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Miniature Drug Delivery System Patent Search and Analysis Report
Miniature Drug Delivery System Patent Search and Analysis Report
Miniature Drug Delivery System Patent Search and Analysis Report
Miniature Drug Delivery System Patent Search and Analysis Report
Miniature Drug Delivery System Patent Search and Analysis Report
Miniature Drug Delivery System Patent Search and Analysis Report
Miniature Drug Delivery System Patent Search and Analysis Report
Miniature Drug Delivery System Patent Search and Analysis Report
Miniature Drug Delivery System Patent Search and Analysis Report
Miniature Drug Delivery System Patent Search and Analysis Report
Miniature Drug Delivery System Patent Search and Analysis Report
Miniature Drug Delivery System Patent Search and Analysis Report
Miniature Drug Delivery System Patent Search and Analysis Report
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Miniature Drug Delivery System Patent Search and Analysis Report

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Miniature Drug delivery System uses micro-fabricated devices to administer drugs to the host and has advantages over a conventional drug delivery

system.

A MEMS based Implantable Drug Delivery System (IDDS) is discussed. The heart of the system is an in-plane MEMS micropumps enables us to make a

compact, inexpensive system. A conceptual IDDS design is proposed. This design consists of an implantable unit which houses the micropumps,

electronic and power circuitry. This implantable unit is connected to a subcutaneous port via a silicone catheter. The subcutaneous port acts as

a refillable reservoir. This leads to a reduction in unit volume and makes the system customizable. The IDDS pumps drug into surrounding tissue

with the help of a MEMS based micropumps. Similarly Microneedles are also used in drug administration.

This report gives an overview of patenting activity around Miniature Drug Delivery System. Smart drug delivery system is used for delivering

drugs to the host effectively and improves the quality of life of the patients. Patents were categorized as per key Drug Delivery administration

methods, types of sensors, applications, communication techniques and analyzed for generating different trends with Patent iNSIGHT Pro.

Miniature Drug Delivery System technology has seen a consistent increase in the number of patent publications from 2008 till 2012 as the need for

smart drug delivery has increase globally.

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Miniature Drug Delivery System Patent Search and Analysis Report

  1. 1. Page 1 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comMiniature Drug DeliverySystemMiniature or smart drug delivery system is used to deliver drugs to apatient using the biological information. This info is detected with the helpof various sensors. MEMS & NEMS technology is used for delivery.Bio-MEMS typically focuses on mechanical parts and microfabricationtechnologies made suitable for biological applications. A broad definitionfor bio-MEMS can be used to refer to the science and technology ofoperating at the microscale for biological and biomedical applications,which may or may not include any electronic or mechanical functions.This report takes a look into the patenting activity around miniature/smartdrug delivery system, uncovering the key companies, inventors, anddifferent sub categories.Technology Insight ReportDisclaimer: This report should not be construed as business advice and the insights are not to be used as the basisfor investment or business decisions of any kind without your own research and validation. Gridlogics TechnologiesPvt. Ltd disclaims all warranties whether express, implied or statutory, of reliability, accuracy or completeness ofresults, with regards to the information contained in this report.
  2. 2. Page 2 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comIntroduction to Miniature drug delivery systemNanoelectromechanical systems (NEMS) are devices integrating electrical and mechanicalfunctionality on the nanoscale. NEMS form the logical next miniaturization step from so-calledelectromechanical system, or MEMS devices. NEMS typically integrate transistor-like nanoelectronics with mechanical actuators, pumps, or motors, and may thereby formphysical, biological, and chemical sensors. The name derives from typical device dimensions inthe nanometer range, leading to low mass, high mechanical resonance frequencies, potentiallylarge quantum mechanical effects such as zero point motion, and a high surface-to-volume ratiouseful for surface-based sensing mechanisms.Microelectromechanical systems (MEMS) also referred to as micro-electro-mechanical,MicroElectroMechanical or microelectronic and microelectromechanical systems) is thetechnology of very small devices; it merges at the nano-scale into nanoelectromechanicalsystems (NEMS) and nanotechnology. MEMS are also referred to as micromachines, or microsystems technology – MST.MEMS & NEMS based micropumps and microneedles are extensively used. These help toadminister accurate doses effectively. Sensors and different communication techniques are usedto felicitate the precise diagnosis and treatment.OverviewWith the help of Patent iNSIGHT Pro, we will analyze the patent data around miniature drugdelivery to find answers to the following:What does the IP publication trend for miniature drug delivery look like and how havethe filings evolved?Who are the top assignees or key players in miniature drug delivery and what are theirtechnology wise trends?How is research in miniature drug delivery spread across different countries?What are the different types of sensors used by various companies?How different methods of drug delivery used for various applications?How is the company portfolio spread across different applications?
  3. 3. Page 3 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comPatent CategorizationTo get deeper insights the patent set has been classified as follows:Methods-Drug DeliveryExternalInternalProgrammableTimedSensorsAmperometricBio-SensorsCalorimetricElectro-OpticFlowGlucoseImpedancePhoto-ReflectivePressureTemperatureMicropumpOsmoticPiezoelectricValveMicroneedleHollowPorousSolidStacked ConfigurationCommunication SystemBluetoothOpticalRadio Frequency (RF)WirelessApplicationsAtherosclerosisBlood InfectionCancerCardiacCoronary Artery DiseaseDermal DisorderDiabetesHypertensionMuscleNeurologicalPeripheral Vascular DiseaseSkinTraversing Alimentary Tract
  4. 4. Page 4 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comThe illustration below shows the different categories prepared and the number of records ineach. The categorization involved defining a search strategy for each topic and then conductingthe search using the Advanced Searching capability in Patent iNSIGHT Pro. Details of searchstrings used for each category are given in Appendix A.CATEGORIZATION TREE
  5. 5. Page 5 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comSearch StrategyUsing the commercial patent database PatSeer as our data source we used the following searchquery to create our patent set.TAC – Title Abstract ClaimsC-ClaimsIC- International ClassificationPBY- Publication YearThe queries were combined using the ‘OR’ operator to search intitle, abstract, claims and a patent set of 2545 records with onepublication per family was generated.The publications included in the report are updated as of14th March, 2013.TAC:(Microelectromechanical* or Micropump* ornanopump* or Microneedle* or nanoneedle* orsensor* or nanoject* or Microosmotic* or "MEMS" or"BioMEMS" or "micro-electro-mechanical" ormicroelectronic* or ("transdermal micro needle"%3 OR"transdermal microneedle*"%3) or ("(micro or nano)(system* or technology or pump* orelectromechanical* or needle* or medic* or osmotic*or sensor*)"%3) or nanoelectromechanical or "NEMS"or "BioNEMS" )ANDC:(("(drug* or pharma* or medic*) (inject* or deliver*or infuse* or diffuse* or perfuse* or releas* or syringe*or implant*)"%3))ANDIC:(A61M37/00 or A61K9/00 or A61K9/16 orA61P35/00 or A61M5/142 or A61K9/14 or A61M31/00or A61K47/34 or A61M5/00 or A61B5/00 or A61K47/36or A61K9/22 or A61K9/52 or A61K9/51)AND(PBY: [1990 TO 2013])Class Descriptions of Classes used in SearchStrategyA61K9/00: Medicinal preparations characterizedby special physical formA61M37/00: Other apparatus for introducingmedia into the body (for reproduction orfertilisationA61K9/16: Agglomerates; Granulates;MicrobeadletsA61P35/00: Antineoplastic agentsA61M5/142: Pressure infusion, e.g. using pumpsA61K9/14: Particulate form, e.g. powders(microcapsules A61K 9/50)A61M31/00: Devices for introducing or retainingmedia, e.g. remedies, in cavities of the bodyA61K47/34: Macromolecular compoundsobtained otherwise than by reactions onlyinvolving carbon-to-carbon unsaturated bondsA61M5/00: Devices for bringing media into thebody in a subcutaneous, intra-vascular orintramuscular wayA61B5/00: Measuring for diagnostic purposes(radiation diagnosis A61B 6/00; diagnosis byultrasonic, sonic or infrasonic waves A61B 8/00);Identification of personsA61K47/36: Polysaccharides; Derivatives thereofA61K9/22: Sustained or differential release typeA61K 9/50: MicrocapsulesA61K 9/50: Nanocapsules
  6. 6. Page 6 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comPublication TrendWhat has been the IP publication trend for miniature drug delivery system?The data shows an overall peak of patent activity in 2010.We can see that there are two periodsof growth in the last 10 years confirming that since the turn of the century the overall trend isfor a rise in the number of applications being published.The initial phase (1990-2002) in this field lasted up to the year 2002 having around 40publications during these years. This initial phase was followed by a transition phase (2003-2008) resulting in substantial increase in the patenting activity with around 145 publications.The transition phase, in turn, was followed by a period of very large number of publicationsduring the period 2009-2012 showing a huge increase in patenting activity reaching 225publications in just three years. Year 2010 comes out to be the year where there were thehighest number of publications followed by years 2009, 2012 and 2008.How we did it?Once the patents were populated in Patent iNSIGHT Pro, the publication trend chart was generated on asingle click using the dashboard tool.
  7. 7. Page 7 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comTop AssigneesWho have been the top assignees or the key players within this industry?The top assignees are:How we did it?Once the patents were populated in Patent iNSIGHT Pro, the assignee clean- up tools were used tonormalize the names. Different cleanup tools were leveraged:• To locate assignees for unassigned records• To clean up records having multiple assignees• To locate the correct assignee names for US records using the US assignments databaseOnce the Assignee names were cleaned up, the dashboard tool within Patent iNSIGHT Pro was used tofind the top 20 assignees within the given patent set. A visual graph was created based on the results ofthe top assignees with the number of patents alongside each one.The complete Assignee table in available in the following Excel file:http://www.patentinsightpro.com/techreports/0313/List%20of%20Assignees.xls11. BECTON DICKINSON & CO12. MILUX HOLDING SA13. UNIV SHANGHAI14. SEARETE LLC15. 3M CO16. ROCHE HOLDING AG17. BOSTON SCIENTIFIC CORP18. UNIV CALIFORNIA19. DEXCOM INC20. UNIV TSINGHUA1. MEDTRONIC INC2. CARDIAC PACEMAKERS INC3. PHILIPS CORP4. ABBOTT LAB5. PACESETTER INC6. NOVO NORDISK AS7. BAXTER INTERNATIONAL INC8. MICROCHIPS INC9. SANOFI SA10. ALZA CORP
  8. 8. Page 8 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comTop CountriesHow is research around miniature drug delivery spread across different countries?In terms of regional pockets where patent protection is being sought most frequently for thesetechnologies, US leads the count, followed by the CN and EP .The table below ranks top prioritycountries and helps provide an indication of where innovation in this area is originating:How we did it?The map was generated using the Priority country coverage map option provided in the dashboard toolwithin Patent iNSIGHT Pro.CountryCodeTotalUS 1695CN 301EP 92GB 52AU 38
  9. 9. Page 9 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comCompanies - Key StatisticsHere we summarize key parameters of Top 15 companies such as filing trend, Avg. number ofForward citations per record, Top inventors in each Assignee, Top Co-Assignees and Coverage ofunderlying patent familiesAssigneeTotal No.of RecordsAvg.No. ofFwdCitesperPatentsFiling Trend( Cumulative)FilingYearRangeKey Inventor(Top 5)Co-AssigneesCoverage(Includes families)USEPJPDECNAUKRMEDTRONICINC254 (10%)5.58 1993-2012MIESELKEITH A(28)HERUTHKENNETHT(15)GERBERMARTINT(14)DENISONTIMOTHYJ(12)CINBISCAN(11)INST NAT SANTERECH MED(1)MARKOWITZ HTOBY(1)234 137 47 54 14 32 1CARDIACPACEMAKERSINC67 (2.6%) 1.732001-2011STAHMANNJEFFREYE(11)HATLESTADJOHN D(9)LEE KENT(8)VON ARXJEFFREY A(8)HARTLEYJESSE W(7)No Co-AssigneePresent65 38 33 4 2 18 0PHILIPS CORP 34 (1.3%) 0.262005-2011NISATOGIOVANNI(7)IORDANOVVENTZESLAVP(6)KRIJNSENHENDRIKAC(6)VANBRUGGENMICHEL PB(6)KASSIESROELF(6)JANNER ANNA-MARIA(2)RUBINGH JAN-ERIC J M(1)17 21 18 1 19 0 0
  10. 10. Page 10 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comABBOTT LAB 31 (1.2%) 0.71 1995-2011HAYTERGARY(4)ELSTROMTUAN A(3)HENNINGTIMOTHYP(3)RUSHBENJAMIN(3)SHAIN ERICB(3)No Co-AssigneePresent29 15 7 4 6 9 0PACESETTERINC26 (1%) 18.61987-2011KOHSTEVE(4)EIGLER NEALL(3)MANNBRIAN(3)TURCOTTROBERT(3)COLMANFREDRICC(2)No Co-AssigneePresent24 12 5 6 0 2 0NOVONORDISK AS25 (1%) 5.121991-2012NIELSEN OLECHRISTIAN(8)PREUTHUNJANHARALD(5)RADMERJIM(5)BENGTSSONHENRIK(4)POULSENJENSULRIK(4)INST OFBIOCYBERNETICS AND BIO(1)TEISEN-SIMONYCLAUDE(1)17 18 8 8 7 6 3BAXTERINTERNATIONAL INC24 (0.9%) 0.211988-2010JACOBSONJAMES D(5)STEWARTJANICE(5)BELLODEBRA K(4)BUI TUAN(4)MEINZERRANDOLPH(4)No Co-AssigneePresent16 18 15 7 12 20 2MICROCHIPSINC22 (0.9%) 3.552000-2009HERMANSTEPHENJ(10)SANTINIJOHN T JR(9)SANTINI JRJOHN T(8)SHEPPARDNORMAN FJR(6)UHLANDSCOTT A(6)No Co-AssigneePresent22 15 9 9 3 15 2
  11. 11. Page 11 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comSANOFI SA 19 (0.7%) 0.051990-2012RICHTERRENE(7)NAGELTHOMAS(4)WITTROBERT(4)BASSONILS(3)CLARKEALASTAIR(2)No Co-AssigneePresent11 14 10 4 9 10 6ALZA CORP 18 (0.7%) 2.561992-2007CORMIERMICHEL JN(2)MARIKAKAMBERI(2)PETERDADDONA(2)RAJANPATEL(1)WONGPATRICK SL(1)No Co-AssigneePresent16 15 15 2 17 15 11BECTONDICKINSON &CO18 (0.7%) 4.671999-2010PETTISRONALD J(9)DOWNJAMES A(3)HARVEYNOEL G(3)SEARLEGARY(3)MIKSZTAJOHN A(3)HARVEY NOELG(1)16 15 13 7 7 12 1MILUXHOLDING SA17 (0.7%) 0.122009-2010FORSELLPETER(16)PETERFORSELL(1)No Co-AssigneePresent15 15 2 0 2 6 0UNIVSHANGHAIJIAOTONG16 (0.6%) 02004-2012HONGZHUAN CHEN(5)CHAOFANG(4)DEHONGYU(4)QIN LU(4)FAN BAI(3)No Co-AssigneePresent0 0 0 0 16 0 0SEARETE LLC 15 (0.6%) 0.732004-2011WOOD JRLOWELLL(12)HYDERODERICKA(11)ISHIKAWAMURIEL Y(9)WOODVICTORIA YH(9)SWEENEYNo Co-AssigneePresent15 2 1 0 0 0 1
  12. 12. Page 12 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comHow we did it?From the Assignee 360° report options, we selected Top 15 Assignees and the different pieces ofinformation we wanted to include in the singular display and then ran the report. The generated reportwas then exported to Excel using the option provided for the same.ELIZABETHA(9)3M CO 13 (0.5%) 2.621998-2012FREDERICKSONFRANKLYNL(4)DUANDANIEL C(3)CARTERCHAD J(2)JOHNSONPETER R(2)KEISTERJAMIESONC(1)ERDOGAN-HAUG BELMA(1)8 9 6 2 4 7 2
  13. 13. Page 13 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comInventor - Key StatisticsHere we summarize key parameters of Top 15 Inventors such as filing trend, average number offorward citations per record, key associated companies and top 5 co-inventors.InventorTotalNo. ofRecordsAvg.No. ofFwdCitesperPatentsFiling Trend(Cumulative)FilingYearRangeKey Assignees(Top 5)Co-InventorsMIESELKEITH A29(1.1%)10.551998-2011MEDTRONICINC(28)GEIGER MARKALLEN(1)KINGHORNCURTIS D.(1)LECKRONEMICHAELEUGENE(1)MIESEL KEITHALAN(1)HERUTH KENNETH T(9)STYLOS LEE(6)DENISON TIMOTHY J(3)ALI IRFAN Z(2)CHRISTOPHERSON MARKA(2)FORSELLPETER19(0.7%)0.112003-2010MILUX HOLDINGSA(16)PROSTHESICAAG(2)INJECTICA AG(1)No Co-Inventor PresentSTAHMANNJEFFREY E16(0.6%)52002-2011CARDIACPACEMAKERSINC(11)STAHMANNJEFFREY E.(3)LEE KENT(2)NI QUAN(2)STAHMANNJEFFREY E(2)HARTLEY JESSE W(8)LEE KENT(7)NI QUAN(7)HATLESTAD JOHN D(5)ZHU QINGSHENG(4)GERBERMARTIN T15(0.6%)1.42002-2010MEDTRONICINC(14)GERBERMARTIN(1)OLESONKIMBERLY(1)RONDONI JOHN C(9)OLESON KIMBERLY(1)HERUTHKENNETH T15(0.6%)31999-2011MEDTRONICINC(15)MIESEL KEITH A(9)LENT MARK S(4)BLANCO JUSTIN A(2)GRAVES NINA M(2)LAPORTE STEVE R(2)
  14. 14. Page 14 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comWOOD JRLOWELL L15(0.6%)0.272004-2011SEARETE LLC(12)INVENTIONSCIENCE FUND ILLC(2)HYDE RODERICKA(1)ISHIKAWAMURIEL Y(1)LEUTHARDT ERICC(1)HYDE RODERICK A(12)ISHIKAWA MURIEL Y(11)WOOD VICTORIA Y H(10)LEUTHARDT ERIC C(9)SWEENEY ELIZABETH A(9)CINBIS CAN13(0.5%)0.542006-2012MEDTRONICINC(11)CARNEY JAMESK(2)CINBIS CAN(2)SCHUGT MICHAELA(1)YE QINGSHAN(1)CARNEY JAMES K(6)KUHN JONATHAN L(6)ANDERSON DAVID A(3)DAVIS TIMOTHY J(3)ECKER ROBERT M(3)PETTISRONALD J13(0.5%)1.382001-2007BECTONDICKINSON &CO(9)PETTIS RONALDJ.(3)HARVEY NOELG(2)ALCHAS PAULG.(2)DOWN JAMES(2)HARVEY NOEL G(7)DOWN JAMES A(6)ALCHAS PAUL G(3)FERRITER MATTHEW S(2)MARTIN FRANK(2)DENISONTIMOTHY J12(0.5%)1.672007-2011MEDTRONICINC(12)MIESEL KEITH A(3)SANTA WESLEY A(3)MOLNAR GREGORY F(2)ANDERSON JOEL A(1)CONG PENG(1)HATLESTADJOHN D12(0.5%)42002-2011CARDIACPACEMAKERSINC(9)HATLESTAD JOHND(2)HATLESTADJOHN(1)STAHMANNJEFFREY E.(1)ZHUQINGSHENG(1)STAHMANN JEFFREY E(5)ZHU QINGSHENG(4)LEE KENT(3)SIEJKO KRZYSZTOF Z(3)COOK JEFFREY P(2)HYDERODERICK A12(0.5%)0.172007-2011SEARETE LLC(11)HYDE RODERICKA(1)ISHIKAWAMURIEL Y(1)LEUTHARDT ERICC(1)SMITH MICHAELA(1)WOOD JR LOWELL L(12)ISHIKAWA MURIEL Y(10)WOOD VICTORIA Y H(10)LEUTHARDT ERIC C(9)KARE JORDIN T(8)
  15. 15. Page 15 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comHERMANSTEPHEN J11(0.4%)2.092001-2009MICROCHIPSINC(10)GENZYMECORP(1)SANTINI JR JOHN T(5)AUSIELLO DENNIS(3)POLITO BENJAMIN F(3)SANTINI JOHN T JR(3)UHLAND SCOTT A(3)HICKLERANDALL S11(0.4%)1.271999-2012SCOTT LABINC(10)ETHICON INC(1)COBB NICHOLAS E(2)ADAIR W PATRICK(1)ADAIR WILLIAM P(1)BISHOP GREGORY D(1)BRUGGEMAN PAUL J(1)ISHIKAWAMURIEL Y11(0.4%)0.182007-2011SEARETE LLC(9)HYDE RODERICKA(1)ISHIKAWAMURIEL Y(1)LEUTHARDT ERICC(1)SMITH MICHAELA(1)WOOD JR LOWELL L(11)HYDE RODERICK A(10)WOOD VICTORIA Y H(10)LEUTHARDT ERIC C(9)KARE JORDIN T(7)THOMPSONDAVID L11(0.4%)30.21993-2011MEDTRONICINC(11)GOEDEKE STEVEN D(3)GREENINGER DANIEL R(2)BLAHA ERIC V(1)BONDE ERIC(1)COBIAN RYAN(1)How we did it?From the Inventor 360° report options, we selected the different pieces of information we wanted toinclude in the singular display and then ran the report. The generated report was then exported to Excelusing the option provided for the same.
  16. 16. Page 16 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comDrug Delivery: Company focus across various sensorsWhat are the different types of sensors used by various companies?Chart shows that pressure sensors are the most favored sensors amongstinventors/applicants in sensors technology space.Use of pressure sensor by most of the companies.Research around pressure sensors is fairly saturated followed by flow and glucosesensors.How we did it?The clusters that were created for analysis were correlated using the co‐occurrence analyzer and then theresulting matrix was converted into a 3-D column chart.
  17. 17. Page 17 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comDrug Delivery: Applications across various sensorsHow are various sensors spread across different applications?Pressure, temperature & glucose sensors are the most used sensors.There is substantial potential for research amongst other types of sensors as comparedto the top 3 typesHow we did it?The clusters that were created for analysis were correlated using the co‐occurrence analyzer and then theresulting matrix was converted into a clustered column chart.
  18. 18. Page 18 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comDrug Delivery: Company focus across micropumpsHow is the Assignee portfolio spread across different micropumps?Chart below shows that osmotic and valve micropumps are widely used.Principal AB has research focused on piezoelectric pumps; whereas Medtronics hasresearch interest in all the types of micropumps.How we did it?The clusters that were created are correlated using the co‐occurrence analyzer and the resulting matrixwas converted into a Stacked Column chart.
  19. 19. Page 19 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comDrug Delivery: Company across various applicationsHow is the Assignee portfolio spread across different applications?Chart below shows that all the companies except ST Jude Medical and Pacesetter Inchave developed technologies to administer drugs through/to skin.It can also be seen that there is minimal research around neurological, TraversingAlimentary Tract and Peripheral Vascular Disease drug administration.How we did it?The clusters that were created were correlated using the co‐occurrence analyzer and then the resultingmatrix was converted into a bubble chart.
  20. 20. Page 20 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comDrug Delivery: Applications Vs MethodsWhich methods are used across key application areas?Chart below shows the different methods used to administer drugs for specific diseases.
  21. 21. Page 21 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comHow we did it?The clusters that were created were correlated using the co‐occurrence analyzer and the resulting matrixwas converted into a 4-D Matrix containing methods of drug delivery and some filtered applications,publication year and results were restricted to last decade.
  22. 22. Page 22 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comDrug Delivery: Company focus across various types ofmicroneedlesHow is the company portfolio spread across different microneedles?Chart below shows that there is extensive research activity around Hollowmicroneedles.How we did it?The clusters that were created were correlated using the co‐occurrence analyzer and then the resultingmatrix was represented as stacked column area.
  23. 23. Page 23 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comAnalysis across different technologiesThe matrixes below show the filing trend, top companies and Inventors across respectivetechnologies.From the Technology 360° report options, we selected the different pieces of informationwe wanted to include in the singular display and then ran the report. The generated reportswere then exported to Excel using the option provided for the same.ApplicationsApplicationsTotalNo. ofRecordsAvg.No. ofFwdCitesperPatentsFilingYearRangeTop 5 Assignees Top 5 InventorsSkin518(20.4%)3.421989-2012MEDTRONIC INC(17)MILUX HOLDING SA(15)BECTON DICKINSON & CO(13)NOVO NORDISK AS(11)ABBOTT LAB(9)FORSELL PETER(16)PETTIS RONALD J(11)MIESEL KEITH A(7)BITTON GABRIEL(7)NAGAR RON(7)Cancer221(8.7%)0.691988-2012NOVARTIS AG(5)ALZA CORP(4)EURO CELTIQUE SA(4)UNIV CALIFORNIA(4)UNIV SHANGHAI JIAOTONG(4)DRIZEN ALAN(4)QIN LU(3)HOLGER PETERSEN(3)CHASIN MARK(3)MARKUS AHLHEIM(3)Muscle213(8.4%)2.411988-2012MILUX HOLDING SA(15)MEDTRONIC INC(14)BIOSENSE INC(4)PNEUMOFLEX SYSTEMS LLC(4)ALLERGAN INC(3)FORSELL PETER(15)ADDINGTON ROBERT(4)MILLER STUART(4)STEPHENS ROBERT(4)ZHOU XIAOHONG(3)Cardiac175(6.9%)5.771988-2012MEDTRONIC INC(30)CARDIAC PACEMAKERS INC(24)PACESETTER INC(9)ST JUDE MEDICAL INC(8)BIOSENSE INC(5)FISCHELL DAVID R(6)CARLSON GERRARD M(6)STAHMANN JEFFREY E(6)BROCKWAY MARINA(5)HATLESTAD JOHN D(5)Diabetes157(6.2%)2.591988-2012MEDTRONIC INC(7)ABBOTT LAB(7)BECTON DICKINSON & CO(5)INSULINE MEDICAL LTD(4)NOVO NORDISK AS(4)BITTON GABRIEL(5)NAGAR RON(5)PESACH BENNY(5)WEISS RAM(3)PALMER CYNTHIA LOUISE(2)Dermal Disorder127(5%)4.81989-2012BECTON DICKINSON & CO(8)ALZA CORP(6)ELAN CORP PLC(5)PRINCIPAL AB(3)PETTIS RONALD J(10)HARVEY NOEL G(5)DOWN JAMES A(5)GROSS JOSEPH(5)
  24. 24. Page 24 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comUNIV RUTGERS(3) KELLY JOHN GERARD(4)Hypertension120(4.7%)1.291987-2012MEDTRONIC INC(5)ZHANG QINGLONG(3)ALTEA THERAPEUTICS CORP(3)NITROMED INC(3)ACIST MEDICAL SYS INC(3)EPPSTEIN JONATHAN A(4)GARVEY DAVID S(4)ZHANG QINGLONG(3)SMITH ALAN(3)WILSON ROBERT F(2)Coronary ArteryDisease105(4.1%)3.71988-2011MEDTRONIC INC(13)CARDIAC PACEMAKERS INC(7)BIOSENSE INC(5)BIOTRONIK CRM PATENT AG(3)MATREGEN CORP(2)FISCHELL DAVID R(3)ROSS JEFFREY(3)MATCOVITCH AVRAHAM(3)CAFFERATA ROBERT(3)YARON URI(3)Blood Infection92(3.6%)1.11989-2010ALTEA THERAPEUTICS CORP(3)GENENTECH INC(2)UNIV TEXAS(2)SPECTRX INC(2)MEDTRONIC INC(2)EPPSTEIN JONATHAN A(3)HATCH MICHAEL R(3)BORCHARDT ALLEN J(2)MCALLISTER DEVIN V(2)KANIA ROBERT STEVEN(2)PeripheralVascular Disease31(1.2%)2.842000-2011ANGIOTECH INT AG(2)ENDOBIONICS INC(2)NITROMED INC(2)MICHIGAN CRITICAL CARECONSULT(1)MOR RESEARCH APPLIC LTD(1)GARVEY DAVID S(3)GOLD MARK S(2)MELKER RICHARD J(2)SACKELLARES JAMES C(2)BARR LYNN MATEEL(2)Atherosclerosis 26 (1%) 1.51999-2011UNIV SHANGHAI JIAOTONG(3)NITROMED INC(2)UNIV MICHIGAN(1)ANGIOTECH INT AG(1)UNIV MARYLAND(1)FAN BAI(3)HONGZHUAN CHEN(3)MEI ZHAO(3)QIN LU(3)GARVEY DAVID S(3)Vaccination9(0.4%)02001-2012OXFORD GLYCOSCIENCES UKLTD(1)ALZA CORP(1)US GOV HEALTH & HUMANSERV(1)UCB PHARMA SA(1)SANOFI SA(1)CHAMBERS RICHARD C(1)SCHLOM JEFFREY(1)OKULAN NIHAT(1)STAMPS ALASDAIR CRAIG(1)CIGARINI SANDRINE(1)Neurological5(0.2%)1.62003-2010MEDTRONIC INC(2)WILLENBRING JAMES E(1)HOBBS JONATHAN P(1)NEUROPACE INC(1)AUDET SARAH A(1)GOTTESMAN JANELL M(1)HILL GERARD J(1)MANRODT CHRISTOPHER M(1)MARKOWITZ H T(1)RUETER JOHN C(1)TraversingAlimentary Tract2(0.1%)0 2006PHILIPS CORP(2) NAAMAT JUDY RUTH(2)TROVATO KAREN I(2)HERZKA DANIEL(1)OUWERKERK MARTIN(1)
  25. 25. Page 25 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comSensorsSensorsTotalNo. ofRecordsAvg.No. ofFwdCitesperPatentsFilingYearRangeTop 5 Assignees Top 5 InventorsPressure 431 6.011986-2012MEDTRONIC INC(52)MILUX HOLDING SA(15)CARDIAC PACEMAKERS INC(14)PACESETTER INC(10)BIOSENSE INC(5)FORSELL PETER(16)MIESEL KEITH A(12)STYLOS LEE(6)GROSS JOSEPH(6)HETTRICK DOUGLAS A(5)Temperature 256 6.631988-2012MEDTRONIC INC(22)CARDIAC PACEMAKERS INC(7)ZARS INC(6)INSULINE MEDICAL LTD(5)EKOS CORP(5)MIESEL KEITH A(6)BITTON GABRIEL(5)NAGAR RON(5)PESACH BENNY(5)ZHANG JIE(5)Flow 145 6.121986-2012MEDTRONIC INC(8)SANOFI SA(6)HOSPIRA INC(5)MINIPUMPS LLC(4)SENSILE PAT AG(3)RICHTER RENE(6)CAFFEY SEAN(5)NAGEL THOMAS(4)WITT ROBERT(4)JACOBSON JAMES D(4)Glucose 127 7.311988-2012MEDTRONIC INC(21)ABBOTT LAB(11)DEXCOM INC(10)MINIMED INC(5)INSULINE MEDICAL LTD(4)LEBEL RONALD J(7)BRAUKER JAMES H(7)STARKWEATHER TIMOTHY J(6)WEISS PHILLIP T(6)KAMATH APURV U(6)Impedance 73 5.481989-2012MEDTRONIC INC(18)CARDIAC PACEMAKERS INC(10)PACESETTER INC(3)BROCKWAY MARINA(2)HERNDON TERRY O(2)CHO YONG KYUN(4)BROCKWAY MARINA(4)SALO RODNEY(3)ZHANG YI(3)CARLSON GERRARD M(3)Photo-Reflective 55 14.331988-2011MEDTRONIC INC(5)BAXTER INTERNATIONAL INC(3)BIOSENSE INC(2)FORHEALTH TECHNOLOGIESINC(2)FLAHERTY J C(2)DAVIS TIMOTHY J(3)REINKE JAMES D(3)FLAHERTY J C(2)NASIRI ABDOLHOSEIN(2)QUN LI(2)Bio Sensors 51 8.271991-2012MEDTRONIC INC(10)HERBST EWA(3)CARDIAC PACEMAKERS INC(3)CARDIOMEMS INC(3)BIOSENSE INC(2)DENISON TIMOTHY J(4)WHITE JASON(3)HERBST EWA(3)HILL GERARD J(3)ZHANGMIN YANG(2)Amperometric 48 6.521995-2011ABBOTT LAB(4)DEXCOM INC(3)MEDTRONIC INC(3)UNIV CONNECTICUT(2)HAN IN SUK(3)HUNTER WILLIAM L(3)MAGDA JULES JOHN(3)SHAH RAJIV(3)
  26. 26. Page 26 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comBIOTECH INC M(2) GONNELLI ROBERT R(3)Calorimetric 14 0.431996-2011UNIV RUTGERS(2)AVENTIS PHARMA LTD(1)MILLENNIUM PHARMA INC(1)DOW GLOBAL TECHNOLOGIESINC(1)ARX JEFFREY ALLEN VON(1)KOHN JOACHIM B(2)KWOK JONATHAN(1)LECHUGA-BALLESTEROSDAVID(1)HENGERER ARNE(1)PATTON JOHN S(1)Electro-Optic 11 5.271994-2012PRINCIPAL AB(3)BIOTRONIK CRM PATENT AG(2)GERRANS LAWRENCE J(1)GUNDAY ERHAN H(1)CARDIAC PACEMAKERS INC(1)SVEDMAN PAL(3)DOERR THOMAS(2)WEISS INGO(2)WOOD JR LOWELL L(1)GERRANS LAWRENCE J(1)CommunicationCommunicationTotalNo. ofRecordsAvg.No. ofFwdCitesperPatentsFilingYearRangeTop 5 Assignees Top 5 InventorsWireless 190 6.251989-2012MEDTRONIC INC(19)CARDIAC PACEMAKERS INC(12)ABBOTT LAB(5)BAXTER INTERNATIONAL INC(4)PHILIPS CORP(4)VON ARX JEFFREY A(5)CHAVAN ABHI(5)MAILE KEITH R(5)FISCHELL DAVID R(4)HILL GERARD J(4)RadioFrequency(RF)47 3.661996-2012MEDTRONIC INC(7)CARDIAC PACEMAKERS INC(6)HITACHI GLOBAL STORAGETECHNOLOGIES LTD(4)ABBOTT LAB(3)DEXCOM INC(2)VON ARX JEFFREY A(5)FELISS NORBERT(4)GILLIS DONALD RAY(4)CHAVAN ABHI(3)MAZAR SCOTT T(3)Optical 25 3.21999-2012MEDTRONIC INC(2)GUILLORY K S(1)SERRUYA MIJAIL D(1)CARDIAC PACEMAKERS INC(1)ARX JEFFREY ALLEN VON(1)CHAVAN ABHI(2)MAZAR SCOTT T(2)VON ARX JEFFREY A(2)BITTON GABRIEL(2)NAGAR RON(2)Bluetooth 8 02003-2012ABBOTT LAB(2)DEXCOM INC(2)YERUSHALMY ISRAEL(1)AWARE TECHNOLOGIES INC(1)CHRISTOPHER ELLEDGE(1)DOBBLES JOHN MICHAEL(2)KAMATH APURV U(2)MENSINGER MICHAEL ROBERT(2)YANG RICHARD C(2)RUPPERT DEBORAH M(1)
  27. 27. Page 27 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comMethods- Drug DeliveryMethods -DrugDeliveryTotalNo. ofRecordsAvg.No. ofFwdCitesperPatentsFilingYearRangeTop 5 Assignees Top 5 InventorsExternal 252 4.991989-2012MEDTRONIC INC(79)CARDIAC PACEMAKERS INC(28)MINIMED INC(5)INSULINE MEDICAL LTD(5)PHILIPS CORP(5)MIESEL KEITH A(13)HERUTH KENNETH T(10)GERBER MARTIN T(9)BARDY GUST H(7)DENISON TIMOTHY J(7)Internal 81 1.421994-2012MEDTRONIC INC(7)INSULINE MEDICAL LTD(4)BIOSENSE INC(3)GONNELLI ROBERT R(2)PACESETTER INC(2)GONNELLI ROBERT R(3)BITTON GABRIEL(3)NAGAR RON(3)PESACH BENNY(3)WEISS RAM(3)Programmable 59 8.811987-2012MEDTRONIC INC(16)MEDICAL RES GROUP(4)MINIMED INC(4)CHRONO THERAPEUTICS INC(3)NILIMEDIX LTD(2)LEBEL RONALD J(7)STARKWEATHER TIMOTHY J(6)WEISS PHILLIP T(6)SHAHMIRIAN VARAZ(5)VILLEGAS DANIEL H(5)Timed 19 7.681994-2012CHRONO THERAPEUTICS INC(2)BALL SEMICONDUCTOR INC(2)EV3 INC(1)STAAB ROBERT J(1)INT MEDICAL ASSOCIATES INC(1)DIPIERRO GUY(2)AHN SAMUEL S(2)AHN SUZANNE I(2)GAFFNEY F ANDREW(2)HAYS STEVEN R(2)
  28. 28. Page 28 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comMicropumpMicropumpTotalNo. ofRecordsAvg.No. ofFwdCitesperPatentsFilingYearRangeTop 5 Assignees Top 5 InventorsValve 85 4.261987-2012MEDTRONIC INC(5)HOSPIRA INC(4)MILUX HOLDING SA(4)BIOSENSE INC(3)SEARETE LLC(3)FORSELL PETER(6)GARVEY DAVID S(3)ECKHOFF PHILIP A(3)HYDE RODERICK A(3)ISHIKAWA MURIELY(3)Osmotic 61 0.741994-2011LUNAN PHARM GROUPCORP(7)BEIJING COSCI MED TECHCO LTD(3)EURO CELTIQUE SA(3)NEUROSYSTEC CORP(3)BIOSENSE INC(3)ZHIQUAN ZHAO(7)HAISONG JIANG(3)JINGANG WANG(3)OSHLACKBENJAMIN(3)WRIGHT CURTIS(3)Piezoelectric 29 5.381988-2012PRINCIPAL AB(3)BECTON DICKINSON & CO(3)BOEHRINGER INGELHEIMGMBH(2)CHRONO THERAPEUTICSINC(2)HARVEY NOEL G(2)SVEDMAN PAL(3)DOWN JAMES A(3)PETTIS RONALD J(3)DIPIERRO GUY(2)ALCHAS PAUL G(2)
  29. 29. Page 29 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comMicroneedleMicroneedleTotalNo. ofRecordsAvg.No. ofFwdCitesperPatentsFilingYearRangeTop 5 Assignees Top 5 InventorsHollow 96 6.911993-2012BECTON DICKINSON &CO(8)NOVO NORDISK AS(8)BIOSENSE INC(6)3M CO(5)ELAN CORP PLC(5)PETTIS RONALD J(8)RADMER JIM(5)GROSS JOSEPH(5)DOWN JAMES A(5)HARVEY NOEL G(5)Porous 34 1.51999-2012GEORGIA TECH RES INST(4)3M CO(3)GONNELLI ROBERT R(2)NOVO NORDISK AS(2)PALO ALTO RESEARCHCENTER INC(2)PRAUSNITZ MARK R(4)GONNELLI ROBERTR(3)DUAN DANIEL C(3)JOHNSON PETER R(3)BAI XU(2)Solid 30 4.231993-2012GEORGIA TECH RES INST(2)UNIV TSINGHUA(2)UNIV JILIN(2)BEIJING LINGRUI HIGHTECH CO LTD(1)SHANGHAI TAIYIN BIOLOGTECHNOLOGY CO LTD(1)RUIFENG YUE(2)YAN WANG(2)JINGYING ZHANG(2)MINJIE LI(2)XIAOAN ZHANG(2)StackedConfiguration7 4.712001-2011GONNELLI ROBERT R(2)REDEON INC(1)BIOVALVE TECHNOLOGIESINC(1)JANISYS LTD(1)UNGER EVAN C.(1)GONNELLI ROBERTR(3)ACKLEY DONALD E(1)NICKEL JANICE H(1)UNGER EVAN C(1)WU YUNQIU(1)
  30. 30. Page 30 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comLandscape for different methods used for drug deliveryThe contour map below represents different technologies in drug delivery with respect tocomplete patent portfolio. Clusters for treatment element and growth factor are close toeach other as there is high degree of relevance between the records present in thosetechnology areas. Whereas medicament delivery is represented as a different cluster as ithas less relevance with the other technologies present in the portfolio.Note: In the map above, records are placed based on their contextual similarity shared withneighboring records. Closer the clusters, more is the overlap or correlation between them.Each cluster or topic appears as either a shallow water area or land mass. Closely relatedtopics collate to form larger land masses having individual peaks based on those topics thathave maximum records. Labels for topics that are shared across various peaks appearbetween them.
  31. 31. Page 31 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comHow we did it?The categories created at the top level on methods for drug delivery were used as the base set forcreating technology landscapes. Each category was loaded into VizMAP and then contextually clustered(using Title and Abstract as the text) using the ‘Context Mode’ option to generate its technologylandscape. (The contour based thematic coloring option is automatically enabled in the Context mode inVizMAP.) We refined each of the generated map in two ways. We removed unrelated patents using the“Hide Unrelated records” option. In such maps unrelated records are those that do not share anysimilarity with any of the generated technology. Clusters appear usually in the blue ocean areas awayfrom the land parcels. Since they don’t have any significance for the map, and then can simply beremoved using the above mentioned option.
  32. 32. Page 32 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comUpcoming Companies: Focus on priority countries, filings andtechnology areasThe table below shows the research activity for the companies in different countries.How we did it?We researched online for some of the companies focusing on drug delivery technologies of which wegrouped companies present in our data set and filtered those within reports dashboard and using theAssignees tab identified respective priority countries.Note: Please refer Appendix B for patent details for these companiesCompaniesPriority CountriesUS FR CH IB EP JP IE IL AUALTEA THERPEAUTICS CORP 4ARDIGAM CORP 7ARTENGA ING 2CARDIOMEM INC 4CRISI MEDICAL SYSTEMS INC 2DEBIOTECH SA 2 1 1 2DEXCOM INC 11EKOS CORP 4 1ELAN CORP PLC 2 4FLUGEN INC 4HOSPIRA INC 8INTELLIJECT INC 2 1MEDINGO LTD 3 1MINIPUMPS LLC 5NEKTAR THERAPEUTICS 1NEUROSYSTECH CORP 4OREXO AB 1PSIVIDA INC 2RATIO INC 3SICEL TECHNOLOGIES INC 4SPECTRX INC 2STEADYMED LTD 1 2
  33. 33. Page 33 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comThe below matrix shows year wise filings for the companiesFiling YearTotal19931994199519961997199819992000200120022003200420052006200720082009201020112012CompaniesTotal 86 1 2 4 3 2 5 1 1 2 6 1 5 2 6 9 9 10 8 7 2Dexcom Inc 11 1 1 5 4Hospira Inc 8 1 2 1 1 2 1Aradigm Corp 7 3 1 2 1Elan Corp Plc 6 1 1 1 2 1Debiotech SA 6 1 1 1 1 1 1Minipumps Llc 5 2 2 1Ekos Corp 5 3 1 1SicelTechnologies Inc4 2 2NeurosystechCorp4 2 2Medingo Ltd 4 1 1 1 1Cardiomem Inc 4 2 2AlteaTheapeuticsCorp4 1 1 2Steadymed Ltd 3 1 1 1Ratio Inc 3 2 1Intelliject Inc 3 1 1 1Spectrx Inc 2 1 1Psivida Inc 2 1 1Crisi MedicalSystems Inc2 1 1Artenga Inc 2 1 1Orexo AB 1 1NektarTherapeutics1 1Flugen Inc 1 1
  34. 34. Page 34 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comHow we did it?Once upcoming companies were identified, we filtered records for those companies and moved those torespective user defined categories. In co‐occurrence analyzer, within Matrix Parameters, filing year wasselected and clusters were correlated with time and the resulting matrix was exported to Excel file.The contour below shows the field of research for the companies wherein most of theresearch activity is concentrated around pumps, microneedle and medical administration.Ekos Corp concentrates only on Ultrasound technology; it can be seen as a different clusteras it’s unrelated to other clusters.How we did it?The companies were loaded on the map using Analyze By option. They were then expanded on the basisof categories created and then contextually clustered (using Title, Abstract, Claims as the text) using the‘Context Mode’ option to generate its technology landscape. (The contour based thematic coloring optionis automatically enabled in the Context mode in VizMAP.) We removed unrelated patents using the “HideUnrelated records” option.
  35. 35. Page 35 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comUpcoming Company Portfolio spread across main IPCThe generated map below highlights activity assignees across top IPC.It can be seen that most of the companies have research activity across A61M.How we did it?We filtered records for the upcoming companies using the analyze option in Vizmap. These records werethen expanded by IPC to generate the above map.
  36. 36. Page 36 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comAppendix A: Search Strings Used for CategorizationCategorization: Sensors1. AmperometricAmperometric(TAC) contains (amperomet* w/5 sens*) 48 results2. Bio SensorsBio Sensors(TAC) contains ((bio* w/5 sens*) and not (biolog* or biopsy* biofouling orbiodegrad* or biomolecule* or biofeedback))51 results3. CalorimetricCalorimetric(TAC) contains (calorimet* w/5 sens*) 14 results4. Electro-OpticElectro-Optic(TAC) contains ((electro-optic* or electrooptic* or "electro optic*") w/5 sens*) 11 results5. FlowFlow(TAC) contains (flow* w/5 sens*) 145 results6. GlucoseGlucose(TAC) contains (glucose* w/5 sens*) 127 results7. ImpedanceImpedance(TAC) contains (impedance* w/5 sens*) 73 results8. Photo-ReflectivePhoto-Reflective(TAC) contains (photo* w/5 sens*) 55 results9. PressurePressure(TAC) contains (pressure* w/5 sens*) 431 results
  37. 37. Page 37 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com10. TemperatureTemperature(TAC) contains (temperature* w/5 sens*) 256 resultsCategorization: Microneedle1. HollowHollow(TAC) contains (hollow* w/5 (micro-needle* or microneedle* or "micro needle"or needle*))95 results2. PorousPorous(TAC) contains (porous w/5 (micro-needle* or microneedle* or "micro needle" orneedle*))34 results3. SolidSolid(TAC) contains (solid* w/5 (micro-needle* or microneedle* or "micro needle" orneedle*))30 results4. Stacked ConfigurationStacked Configuration(TAC) contains (Stacked* w/5 (micro-needle* or microneedle* or "micro needle"or needle*))7resultsCategorization: Micropump1. OsmoticOsmotic(TAC) contains (osmotic* w/5 (diuretic or dispenser* or dose* or dosage* orpump* or micropump* or "micro* pump*" or ((micro or mini) w/3 pump*) orminipump*) or ((electroosmotic or "electro osmotic") w/2 pump*) or "EOP" or"EO pump")61 results2. PiezoelectricPiezoelectric(TAC) contains ((piezoelectric* or piezo-electric* or piezo*) and (micropump* ormicro-pump* or "micro pump*" or minipunp* or "minp-pump*" or pump*))29 results3. ValveValve(TAC) contains ((valve*) w/5 (micropump* or micro-pump* or "micro pump*" orminipump or "mini*pump" pump*))85 results
  38. 38. Page 38 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comCategorization: Methods- Drug Delivery1. ExternalExternal(TAC) contains (external* w/5 ((drug* or pharma* or medic*) w/3 (inject* ordeliver* or infus* or diffus* or perfus* or releas* or syringe* or implant*)))252 results2. InternalInternal(TAC) contains (internal* w/5 ((drug* or pharma* or medic*) w/3 (inject* ordeliver* or infus* or diffus* or perfus* or releas* or syringe* or implant*)))81 results3. ProgrammableProgrammable(TAC) contains (programmable* w/5 ((drug* or pharma* or medic*) w/3 (inject*or deliver* or infus* or diffus* or perfus* or releas* or syringe* or implant*)))59 results4. TimedTimed(TAC) contains (timed* w/5 ((drug* or pharma* or medic*) w/3 (inject* ordeliver* or infus* or diffus* or perfus* or releas* or syringe* or implant*)))19 resultsCategorization: Communication1. BluetoothBluetooth(TAC) contains ((bluetooth* or “blue-tooth”) w/5 communicat*) 8 results2. OpticalOptical(TAC) contains ("optical*" w/5 communicat*) 25 results3. Radio FrequencyRadio Frequency(TAC) contains (("radio frequency" or RF or "radio-frequency*") w/5communicat*)47 results4. WirelessWireless(TAC) contains (wireless* w/5 communicat*) 190 results
  39. 39. Page 39 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comCategorization: Applications1. AtherosclerosisAtherosclerosis(TAC) contains (atherosclerosis* and ((drug* or pharma* or medic*) w/3 (inject*or deliver* or infuse* or diffuse* or perfuse* or releas* or syringe* or implant*))) 26 results2. Blood InfectionBlood Infection(TAC) contains (blood and infect*) and ((drug* or pharma* or medic*) w/3(inject* or deliver* or infuse* or diffuse* or perfuse* or releas* or syringe* orimplant*))92 results3. CancerCancer(TAC) contains (cancer* or (malignant w/3 neoplasm) or Hyperplasia or Cyst orPseudocyst or Hamartoma or Dysplasia or "Carcinoma in situ" or Metastasis) and((drug* or pharma* or medic*) w/3 (inject* or deliver* or infuse* or diffuse* orperfuse* or releas* or syringe* or implant*))221 results4. CardiacCardiac(TAC) contains ((cardiac* and heart) and ((drug* or pharma* or medic*) w/3(inject* or deliver* or infuse* or diffuse* or perfuse* or releas* or syringe* orimplant*)))175 results5. Coronary Artery DiseaseCoronary Artery Disease(TAC) contains ((coronary* w/5 arter*) or myocardium* or "cardiac vein*" orischemia or tricuspid or mitral or systole) and ((drug* or pharma* or medic*)w/3 (inject* or deliver* or infuse* or diffuse* or perfuse* or releas* or syringe* orimplant*))105 results6. Dermal DisorderDermal Disorder(TAC) contains (dermal* or Fibroblasts* or Macrophages* or Adipocyte* ordermis* or corium) and ((drug* or pharma* or medic*) w/3 (inject* or deliver* orinfuse* or diffuse* or perfuse* or releas* or syringe* or implant*))127 results7. DiabetesDiabetes(TAC) contains (mellitus or diabetes or (insulin w/3 pump) or "NIDDM" or "IDDM"or polyuria or polydipsia or polydipsia or Kussmaul) and ((drug* or pharma* or157 results
  40. 40. Page 40 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.commedic*) w/3 (inject* or deliver* or infuse* or diffuse* or perfuse* or releas* orsyringe* or implant*))8. HypertensionHypertension(TAC) contains (hypertension or (high w/3 pressure) or (arterial w/3hypertension)) and ((drug* or pharma* or medic*) w/3 (inject* or deliver* orinfuse* or diffuse* or perfuse* or releas* or syringe* or implant*))120 results9. MuscleMuscle(TAC) contains (muscle* and ((drug* or pharma* or medic*) w/3 (inject* ordeliver* or infuse* or diffuse* or perfuse* or releas* or syringe* or implant*)))213 results10. NeurologicalNeurological(TAC) contains (neurologic* w/5 ((drug* or pharma* or medic*) w/3 (inject* ordeliver* or infuse* or diffuse* or perfuse* or releas* or syringe* or implant*)))5 results11. Peripheral Vascular DiseasePeripherical Vascular Disease(TAC) contains (vascular* w/5 disease*) and ((drug* or pharma* or medic*) w/3(inject* or deliver* or infuse* or diffuse* or perfuse* or releas* or syringe* orimplant*))31 results12. SkinSkin(TAC) contains "skin" and ((drug* or pharma* or medic*) w/3 (inject* or deliver*or infuse* or diffuse* or perfuse* or releas* or syringe* or implant*))518 results13. Traversing Alimentary TractTraversing Alimentary Tract(TAC) contains (traversing* w/3 alimentary*) and ((drug* or pharma* or medic*)w/3 (inject* or deliver* or infuse* or diffuse* or perfuse* or releas* or syringe* orimplant*))2 results14. VaccinationVaccination(TAC) contains (vaccinat*) and ((drug* or pharma* or medic*) w/3 (inject* ordeliver* or infuse* or diffuse* or perfuse* or releas* or syringe* or implant*))9 results
  41. 41. Page 41 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comAppendix B: List of Patents for Upcoming Companies in thistechnologyPatent Number Title Assignees Filing Date AbstractAU2001279072Closed-loop flowcontrol for IV fluiddeliveryHOSPIRA INC 27/Jul/2001In a closed-loop process, a controller uses a flowsensor to monitor the flow of a medicinal fluidbeing infused into a patient, to achieve a desiredrate of flow. A relatively inexpensive peristalticpump or electronically controlled valve can beused to vary the flow of the medicinal fluidthrough a fluid line. A Y site within the fluid lineincludes an integral flow sensor having anorifice. The flow sensor includes proximal anddistal pressure sensors disposed on oppositesides of the orifice to monitor the distal andproximal pressure, producing a signal indicativeof the rate of flow of the medicinal fluid throughthe fluid line. A signal produced by the controlleris input to a motor driving the pump or to thevalve to vary the rate of flow as required toachieve the desired infusion rate of themedicinal fluid. [WO0209795A2]AU2002248586Disposable infusioncassette with low airbubble retention andimproved valvesHOSPIRA INC 11/Mar/2002A disposable cassette for use with a medicalinfusion pump. An elastomeric membrane iscaptured between a facing member and a baseof the cassette and is displaced into a pumpingchamber. The elastomeric membrane includes agenerally T-shaped lip, and correspondinggrooves are provided on the facing member andbase. As the cassette is assembled, aninterference fit between the lip and the groovescauses the membrane to stretch taut and to besecurely anchored, eliminating a break-in periodwhen the cassette is initially used. "Lobes" ofincreased thickness provided on theundersurface of a portion of the elastomericmembrane overlying the pumping chamberreduce the residual volume of the pumpingchamber, thereby reducing the volume of airretained within the chamber and increasing theaccuracy of the cassette. The lobes also sweepair bubbles from the sides of the pumpingchamber during operation, further reducing airbubbles retained in the pumping chamber. Adistal tube support retains a distal fluid linebetween air or pressure sensors included on apump drive mechanism, thus reducing thelikelihood of sensing errors. Inlet and outletvalve flaps and corresponding seating surfacesincluded in the base are configured to providequieter operation, further reduce the residualvolume of the pumping chamber, increase fluidvelocity through the outlet valve to sweep airbubbles from the pumping chamber, and protectagainst a "blown" inlet valve. [US2002159900A1]
  42. 42. Page 42 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comAU2002361897PULMONARYDELIVERY OFAMINOGLYCOSIDESNEKTARTHERAPEUTICS19/Dec/2002The present invention is directed to theadministration of aminoglycosides. In particular,the present invention is directed tocompositions and methods for the pulmonaryadministration of aminoglycosides. According toa preferred embodiment, compositions andmethods are provided for the localizedtreatment of respiratory infections.[WO03053411A1]AU2004201488Fluid management ina continuous fluidcollection and sensordeviceALTEATHERAPEUTICSCORP,SPECTRXINC07/Apr/2004 NoneAU2004214420In vivo fluorescencesensors, systems, andrelated methodsoperating inconjunction withfluorescent analytesSICELTECHNOLOGIESINC17/Feb/2004Methods, systems, devices and computerprogram product include: (i) administering afluorescent analyte to a subject; (ii) repetitivelyemitting excitation light from an implantedsensor over a desired monitoring period; (iii)detecting fluorescence intensity in response tothe excitation light using the implanted sensorthat outputs the excitation light; and (iv) usingdata associated with the detected fluorescenceintensity to perform at least one of: (a) calculatethe concentration or dose of the analytereceived proximate to the implanted sensor site;(b) evaluate the pharmacodynamic orpharmacokinetic activity of the fluorescentanalyte; (c) confirm Ab attachment to a tumorsite; (d) monitor a non-target site to confirm it isnot unduly affected by a therapy; (e) monitor forchanges in cellular properties; (f) use thecalculated dose or concentration data to adjustor customize a therapeutic amount of theanalyte administered to the subject; (g) confirmmicelle concentration at a target site and thenstimulate toxin release based on theconfirmation; and (h) monitor for the expressionof a protein produced from a gene therapymodification. In particular embodiments, theintensity of the excitation signals emitted to thelocalized tissue can be varied in a predeterminedmanner to generate optical profiling data of theresponse of the tissue proximate the sensor.[WO2004075032A2]AU2004284914Method fortransdermal deliveryof permeantsubstancesALTEATHERAPEUTICSCORP21/Oct/2004A method for delivering permeant substancestransdermally into a membrane of an animalincludes forming at least one delivery opening inthe skin tissue, with the at least one deliveryopening having a mean opening depth ofbetween about 40 and about 90 microns.[US2005090800A1]
  43. 43. Page 43 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comAU2006262233Method andapparatus fordelivering animplantable wirelesssensor for in vivopressuremeasurementCARDIOMEMSINC21/Jun/2006An apparatus for implanting an implant devicehaving a corkscrew-type anchor associatedtherewith into a patient includes an elongated,flexible shaft. A retention mechanism is locatedat the distal end of the shaft for retaining thedevice at the distal end of the shaft. Theapparatus includes means selectively operablefor disengaging the retention mechanism fromthe implant device when the anchor has beenanchored into tissue at a target site. In anotheraspect, an apparatus for releasing an implantinto a vessel within a patient includes anelongated shaft for inserting into the vessel ofthe patient. A tether wire extends through theproximal portion of a secondary lumen, exits afirst port, engages a portion of the implant,enters a second port, and extends through atleast a portion of a distal portion of thesecondary lumen. The implant is therebytethered to the side of the elongated shaft, andpulling the tether wire disengages the tetherwire from the distal portion of the secondarylumen and the implant so as to release theimplant from the shaft. [WO2007002224A2]AU2006262234Implantable wirelesssensor for in vivopressuremeasurementCARDIOMEMSINC21/Jun/2006A sensor suitable for in vivo implantation has acapacitive circuit and a three-dimensionalinductor coil connected to the capacitive circuitto form an LC circuit. The LC circuit ishermetically encapsulated within an electricallyinsulating housing. An electrical characteristic ofthe LC circuit is responsive to a change in anenvironmental parameter. [US2006287602A1]AU2007248475Implantable wirelesssensor for in vivopressuremeasurement andcontinuous outputdeterminationCARDIOMEMSINC04/May/2007A method and apparatus for determining cardiacparameters within the body of a patient includesa wireless sensor positioned in the patientspulmonary artery. An external RF telemetrydevice communicates wirelessly with the sensorand interrogates the sensor to determinechanges in pressure in the pulmonary arteryover time. The peak pressure difference isdetermined. Then, assuming zero blood flowvelocity at the time of valve opening and at thetime of valve closing, a velocity-time function isdetermined. The velocity-time function is usedto determine a velocity-time integral. Thevelocity-time integral is then used to determinecardiac stroke volume. The cardiac strokevolume is multiplied times the heartbeat rate todetermine cardiac output. The cardiac outputcan be monitored over time to determinecontinuous cardiac output. [WO2007130628A2]AU2007270770Medical device foradministering asolutionDEBIOTECH SA 18/Jun/2007The device has a communication unit allowingcommunication between a reservoir and apumping unit, where the reservoir containsmedical solution i.e. insulin, and a patient lineadapted for connecting the device to a patient. Adetermination unit determines physico-chemicalcharacteristics e.g. evaporation characteristics,of the solution based on time by using amathematical model. A variation unit varies theadministration of the solution based on avariation of concentration of the determined
  44. 44. Page 44 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comsolution. [EP1875933A1]AU2007286645System and methodfor improved lowflow medical pumpdeliveryHOSPIRA INC 23/Aug/2007A medical pump with an improved continuitylow flow delivery system and method for usewith a pumping chamber, for example in acassette, is disclosed. The pump includes a pumpdrive for exerting a force on the pumpingchamber and a sensor for sensing theforce/pressure exerted by the pump drive on thepumping chamber. The pump drive positionsensor senses the position of the pump drive.The medical pump also includes a processingunit and a memory having a programming codeadapted to calculate the rate of change of thesensed force/pressure values and determinewhether the rate of change of the sensedforce/pressure values meets a rate of changethreshold. Once the rate of change threshold ismet, the programming code is adapted tocalculate a remaining pump drive travel value fordetermining how much farther the pump driveshould travel before the end of an effectivepump cycle. The programming code is furtheradapted to trigger one or more signals to drivethe pump drive for the remainder of theeffective pump cycle using the remaining pumpdrive travel value. [US2007058412A1]AU2007294526Physiological dataacquisition andmanagement systemfor use with animplanted wirelesssensorCARDIOMEMSINC10/Sep/2007Aspects and embodiments of the presentinvention provide a system for obtaining,processing and managing data from animplanted sensor. In some embodiments, apatient or other persons can use a flexibleantenna to obtain data from the implantedsensor. The flexible antenna includes at leastone transmit loop and at least one receive loop.The transmit loop is adapted to propagateenergizing signals to the implanted sensor. Thereceive loop is adapted to detect a responsesignal from the implanted sensor. The transmitloop includes a capacitor formed by adiscontinuous area. The capacitor is adapted toallow the loop to be tuned. The flexible antennacan communicate with a patient device thatcollects the data from the implanted sensor,creates a data file and transmits the data file to aremote server over a network. A physician orother authorized person may access the remoteserver using an access device.[WO2008031095A1]AU2008227836User interface forselecting bolus dosesin a drug deliverydeviceMEDINGO LTD 19/Mar/2008An apparatus and system for selecting a bolusdose of a drug in a drug delivery device isdisclosed. A bolus dose is selected from a pre-determined schedule of bolus doses, whereineach dose corresponds to a range of a bodyanalyte levels. [WO2008114254A1]
  45. 45. Page 45 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comAU2009311600Fluid medicationdelivery systems fordelivery monitoringof secondarymedicationsHOSPIRA INC 10/Jun/2009A fluid medication delivery system comprises aprimary medication reservoir, a secondarymedication reservoir, an infusion pump, a firstvalve assembly, a second valve assembly, a firsty-site, and a fluid flow sensor assembly. Theprimary medication reservoir has a first fluid.The secondary medication reservoir has asecond fluid. The infusion pump pumps fluidfrom at least one of the primary medicationreservoir and the secondary medicationreservoir. The first valve assembly controls theflow of fluid from the primary medicationreservoir in a first fluid line segment. The secondvalve assembly controls the flow of fluid fromthe secondary medication reservoir in a secondfluid line segment. The fluid flow sensorassembly determines the flow rate of a fluidfrom the secondary medication reservoir in thesecond fluid line segment. [US2010114027A1]AU2010231527Devices and methodsfor enhancing drugabsorption rateMEDINGO LTD 06/Apr/2010Devices, systems and methods directed to a drugdelivery device including a soft subcutaneouslyinsertable cannula are disclosed. Someembodiments of the cannula include anelongated soft tube having a plurality ofapertures spaced around and/or along a wall ofthe elongated soft tube. The plurality ofapertures is configured for fluid flowtherethrough resulting-in/causing an increase inan absorption rate of the fluid in the body of theuser. The drug delivery device can be an insulinpump.AU2010246067Porous silicon drug-eluting particlesPSIVIDA INC 04/May/2010The invention provides a biodegradable drug-eluting particle useful for the delivery ofdiagnostic or therapeutic agents. In certainembodiments, the drug-eluting particle of theinvention comprises a biodegradable poroussilicon body, a reservoir formed within theporous silicon body having at least one openingto an exterior of the body, wherein the reservoircontains a therapeutic or diagnostic agent, andan agent- permeable seal disposed over the atleast one opening. The invention furtherprovides a method for treating a patient toobtain a desired local or systemic physiologicalor pharmacological effect comprisingadministering a sustained release drug deliveryparticle of the invention. The invention alsoprovides methods of fabricating a drug- elutingparticle for releasing therapeutic agents.AU2010284216Electrolytic drug-delivery pump withadaptive controlMINIPUMPS LLC 18/Aug/2010Actuation of a drug-delivery pump is controlledbased on a change in a condition of the pump.
  46. 46. Page 46 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comAU2011203724 Drug delivery deviceFLUGENINC,RATIO INC04/Jan/2011A drug delivery device for delivering a drug to asubject includes a microneedle configured tofacilitate delivery of the drug to the subject. Themicroneedle includes a tip portion and ismoveable from an inactive position to anactivated position. When the microneedle ismoved to the activated position, the tip portionof the microneedle is configured to penetratethe skin of the subject to provide drug deliveryinto the skin of the subject.AU2012201481Devices, systems,and methods formedicament deliveryINTELLIJECT INC 13/Mar/2012Certain exemplary embodimets can comprise anauto-injector (1000), which can comprise: a vial(4300) configured to store and/or contain aninjectable medicament, the vial defining a viallongitudinal axis, and a housing (1800)comprising the vial. In various embodiments, theinjectable medicament can be a medicine,medication, drug, pharmaceutical, prescriptive,agent, antidote, anti-veno hormone, stimulant,vasodilator, anesthetic, and/or nutritionalsupplement that is substantially ready forinjection.AU685694Creating anaerosolizedformulation of insulinARADIGM CORP 27/Oct/1995Devices, packaging and methodology forefficiently and repeatably creating aerosolizedbursts of an insulin containing formulation aredisclosed. Devices are hand-held, self-containedunits which are automatically actuated at thesame release point in a patients inspiratory flowcycle. The release point is automaticallydetermined either mechanically or, morepreferably calculated by a microprocessor whichreceives data from a sensor making it possible todetermine inspiratory flow rate and inspiratoryvolume. Actuation of the device forces insulinformulation through a porous membrane (3) ofthe container (1) which membrane has poreshaving a diameter in the range of about 0.25 to3.0 microns, preferably 0.25 to 1.5 microns.[WO9613161A1]AU693279Analyte-controlledliquid delivery deviceand analyte monitorELAN CORP PLC 27/Oct/1995A liquid delivery device (40) comprising ahousing (41) having a lower surface (51) forapplication to the skin of a subject and having areservoir (42) and a gas generation chamber (43)therein separated by a displaceable membrane(45). Gas generated by an electrolytic cell (44)under the control of a microprocessor (46)causes the gas generation chamber (43) toexpand and the reservoir (42) to contract,thereby discharging a liquid drug, such as insulin,from the reservoir via a hollow delivery needle(49) extending from the lower surface (51). Thedelivery needle (49) and a sensor needle (48)both extend from the lower surface a sufficientdistance so as to penetrate through theepidermis and into the dermis when the housingis pressed against the skin. The sensor needle(48) has an enzymatic coating for the detectionof an analyte, such as glucose in the subjectsplasma. The delivery needle (49) is made ofplatinum-iridium, and a current passes betweenthe needles (48, 49) and a potentiostat circuit(47) according to the amount of glucosedetected. A reference electrode (silver/silver
  47. 47. Page 47 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comchloride) (50) which rests against the subjectsskin increases the accuracy of the glucosemeasurement. The current through thepotentiostat circuit (47) is measured by avoltmeter (53) and a signal from the voltmeter(53) is amplified and communicated to themicroprocessor (46) which determines thecorrect rate of delivery of the drug on the basisof the level of analyte detected in the subjectsplasma. [WO9614026A1]AU734896Medical device forinjecting liquidDEBIOTECH SA 18/Dec/1997The invention concerns a device for injectingliquid comprising a connection piece on which islocated at least a first liquid occlusion system(7). The invention is characterised in that aregulating system (4) is located upstream of thefirst occlusion system, the two systems definingan intermediate segment in which the pressure,in the absence of injection, is higher than thepressure prevailing downstream of the firstocclusion system for directing downstream anyleak at the first occlusion system. The inventionis applicable to a pump used for injectingcontrast liquid for medical imaging.[FR2757069A1]AU741913Device foradministering insulinin controlled dosagesby controlling totalinhaled volumeARADIGM CORP 23/Apr/1998Dosages of inhaled insulin are controlled withina narrow range by controlling the total volumeof air inhaled by a patient. By repeatedlydelivering aerosolized insulin with the same totalinhaled volume of air, the amount of insulindelivered to the patient each time is consistent.A device (40) comprises a means (11, 29) formeasuring inhaled volume and for haltinginhalation at a predetermined point. The devicealso comprises an adjustable means (9) forapplying various amounts of force to a container(1) of formulation (5) to expel different amountsof drugs from the container based on the forceapplied. [WO9848873A1]AU770388Fluid management ina continuous fluidcollection and sensordeviceALTEATHERAPEUTICSCORP,SPECTRXINC20/Jul/1999A fluid collection and sensor device forplacement over at least one artificial openingmade in a biological membrane for measuring acharacteristic of a biological fluid collected fromthe tissue through the at least one artificialopening. The device comprises a sensor (110)positioned in a flow path (105) of the biologicalfluid for contacting a quantity of the biologicalfluid and generating an indication of acharacteristic of the biological fluid. According toone aspect of the invention, a waste fluidstorage element (120), such as a reservoir, ispositioned in the device (100) to collect thebiological fluid after it has made contact with thesensor (110). According to another aspect of theinvention, various surfaces of the fluid flow path(105) of the fluid collection and sensor device(100) are treated with an agent to limit orminimize clotting, aggregation or sepsis of thebiological fluid, blockage or clogging of the flowpath (105) or degradation of the sensor (110).According to still another aspect of theinvention, various configurations of a fluidsensor and collection device (100) are providedthat are designed to ensure that measurements
  48. 48. Page 48 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comare made on independent fluid samples.[WO0004821A1]AU780752Apparatus formicroporation ofbiologicalmembranes usingthin film tissueinterface devices,and method thereforALTEATHERAPEUTICSCORP08/Jun/2000The invention provides for improved devices andmethods for forming openings in a biologicalmembrane for delivering substances into ananimal through the biological membrane fortreatment applications, or extracting substancesfrom the animal through the biologicalmembrane for monitoring or other diagnosisapplications and for increased transmembraneflux. [WO0074767A2]CA2577457MICROBUBBLEMEDICAL DEVICESARTENGA INC 06/Feb/2007Method and medical devices for generating andstabilizing micro or nano bubbles, and systemsand methods for therapeutic applications usingthe bubbles, is provided. Two novel bubblegenerating means are provided: in-line capillarytubes and mix chambers flow focusing, and crossflow bubble generation with optimized bubb ledetachment means. A method and medicaldevice to stabilize bubble sizes and improvebubble size homogeneity through rectifieddiffusion is disclosed. A method and system tofacilitate acoustic activation of therapeuticagents using ultrasound energy is provided.Methods, systems, selected additives, anddevices to permit therapeutic benefits such asultrasound-guided precision drug delivery andreal-time verification, acoustic activation of largetumour masses while avoiding acousticshadowing, enhance d acoustic activationthrough longer retention of therapeutic agentsat the point of interest, on demand means tocombine inertial and non-inertial acousticactivation in a single treatment, enhancement ofhigh intensity focused ultrasound treatment s,light activation of photodynamic drugs at adepth within a patient using extracorporeal lightsources, probes, or sonoluminescence, andinitiation of time reversal acoustics focusedultrasound to permit highly localized treatment,are provided.</SDOA B>CA2657380DEVICES, SYSTEMSAND METHODS FOROPHTHALMIC DRUGDELIVERYNEUROSYSTECCORP20/Jul/2007Devices, systems and techniques for deliveringdrugs to an ocular tissue are described. In atleast some embodiments, a terminal component(e.g., a n eedle or open end of a catheter) isimplanted in an ocular tissue and used t o deliverone or more drugs. The delivered drugs maycome from a source whic h is also implanted, ormay be introduced from an external source (e.g.,via a port). Both solid and liquid drugformulations can be used. Ocular implan ts canalternatively include a thin film coating thatreleases a drug into a n ocular tissue.CN101528283Apparatus andmethod fordeliveringtherapeutic and/orother agents to theinner ear and toother tissuesNEUROSYSTECCORP24/Jan/2006The present invention discloses an apparatusmay include a needle for sustained delivery ofdrugs and other agents to the inner ear or othertissues of a human or an animal. The needle caninclude an insertion stop, and can be placedthrough the round window membrane orthrough a surgically-prepared hole in a bone.The needle can be in fluid communication with aport and/or with a micro-infusion or osmoticpump. A cochlear implant electrode can be used
  49. 49. Page 49 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.cominstead of a needle.EP1381395SYSTEMS, METHODSAND DEVICES FOR INVIVO MONITORINGOF A LOCALIZEDRESPONSE VIA ARADIOLABELEDANALYTE IN ASUBJECTSICELTECHNOLOGIESINC23/Apr/2002Methods, systems, devices and computerprogram products monitor in vivo detectedradiation in a target localized site within asubject, over a selected time period, to do oneor more of: (a) quantify a radiation dosereceived at a local site; (b) assessbioreceptiveness to a particular treatment timeor type; (c) evaluate the pharmacokinetics of aradiolabeled analyte corresponding to a non-radiolabeled analyte; (d) monitor or evaluatemetabolic activity; or (e) evaluate a tumor priorto or after a therapeutic treatment.[WO02086449A2]EP1695734Microneedles forminimally invasivedrug delivery or fordiagnostic samplingHOSPIRA INC 22/May/2002The present invention provides a microneedleincorporating a base that is broad relative to aheight of the microneedle, to minimizebreakage. The microneedle further includes afluid channel and a beveled non?coringtip. Preferably arrays of such microneedles arefabricated utilizing conventional semiconductorderived micro?scale fabricationtechniques. A dot pattern mask is formed on anupper surface of a silicon substrate, with eachorifice of the dot pattern mask corresponding toa desired location of a microneedle. Orifices areformed that pass completely through thesubstrate by etching. A nitride pattern mask isformed to mask all areas in which a nitride layeris not desired. A nitride layer is then depositedon the bottom of the silicon substrate, on thewalls of the orifice, and on the top of the siliconsubstrate around the periphery of the orifice.The nitride layer around the periphery of theorifice is offset somewhat, such that one side ofthe orifice has a larger nitride layer. Anisotropicetching is used to remove a substantial portionof the substrate, creating a plurality of angular,blunt, and generally pyramidal-shapedmicroneedles. A subsequent removal of thenitride layer, followed by an isotropic etchingstep, softens and rounds out the blunt angularmicroneedles, providing generally conical-shaped microneedles. The uneven nitride layeradjacent the orifice ensures that themicroneedles will include a beveled tip. Suchmicroneedle arrays are preferably incorporatedinto handheld diagnostic and drug deliverysystems. [WO02100474A2]EP1861161APPARATUS ANDMETHOD FORDELIVERINGTHERAPEUTICAND/OR OTHERAGENTS TO THEINNER EAR AND TOOTHER TISSUESNEUROSYSTECCORP24/Jan/2006An apparatus may include a needle for sustaineddelivery of drugs and other agents to the innerear or other tissues of a human or an animal.The needle can include an insertion stop, andcan be placed through the round windowmembrane or through a surgically-prepared holein a bone. The needle can be in fluidcommunication with a port and/or with a micro-infusion or osmotic pump. A cochlear implantelectrode can be used instead of a needle.[US2006264897A1]
  50. 50. Page 50 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comEP2058020Devices formedicament deliveryINTELLIJECT INC 01/Feb/2006An apparatus (1000) comprising: a housing(1100); a medicament delivery mechanismconfigured to be disposed within the housing;and an electronic circuit system configured tobe coupled to the housing, the electronic circuitsystem further configured to produce an output.[EP2058020A2]EP2152350INTEGRATEDMEDICAMENTDELIVERY DEVICEFOR USE WITHCONTINUOUSANALYTE SENSORDEXCOM INC 05/Jun/2008An integrated system for the monitoring andtreating diabetes is provided, including anintegrated receiver/hand-held medicamentinjection pen, including electronics, for use witha continuous glucose sensor. In someembodiments, the receiver is configured toreceive continuous glucose sensor data, tocalculate a medicament therapy (e.g., via theintegrated system electronics) and toautomatically set a bolus dose of the integratedhand-held medicament injection pen, wherebythe user can manually inject the bolus dose ofmedicament into the host. In someembodiments, the integrated receiver and hand-held medicament injection pen are integrallyformed, while in other embodiments they aredetachably connected and communicated viamutually engaging electrical contacts and/or viawireless communication. [US2008306434A1]EP2232216DIFFERENTIALPRESSURE BASEDFLOW SENSORASSEMBLY FORMEDICATIONDELIVERYMONITORING ANDMETHOD OF USINGTHE SAMEHOSPIRA INC 17/Dec/2008A differential pressure based flow sensorassembly and method of using the same todetermine the rate of fluid flow in a fluid system.The sensor assembly comprises a disposableportion, and a reusable portion. A flowrestricting element is positioned along a fluidflow passage between an inlet and an outlet.The disposable portion further has an upstreamfluid pressure membrane and a downstreamfluid pressure membrane. The reusable portionhas an upstream fluid pressure sensor and adownstream fluid pressure sensor. Theupstream fluid pressure sensor senses theupstream fluid pressure at a location within thefluid flow passage between the inlet and theflow restricting element. The downstream fluidpressure sensor senses the downstream fluidpressure at a location within the fluid flowpassage between the flow restricting elementand the outlet. The process utilizes output of thesensors to calculate the flow rate of the fluid.[US2009157040A1]EP2252196SYSTEMS ANDMETHODS FORPROCESSING,TRANSMITTING ANDDISPLAYING SENSORDATADEXCOM INC 20/Feb/2009Systems and methods for continuousmeasurement of an analyte in a host areprovided. The system generally includes acontinuous analyte sensor configured tocontinuously measure a concentration of analytein a host and a sensor electronics modulephysically connected to the continuous analytesensor during sensor use, wherein the sensorelectronics module is further configured todirectly wirelessly communicate displayablesensor information to a plurality of differenttypes of display devices. [WO2009105709A1]
  51. 51. Page 51 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comEP2496283MEDICATIONINJECTION SITE ANDDATA COLLECTIONSYSTEMCRISI MEDICALSYSTEMS INC03/Nov/2010A medication delivery apparatus for use with amedication container includes a housing, a fluidconduit at least partially extending within thehousing and configured to deliver medicationwithin the medication container to a patient, amedication port extending from the housing andconfigured to be coupled to a fluid outlet of themedication container, the medication port beingfluidically coupled to the fluid conduit, and atleast one sensor disposed within the housing togenerate information characterizingadministration of the medication for processingby a remote data collection system. The housingcan have a size and shape that enables it to besupported by a first hand of a user while theuser administers the medication from themedication container via the medication portusing a second hand of the user. Relatedapparatus, systems, kits, and techniques are alsodescribed. [WO2011056888A2]US20040199059Optimized sensorgeometry for animplantable glucosesensorDEXCOM INC 22/Aug/2003An implantable sensor for use in measuring aconcentration of an analyte such as glucose in abodily fluid, including a body with a sensingregion adapted for transport of analytesbetween the sensor and the bodily fluid,wherein the sensing region is located on acurved portion of the body such that when aforeign body capsule forms around the sensor, acontractile force is exerted by the foreign bodycapsule toward the sensing region. The body ispartially or entirely curved, partially or entirelycovered with an anchoring material forsupporting tissue ingrowth, and designed forsubcutaneous tissue implantation. Thegeometric design, including curvature, shape,and other factors minimize chronic inflammatoryresponse at the sensing region and contribute toimproved performance of the sensor in vivo.US20080107720Topical delivery ofcodrugsPSIVIDA INC 04/Jan/2008The present invention provides pharmaceuticalcompositions for topical delivery comprising asuitable carrier and a codrug capable ofpenetrating, or being transported across, thedermis. The codrug according to the inventioncomprises a first constituent moiety linked to asecond constituent moiety, wherein the secondconstituent moiety is the same as, or differentfrom, the first constituent moiety. The first andsecond constituent moieties are so linked thatthey are easily transported into or across thedermis, into the skin, or into the blood orlymphatic system, and are reconstituted in vivoto form the first and second constituentmoieties.US20080195232BIOINTERFACE WITHMACRO- ANDMICRO-ARCHITECTUREDEXCOM INC 15/Apr/2008Disclosed herein are biointerface membranesincluding a macro-architecture and a micro-architecture co-continuous with and bonded toand/or located within at least a portion of themacro-architecture. The macro- and micro-architectures work together to manage andmanipulate the high-level tissue organizationand the low-level cellular organization of theforeign body response in vivo, therebyincreasing neovascularization close to a device-
  52. 52. Page 52 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comtissue interface, interfering with barrier cell layerformation, and providing good tissue anchoring,while reducing the effects of motion artifact, anddisrupting the organization and/or contractureof the FBC. The biointerface membranes of thepreferred embodiments can be utilized withimplantable devices such as devices for thedetection of analyte concentrations in abiological sample (for example, from a body),cell transplantation devices, drug deliverydevices, electrical signal delivering or measuringdevices, and/or combinations thereof.US20080287765INTEGRATEDRECEIVER FORCONTINUOUSANALYTE SENSORDEXCOM INC 29/Jul/2008A system is provided for monitoring glucose in ahost, including a continuous glucose sensor thatproduces a data stream indicative of a hostsglucose concentration and an integratedreceiver that receives the data stream from thecontinuous glucose sensor and calibrates thedata stream using a single point glucose monitorthat is integral with the integrated receiver. Theintegrated receiver obtains a glucose value fromthe single point glucose monitor, calibrates thesensor data stream received from thecontinuous glucose sensor, and displays one orboth of the single point glucose measurementvalues and the calibrated continuous glucosesensor values on the user interface.US20090192366SYSTEMS ANDMETHODS FORPROCESSING SENSORDATADEXCOM INC 24/Oct/2008Systems and methods for processing sensor dataare provided. In some embodiments, systemsand methods are provided for calibration of acontinuous analyte sensor. In someembodiments, systems and methods areprovided for classification of a level of noise on asensor signal. In some embodiments, systemsand methods are provided for determining arate of change for analyte concentration basedon a continuous sensor signal. In someembodiments, systems and methods for alertingor alarming a patient based on prediction ofglucose concentration are provided.US20090192380SYSTEMS ANDMETHODS FORPROCESSING SENSORDATADEXCOM INC 24/Oct/2008Systems and methods for processing sensor dataare provided. In some embodiments, systemsand methods are provided for calibration of acontinuous analyte sensor. In someembodiments, systems and methods areprovided for classification of a level of noise on asensor signal. In some embodiments, systemsand methods are provided for determining arate of change for analyte concentration basedon a continuous sensor signal. In someembodiments, systems and methods for alertingor alarming a patient based on prediction ofglucose concentration are provided.US20090203981SIGNAL PROCESSINGFOR CONTINUOUSANALYTE SENSORDEXCOM INC 15/Apr/2009Systems and methods for dynamically andintelligently estimating analyte data from acontinuous analyte sensor, including receiving adata stream, selecting one of a plurality ofalgorithms, and employing the selectedalgorithm to estimate analyte values. Additionaldata processing includes evaluating the selectedestimative algorithms, analyzing a variation ofthe estimated analyte values based on statistical,clinical, or physiological parameters, comparing
  53. 53. Page 53 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comthe estimated analyte values with correspondingmeasure analyte values, and providing output toa user. Estimation can be used to compensatefor time lag, match sensor data withcorresponding reference data, warn of upcomingclinical risk, replace erroneous sensor datasignals, and provide more timely analyteinformation encourage proactive behavior andpreempt clinical risk.US20090299156CONTINUOUSMEDICAMENTSENSOR SYSTEM FORIN VIVO USEDEXCOM INC 04/Feb/2009Systems and methods for continuousmeasurement of a medicament in vivo areprovided. In some embodiments, the system isconfigured to provide information associatedwith medicament titration and includes acontinuous analyte sensor and a communicationdevice. In some embodiments, the system isconfigured for continuous ambulatory drugtesting, including an ambulatory host monitorhaving a continuous sensor, a location module, aprocessor module and a transmitter. In someembodiments, the system is configured forcontinuously monitoring a hormone level andincludes a continuous hormone sensor and acommunication device configured to outputhormone information in real time. Yet anotherembodiment provides an analyte sensor forcontinuous monitoring of a hosts nutritionalstatus, and is configured for both continuousglucose detection and continuous albumindetection.US20100022992 Drug Delivery Device STEADYMED LTD 06/May/2007The present application provides a drug-deliverydevice comprising a drug reservoir chamber 16,containing a substance to be delivered, in fluidconnection with a drug administration means18, and an electrically-controlled battery unit 10comprising at least one displacement-generatingbattery cell 19 coupled to the drug reservoirchamber 16 by a coupling means 14, thearrangement being such that the displacementderived from the battery unit 10 is conveyed bythe coupling means 14 to the drug reservoirchamber 16 such that the substance is expelledfrom the drug reservoir chamber 16 towards thedrug administration means 18.US20100280486SYSTEM ANDMETHOD FORDELIVERING ANDMONITORINGMEDICATIONHOSPIRA INC 08/Jun/2009A method of delivering medication to a patientutilizing a medication delivery system isprovided. A first medication to be delivered tothe patient is supplied. The patients identity isverified. The first medication is selected on auser interface to be delivered to the patient. Thevolume of the medication the patient willreceive is entered. The first medication isinjected into the patient through a flow sensorassembly. The flow rate and the volume of thefirst medication delivered to the patient aremonitored by the flow sensor assembly whilethe injection occurs. A visual display providesinformation related to the injection. The methodupdates the patients electronic medicaladministration record to capture the informationregarding the injection of the first medication.
  54. 54. Page 54 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comUS20110172609MICRONEEDLECOMPONENTASSEMBLY FORDRUG DELIVERYDEVICEFLUGENINC,RATIO INC08/Jan/2010A device for delivering a drug to a subject isprovided. The device includes a drug reservoir, aconduit coupled to the drug reservoir and amicroneedle component. The microneedlecomponent includes a body, an engagementstructure coupling the microneedle componentto the conduit, a hollow microneedle extendingfrom the body, and a handling feature locatedon the body. The microneedle component isconfigured to be releasably coupled to anassembly tool via the handling feature duringassembly of the device.US20110172645WEARABLE DRUGDELIVERY DEVICEINCLUDINGINTEGRATEDPUMPING ANDACTIVATIONELEMENTSFLUGENINC,RATIO INC08/Jan/2010A drug delivery device for delivering a drug to asubject is provided. The drug delivery deviceincludes a housing, a drug reservoir supportedby the housing containing the drug and a hollowmicroneedle supported by the housing. Thehollow microneedle is moveable from aninactive position to an activated position,wherein, when the hollow microneedle is movedto the activated position, the tip portion of thehollow microneedle is configured to penetratethe skin of the subject. The drug delivery deviceincludes a channel having an input incommunication with the drug reservoir and anoutput in communication with the hollowmicroneedle. The channel provides fluidcommunication between the drug reservoir andthe hollow microneedle, such that the drug ispermitted to flow from the drug reservoirthrough the channel and through the hollowmicroneedle. The channel moves from a firstposition to a second position as the hollowmicroneedle moves from the inactive position tothe activated position, and the position of thedrug reservoir relative to the housing remainsfixed as the hollow microneedle moves from theinactive position to the activated position.US20110270188FILL-STATUSSENSORS FOR DRUGPUMP DEVICESMINIPUMPS LLC 20/Apr/2011The filling status of a drug reservoir in a drugpump devices may be determined withmechanical and/or magnetic position sensorassociated with a reservoir boundary.US20120016299CATHETER DRUGPUMPMINIPUMPS LLC 19/Jul/2011A miniaturized drug pump can actively dispensefluid at a controlled (or controllable) flow rateemerging at or near the distal tip of a catheter.US20120095389ULTRASOUNDCATHETER FORPROVIDING ATHERAPEUTIC EFFECTTO A VESSEL OF ABODYEKOS CORP 21/Dec/2011The invention relates to a catheter system. Thesystem comprises a catheter body having achamber containing a low acoustic impedancemedium. The catheter body includes anelongated body with an external surface and anultrasound transducer having an external sidebetween a first end and a second end. Theultrasound transducer is positioned over theexternal surface of the elongated body such thatthe first end is adjacent to the chamber.

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