Annual Report
                                        Division of Endocrinology
                                          ...
Research Topics:

     a.         The Global Hypopituitary Control and Complications Study: Principle Investigator- Indust...
Annual Report of Educational Activities
                              Department of Internal Medicine
                    ...
IV. Affiliated Hospital Program        None

V. UPMC Medical Grand Rounds           None




                             ...
Annual Report
                                            Division of Endocrinology
                                      ...
(4) Adverse Events and Procedure Review

       k     (5) Professional Standard Board, VAPHS

       l     (6) Acute Care ...
Annual Report of Educational Activities
                                  Department of Internal Medicine
                ...
Annual Report
                                         Division of Endocrinology
                                         ...
Grants/Awards/Contracts:

Active Grant Support:                                                                      Direc...
Transfer of Constitutively Active Akt Markedly Improves Human Islet Transplant Outcomes in
       Diabetic SCID Mice. Diab...
Annual Report of Educational Activities
                               Department of Internal Medicine
                   ...
Annual Report
                                        Division of Endocrinology
                                          ...
Syndrome.” Saint Luke’s – Roosevelt Hospital Center Columbia University College of
      Physicians & Surgeons. New York, ...
Grants/Awards/Contracts:

a. Active                                                                       Direct Costs

1....
measures in older black and white adults. American Journal of Clinical Nutrition 80:576-583,
       2004

   3. Holvoet P,...
4. Goodpaster BH, Brown NF: Exercise and the Role of Muscle Triglyceride in Obesity, Insulin
      Resistance and Type 2 D...
Annual Report of Educational Activities
                                Department of Internal Medicine
                  ...
Course, School of Health and Recreation
                                  Education: Summer terms 2004.


       C. Others...
Annual Report
                                    Division of Endocrinology
                                           200...
b.   University:         Multidisciplinary Advisory Committee, K12 Clinical Research Scholars
                            ...
m.     December 10, 2004. “Dual X-ray Absorptiometry,” Case Based Learning Module, Division of
            Endocrinology a...
5.        P30 AG024827-02 (Greenspan, Core PI) NIH/NIA                 9/04-5/09        $79,765
          Pittsburgh Older...
4.   Greenspan SL, et al. Assessing the risk of bone disease and fracture. In U.S. Department of
       Health and Human S...
Annual Report of Educational Activities
                                Department of Internal Medicine
                  ...
II.Lecture/Seminar

      A. For Residents                   Miscellaneous lectures to Adult Endocrinology,
              ...
Annual Report
                                          Division of Endocrinology
                                        ...
g. Effect of a once yearly infusion of a new bisphosphonate, zolendronate, in the prevention of
        postmenopausal ost...
Annual Report of Educational Activities
                                 Department of Internal Medicine
                 ...
Annual Report
                                        Division of Endocrinology
                                          ...
j. November 18, 2004 Yale University, Endocrinology Grand Rounds: “PET Imaging of Insulin
         Resistance“
   k. Febru...
7-04-MN-23 (Kelley)                     ADA            7/1/04-6/30/08   $180,000
Mentor-Based Postdoctoral Fellowship
Skel...
In Press or Submitted:

1. Menshikova EV, Ritov VB, Toledo F, Ferrell R, Goodpaster B, Kelley DE Effects of
   weight loss...
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Annual Report 2005.doc

  1. 1. Annual Report Division of Endocrinology University of Pittsburgh School of Medicine 2004-2005 Academic year 2004-2005 has been another banner year for the Division of Endocrinology, on the academic, patient care, administrative front, teaching, training, and the national and international recognition fronts. With 33 faculty members, the Division is without question one of the largest, strongest and most stable in the US, and is a leader in academic, didactic and clinical endocrinology. Faculty (As of July 1, 2005). Full Time M.D. Full Time Ph.D. 1. Janet Amico 1. Alessandro Bisello 2. Bankim Bhatt 2. Nicholas Brown 3. Sue Challinor 3. James DeLany 4. Fred DeRubertis 4. Nathalie Fiaschi-Taesch 5. Susan Greenspan 5. Adolfo Garcia-Ocaña 6. Steven Hodak 6. Bret Goodpaster 7. Jennifer Holst 7. Gary Marshall 8. Mara Horwitz 8. Robert O’Doherty 9. David Kelley 9. Linda Siminerio 10. Mary Korytkowski 10. Rupangi Vasavada 11. Haruko Kuffner 12. Shane LeBeau 13. Harsha Rao 14. Michelle Roberts Research Associates 15. Roseanne Salata 1. Lisa Menchikova 16. Maja Stefanovic-Racic 2. Vladimir Ritov 17. Andrew Stewart 3. Karen Takane 18. Frederico de Toledo 4. Cyrous Kangani 19. Anthony Vagnucci Clinical Care. Visits to the endocrine clinics at the University of Pittsburgh School of Medicine and UPMC continue to increase, as do clinical revenues. In recognition of this, UPMC leadership has expanded nursing and support staff substantially, is expanding the clinic space from 4000 to 7000 sf, and expanded the number of designated full time clinical endocrinologists from seven to ten, complemented by nine additional research-oriented MD faculty, who also perform clinical patient care. This means that the 19 MD faculty, together with the 14 PhD faculty, comprise one of the largest Endocrinology Divisions in the US. Over the past year, we have also developed a new and fully-staffed inpatient diabetes hospitalist service, comprised of an attending endocrinologist, two nurse practitioners and a designated clinical fellow, as well as residents and students. In addition to these services at UPMC, four Division endocrinologists provide outpatient and inpatient care at the Pittsburgh VA Medical Center, and this will increase to five with the addition of a fifth full time endocrinologist beginning in July, 2006. In regional terms, we have developed and validated a database of 90,000 patients with diabetes cared for in the 19 UPMC hospitals and their associated outpatient facilities and clinics in western
  2. 2. Pennsylvania. Remarkably, this is the largest diabetes registry of unselected patients in the US. (Medicare, the VA and Kaiser-Permanente have larger, but demographically selected diabetes registries.) We have also developed the second or third largest ADA-certified diabetes educator network in the US. Working with this University of Pittsburgh Diabetes Institute Registry and ADA-Certified Diabetes Education Network, we have launched quality improvement initiatives on a scale not possible in almost any other hospital system. We have also implemented system-wide computer-based physician order-entry initiatives targeting the inpatient management of hypoglycemia and sliding scale management of hyperglycemia, and also to site-specific and physician-specific reporting of ADA management targets. These have led to marked, large scale improvements in the management and outcomes relating to hypoglycemia, hospital length of stay, and achievement of compliance targets for diabetes management. Compliance measures and outcomes System-wide far exceed national averages and ADA guidelines. Finally, five of our clinicians were ranked among the Best Doctors in the US. Research. Research continues to expand in the Division. In FY ’05, faculty within the Division received a total of $8,500,000 in research support from the NIH, the ADA, the JDRF, the AHA the VA, and from pharmaceutical trials, with the large majority coming from the NIH. Twelve of 15 research faculty cover all or most of their salary from NIH grants, and the remainder cover the large majority of their salary from the NIH and other foundations. Areas of excellence include clinical research in diabetes, obesity, calcium metabolism and osteoporosis, and basic research in diabetes, insulin resistance, pancreatic beta cell function, survival and regeneration, osteoblast and osteoclast biology, and arterial smooth muscle in health and disease. Research is supported by an NIH Training Grant, now in its 38th year, and which was recently renewed, by the NIH-funded General Clinical Research Center, and by the NIH-funded Obesity and Nutrition Research Center. Outstanding facilities for microarray gene profiling, DNA and protein synthesis and sequencing, animal care, proteomics, cellular imaging, and bioinformatics and biostatistics are available. Remarkably, Drs. Kelley, Greenspan, Stewart within the Division, and Drs. David Roodman and Mark Sperling who closely collaborate with Division members all have had one or more papers in the New England Journal of Medicine in the past year. From a research perspective, then, the Division clearly ranks among the top ten in the US. This excellence in research within the Division is complemented by the NIH ranking of the overall University of Pittsburgh, which ranked #7 out of 130 US Medical Schools in NIH support for 2003, the most recent year for which these numbers are available. Teaching and Training. Division faculty rank among the best in the Medical School once again in both the second year medical students course, and also among resident and fellow teaching. In parallel, improvements in the quality and quantity of applicants for the fellowship has increased dramatically over the past five years. For example, for fellowship training slots beginning both in July 2005 and 2006, we received approximately 140-150 applicants per year, interviewed 10-12, and selected three to four per year. Of eight positions offered in the past two years, seven applicants accepted this program. Thus, 140-150 applicants compete for 3-4 slots per year. Training in clinical endocrinology is intense, rich, high-volume, and exceptionally diverse. Teaching and supervision are equally outstanding. Clinical care is also outstanding, and occurs at the University, Magee Women’s Hospital, Children’s Hospital of Pittsburgh, and the Oakland VA Medical Center. Training excellence is documented by 100 passage rate on the Endocrinology Board exams for the past 27 years, by the large proportion of training graduates who enter academic careers, and by the recent excellent score of our NIH Training Grant which will allow another five years of training support. A concrete example of the excellence in teaching is Dr. Rao’s winning (again!) the Distinguished Housestaff Teacher Award for the Department of Medicine 2
  3. 3. Faculty Honors and Recognition. Amico: Best Doctors in America 2004-2005 DeRubertis: Top Ranked Clinical Teacher in the Division 2004-2005 Garcia-Ocana: Senior Vice Chancellor’s Distinguished Lecture 2004 Greenspan: Appointed Clinical Program Chair, ASBMR Annual Meeting, 2006. Best Doctors in America 2004-2005 Councilor, ASBMR Coordinating Author, US Surgeon General’s Report on Osteoporosis, 2005 Vice Chair, Professional Practice Committee, National Osteoporosis Foundation Kelley: Elected to Association of American Physicians American Diabetes Association Board of Directors Korytkowski: America’s Best Doctors 2004-2005 UPMC Presbyterian Presidential Performance Award for Patient Safety Kuffner: Keynote Speaker, Japan-North America Medical Exchange Foundation, 2004 Rao: Physician Performance Award, VA Pittsburgh Health System Distinguished Housestaff Teacher Award, Department of Medicine Salata: Best Doctors in America 2004-2005 Siminerio: Vice President and Member, Board of Directors, International Diabetes Federation Chancellor’s Distinguished Public Service Award Stewart: Co-Chair, NIH-ASBMR Conference on Anabolic Skeletal Agents for Osteoporosis, 2004 Invited Symposium Speaker, Royal Society of Medicine, London, 2004 Best Doctors in America 2004-2005 Chair, Science Policy Committee, American Diabetes Association Individual Faculty Annual Reports. Individual Annual Reports from each Faculty Member follow below. Note that Drs. Bhatt, DeLany, LeBeau, Hodak, Holst are new arrivals and therefore have no Annual Repots. 3
  4. 4. Annual Report Division of Endocrinology 2004-2005 Name: Janet A. Amico, MD Title: Professor Section: Primary Appointment: Endocrinology, Department of Medicine, School of Medicine (SOM) Secondary Appointment: Department of Pharmaceutical Sciences, School of Pharmacy (SOP) Honors/ Committees: a. National: America’s Top Doctors, 2004-2005 Ad Hoc peer review 2004-2005: Endocrinology, JCEM, Brain Research, J of Neuroscience, Am J of Physiology, European J of Neuroscience, Arch Int Med, Hormones and Behavior, European J Pharmacology, J Neuroendocrinol, Experimental Neurology Ad hoc peer review for NIH, Dept of Veterans Affairs, NIMH, Howard Hughes Medical Institute, New Zealand Research Council b. University: Institutional Review Board for Biomedical Research (SOM/SOP) c. Hospital: Utilization Review Committee (SOM) d. Departmental: - Appointments and Promotions Committee (SOM) - Internship Interview Committee (SOM) - Medical School Interview Committee (SOM) - Focus Leader, Graduate program in NeuroEndocrine Pharmacology (SOP) - Graduate Program Council (SOP) - Graduate Admissions Committee (SOP) - Distinguished Lectureship Committee (SOP) - Admissions Committee (SOP) - Ad Hoc Faculty Search Committees (SOP) e. VA Hospital: None 4
  5. 5. Invited Lectures/ Sessions: U of North Carolina School of Medicine Sept 2004 ‘”Anxiety-related behavior and stress responses in female oxytocin deficient mice” Research Topics Stress, Anxiety and Ingestive Behaviors in the Oxytocin Deficient Mouse Interrelationship of Oxytocin and Steroids in Cognitive Function and Affective Disorders Grants/Awards/Contracts: Active: 1) 1RO1 HD044898-01 (Amico) 12-01/04-11/30/08 “Anxiety and Stress Responses in Oxytocin Deficient Mice” Studies investigate the role of oxytocin in anxiety and stress 2) DOD BC030242 (Weihs) 01/01/05- 12/31/10 “Longitudinal effects of intimate partner relationship quality on serum oxytocin levels in newly diagnosed breast cancer patients” Studies investigate if breast cancer patients with better quality relationships will have higher average blood levels of oxytocin than women without such relationships and if the blood level of oxytocin correlates with better outcome of the disease. 3) R01 HD37268 (Amico) 04/01/2000- 03/31/05 “Oxytocin Regulation by Neurosteroids & GABA-A Receptor” Studies focus upon the GABA A mediated effects of steroids upon central oxytocin expression. 4) R01 HL068862 (Smith) 06/1/2003 - 5/31/08 “Cardiovascular-Oxytocin Links in Social Interactions” Studies investigate the role of oxytocin on stress markers in patients with cardiovascular disease 5) R01 DA05952 (Mezzich) 09/30/2001-05/31/06 “Female Adolescent Drug Abuse: Biobehavioral Development” Studies investigate psychological and hormonal markers of substance abuse 6) K01 MH64144 (Cyranowski) 08/20/2001-7/31/05 “Biobehavioral Mechanisms of Depression in Women Mentored Research Scientist Development Award (MRSDA) investigates hormonal parameters affecting the etiology of depression in women. 5
  6. 6. PENDING 7) 1RO1 MH074850 (Pedersen) 07/01/05 – 06/30/10 20% “Oxytocin & Nurture: Anxiety, Despair, & Mothering in Mice” Studies investigate if altered maternal care has long term consequences in mice such as vulnerability to stress induced behavior 8) R01 HL64927 (Light) 12/01/05 -11/30/10 “Cardiovascular Benefits of Family Support and Oxytocin” The goal of the proposed research is to understand mechanisms by which oxytocin affects blood pressure response, cardiovascular reactivity and stress responses in humans. PLANNED 9) (Amico) 12/01/05-11/30/10 “” Ingestive behaviors in oxytocin deficient mice” Studies investigate the effects of oxytocin upon abnormal ingestive behiors Publications for 2004-2005 a. Manuscripts Published 1. Fabian TJ, Amico JA, Kroboth PD, Mulsant Bh, Corey SE, Bagley AE, Bensasi SG, E, Dew MA, Reynolds, CF, Pollock BG. Paroxetine –induced hyponatremia in older adults: a twelve week prospective study Arch Int Med 164:327-332, 2004. 2. Amico JA, *Mantella RC, Vollmer RR, Li X, Cai HM. Anxiety and stress responses in female oxytocin deficient mice J of Neuroendocrinology 16:319-324, 2004. 3. Amico JA, Volmer RR, *Karam JR, Lee, PR, LI, X, Koenig JI, McCarthy MM Centrally administered oxytocin elicits exaggerated grooming in oxytocin null mice Pharmacology, Biochemistry and Behavior, 78:333-338, 2004. 4. Mantella RC, Rinaman L, Vollmer RR, Li X, Amico JA Enhanced plasma corticosterone concentrations and diminished Fos expression in the medial amygdala of female oxytocin deficient mice exposed to psychogenic stress American Journal of Physiology. , 287:R1494-R1504, 2004 5. Light KC, Grewen KM, Amico JA, Boccia M, Brownley KA, Johns JM Deficits in plasma oxytocin responses and increased negative affect, stress and blood pressure in mothers with cocaine exposure during pregnancy Addictive Behaviors, 29:1541-1564, 2004. In Press 1. Rinaman L, Volmer RR, *Karam JR, Li X, Amico JA Attenuation of dehydration anorexia in oxytocin deficient mice American Journal of Physiology. in press, 2005. 2. Grewen K, Girdler SS, Amico JA, Light KC Effects of partner support on resting oxytocin, cortisol, norepinephrine, and blood pressure before and after warm partner contact Psychosomatic Medicine, in press, 2005. 6
  7. 7. 3. Light KC, Grewen KM, Amico JA More frequent partner hugs and higher oxytocin levels are linked to lower blood pressure and heart rate in premenopausal women Biological Psychology in press, 2005. 4. Light KC, Grewen KM, Amico JA, Brownley KA, West SG, Hinderliter AL, Girdler SS Oxytocinergic activity is linked to lower blood pressure and vascular resistance during stress in postmenopausal women on estrogen replacement Hormones and Behavior, in press, 2005. 5. Hruska MW, Amico JA, Langaee TY, Ferrell R, Fitzgerald SM, Frye RF The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects British Journal of Clinical Pharmacology in press, 2005. Submitted 1. Pedersen CA, Boccia ML, Vadlamudi SV, Amico JA Maternal behavior deficits in nulliparous oxytocin knockout mice Genes, Brain and Behavior [submitted] 2. Mantella RC, Vollmer RR, Amico JA Overnight fluid deprivation heightens plasma corticosrterone concentratiojns in male oxytocin deficient mice Brain Research [submitted] Abstracts : 5 7
  8. 8. Annual Report of Educational Activities Department of Internal Medicine University of Pittsburgh School of Medicine 2004-2005 Name: Janet A. Amico, M.D. Section: Medicine, Endocrinology Type of Activity Date(s) Location/Course I. Attending A. Inpatient General Medicine B. Outpatient 1. Residents/fellows Weekly Clinic Weekly (Endo Clinic,SOM) Falk 2B 2. Residents Ambulatory Block 3. Students Ambulatory Block C. Consult Service 1. General Medicine 2. Subspecialty (Endocrinology) August, 2004 (SOM) PUH/MUH/VA D. Student Teaching Attending E. 2nd Year Clinical Tutor - Clinical Skills October 2004, 12 h(SOM) PUH/MUH F. Others (specify) Research Advisor: Rose Mantella (Ph D candidate, Pharmaceutical Sciences, SOP). Research Advisor: Julie Miedlar (Ph D candidate, Pharmaceutical Sciences, SOP). II.Lecture/Seminar A. For Residents/ Fellows - MKSAP Review, Thyroid (1 h) (SOM) Summer lecture series, Physiology of Anterior and Posterior Pituitary (SOM) B. For Students - Course-CoDirector, Endocrine Disorders Course (SOM), Nov- Dec 2004 (3 weeks); two lectures (2 h), 3 PBL sessions (4 h) - Course Coordinator 4th yr Selective in Endocrinology, I h/month 8
  9. 9. -Doctoral Thesis Committees (4 students SOP and 1 student SOM) -Pharm 3000 Topics in Neuroscience (SOP) Course Director - 1h weekly , 9/04 to 4/05 Pharm 5110: Exploring Research (3h) (SOP) Oct 2004 III. UPMC Medical Grand Rounds IV. University Lectures University Endocrine Conference 4/05 Vasopressin Receptor Antagonists: Development and Use in Patients with hyponatremia (SOM) V. Teaching Evaluations: (SOM) Second Year Medical Students Rating of Teaching in the Endocrine Disorders Course: 3.8 for Lectures; 4.0 for PBL (Range 1 - 5, with 5 the best) (SOM) Endocrine Fellows Rating of Teaching in the Fellowship Program: ranked # 3 out of 17 faculty in the Endocrinology Division( 5 yr average is also # 3) 9
  10. 10. Annual Report Division of Endocrinology 2004 - 2005 Name: Alessandro Bisello, Ph.D. Title: Assistant Professor of Medicine Assistant Professor of Pharmacology (secondary) Section: Endocrinology Honors: Ad hoc reviewer for PNAS, Journal of Biological Chemistry, Endocrinology, Biochemistry, the Journal of Bone and Mineral Research, Trends in Endocrinology. Committees: a. National: Ad hoc Skeletal Biology Structure & Regeneration Study Section- NIH 2004 Scientific Program Committee for the 26th Annual Meeting of the American Society of Bone and Mineral Research, Seattle, WA, USA. b. University: NONE c. Hospital: NONE d. Departmental: Organizer Research Conference Series e. Veterans Hospital:NONE Invited Lectures, Seminars: 5/2004 Local Traffic 2004, University of Pittsburgh Title: Trafficking of the parathyroid hormone receptors: structural and functional significance” Editor, Associate Editor: NONE Research Topics: a. Mechanisms of signal transduction of parathyroid hormone and PTH-related protein b. Structure-activity studies on parathyroid hormone and PTH-related protein c. Regulation of the Glucagon-like peptide 1 receptor. 10
  11. 11. Grants/Awards/Contracts: Active Direct Costs 1. R01 DK062078-01(Bisello) NIH 07/02-06/06 $600,000 Parathyroid Hormone Signaling in Bone Cells 2. R01-51081 (Stewart) NIH 3/03-3/08 $50,000 Pathophysiology of PTH-related Protein (1-35) in Humans 3. 2R01 DK54171-18-23(Friedman) NIH 7/03-7/08 $50,000 Cellular Calcium Transport in Urinary Epithelia 4. Pilot/Feasibility Grant (Bisello) ONRC(NIH) 7/1/05-6/30/05 $15,000 Regulation of the GLP-1 Receptor Pending 1. 1R01 DK071158 (Bisello) NIH 2005-2010 $1,125,000 PTH receptors in vascular smooth muscle cells. 2. R01 (Friedman) NIH 2005-2010 $100,000 EBP50 regulation of PTH receptor signaling and trafficking. Publications for 2004-2005 a. Manuscripts Published: 1. Bisello A, Manen D, Pierroz DD, Usdin TB, Rizzoli R, Ferrari SL. Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization. Mol Endocrinol. 2004; 18:1486-98. 2. Sneddon WB, Magyar CE, Willick GE, Syme CA, Galbiati F, Bisello A, Friedman PA. Ligand- selective dissociation of activation and internalization of the parathyroid hormone (PTH) receptor: conditional efficacy of PTH peptide fragments. Endocrinology. 2004;145:2815-23. 3. Bisello A, Horwitz MJ, Stewart AF. Parathyroid hormone-related protein: an essential physiological regulator of adult bone mass. Endocrinology. 2004; 145:3551-3. 4. Syme CA, Friedman PA, Bisello A. Parathyroid hormone receptor trafficking contributes to the activation of extracellular signal-regulated kinases but is not required for regulation of cAMP signaling. J Biol Chem. 2004 Dec 17; [Epub ahead of print]. 11
  12. 12. In press or submitted: 1. Horwitz MJ, Tedesco MB, Sereika SM, Syed MA, Garcia-Ocaña A, Bisello A, Hollis BW, Rosen CJ, Wysolmerski JJ, Dann P, Gundberg CM, Stewart AF. Continuous infusion of parathyroid hormone versus parathyroid hormone-related protein in humans: discordant effects on 1,25(OH)2 vitamin D and prolonged suppression of bone formation. (submitted) 2005. 2. Horwitz MJ, Tedesco MB, Sereika SM, Garcia-Ocaña A, Bisello A, Hollis BW, Gundberg CM, Stewart AF. Safety and Tolerability of Subcutaneous PTHrP(1-36) in Healthy Human Volunteers: A Dose Escalation Study. (submitted) 2005. b. Abstracts: Four 12
  13. 13. Annual Report of Educational Activities Department of Internal Medicine University of Pittsburgh School of Medicine 2004 - 2005 Name: Alessandro Bisello, PhD Section: Internal Medicine, Endocrinology Type of Activity Date(s) Location/Course I. Attending A. Inpatient General Medicine NA B. Outpatient 1. Residents Weekly Clinic 2. Residents Ambulatory Block 3. Students Ambulatory Block C. Consult Service 1. General Medicine 2. Subspecialty (Endocrinology) NA D. Student Tutor E. 2nd Year Clinical Tutor F. Others (specify) Research Advisor: Colin Syme, PhD II. Lecture/Seminar A. For Residents NONE B. For Students January 2005; “Principles of Pharmacology” - 2 lectures C. Others August 2004; “Introduction to signaling”. Lecture series for endocrine fellows III. UPMC Medical Grand Rounds NONE IV. Affiliated Hospital Program NONE 13
  14. 14. Annual Report Division of Endocrinology 2004 - 2005 Name: Nicholas F. Brown, Ph.D. Title: Assistant Professor Section: Endocrinology Honors: None Committees: a. University: Redesign of MS 1 Fuel Metabolism Course curriculum Invited Lectures, Seminars: a. Tularik Inc., South San Francisco, CA (Aug, 2004) “Novel aspects of fatty acid metabolism in muscle and liver cells” b. Bristol Myers Squib, Princeton, NJ (Aug, 2004) “Novel aspects of fatty acid metabolism in muscle and liver cells” c. Wellstat Pharmaceuticals, DC (Sep, 2004) “Novel aspects of fatty acid metabolism in muscle and liver cells” d. Metabasis Pharmaceuticals, San Diego, CA (Dec, 2004) “Beneficial effects of increased fatty acid oxidation in muscle and liver cells” e. Novartis Institute for Biomedical Research, Cambridge, MA (Jan 2005) “Beneficial effects of increased fatty acid oxidation in muscle and liver cells Editor, Associate Editor: None Research Topics: a. Investigation of the structure/function and regulation of the mitochondrial carnitine palmitoyltransferase (CPT) system of enzymes at a molecular level. b. Role of CPT I and acyl-CoA in the etiology of skeletal muscle insulin resistance. c. Role of immunosuppressant drugs in regulation of lipid metabolism. d. Role of CPT I in regulation of hepatic lipid metabolism in normal and disease states. 14
  15. 15. Grants/Awards/Contracts: Active Grant Support: Direct Costs 1. Junior Faculty Award (Brown) ADA 1/1/03-12/31/05 $120,000/yr Carnitine palmitoyltransferase, fatty acids and diabetes 2. Pilot and Feasibility Award (Brown) CMRF 1/7/02 - 6/30/05 $25,000 total Skeletal muscle carnitine palmitoyltransferase I and insulin resistance 3. K08 (Stefanovic-Racic; Brown, mentor) NIH/NIDDK 4/1/04-3/31/09 $116,000/yr Hepatic fatty acid metabolism and insulin resistance 4. R01 (Kelley; Brown, co-invest) NIDDK/NIH 7/1/04 - 6/30/09 Mitochondrial impairment in muscle insulin resistance 5. R01 (Goodpaster; Brown, co-invest) NIH/NIDDK 7/1/04 – 6/30/08 Muscle lipid and insulin resistance in aging Publications for 2004-2005 a. Manuscripts Published: 1. Perdomo, G., Commerford, S.R., Adams, S.H., O’Doherty, R.M. and Brown, N.F. Increased β- oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid induced insulin resistance despite intramyocellular lipid accumulation. J. Biol. Chem.2004; 279, 27177-27186 2. Sinha, S., Perdomo, G., Brown, N.F. and O’Doherty, R.M. Fatty acid induced insulin resistance in L6 myotubes requires nuclear translocation of NFκB. J. Biol. Chem. 2004; 279, 41294-41301 3. Goodpaster, B.E. and Brown, N.F. Exercise and the role of skeletal muscle triglyceride in insulin resistance. Exercise and Sports Medicine Reviews 2005; (in press) In Press or Submitted: 1. Perdomo, G., Stefanovic-Racic, M., Sipula, I. and Brown, N.F. Rapamycin promotes fatty acid oxidation and diminishes lipogenic pathways in primary cultures of rat hepatocytes. (submitted) Abstracts: Two 15
  16. 16. Annual Report of Educational Activities Department of Internal Medicine University of Pittsburgh School of Medicine 2004 - 2005 Name: Nicholas F. Brown, Ph.D. Section: Internal Medicine, Endocrinology Type of Activity Date(s) Location/Course I. Attending Not applicable II. Lecture/Seminar A. For Fellows July 2004 Techniques for isolating, characterizing and quantifying proteins. In, Introduction to Core Research Techniques. Aug 2004 Lipoprotein Metabolism. In, Summer Lecture Series. B. For Students Jan 2005 MS I Course, Fuel Metabolism: 5 lectures 16
  17. 17. Annual Report Division of Endocrinology 2004 - 2005 Name: Sue Challinor, MD Title: Assistant Professor of Medicine Section: Endocrinology Honors: Best Doctors in America 2003-2004 Committees: a. National: None b. University: Director, Pituitary Conference c. Hospital: None d. Departmental: None e. Veterans Hospital:None Invited Lectures, Seminars: a. Aug 2004 Cushings Syndrome: Endocrine Fellows Summer Lecture Series b. Oct/Nov 2004 Pituitary Diseases: Pituitary Adenomas and Cushings Syndrome and Adrenal Insufficiency – Two lectures for 2nd year medical students – Endocrine Disorders Course 2 Problem-Based Learning Session on MEN 1 c. February 2005 The Utility of Gamma-Knife in the Treatment of Pituitary Tumors – The Pittsburgh Experience for University-Wide Endocrine Conference d. April 2005 Pituitary Tumors: Noon Lecture Series for the Internal Medicine Housestaff at University of Pittsburgh Montefiore Hospital and at VA Hospital Editor, Associate Editor: None 17
  18. 18. Research Topics: a. The Global Hypopituitary Control and Complications Study: Principle Investigator- Industry- sponsored outcome study of GH therapy in hypopituitary patients Research Grants: None Publications for 2004-2005 a. Manuscripts Published: None Submitted: Hypterthyroidism after Parathyroid Exploration. Stang MT, Yim JH, Challinor SM, Bahl S, Carty SE. submitted to Surgery, Feb 2005. b. Abstracts: None Other: Certification in Thyroid Ultrasound, at the AACE Thyroid Ultrasound and FNA Biopsy Accreditation Course, Jan 21-23, 2005. Radiosurgery Practice Guidelines Initiative: Stereotactic Radiosurgery for Patients with Pituitary Adenomas, member of the Radiosrugery Guidelines Committee, 2005. www.guidelines.gov, and www.irsa.gov 18
  19. 19. Annual Report of Educational Activities Department of Internal Medicine University of Pittsburgh School of Medicine 2004-2005 Name: Sue Challinor, M.D. Section: Internal Medicine, Endocrinology ____________________________________________________________________________ Type of Activity Date(s) Location/Course I. Attending A. Outpatient 1. UPMC-Internal Medicine Residents Weekly UPMC-CDE 2. Endocrinology Fellow Weekly UPMC-CDE 3. Nurse Practitioner Weekly UPMC-CDE B. Consult Service 2. Subspecialty (Endocrinology) One/Mo. 2004 PUH/Montefiore/VA C. Others (specify) None II. Lecture/Seminar A. Residents Noon Patient Management Conference on Cushings Syndrome and Pituitary Adenomas B. Students 2 – two hour long PBL sessions for the Endocrinology course for the 2nd year Medical School Curriculum 2 hour long lectures on Pituitary Disease and Cushings Syndrome/Adrenal Insufficiency – Oct- Nov 2004 for Endocrine Disorders Course C. Fellows Endocrine Summer Lecture Series: Cushings Syndrome, Aug 2004 D. Others: Pituitary Conference – a multidisciplinary conference for Endocrinology fellows, faculty and neurosurgery residents and faculty – 3 sessions/year University-Wide Endocrine Conference: The Utility of Gamma-Knife in the Treatment of Pituitary Tumors- The Pittsburgh Experience, Feb 2005 III. UPMC Medical Grand Rounds None 19
  20. 20. IV. Affiliated Hospital Program None V. UPMC Medical Grand Rounds None 20
  21. 21. Annual Report Division of Endocrinology 2004-2005 Name: Frederick R. DeRubertis Title: Professor of Medicine Vice Chair, Department of Medicine Co-Director Fellowship Training Program in Endocrinology, Diabetes, Metabolism Chief Medicine, VA Pittsburgh Healthcare System Section: Endocrinology Honors: None Committees: a. National: None b. University: (1) Co-Director, Endocrine Disorder Course – PMS II Class (2) Dean’s Committee, VA Medical Center, School of Medicine, University of Pittsburgh c. Hospital: None at PUH/MUH d. Departmental: (1) Chairman, Committee for Promotion and Appointments, Department of Medicine, University of Pittsburgh (2) House Staff Selection Committee, Department of Medicine, University of Pittsburgh (3) House Staff Competence Committee, Department of Medicine, University of Pittsburgh (4) Curriculum Committee, Fellowship Training Program, Endocrine Division, UPMC (5) Endocrine Fellow Selection Committee, Endocrine Division, UPMC (6) Co-Director Endocrine Fellowship Program e e. Veterans Hospital: f (1) Chief, Medical Service g h (2) Medical Executive Board i j (3) Executive Leadership Board 21
  22. 22. (4) Adverse Events and Procedure Review k (5) Professional Standard Board, VAPHS l (6) Acute Care Task Force, VISN 4, VA m (7) Residency Review Committee, VAPHS, Chair n (8) Multiple ad hoc VA Committee Assignments Invited Lectures, Seminars: None Editor, Associate Editor: Associate Editor, Metabolism. Ad hoc reviewer for: Kidney International, Journal American Society of Nephrology, Metabolism, Journal of Clinical Investigation, Diabetes, American Journal of Medicine Research Topics: a. Role of reactive oxygen species/oxidant stress in diabetic nephropathy. b. Role of nitric oxide in the pathogenesis of diabetic nephropathy. c. Control of mesangial cell matrix protein production. Grants/Awards/Contracts: a. Active Direct Costs 1. VA Merit Award (DeRubertis) 03/01/01-2/28/06 $764,700 Effects of Altered Superoxide Dismutase Activity on Diabetic Nephropathy. b. Pending Publications for 2002-2003 a. Manuscripts Published: 1. DeRubertis,FR, Craven,PA, Melhem,MF; Salah,EM. Attenuation of Renal Injury in db/db Mice Overexpressing Superoxide Dismutase: Evidence for Reduced Superoxide-Nitric Oxide Interaction. Diabetes 53:762-768, 2004. b. Submitted 1. DeRubertis,FR, Craven,PA, Melhem, M. Accelerated Renal Injury in Diabeteic Mice with Superoxide Dismutase Deficiency. 2. DeRubertis,FR and Craven,PA. Oxidative and Glycooxidative Stress in Diabetic Nephropathy. c. Abstracts: None 22
  23. 23. Annual Report of Educational Activities Department of Internal Medicine University of Pittsburgh School of Medicine 2004-2005 Name: Frederick R. DeRubertis, M.D. Section: Internal Medicine, Endocrinology Type of Activity Date(s) Location/Course I. Attending A. Endocrine In-patient Consult/ Jan, 2005 PUH/MUH/VA/WPIC Teaching Rounds B. Endocrine Fellow Weekly VA Clinic Each Monday 2 Endo Fellows/Week (0.5 day) C. Teaching In-Patient Attending May, 2005 VAPHS For General Medicine Wards II. Lecture/Seminar A. Adrenal Cortex - Lecture Nov, 2004 Endo Disorders Course-PMS II Class B. Mineralocorticoids - Lecture Nov, 2004 Endo Disorders Course-PMS II Class C. PBL Facilitator Nov 2004 Four sessions in Endocrine Disorders Course – PMS II Class D. Workshop on the Adrenal Nov 2004 Endo Disorders Course – PMS II Class E. Paraneoplastic Syndromes May, 2004 Host Defense Course–PMS II Lecture F. Misc. lectures and presentations Throughout Resident Noon Cnferences, to Endo Fellows, Medical Residents year Chief Conferences, Endo Fellow Summer Lecture Series, Others III. UPMC Medical Grand Rounds - None IV. Affiliated Hospital Program - Medical Grand Rounds Oct, 2004 Mercy Hosp, Pgh, PA Primary Hyperaldosteronism 23
  24. 24. Annual Report Division of Endocrinology 2004 - 2005 Name: Adolfo Garcia-Ocaña, PhD Title: Assistant Professor of Medicine Assistant Professor of Cell Biology and Physiology (secondary appointment) Section: Endocrinology Honors: Editorial Board, Endocrinology, 2001-2004 Senior Vice-Chancellor’s Research Seminar, July 9th 2004 Invited Course Speaker, European Renal Association/European Dialysis and Transplant Association, Tenerife, Spain, October 2nd 2004. Committees: a. National: None b. University: None c. Hospital: None d. Departmental: Endocrine Research Conference Co-Coordinator. e. Veterans Hospital:None Invited Lectures, Seminars: a. July 9, 2004. Senior Vice Chancellor’s Research Seminar. “Unraveling the Physiology and Therapeutic Potential of HGF in the Pancreatic Beta Cell”. University of Pittsburgh. b. October 1, 2004. “The Future of Islet Transplantation”. Inaugural Conference of the Clinical Research Conference Series for the Academic year 2004-2005, Canary Islands General University Hospital, Tenerife, Spain. c. October 2, 2004. CME Course: Genetics in renal transplantation held by EDTA/ERA (European Renal Association/European Dialysis and Transplant Association). Conference: “Gene- and Cell-Based Therapeutics for Type I Diabetes Mellitus”. Tenerife, Spain. Editor, Associate Editor: Editor -- None Associate Editor—None Editorial Boards-- Endocrinology 2001-2004. Research Topics: a. Gene therapy approaches to improve islet transplantation. d. Physiologic and therapeutic effects of hepatocyte growth factor on the pancreatic beta cell. e. Physiologic and therapeutic effects of hepatocyte growth factor on renal growth and development. 24
  25. 25. Grants/Awards/Contracts: Active Grant Support: Direct Costs 1. Junior Faculty Award (Garcia-Ocaña) ADA 1/1/02-12/31/04 $120,000/yr “Transcriptional regulation of insulin, Glut-2 and glucokinase genes by hepatocyte growth factor in islet beta cells”. 2. R-01-DK 067351-01 (Garcia-Ocaña) NIH/NIDDK 3/1/04-2/28//09 $143,500/yr “Hepatocyte Growth Factor and the pancreatic beta cell”. 3. R-21-DK 068836-01 (Garcia-Ocaña) NIH/NIDDK 7/1/04-6/30/06 $125,000/yr “Protein Kinase B/Akt in the human islet” 4. R-01-DK 51081-04 (Stewart) NIH/NIDDK 7/1/96-3/31/08 $256,000/yr “Pathophysiology of PTH-related protein (1-36) in humans” 5. R-33 066127 (Stewart) NIH/NIDDK 10/1/03-9/30/06 $500,000/yr “Islet Allograft Gene Therapy in Diabetes” 6. No # (Stewart Project 2 PI) JDRF 10/1/99-9/30/04 $200,000/yr “Viral Gene Delivery of Islet Growth Factors” Pending: None Publications for 2004-2005 a. Manuscripts Published: 1. Fiaschi-Taesch N.M., Santos S., Reddy V., Van Why S., Phillbrick W.F., Ortega A., Esbrit P., Orloff J.J., Garcia-Ocaña A. Prevention of acute ischemic renal failure by targeted delivery of growth factors to the proximal tubule in transgenic mice: The efficacy of HGF and PTHrP. J. Am. Soc. Nephrol. 15:112-125, 2004. 2. Lopez-Talavera J-C., Garcia-Ocaña A., Sipula I., Takane K.K., Cozar I., Stewart A.F. Hepatocyte Growth Factor Gene Therapy for Pancreatic Islets: Reducing the Minimal Requisite Islet Transplant Mass in a Glucocorticoid-free Rat Model of Allogeneic Portal Vein Islet Transplantation. Endocrinology 145:467-474, 2004. 3. Fujinaka Y., Sipula D., Garcia-Ocaña A., Vasavada R.C.. Characterization of mice doubly transgenic for parathyroid hormone-related protein and murine placental lactogen: a novel role for placental lactogen in pancreatic beta cell survival. Diabetes 53:3120-3130, 2004. 4. Rao P., Cozar I., Roccisana J., Vasavada R.C., Garcia-Ocaña A. Hepatocyte growth factor gene therapy for islet transplantation. Expert Opinion on Biological Therapy 4:507-518, 2004. 5. Garcia-Ocaña A. Protein kinase B/Akt and the pancreatic beta cell. Cellscience Reviews 1(3):36-43, 2005. In Press or Submitted: 1. Rao P., Roccisana J., Takane K. K., Bottino R., Zhao A., Trucco M., García-Ocaña A. Gene 25
  26. 26. Transfer of Constitutively Active Akt Markedly Improves Human Islet Transplant Outcomes in Diabetic SCID Mice. Diabetes, in press, 2005. 2. Roccisana J., Reddy V., Vasavada R. C., Gonzalez-Pertusa J. A., Magnuson M. A., and Garcia- Ocaña A. Targeted inactivation of HGF receptor, c-met, in beta cells leads to defective insulin secretion and Glut-2 downregulation without alteration of beta cell mass. Diabetes, in press, 2005. 3. Horwitz M.J., Tedesco M.B., Sereika S.M., Syed M.A., Garcia-Ocaña A., Bisello A., Hollis B.W., Rosen C.J., Wysolmerski J.J., Dann P., Gundberg C.M., Stewart A.F. Continuous infusion of parathyroid hormone versus parathyroid hormone-related protein in humans: discordant effects on 1,25(OH)2 vitamin D and prolonged suppression of bone formation. J Bone Miner Res. (in revision) 2005. 4. Horwitz M.J., Tedesco M.B., Sereika S.M., Garcia-Ocaña A., Bisello A., Hollis B.W., Gundberg C.M., Stewart A.F. Safety and Tolerability of Subcutaneous PTHrP(1-36) in Healthy Human Volunteers: A Dose Escalation Study. J Bone Miner Res. (in revision) 2005. b. Abstracts: Three 26
  27. 27. Annual Report of Educational Activities Department of Internal Medicine University of Pittsburgh School of Medicine 2004 - 2005 Name: Adolfo Garcia-Ocana, PhD Section: Endocrinology Type of Activity Date(s) Location/Course I. Attending A. Inpatient General Medicine B. Outpatient 1. Residents Weekly Clinic 2. Residents Ambulatory Block 3. Students Ambulatory Block C. Consult Service 1. General Medicine 2. Subspecialty (Endocrinology) D. Student Tutor E. 2nd Year Clinical Tutor F. Others (specify) 2004-2005 Research Advisor: P. Rao, MD; J.A. Gonzalez-Pertusa, PhD. II. Lecture/Seminar A. For Residents 07/04 Introduction to Core Research Techniques: “The characterization and manipulation of DNA in vitro”. B. For Students C. Others III. UPMC Medical Grand Rounds IV. Affiliated Hospital Program 27
  28. 28. Annual Report Division of Endocrinology 2004 - 2005 Name: Bret H. Goodpaster, PhD Title: Assistant Professor of Medicine; Adjunct Assistant Professor of Health and Education Recreation Section: Endocrinology Honors: Study section member, ad hoc, NIH/NIDDK March 22-24, 2004. Study section member, ad hoc, NIH/EDCA June 21-22, 2004. Study section member, ad hoc, NIH/NCAM November 3-4, 2004. Invited Symposium Speaker, American Geriatrics Society, Baltimore, 2004. Invited Symposium Speaker. American College of Sports Medicine. Indianapolis. 2004. Invited Symposium Speaker, Geriatrics Society of America, Washington D.C., 2004. Invited Symposium Speaker. American College of Sports Medicine. Nashville. 2005. Invited Speaker, Advances for the Treatment of Obesity, Albuquerque. 2004. Obesity Nutrition Research Center Grants Review Committee, 2004-2005. Committees: a. National: None b. University: General Clinical Research Center Advisory Committee Magnetic Resonance Research Center Advisory Committee Co-director, Energy Balance Core of the Obesity Nutrition Research Center c. Hospital: None d. Departmental: Endocrinology Division Website Committee e. Veterans Hospital:None Invited Lectures, Seminars: a. February 27, 2004. Invited Speaker. Advances in the Treatment of Obesity, “Treatment of Obesity: Exercise, Weight Loss and Insulin Resistance.” Albuquerque, NM. b. January 28, 2004. Invited Symposium Speaker. “Skeletal Muscle Mass and Quality as Contributors of Frailty.” American Geriatrics Society, Baltimore, MD. c. June 2, 2004. Invited Symposium Speaker. “Interactions between Physiology and Exercise Related to Obesity.” American College of Sports Medicine. Indianapolis, IN. d. June 3, 2004. Invited Symposium Speaker. “Physical Activity, Intramuscular Fat, and Insulin Resistance.” American College of Sports Medicine. Indianapolis, IN. e. May 21, 2004. Obesity Center Conference. “Regional Fat Distribution and the Metabolic 28
  29. 29. Syndrome.” Saint Luke’s – Roosevelt Hospital Center Columbia University College of Physicians & Surgeons. New York, NY. f. November, 2004. Invited Symposium Speaker. “Muscle fat infiltration as a marker of muscle quality in older adults.” Geriatric Society of America. Baltimore, MD. g. February 17, 2005. Invited Speaker. “Muscle lipid accumulation and insulin resistance: What is the role of mitochondria and exercise?” National Institutes of Health, Phoenix, AZ. h. March 17, 2005. University of Pittsburgh Endocrinology and Metabolism Research Conference. “Insulin Resistance and Type 2 Diabetes in Aging.” i. March 14, 2005. Invited Speaker, Endocrine Grand Rounds. “Skeletal Muscle Lipid Accumulation: An Important Link Among Fitness, Fatness, and Insulin Resistance?” University of Oregon Health Sciences, Portland, OR. j. March 14, 2005. Invited Speaker, Portland Bone Club Seminar. “Sarcopenia and Skeletal Muscle Quality in Older Men and Women: Implications for Frailty and Fracture.” University of Oregon Health Sciences, Portland, OR. k. March 30, 2005. Invited Speaker. “Insulin resistance and type 2 diabetes in aging: What is the role of muscle lipid and mitochondria function?” John Pierce Laboratory, Yale University, New Haven, CT. Editor, Associate Editor: Editor -- none Associate Editor – Journals of Gerontology Medical Sciences, 2005; Medicine and Science in Sports and Exercise, 2005 Editorial Boards-- Diabetes Forecast Reviewer for: The Lancet, Diabetes, Diabetes Care, Journal of Clinical Endocrinology and Metabolism, American Journal of Clinical Nutrition, American Journal of Physiolog,, Journal of Applied Physiology, Obesity Research, Metabolism, Medicine and Science in Sports and Exercise, Journal of the American Geriatrics Society, Journals of Gerontology, 2004-2005. Research Topics: a. Skeletal muscle composition in obesity, type 2 diabetes, and aging b. In vivo substrate metabolism in obesity, type 2 diabetes and aging c. Effects of exercise training on skeletal muscle metabolism in obesity and in the elderly d. Muscle structure and function in aging and in patients with osteoarthritis 29
  30. 30. Grants/Awards/Contracts: a. Active Direct Costs 1. R01 AG20128-01(Goodpaster) NIH/NIA 7/04-06/08 $880,000 Muscle Lipid and Insulin Resistance in Aging 2. Clinical Research Award(Goodpaster) ADA 1/04-1/07 $260,871 Skeletal Muscle Lipid and Insulin Resistance: Effects of Physical Activity and Weight Loss 3. N01-AG-6-2101 (Newman) NIH/NIA 3/96-11/07 $25,333 Dynamics of Health, Aging and Body Composition (Health ABC) – Field Center 4. R01 AG021024-01 (Ferrell) NIH/NIA 3/03-2/98 $56,295 Genetic Epidemiology of Musculoskeletal Aging 5. R01 HL70257-01A1 (Jakicic) NIH 1/03-12/06 $22,518 Effects of Exercise on Prevention of Weight Gain 6. P30 DK46204 (Kelley) NIH/NIDDK 4/03-3/08 $56,295 Obesity Nutrition Research Center 7. N01-AR-2-2260 (Kwoh) NIH/NIAMS 7/02-05/09 $19,703 Osteoarthritis Initiative – Clinical Center 8. Experimental and Applied Sciences (Goodpaster) 4/04-9/05 $121,520 The Effects of Exercise Training and Dietary Supplementation on Fat Metabolism and Body Composition in Obese Women 9. U01-AG022376-01 (Newman) NIH/NIA 7/03-09/07 $33,777 Exercise to Prevent Disability Pilot Study b. Pending 1. ADA Program Project Grant (Goodpaster) ADA 1/06-12/07 $347,826 Linking Mitochondrial Function to the Prevention Publications for 2004-2005 a. Manuscripts Published: 1. Goodpaster BH, Stenger A, Boada F, McKolanis T, Davis D, Ross R, Kelley D: Skeletal Muscle Lipid Concentration Quantified by MRI. American Journal of Clinical Nutrition, 79:748-754, 2004. 2. Ruhl CE, Everhart JE, Ding J, Goodpaster BH, Kanaya AM, Simonsick EM, Tylavsky FA, Harris TB, Health A, Body Composition S: Serum leptin concentrations and body adipose 30
  31. 31. measures in older black and white adults. American Journal of Clinical Nutrition 80:576-583, 2004 3. Holvoet P, Kritchevsky SB, Tracy RP, Mertens A, Rubin SM, Butler J, Goodpaster BH, Harris TB: The metabolic syndrome, circulating oxidized LDL, and risk of myocardial infarction in well- functioning elderly people in the health, aging, and body composition cohort. Diabetes 53:1068-1073, 2004 4. Kanaya AM, Harris T, Goodpaster BH, Tylavsky F, Cummings SR: Adipocytokines attenuate the association between visceral adiposity and diabetes in older adults. Diabetes Care 27:1375-1380, 2004 5. He J, Goodpaster BH, Kelley DE: Effects of weight loss and physical activity on muscle lipid content and droplet size. Obesity Research 12:761-769, 2004 6. Pruchnic R, Katsiaras A, He J, Kelley DE, Winters C, Goodpaster BH: Exercise training increases intramyocellular lipid and oxidative capacity in older adults. Am J Physiol Endocrinol Metab 287:E857-E862, 2004 7. Kanaya AM. Fyr CL. de Rekeneire N. Shorr RI. Schwartz AV. Goodpaster BH. Newman AB. Harris T. Barrett-Connor E. Predicting the development of diabetes in older adults: the derivation and validation of a prediction rule. Diabetes Care. 28(2):404-8, 2005 8. Ritov VB. Menshikova EV. He J. Ferrell RE. Goodpaster BH. Kelley DE. Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes. 54(1):8-14, 2005 9. Katsiaras A, Newman AB, Kriska A, Brach J, Krishnaswami S, Feingold E, Kritchevsky SB, Li R, Harris TB, Schwartz A, and Goodpaster BH. Skeletal Muscle Fatigue, Strength and Quality in the Elderly: The Health ABC Study. J Appl Physiol, Feb 2005. 10. Menshikova EV, Ritov VB, Toledo FGS, Ferrell RE, Goodpaster BH, and Kelley DE. Effects of Weight Loss and Physical Activity on Skeletal Muscle Mitochondrial Function in Obesity. Am J Physiol Endocrinol Metab, Dec 2004. 11. Goodpaster, BH, Wolf D: Skeletal muscle lipid accumulation in obesity, insulin resistance and type 2 diabetes. Pediatric Diabetes 5:219-226, 2004. In Press or Submitted: 1. Goodpaster BH, Krishnaswami S, Harris T, Katsiaras A, Kritchevsky S, Simonsick E, Nevitt M, Holvoet P, Newman A: Regional Body Fat Distribution and The Metabolic Syndrome in Older Men and Women. Archives of Internal Medicine, In Press. 2. Menshikova EV, Ritov VB, Fairfull L, Ferrell RE, Kelley DE and Goodpaster BH. Effects of Exercise on Subsarcolemmal and intermyofibrillar mitochondria in human skeletal muscle. Journal of Gerontology Biological Sciences, In Review. 3. Fleet, S, Wolf, D, Katsiaras, A, Goss, F, Jakicic, J and Goodpaster, BH. Substrate Oxidation during Exercise in Overweight and Normal Weight Women. Medicine and Science in Sports and Exercise, submitted. 31
  32. 32. 4. Goodpaster BH, Brown NF: Exercise and the Role of Muscle Triglyceride in Obesity, Insulin Resistance and Type 2 Diabetes. Exercise & Sport Sciences Reviews, In Press. b. Abstracts: Six. 32
  33. 33. Annual Report of Educational Activities Department of Internal Medicine University of Pittsburgh School of Medicine 2004 - 2005 Name: Bret H. Goodpaster, Ph.D. Section: Endocrinology Type of Activity Date(s) Location/Course I. Attending A. Inpatient General Medicine None B. Outpatient 1. Residents Weekly Clinic 2. Residents Ambulatory Block 3. Students Ambulatory Block C. Consult Service 1. General Medicine 2. Subspecialty (Endocrinology) None D. Student Tutor E. 2nd Year Clinical Tutor F. Others (specify) Research Advisor: Carena Winters PhD. Dissertation: “Substrate Availability and Utilization During Exercise in the Elderly” Completed December 2004. Role: Research advisor and committee chair. Andy Katsiaras PhD, Dissertation: “Effects of Exercise Training on Skeletal Muscle Lipid Content and Insulin Sensitivity in the Elderly” Completed December 2003. Role: Research advisor and committee chair. Sara Fleet, Masters degree candidate, Thesis: “The effects of resistive or aerobic training on fat metabolism in obese women” Completed May 2004. Role: Research advisor and committee chair. Donna Wolf, PhD candidate. John Dube, Post-doctoral Fellow. Project, “Effects of exercise and weight loss on lipid accumulation in human skeletal muscle.” Role: Mentor. II. Lecture/Seminar A. For Residents None B. For Students Exercise in Obesity and Type 2 Diabetes Mellitus, Graduate Course, School of Health and Recreation Education: Summer terms 2004. Skeletal Muscle Biochemistry, Graduate Course, School of Health and Recreation Education: Summer terms 2005. Exercise, Obesity and Diabetes, Graduate 33
  34. 34. Course, School of Health and Recreation Education: Summer terms 2004. C. Others Introduction to Core Research Techniques, Division of Endocrinology, 2004 and 2005. School of Health Education: Two lectures Graduate School of Public Health: Two lectures Miscellaneous Lectures to Adult Endocrinology and Geriatric Medicine Conferences. III. UPMC Medical Grand Rounds None. IV. Affiliated Hospital Program March 4, 2004. Outreach Lecture, Brownsville, Hospital 34
  35. 35. Annual Report Division of Endocrinology 2004 - 2005 Name: Susan L. Greenspan, MD Title: Director, Osteoporosis Prevention and Treatment Center Professor of Medicine Associate Program Director, General Clinical Research Center Section: Endocrinology / Geriatric Medicine Honors: Invited speaker, Plenary Session, Annual Meeting of the American Society for Bone and Mineral Research, Seattle, Washington, 2004 America’s Top Doctors, 2004 Who’s Who in Medicine and Healthcare, 2002- Council Member, American Society for Bone and Mineral Research, 2002- Co-Editor, Osteoporosis: Clinical Updates, National Osteoporosis Foundation, 2002-2004 Coordinating Author, Surgeon General’s Report on Osteoporosis, 2002-2004 Editorial Board, Journal of Clinical Endocrinology and Metabolism, 2001- Board of Trustees, International Society for Clinical Densitometry, 2001-2004 Editorial Board, Journal of Gerontology: Medical Sciences, 1999- Editorial Board, Journal of Clinical Densitometry, 1998- Best Doctors in America, U.S. News and World Report, 1998-00, 2002- Editorial Board, Journal of Bone and Mineral Research, 1996- Committees: a. National: Member, Expert Blue Ribbon Panel, U.S. Administration on Aging, Whole Woman Strategy and Action Plan to Raise Awareness About Osteoporosis, 2004- Nomination Committee, American Society for Bone and Mineral Research, 2004 Chair, Osteoporosis Pathophysiology Section, Scientific Program Committee, American Society for Bone and Mineral Research, 2004 Session Chair, Annual Meeting of the American Society for Bone and Mineral Research, 2004 Vice Chair, Professional Practice and Policy Subcommittee, Scientific Advisory Board, National Osteoporosis Foundation, 2002-2004 Scientific Advisory Council, International Society for Clinical Densitometry, 2001- Scientific Advisory Board, National Osteoporosis Foundation, 1995-2004 Mid-Atlantic Osteoporosis Board, 2000- 35
  36. 36. b. University: Multidisciplinary Advisory Committee, K12 Clinical Research Scholars Program, Department of Medicine, 2004- Standing Committee for Non-Tenured Faculty Promotions and Appointments, Department of Medicine, 2001-2004 Chair, Education Subcommittee, General Clinical Research Center, 2001- Institutional Data and Safety Monitoring Board Subcommittee, 2001- Scientific Advisory Committee, General Clinical Research Center, 1999- Prevention Task Force, School of Public Health, 1999- c. Hospital: Clinical Research Steering Committee, 1999- d. Departmental: Geriatric Fellowship Selection Committee, 2002- Committee on Women’s Status at the University of Pittsburgh, Department of Medicine, 2000- Endocrinology Fellowship Selection Committee, 1999- Internal Medicine Residents Selection Committee, 1999- e. Veterans Hospital:None Invited Lectures, Seminars: a. July 7, 2004. “The Impact of Androgen Deprivation Therapy on Bone Loss in Men with Prostate Cancer,” Pittsburgh, PA b. July 30, 2004. “Advances in Osteoporosis,” Fellows Conference, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA c. August 5, 2004. “Bone Loss Following Chemotherapy in Women with Breast Cancer,” Pittsburgh, PA d. August 19, 2004,” Steroid-Induced Bone Loss,” Pittsburgh, PA e. October 2, 2004. “Anabolic Treatment for Osteoporosis,” Plenary Session, Annual Meeting of the American Society for Bone and Mineral Research, Seattle, WA f. October 3, 2004. “”Combination Therapy with PTH and Antiresorptives,” NPS Pharmaceuticals Symposium, Annual Meeting of the American Society for Bone and Mineral Research, Seattle, WA g. October 3, 2004. “Combination Therapy Roundtable,” Annual Meeting of the American Society for Bone and Mineral Research h. November 3, 2004. “Combination Therapy with Parathyroid Hormone,” Endocrine Grand Rounds, University of California, San Francisco, CA i. November 3, 2004. “Osteoporosis in Men,” Endocrine Metabolism Noon Conference, VAMC, San Francisco, CA j. November 3, 2004, Endocrine Fellow Cases, University of California, San Francisco, CA k. November 9, 2004. “Osteoporosis,” Problem Based Learning Module, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA l. November 13, December 7 and 14, 2004. “Clinical Skills Course,” Department of Medicine, University of Pittsburgh, Pittsburgh, PA 36
  37. 37. m. December 10, 2004. “Dual X-ray Absorptiometry,” Case Based Learning Module, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA n. February 28, 2005. “Head to Head Comparisons of Antiresorptive Therapies,” Pittsburgh, PA o. March 28, 2005. “Osteoporosis,” Montefiore Hospital Housestaff, University of Pittsburgh Medical Center, Pittsburgh, PA p. March 30, 2005. “Surrogate Markers for Fracture Reduction,” Pittsburgh, PA q. April 8, 2005. “Osteoporosis Update,” 13th Annual Clinical Update in Geriatric Medicine, University of Pittsburgh, Pittsburgh, PA r. April 9, 2005. “Bisphosphonates: What We Know and Don’t Know,” 6th International Symposium on Osteoporosis, National Osteoporosis Foundation, Washington, DC s. June 17, 2005. “Combination Therapy for Osteoporosis,” University-Wide Endocrine Conference, University of Pittsburgh, Pittsburgh, PA Editor, Associate Editor: Co-Editor --Osteoporosis: Clinical Updates, National Osteoporosis Foundation Editorial Boards --Journal of Bone and Mineral Research --Journal of Clinical Endocrinology and Metabolism --Journal of Clinical Densitometry --Journal of Gerontology: Medical Sciences --Osteoporosis: Clinical Updates, National Osteoporosis Foundation Research Topics: a. Osteoporosis in elderly men and women f. Combination therapy for the treatment of osteoporosis g. Osteoporosis in men with prostate cancer h. New assessments of bone density and rate of bone loss in elderly women Grants/Awards/Contracts: a. Active Direct Costs 1. M01 RR00056-42 NIH/NCRR 12/03-11/08 $212,670 (Levine, PI – Greenspan, Assoc. Program Director) General Clinical Research Center, University of Pittsburgh 2. N01 AR-9-2245 (Black) NIH/NIAMS 10/99-10/05 $572,731 PTH and Alendronate in Combination in the Treatment of Osteoporosis 3. R01 DK61536-03 (Greenspan) NIH/NIDDK 12/02-11/06 $740,000 Prevention of Osteoporosis in Men with Prostate Cancer on Androgen Deprivation Therapy (POP Study) 4. K24 DK062895-02 (Greenspan) NIH/NIDDK 1/03-11/07 $650,714 Osteoporosis in Older Men and Women 37
  38. 38. 5. P30 AG024827-02 (Greenspan, Core PI) NIH/NIA 9/04-5/09 $79,765 Pittsburgh Older American Independence Center 6. Pharmaceutical Study (Greenspan) Aventis Pharm. 11/02-6/07 $34,945 The Effect of Bisphosphonate on Bone Mass, Bone Turnover and Bone Mineral Metabolism in Premenopausal and Newly Postmenopausal Women with Breast Cancer Following Chemotherapy 7. FACT Study (Greenspan) Merck & Co 9/02-8/05 $61,251 A Randomized Double-blind, Double-dummy, Parallel Group, Multicenter Study to Evaluate and Compare the Effects of Once Weekly Alendronate and Risedronate on Bone Mineral Density in Postmenopausal Women with Osteoporosis 8. Pharmaceutical Study (Greenspan) Novartis Pharm. 9/03-3/06 $60,000 The Impact of Prostate Cancer on Skeletal Health in Men 9. Pharmaceutical Study (Greenspan) Aventis Pharm. 3/04-2/06 $34,080 Open-Label Study to Determine How Prior Therapy with Risendronate or Alendronate in Postmenopausal Women with Osteoporosis Influences the Clinical Effectiveness of Teriparatide 10. Pilot Award (Greenspan) UPCI 5/04-5/06 $25,000 (Univ. of Pittsburgh Cancer Institute) Genetic Determinants of the Response to Osteoporosis Treatment in Men with Prostate Cancer on Androgen Deprivation Therapy 11. Aging Pilot Award (Greenspan) UPCI 8/04-7/06 $25,000 (Univ. of Pittsburgh Cancer Institute) Genetic Determinants of Bone Loss in Men with Prostate Cancer 12. Pharamceutical Study (Greenspan) Aventis 2/05-1/06 $26,485 The Effect of High Impact Exercise on Skeletal Integrity in Master Athletes b. Pending 1. Competitive Medical Research Fund UPMCHS 5/05-4/06 $25,000 Effect of Lower Extremity Loading on Bone Density and Muscular Strength in Life-Long Competitive Athletes Publications for 2003-2004 a. Manuscripts Published: 1. Coates PS, Fernstrom JD, Fernstrom MH, Schauer PR, Greenspan SL. Gastric bypass surgery for morbid obesity leads to an increase in bone turnover and a decrease in bone mass. J Clin Endocrinol Metab. 89:1061-1065, 2004. 2. Rosen HN, Parker RA, Greenspan SL, Iloputaife ID, Bookman L, Chapin D, Perlmutter J, Kessel B, Qvist P, Rosenblatt M. Evaluation of ability of biochemical markers of bone turnover to predict a response to increased doses of HRT. Calcif Tissue Int. 74:415-423, 2004. 3. Luckey M, Kagen R, Greenspan S, Bone H, Kiel RD, Simon J, Sackarowitz J, Palmisano J, Chen E, Petruschke RA, De Papp AE. Once-weekly alendronate 70 mg and raloxifene 60 mg daily in the treatment of postmenopausal osteoporosis. Menopause 11:405-415, 2004. 38
  39. 39. 4. Greenspan SL, et al. Assessing the risk of bone disease and fracture. In U.S. Department of Health and Human Services, ed. Bone Health and Osteoporosis: A Report of the Surgeon General. U.S. Department of Health and Human Services, Office of the Surgeon General, Rockville, MD, 2004, pp. 187-217. 5. Greenspan SL, et al. Prevention and treatment for those who have bone diseases. In U.S. Department of Health and Human Services, ed. Bone Health and Osteoporosis: A Report of the Surgeon General. U.S. Department of Health and Human Services, Office of the Surgeon General, Rockville, MD, 2004, pp. 219-253. In Press or Submitted: 1. Greenspan SL, Resnick NM, Parker RA. The effect of hormone replacement on physical performance in community-dwelling elderly women: a randomized, controlled trial. A J Med. 2004 (in press). 2. Dacal K, Sereika SM, Greenspan SL. Quality of life in prostate cancer patients on androgen deprivation therapy. J Am Geriatr Soc. 2004 (submitted). 3. Harpavat M, Greenspan SL, O’Brien C, Chang C-C, Bowen A, Keljo DJ. Altered bone mass in children at time of diagnosis of Crohn’s disease: A pilot study. J Pediatr Gastroenterol Nutr. 2004 (submitted). 4. Greenspan SL, Resnick NM, Parker RA. Vitamin D supplementation in older women. J Gerontol: Med Sci. 2005 (in press). 5. Towers AL, Clay CA, Sereika SM, McIntosh I, Greenspan SL. Skeletal integrity in patients with nail patella syndrome. J Clin Endocrinol Metab. 2005 (in press). 6. Greenspan SL, Resnick NM, Parker RA. Early changes in biochemical markers of bone turnover are associated with long-term changes in bone mineral density in elderly women on alendronate, hormone replacement therapy, or combination therapy: a 3-year, double-blind, placebo- controlled, randomized clinical trial. J Clin Endocrinol Metab. 2005 (in press). 7. Rajakumar K, Fernstrom JD, Janosky JE, Greenspan SL. Vitamin D insufficiency in preadolescent African American children. Clin Pediatr. 2005 (in press). 8. Greenspan SL, Coates P, Sereika SM, Nelson JB, Trump DL, Resnick NM. Bone loss after initiation of androgen deprivation therapy in patients with prostate cancer. J Clin Endocrinol Metab. 2005 (submitted). 9. Greenspan SL, Beck TJ, Resnick NM, Bhattacharya R, Parker RA. The effect of hormone replacement, alendronate, or combination therapy on hip structural geometry: a 3-year, double- blind, placebo-controlled clinical trial. J Clin Endocrinol Metab. 2005 (submitted). 10. Black DM, Bilezikian JP, Ensrud KE, Greenspan SL, Palermo L, Hue T, Lang F, McGowan JA, Rosen CJ. The effect of 1 year of alendronate following 1 year of PTH 1-84: second year results from the PTH and alendronate (PaTH) trial. N Engl J Med. 2005 (submitted). b. Abstracts: Eight 39
  40. 40. Annual Report of Educational Activities Department of Internal Medicine University of Pittsburgh School of Medicine 2004 - 2005 Name: Susan L. Greenspan, M.D. Section: Endocrinology, Geriatric Medicine Type of Activity Date(s) Location/Course I. Attending A. Inpatient General Medicine None B. Outpatient None 1. Residents Weekly Clinic 2. Residents Ambulatory Block 3. Students Ambulatory Block C. Consult Service 1. General Medicine None 2. Subspecialty (Endocrinology) Feb 1-28, 2005 PUH/Montefiore/VA/ Magee D. Student Tutor Cheryl Clay (MS II, Mentored Medical Student in Clinical Research – NIH/NCRR); Kirsten Dacal (John A. Hartford American Federation for Aging Research 2004 Student Scholar); Nicole Velez (John A. Hartford American Federation for Aging Research 2005 Student Scholar), Amy Zhang (John A. Hartford American Federation for Aging Research 2005 Student Scholar) E. 2nd Year Clinical Tutor None F. Others (specify) Fellows: Rajib Bhattacharya (Endocrinology), Matthew Levy (Endocrinology); Julia Warren-Ulanch (Endocrinology) Junior faculty: Kumaravel Rajakumar (General Pediatrics), Manisha Harpavat (Pediatric GI); Pouran Famili (Dentistry), Cheryl Bernstein (Anesthesiology), Jean McCrory (Orthopedics), Adele Towers (Geriatric Medicine) 40
  41. 41. II.Lecture/Seminar A. For Residents Miscellaneous lectures to Adult Endocrinology, Pediatric Endocrinology, General Pediatrics, Geriatric Medicine B. For Students November, 2004 Endocrine 2nd year course, 1 lecture C. Others Miscellaneous lectures to Adult Endocrinology, Pediatric Endocrinology, General Pediatrics, Geriatric Medicine III. UPMC Medical Grand Rounds None IV. Affiliated Hospital Program Internal Medicine and Geriatric Medicine CME Courses 41
  42. 42. Annual Report Division of Endocrinology 2004 - 2005 Name: Mara J Horwitz MD Title: Assistant Professor of Medicine Section: Endocrinology Honors: CME Committee, The Endocrine Society, 2003-2006. Committees: a. National: CME Committee, The Endocrine Society, 2003-2006 b. University: Applicant Interviewer, Medical School Admissions Committee Member, GCRC Advisory Committee Member, ONRC Grant Advisory Committee c. Hospital: None d. Departmental: Member, Task Force on Women and Family Issues e. Veterans Hospital:None Invited Lectures, Seminars: 1. PTHrP: Clinical Aspects. ASBMR Advances in Skeletal Anabolic Agents for the Treatment of Osteoporosis, Bethesda, MD, 2004. 2. The Temporal Profile in Humans of the Acute Skeletal Anabolic Response to Continuous, Steady-State Infusion of PTHrP and PTH. ASBMR Annual Meeting, Seattle, October 2004. Editor, Associate Editor: None Research Topics: a. Human in vivo pathophysiology of parathyroid hormone-related protein b. Parathyroid hormone-related protein and osteoporosis therapy c. Effect of parathyroid hormone alone and in combination with a bisphosphonate, in the treatment of postmenopausal osteoporosis. d. Effect of the SERM, Raloxifene, on heart disease in postmenopausal women with known heart disease e. Effect of the bisphosphonate Alendronate in the prevention of steroid-induced osteoporosis f. Effect of raloxifene compared to Alendronate in the treatment of postmenopausal osteoporosis 42
  43. 43. g. Effect of a once yearly infusion of a new bisphosphonate, zolendronate, in the prevention of postmenopausal osteoporotic fractures h. Effect of a new SERM, lasofoxifene, in the treatment of postmenopausal osteoporosis Grants/Awards/Contracts: Active Direct Costs 1. R01-51081 (Stewart) NIH 7/96-3/08 $297,112 Pathophysiology of PTH-related Protein(1-36) in Humans 2. Multiple Myeloma Research Foundation (MMRF) 1/04-12/07 $0 (Stewart) Pure Anabolic Skeletal Therapy with PTH-related Protein for Myeloma Bone Disease 3. LY139481 (J. Cauley) Eli Lilly Co. 9/98-8/05 $47,538 Raloxifene Hydrochlorid or Placebo in Postmenopausal Women at Risk for Major Coronary Events 4. LY139481 (J Cauley) Eli Lilly Co. 2/02-2/07 $47,538 Raloxifene Alendronate Comparison in Postmenopausal Women with Osteoporosis 5. A2181002 (J Cauley) Pfizer 2/02-1/06 $23,769 Postmenopausal Evaluation and Risk Reduction with Lasofoxifene 6. CZOL466H2301 (Cauley) Novartis 3/02-2/05 $24,957 A Multicenter, Double-blind, Randomized Placebo-Controlled Study to Evaluate the Safety and Efficacy of Zolendronic Acid in the Treatment of Osteoporosis in Postmenopausal Women Taking Calcium and Vitamin D. Publications for 2004-2005 a. Manuscripts Published: 1. Horwitz MJ, Stewart AF. Humoral Hypercalcemia of Malignancy. In Favus MF (ed.), Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Fifth Edition, The Society for Bone and Mineral Research, Washington DC, , pp.246-250. 2. Horwitz MJ, Roodman GD. Paget’s Disease of Bone. In, Andreolli TE (Ed), CECIL Essentials of Medicine, Sixth Edition. WB Saunders Company, Philadelphia, 2004, pp 723-727. 3. Bisello A, Horwitz MJ, Stewart AF. Parathyroid Hormone-related Protein: An Essential Physiologic Regulator of Adult Bone Mass. Endocrinology 145:3551-3, 2004. 4. Horwitz MJ, Tedesco MB, Sereika SM, Syed MA, Garcia-Ocana A, Bisello A, Hollis BW, Rosen CJ, Wysolmerski JJ, Dann P, Gundberg CM, Stewart AF. Continuous infusion of parathyroid hormone versus parathyroid hormone-related protein in humans: Discordant effect on 1,25(OH)2 vitamin D and prolonged suppression of bone formation. (submitted) 2005. 5. Horwitz MJ, Tedesco MB, Sereika SM, Garcia-Ocana A, Bisello A, Hollis BW, Gundbert CM, Stewart AF. Safety and Tolerability of Subcutaneous PTHrP91-36) in Healthy Human Volunteers: A Dose Escalation Study. (submitted) 2005. b. Abstracts: 3 43
  44. 44. Annual Report of Educational Activities Department of Internal Medicine University of Pittsburgh School of Medicine 2004-2005 Name: Mara J Horwitz M.D. Section: Internal Medicine, Endocrinology ____________________________________________________________________________ Type of Activity Date(s) Location/Course I. Attending A. Inpatient General Medicine B. Outpatient 1. Residents Weekly Clinic 2. Residents Ambulatory Block 3 months Falk 2B 3. Students Ambulatory Block C. Consult Service 1. General Medicine 2. Subspecialty (Endocrinology) 11/04 PUH/Montefiore/VA D. Student E. 2nd Year Clinical Tutor 1/05 -2/05 Clinical Skills II Course (PDx III) F. Others (specify) II. Lecture/Seminar A. For Residents Miscellaneous Lectures to epidemiology, orthopedics, endocrinology, and transplant B. For Students Endocrinology Second Year Course 3 PBL sessions C. Others Miscellaneous Lectures to epidemiology, orthopedics, endocrinology III. UPMC Medical Grand Rounds None IV. Affiliated Hospital Program None 44
  45. 45. Annual Report Division of Endocrinology 2004-2005 Name: David E. Kelley Title: Professor of Medicine Director, Obesity & Nutrition Research Center Section: Endocrinology Honors: Member of the Metabolism Study Section NIH-NIDDK (2000-2004) American Diabetes Association, Board of Directors (2001-2005) Committees: a. National: Member of the Metabolism Study Section NIH-NIDDK (2000-2004) American Diabetes Association, Board of Directors (2002-2005) Chairperson, Safety Committee, NIH-NIDDK Look AHEAD Trial Steering Committee Co-Chair, NIH-NIDDK Bariatric Surgery Research Consortium b. University: Member, IRB Director, Obesity and Nutrition Research Center c. Hospital: d. Departmental: Co-Investigator of Endocrinology Training Grant Invited Lectures, Seminars: a. April 26, 2004 Yale University, John B. Pierce Laboratory, “Metabolic Inflexibility and the Pathogenesis of Insulin Resistance in Skeletal Muscle” b. May 10, 2004 NIH-NIDDK, Symposium on “Obesity, Skeletal Muscle and Insulin Resistance” c. May 26, 2004 NIH-NIA, Symposium on Biology of the Perimenopause: “Regional Adiposity and Insulin Resistance” d. June 7, 2005 American Diabetes Association, Invited lecture, “Mitochondrial Dysfunction in Type 2 Diabetes Mellitus“ e. June 14, 2004 Endocrine Society, Invited Lecture, “Metabolic Inflexibility and Insulin Resistance“ f. August 24, 2004 Abbott Laboratory “Mitochondrial Dysfunction in Skeletal Muscle in Type 2 DM and Obesity“ g. September 23, 2004 Pittsburgh Diabetes Update “Regional Adiposity and Obesity in Type 2 Diabetes Mellitus“ h. September 28, 2004 Japan Association for the Study of Obesity, Invited lecture, “Metabolic Inflexibility and Insulin Resistance“ i. November 15, 2004 North American Association for the Study of Obesity, Invited lecture “Mitochondrial Dysfunction in Obesity“ 45
  46. 46. j. November 18, 2004 Yale University, Endocrinology Grand Rounds: “PET Imaging of Insulin Resistance“ k. February 4, 2005 ADA Post Graduate Course, Invited lecture, “Non-alcoholic Steatohepatitis (NASH) “ Editor, Associate Editor: Editorial Board for Diabetes, American Journal of Physiology (Endocrinology/Metabolism), Journal of Clinical Endocrinology and Metabolism. Reviewer for American Journal of Physiology, Diabetes, Diabetes Care, Journal of Clinical Endocrinology and Metabolism, Journal of Clinical Investigation, Science, American Journal of Clinical Nutrition, Obesity Research, New England Journal of Medicine. Research Topics: Skeletal muscle substrate metabolism, insulin resistance; muscle mitochondrial function in insulin resistance; PET imagining, Type 2 diabetes mellitus (pathogenesis, complications and therapies); Obesity (pathogenesis, complications and therapies). Grants/Awards/Contracts: Active Direct Costs 5R01 DK060555 (Kelley) NIDDK 05/15/02-04/30/05 $881,707 Multi-Tracer PET Quantitation of Insulin Action in Muscle 2P30-DK046204 (Kelley) NIDDK 9/30/97-3/31/08 $2,917,036 Obesity/Nutrition Research Center R01-DK049200 (Kelley) NIDDK 7/1/04-11/30/08 $1,100,000 Mitochondrial Impairment in Muscle Insulin Resistance 5U01-DK057002 (Kelley) NIDDK 9/30/99-7/31/06 $5,222,163 Action for Health in Diabetes (LOOK AHEAD) Study of Health Outcomes of Weight Loss (SHOW, Pittsburgh Site) R01 DK60412 (Ravussin) NIDDK 9/01/01-8/31/06 $416,996 Fat Cell Size, Muscle Lipid Infiltration and Insulin Resistance (Look AHEAD Ancillary Study) R01 HL70298 (Gallagher) NHLBI 9/1/01-8/31/05 $171,732 MRI Derived Organ & Tissue Mass Changes with Weight Loss (Look AHEAD Ancillary Study) 1U01-DK066585 (Courcoulas) NIDDK 9/30/03-9/29/08 $87,126 Effect of Bariatric Surgery on Insulin Resistance & CVD R01-AG023977 (Sanders) NIDDK 9/30/03-8/31/07 $50,060 Obstructive Sleep Apnea (OSA) and Metabolic Syndrome: Role of Oxidative Stress R01-HL61744 (Detre) NHLBI 9/30/00-9/29/06 $77,123 BARI II: A Trial of Revascularization and Glycemic Control in NIDDM 46
  47. 47. 7-04-MN-23 (Kelley) ADA 7/1/04-6/30/08 $180,000 Mentor-Based Postdoctoral Fellowship Skeletal Muscle Insulin Resistance in Type 2 DM Publications for 2004-2005 a. Manuscripts Published: 1. Kelley DE, Kuller LH, McKolanis TM, Harper P, Mancino J, Kalhan S. Effects of moderate weight loss and orlistat on insulin resistance, regional adiposity and fatty acids in type 2 diabetes mellitus. Diabetes Care 27:33-40, 2004. 2. Marroquin OC, Kip KE, Kelley DE, Johnson BD, Shaw LJ, Bairey Merz CN, Sharaf BL, Pepine CJ, Sopko G, Reis SE, Metabolic syndrome modifies the cardiovascular risk associated with angiographic coronary artery disease in women Circulation 109:714- 721, 2004 3. Kip KE, Marroquin OC, Kelley DE, Johnson BD, Kelsey SF, Shaw LJ, Rogers WJ, Reis SE Clinical importance of obesity versus the metabolic syndrome in cardiovascular risk in women. Circulation 109:706-713, 2004 4. Goodpaster BH, Stenger VA, Boada F, McKolanis TM, Davis D, Ross R, Stenger A, Kelley DE. Skeletal muscle lipid concentration quantified by MRI. American Journal of Clinical Nutrition 79:748-754 2004 5. He Jing, Goodpaster BH, Kelley DE Effects of weight loss and physical activity on muscle lipid content and droplet size. Obesity Research 12-5:761-769, 2004 6. Ritov VB, Menshikova EV, Kelley DE High-performance liquid chromatography-based methods of enzymatic analysis: electron transport chain activity in mitochondria from human skeletal muscle. Analytical Biochemistry 333:27-38, 2004. 7. Cottam DR, Mattar SG, Barinas-Mitchell E, Kuller L, Kelley DE, Schauer PR The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: implications and effects of weight loss. Obesity Surgery 14:589-600, 2004 8. Heilbronn LK, Rood J, Janderova L, Albu JB, Kelley DE, Ravussin E, Smith SR, Relationship between serum resistin concentrations and insulin resistance in nonobese, obese and obese diabetic subjects. The Journal of Clinical Endocrinology & Metabolism 89: 1844- 1848, 2004 9. Fonseca,VA, Kelley DE, Cefalu W, Baron MA, Purkayastha D, Nestler JE, Hsia S, Gerich JE Hypoglycemic potential of nateglinide versus glyburide in patients with type 2 diabetes mellitus. Metabolism 53-10: 1331-1335, 2004 10. Butt AA, Fultz SL, Kwoh CJ ,Kelley DE, Skanderson M, Justice AC The risk of diabetes in HIV infected veterans the pre- and post-HAART era and the role of hepatitis C virus co- infection. Hepatology 40: 115-119, 2004 11. He J, Kelley DE, Muscle Glycogen content in type 2 diabetes mellitus. American Journal of Physiology (Endocrinology and Metabolism) 287: E1002-E1007, 2004 12. Ritov VB, Menshikova, EV, He J, Ferrell R, Goodpaster BH, Kelley DE Deficiency of sub- sarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes 55: 8-14, 2005 13. Pruchnic R, Katsiaras A, He J, Kelley DE, Winters C, Goodpaster B Exercise training increases intramyocellular lipid and oxidative capacity in older adults. American Journal of Physiology (Endocrinology and Metabolism) 287: E857 – E862, 2004 47
  48. 48. In Press or Submitted: 1. Menshikova EV, Ritov VB, Toledo F, Ferrell R, Goodpaster B, Kelley DE Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesity. American Journal of Physiology (Endocrinology and Metabolism) 288: E000- E000, 2005 2. Bertoldo A, Price J, Mathis C, Mason S, Holt D, Kelley C, Cobelli C, Kelley DE Quantitative assessment of glucose transport in human skeletal muscle: Dynamic PET imaging of [O- Methyl – 11C]3-O-Methyl-D-Glucose. Journal of Clinical Endocrinology & Metabolism 90 (3): 0000-0000, 2005 Reviews and Chapters: 1. Kelley DE, Toledo F.G.S. “NonInvasive Imaging of Insulin Action and Resistance in Humans”. Diabetes Mellitus: A Fundamental and Clinical Text, Third Edition,. Derek LeRoith, Simeon I. Taylor, Jerrold M. Olefsky (ed.) Lippincott Williams & Wilkins, 2004 2. Kelley DE, Storlein L. “Skeletal Muscle and Obesity”. Handbook of Obesity, Etiology and Pathophysiology, Second Edition. George A. Bray, Claude Bouchard (ed): Marcel Dekker, Inc., 2004 3. Goodpaster BH, Kelley DE. “Obesity and Diabetes: Body Composition Determinants of Insulin Resistance”. Human Body Composition, 2nd Edition, S. Heymsfield, T. Lohman, Z. Wang, and S. Going (ed). Human Kinetics. (In Press). 4. Storlien L, Oakes ND, Kelley DE, “Symposium 6: Adipose tissue-liver-muscle interactions leading to insulin resistance, metabolic flexibility” Proceedings of the Nutrition Society Gail Goldberg (ed): The Authors, 63, 363-368, 2004 5.. Kelley, DE “Influence of weight loss and physical activity interventions upon muscle lipid content in relation to insulin resistance” Current Diabetes Report, Edward S. Horton (ed): Current Science, Inc, 2004 6. Kelley, DK “Thermodynamics, liposuction and metabolism. New England Journal of Medicine: 350, 25 2542-2544, 2004 Reviews and Chapters In Press: 1. Buchwald H, O’Leary P, Billington C, Wittgrove A, Garcia V, Wolfe B, Detre K, Kelley DE, Sheldon G, Wadden T, Jensen M, Klein S Bariatric surgery for morbid obesity-2004 Consensus statement of the ASBS Consensus Conference on the state of bariatric surgery and morbid obesity: Health implications for patients, Health Professionals and third-party payers. Journal of the American College of Surgeons (In Press) 2. Toledo, FGS, Kelley, DE Mitochondrial dysfunction in the pathogenesis of insulin resistance associated with obesity, diabetes, and aging. Current Opinion in Endocrinology and Diabetes (In Press) 48

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