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Newcastle University

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Newcastle University

  1. 1. Newcastle University & Northern Deanery/NHS North East Job description for 2010 ACF post: Nephrology (ENTRY LEVEL: ST3) 1. Title of Post Academic Clinical Fellowship Programme in Nephrology 2. Duration of post Up to 3 years. It is expected that appointees will successfully compete for external funding towards PhD training at the end of 3 years. Details of arrangements for appointees failing to secure a research training fellowship at the end of this period are outlined in the NCCRCD Guide on Entry, Eligibility and Exit points 3. Hospitals – bases for training Newcastle upon Tyne Hospitals NHS Foundation Trust [And other hospitals in the Northern Postgraduate Deanery ] 4. Research – base for training Newcastle University: Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) Institute of Human Genetics (http://www.ncl.ac.uk/ihg/) 5. Arrangements for protected research time ACF fellows will have nine months (full time equivalent) dedicated to research during the three years. Configuration of this time will depend in part on the nature of the research project being pursued, but it is expected that the ACF will spend one 6 month and one 3 month period in research. It is also expected that the ACF will experience two separate research environments during protected research time. It is expected that the ACF will generate good pilot data during this time and subsequently extend research training “out of program” towards a PhD after the award of a external fellowship (Wellcome, MRC etc).
  2. 2. 6. Research component of programme The successful candidate will have an excellent opportunity to establish their research in an expanding and dynamic research environment. Renal research in Newcastle is recognised nationally and internationally for the quality of its research output and has an excellent track record in thehay training and development of academic nephrologists. Renal research occurs in three research Institutes: The Institutes of Cellular Medicine, Human Genetics and Cell and Molecular Biosciences and spans many areas of renal pathophysiology including genetics, physiology and immunobiology. In addition there are increasing links between the University and Trust, promoting the development of translational and clinical research. Academic nephrology in Newcastle has demonstrated success through winning competitive grant income from the MRC, Wellcome Trust, Kidney Research UK and other charitable and commercial sources. We have also obtained clinical training fellowships from the MRC, Wellcome Trust and KRUK through national competition. Investigators in Newcastle have contributed to over 250 scientific publications in the last 5 years including papers in Nature Medicine, Nature Genetics, NEJM, Journal of Clinical Investigation, Blood, FASEB Journal, Journal of Immunology, JASN, Kidney International and American Journal of Kidney Disease Institute of Cellular Medicine The Institute of Cellular Medicine has been established to support the highest quality scientific and clinical research and to promote its translation and application in practice in partnership with industry and the healthcare sector. The ICM focuses on important research areas & approaches which can explore the basis of disease, develop new methods for diagnosis and treatment, derive new treatments and assess their impacts in practice. Institute of Human Genetics The Institute of Human Genetics (IHG) is a Research Institute of Newcastle University and is internationally recognised as a centre of excellence for research into genetic diseases. Underpinning these achievements is a simple concept, one of partnership between basic human molecular and developmental genetics and clinical genetics, coupled with a determination to strive always for excellence. From a small existing Human Genetics department in the early 90’s, the IHG has expanded rapidly and now has over 30 academic staff including 15 Professors. Facilities available Bioimaging (including confocal microscopy) Flow cytometry High Throughput sequencing and genotyping Comparative biology centre (including zebrafish) Good Manufacturing Practice (GMP) Suite Clinical research Facility
  3. 3. Academic Staff Dr Simi Ali Institute of Cellular Medicine Reader in Immunology Professor Tim Goodship Institute of Human Genetics Professor of Renal Medicine Dr David Kavanagh Institute of Human Genetics Clinical Lecturer Professor John Kirby Institute of Cellular Medicine Professor of Immunobiology Dr Kevin Marchbank Institute of Cellular Medicine Lecturer in Immunology Dr John Sayer Institute of Human Genetics Clinical Senior Lecturer Professor Nick Simmons ICAMB Professor of Epithelial Physiology Professor Neil Sheerin Institute of Cellular Medicine Professor of Nephrology Consultant Nephrologists Dr Laura Baines Consultant Nephrologist Dr Alison Brown Consultant Nephrologist, Honorary Senior lecturer Dr Katy Jones Consultant Nephrologist Dr Suren Kanagasundaram Consultant Nephrologist, Honorary Senior lecturer Dr John Tapson Consultant Nephrologist, Clinical Director Consultant Transplant Surgeons Mr Bryon Jacques Professor Derek Manas Mr David Rix Mr Naeem Soomro Professor Dave Talbot Mr Steve White Nephrology research profile Laboratory research in Newcastle is focused on 4 broad themes: a) The genetics of atypical Haemolytic Uraemic Syndrome. The Newcastle first described the association between mutations in complement regulatory proteins and aHUS. New mutations and antibodies that interfere with complement regulation have been identified and their functional affects are now been described (Goodship / Kavanagh / Marchbank) b) The immunobiology of chronic kidney injury. The research focuses on the capacity of lymphocytes and complement to cause renal injury and fibrosis. This work spans both native and transplant kidney disease and involves in vitro, in vivo laboratory and clinical studies (Sheerin / Kirby / Ali). c) Tubular physiology, renal cystic disease and renal stone formation. This works studies normal tubular function and animal models of renal disease (mouse and zebrafish) to help understand function and to identify the pathophysiological mechanisms of renal disease. Understanding the functional significance of genetic
  4. 4. mutations leads to insights into disease development and possible therapeutic interventions (Sayer / Simmons). d) The identification of novel genetic influences on renal disease and transplant failure. This includes the identification of novel disease forming mutations and the influence of genetic polymorphic variation on the expression of disease phenotype in native and transplant disease (Sayer / Goodship / Sheerin) There is a strong emphasis on the integration of clinical investigation and science and all of the research programmes above include both clinical and laboratory elements. There are also investigator led clinical studies on acute kidney injury, fatigue and renal replacement therapy. With the Comprehensive Local Research Network and Clinical Research Facility there are active interventional clinical trials in all areas of renal disease. The ACF will be encouraged to participate in these studies during the clinical and research placements. 7. Clinical training component of programme The renal speciality training programme provides the appointee with appropriate training in Nephrology leading to award of a CCT. If required this can be combined with training in acute medicine leading to award of a dual CCT (nephrology plus acute medicine). The ACF will have the option to obtain dual accreditation in medicine, but this will not be compulsory. Some general medicine commitments may be required during clinical training. It is expected that the ACF will be based in Newcastle or at a hospital sufficiently close to allow continued contact with the academic department, although this cannot be guaranteed. The programme director (Dr A Brown) accepts responsibility for ensuring that the appointment provides appropriate experience leading to certification in Renal Medicine. Full details of the clinical training programme are included in the job description for the ST appointments in renal medicine which is available with this application. 8. Academic Programme Director Professor Neil Sheerin Institute of Cellular Medicine Newcastle University Email: neil.sheerin@ncl.ac.uk 9. Clinical Programme Director Dr Alison Brown Consultant Nephrologist Renal Services
  5. 5. Freeman Hospital Email: Alison.brown5@nuth.nhs.uk 10. Programme contact for further information Professor Julia Newton Faculty of Medical Sciences Newcastle University Email: j.l.newton@ncl.ac.uk 11. Deanery contact for further information Hayley Graham Lead Employer Trust (recruiting for the Northern Deanery) Waterfront 4 Goldcrest Way Newburn Riverside Newcastle upon Tyne NE15 8NY Email: hayley.graham@nhs.net 12. Link to NCCRCD website for further information www.nccrcd.nhs.uk/ 13. Training number status This post carries an NTN(A)

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