This document summarizes an exploratory bioinformatic analysis of the interplay between induced pluripotent stem cells and somatic cardiac regeneration. The analysis identified molecules like nucleostemin that interact with key transcription factors involved in inducing pluripotency. Pathway analysis revealed networks linking nucleostemin and these factors to processes involved in cardiovascular development and the maintenance of pluripotency. Specifically, nucleostemin was found to interact with NANOG, a critical pluripotency factor, via the molecules TP53 and FGF. These findings provide potential targets for further research on using iPS cells to enable postnatal cardiac regeneration.