The Journal Club FMDU 1st meeting – 24 may 2012

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The Journal Club of the Faculty of Medicine Diponegoro university is a club that aims to familiarize students with reading comprehension of medical journal articles and promote the sharing of ideas and open discussion

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The Journal Club FMDU 1st meeting – 24 may 2012

  1. 1. THE JOURNAL CLUB 1ST MEETING – 24 MAY 2012Faculty of Medicine Diponegoro University Course Supervisor: RN Tunjungputri, MD
  2. 2. Group 1 Why do you think that we would like to have an HIV vaccine? What is the difficulty in producing an HIV vaccine and in controlling the immune system against HIV? Why did the previous attempts of HIV vaccines were unsuccessful? Can a vaccine that induce cytotoxic T lymphocyte prevent HIV infection? Is “herd effect” immunity in T-cell vaccine for HIV can be achieved? What does the article suggest should be done to find an effective HIV vaccine?Article:Johnston MI, Fauci AS. An HIV vaccine--challenges and prospects. N Engl JMed. 2008 Aug 28;359(9):888-90.http://1.usa.gov/MZ5ypl
  3. 3. Group 2 Why does the knowledge and strategies to produce effective vaccines for many viral diseases cannot be applied to HIV? What is the goal of HIV vaccine? What strategy is most appropriate for designing HIV vaccine? What is a “structure-based vaccine design” for developing vacccines? What is the challenge of this approach? Please explain in your own words! Based on this article, what is a likely approach in designing an effective HIV vaccine?ArticleN Engl J Med. 2011 Sep 8;365(10):873-5. HIV vaccine development--improvingon natural immunity. Johnston MI, Fauci AS.http://1.usa.gov/OohmyN
  4. 4. Group 3 Why is there still high HBV infection rate? Please explain the epidemiology of HIV and HBV co-infection around the world! Which specific population are highly affected? What are the impacts of HIV-HBV co-infection in comparison with HIV or HBV infection alone? What preventive efforts can be done, and what are the challenges that is still posing difficulties in tackling this problem? What is needed to overcome the HIV-HBV co-infection problem?Article: N Engl J Med. 2012 May 10;366(19):1749-52. HIV-HBV coinfection--a global challenge. Kourtis AP, Bulterys M, Hu DJ, Jamieson DJ.http://1.usa.gov/OokAW1

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