ReportsnReports – DNA Sequencing: Emerging Technologies and Applications

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BCC’s goal for this study is to determine the status of current and next generation DNA sequencing technologies and products and assess their worldwide growth potential over a five-year period from 2008 to 2013. Our particular interest is to characterize and quantify the DNA sequencing products market potential by application, technology, analysis type, geography and end user. Sequencing applications market segments that will provide substantial future growth opportunities for next generation DNA sequencing companies include research, drug discovery and development, forensics and human identification, bacterial genomics, agricultural genomics, clinical diagnostics and personal genomics.

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ReportsnReports – DNA Sequencing: Emerging Technologies and Applications

  1. 1. DNA Sequencing: Emerging Technologies and ApplicationsReportsnReports.com adds BCC Research Group Market Research Report “DNA Sequencing:Emerging Technologies and Applications’’ to its store.STUDY GOALS AND OBJECTIVESBCC’s goal for this study is to determine the status of current and next generation DNAsequencing technologies and products and assess their worldwide growth potential over afive-year period from 2008 to 2013. Our particular interest is to characterize and quantifythe DNA sequencing products market potential by application, technology, analysis type,geography and end user. Sequencing applications market segments that will providesubstantial future growth opportunities for next generation DNA sequencing companiesinclude research, drug discovery and development, forensics and human identification,bacterial genomics, agricultural genomics, clinical diagnostics and personal genomics.Our main objective is to present a comprehensive discussion of where the state-of-the-art isin DNA sequencing technologies, and assess the state of the sequencing industry and thecurrent and future commercial potential for the key market segments.REASONS FOR DOING THE STUDYThe Human Genome Project (HGP) moved DNA sequencing technology to the forefront oflife science research as a genetic analysis tool. The HGP relied heavily on Sangersequencing by capillary electrophoresis to decipher the DNA sequence of the bases in thehuman genome. A significant outcome of the HGP was improvements in the efficiency andcosts of DNA sequencing. During this time period, the DNA sequencing industryconsolidated, resulting in one dominant company: Applied Biosystems. In 2008, in the post-HGP era, new DNA sequencing technologies are emerging that will radically alter thestructure of the industry and open up substantial new market applications. Contributing tothe rise of these new sequencing technologies are advances in nanotechnology,microfluidics, imaging, enzymology, and bioinformatics. Based on these market andtechnology dynamics, it is timely to examine the future DNA sequencing markets.Ongoing discoveries in nanotechnology, bioinformatics, microfluidics, imaging, enzymologyand bioinformatics are revolutionizing many life science fields, and providing novel platformsfor next generation DNA sequencing. At the same time this is occurring, there is a growingmarket demand for analysis of the genomes of many species and cancers, and forunderstanding the role of genetic variation among individuals in disease. The geneticanalysis industry seeks to meet these needs with tools such as microarrays, real timepolymerase chain reaction (RT-PCR) and DNA sequencing instruments. With the novel nextgeneration sequencing technologies, applications space vis-à-vis the other genetic analysistools has widened, and this report seeks to understand this trend and its significance forcompanies supplying DNA sequencing products and services.The next generation DNA sequencing technologies will change the dynamics of the currentDNA sequencing industry and create novel market opportunities. This report analyzes thesetrends and their impact on the future markets for DNA sequencing technologies.It is particularly timely to gain an understanding of these industry and technology forces,and the impact on the genetic analysis markets.
  2. 2. INTENDED AUDIENCEWe have compiled a study of existing and next generation technologies that will becommercially important in the major end user segments of life science research, drugdiscovery and development, forensics and human identification, bacterial genomics,agricultural genomics, clinical diagnostics and personal genomics. We present both Sangersequencing and next generation, non-Sanger sequencing technologies as well as marketgrowth driving forces, product formats, market applications, companies and industryalliances, future market potential and product sales forecasts for the period 2008 through2013. We forecast the use of sequencing products for these end user segments: majorsequencing centers, academic genome centers, government labs, pharmaceutical/biotechlabs, small to mid-size labs and sequencing service labs.This study will be of particular interest to life science research tools suppliers,pharmaceutical manufacturers, diagnostics, nanotechnology, and biotechnology companies.It will also be valuable to companies involved in genome sequencing projects, sequencingcenters, manufacturers of microarrays, suppliers of molecular diagnostics assays,bioinformatics companies, and cancer researchers and clinicians.SCOPE OF REPORTThe study scope includes DNA sequencing technologies likely to be commercialized withinthe next five years. Sanger and next generation (non-Sanger sequencing) technologies areincluded. Each technology is analyzed to determine its market status, impact on futuremarket segments, and forecasted growth from 2008 through 2013. Advantages andlimitations of each technology together with market driving forces are discussed.BCC examines the sequencing industry structure, strategic industry alliances andacquisitions, and sequencing patents. The strategies of the main Sanger and nextgeneration sequencing companies are discussed. The markets for sequencing applications,including de novo whole genome sequencing, re-sequencing, ChipSeq, MethylSeq andRNASeq, are analyzed.METHODOLOGYBCC surveyed key users and producers in each of the market applications that will becommercially important during the next five years: research, drug discovery anddevelopment, forensics and human ID, bacterial genomics, agricultural genomics, clinicaldiagnostics and personal genomics. Based on our industry discussions and marketanalysis, we project the future applications of sequencing platforms and forecast salesrevenues for 2008 through 2013.The sequencing market is analyzed by technology, product type, application, customer,analysis type, geography and genome type, with forecasts of market demand from 2008through 2013. We analyze which applications and analyses will be important to the future ofDNA sequencing, and the customer groups that will be consumers of the technologies. Wealso analyze the impact of other genetic analysis technologies like microarrays on thegrowth of sequencing.INFORMATION SOURCESBCC surveyed leading DNA sequencing, biotechnology, and nanotechnology companies aswell as core sequencing facilities and laboratories to obtain data for this study. Includedwere research tools, drug, biotechnology and nanotechnology firms, and leading life scienceresearch institutions. We also spoke with leading industry thinkers. In addition, we compileddata from secondary sources including industry, trade, and government.
  3. 3. Table Of ContentsChapter- 1: INTRODUCTION – ComplimentarySTUDY GOALS AND OBJECTIVESREASONS FOR DOING THE STUDYINTENDED AUDIENCESCOPE OF REPORTMETHODOLOGYINFORMATION SOURCESRELATED BCC REPORTSANALYST CREDENTIALSBCC ONLINE SERVICESDISCLAIMERChapter- 2: SUMMARYTable 0 : GLOBAL VALUE OF DNA SEQUENCING, BY END USE APPLICATION,THROUGH 2013Figure 0 : GLOBAL VALUE OF DNA SEQUENCING, BY END USE APPLICATION, 2006-2013Chapter- 3: OVERVIEWINTRODUCTIONDNA SEQUENCING TECHNOLOGIES COVERED IN THIS REPORTMARKET POTENTIAL OF DNA SEQUENCING PRODUCTSSEQUENCING INDUSTRY GROWTH DRIVING FORCESSEQUENCING PRODUCTSChapter- 4: DNA SEQUENCING TECHNOLOGIESGENETIC ANALYSISHISTORY OF DNA SEQUENCINGOVERVIEW OF SEQUENCING TECHNOLOGIESSEQUENCING WORKFLOWSANGER SEQUENCINGSANGER SEQUENCING COSTSNEXT GENERATION SEQUENCING TECHNOLOGIESChapter- 5: DNA SEQUENCING APPLICATIONSINTRODUCTIONRESEARCH AND DRUG DISCOVERY APPLICATIONSChapter- 6: DNA SEQUENCING INITIATIVESINTRODUCTIONNHGRI $100,000 GENOME AND $1,000 GENOME PROJECTSGENOMICS PROJECTS OVERVIEW AND STATUSGENOME SEQUENCING PROJECTSMEDICAL SEQUENCING PROJECTSCANCER SEQUENCING PROJECTSMICROBIAL SEQUENCING PROJECTSGENOME VARIATION PROJECTS
  4. 4. AGRICULTURAL GENOMICSEPIGENOMICS SEQUENCING PROJECTSIMPACT OF SEQUENCING PROJECTSFigure 26 : GROWTH IN BASE PAIRS DEPOSITIED IN GENBANK, 1986-2006Chapter- 7: DNA SEQUENCING INDUSTRY STRUCTUREINDUSTRY STRUCTURE ANALYSISTHE ROLE OF EARLY ADAPTORSSEQUENCING INSTRUMENT COMPETITOR POSITIONINGCOMPETITOR MARKET SHARESINDUSTRY ACQUISITIONS AND STRATEGIC ALLIANCESREAGENTS SUPPLY ALLIANCESPERSONAL GENOMICS MARKET SEGMENTDNA SEQUENCING END USERSTable 32 : DNA SEQUENCING END USER MARKET SEGMENTSChapter- 8: DNA SEQUENCING MARKETSGROWTH DRIVING FORCESDNA SEQUENCING PRODUCTS MARKETSChapter- 9: DNA SEQUENCING PATENT STATUSRECENT PATENT ACTIVITY IN NEXT GENERATION DNA SEQUENCINGPATENT POSITION OF SEQUENCING COMPETITORSTECHNOLOGY DISTRIBUTION OF NEXT GENERATION SEQUENCING PATENTSSEQUENCING LITIGATION STATUSINTELLECTUAL PROPERTY POSITION OF SELECTED SEQUENCING COMPANIESChapter- 10: COMPANY PROFILES23ANDMEAFFYMETRIX INC.AGILENT TECHNOLOGIES, INC.APPLIED BIOSYSTEMSBASE4INNOVATION LTD.BECKMAN COULTERBIONANOMATRIXCARTESIAN GRIDSPEEDCLINICAL DATA CORPORATION (COGENICS DIVISION)COMPLETE GENOMICS, INC.DANAHER MOTIONDECODEMEDELTADOT LTD.EUROFINS MEDIGENOMIX GMBHEXPRESSION ANALYSIS, INC.FASTERIS SAFOUNDATION FOR APPLIED MOLECULAR EVOLUTIONGATC BIOTECH AGGE HEALTHCAREGENOME CORP.GENOME DIAGNOSTICS B.VGENOME DIAGNOSTICS, INC.
  5. 5. GENOMEQUESTGENOVOXX GMBHHELICOS BIOSCIENCES CORPORATIONHELIX HEALTHILLUMINA, INC.ILLUMINA, INC.INTERNA GENOMICS BVINVITROGENIP GENESIS INC.KNOME, INC.LASERGEN, INC.LI-COR BIOSCIENCESLIGHTSPEED GENOMICSLINGVITAE ASMICROCHIP BIOTECHNOLOGIES, INC.MWG BIOTECH AGNABSYS, INC.NAVIGENICSNANOPHOTONICS BIOSCIENCES INC.NETWORK BIOSYSTEMSOXFORD NANOPORE TECHNOLOGIES LTD.PACIFIC BIOSCIENCESPOPULATION GENETICS TECHNOLOGIES, LTD.REVEO INC.ROCHE LIFE SCIENCESSEIRAD, INC.SEQUENOMSEQWRIGHTSMARTGENESORENSON GENOMICSU.S. GENOMICSVICGENE BIOTECHNOLOGYVISIGEN BIOTECHNOLOGIES, INC.X-PRIZE FOUNDATIONZS GENETICSList of TablesSummary Table : GLOBAL VALUE OF DNA SEQUENCING, BY END USE APPLICATION,THROUGH 2013Table 1 : SCOPE OF THIS REPORTTable 2 : GLOBAL VALUE OF DNA SEQUENCING, BY END USE APPLICATION, THROUGH2013Table 3 : DNA SEQUENCING KEY GROWTH DRIVING FORCESTable 4 : LIFE CYCLE STATUS OF NEXT GENERATION SEQUENCING PLATFORMSTable 5 : COMPANY POSITIONING BY SEQUENCING TECHNOLOGYTable 6 : SCOPE OF KEY GENETIC ANALYSIS TECHNOLOGIESTable 7 : GENETIC ANALYSIS HISTORYTable 8 : LIMITATIONS OF SANGER SEQUENCING TECHNOLOGYTable 9 : IMPROVEMENTS IN SANGER SEQUENCING TECHNOLOGY
  6. 6. Table 10 : COMMERCIAL IN-VITRO AMPLIFICATION NGS TECHNOLOGIESTable 11 : KEY PERFORMANCE METRICS FOR SEQUENCING TECHNOLOGIESTable 12 : COMPARISON OF SELECTED DNA SEQUENCING PLATFORMSTable 13 : LIFE CYCLE OF DNA SEQUENCING TECHNOLOGIESTable 14 : FUTURE PERFORMANCE OF NEXT GENERATION SEQUENCING PLATFORMSTable 15 : READ LENGTHS FOR SELECTED SEQUENCING PLATFORMSTable 16 : STRENGTHS AND LIMITATIONS OF PAIRED END READSTable 17 : TECHNOLOGY CHALLENGES FOR NEXT GENERATION SEQUENCINGTable 18 : SEQUENCING APPLICATIONSTable 19 : DE NOVO VERSUS RE-SEQUENCING REQUIREMENTSTable 20 : CASE STUDY: NEANDERTHAL DNA SEQUENCINGTable 21 : EMERGING GENETIC ANALYSIS APPLICATIONSTable 22 : COMPARISON OF SEQUENCING WITH MICROARRAYS FOR CHIP APPLICATIONSTable 23 : NEXT GENERATION SEQUENCING VERSUS MICROARRAYS IN THE GENEEXPRESSION ANALYSIS SPACETable 24 : NHGRI GRANTS FOR NEXT GENERATION SEQUENCING TO COMMERCIALENTITIES, 2004-2007Table 25 : IMPORTANT SEQUENCING RESEARCH INITIATIVESTable 26 : DNA SEQUENCING INDUSTRY TRANSITIONTable 27 : COMPANY POSITIONING BY SEQUENCING TECHNOLOGYTable 28 : SEQUENCING INDUSTRY ACQUISITIONS, 2006-2008Table 29 : SEQUENCING INDUSTRY STRATEGIC ALLIANCES, 2005-2008Table 30 : PERSONAL GENOMICS KEY COMPETITORSTable 31 : PERSONAL GENOMICS COMPETITOR STRATEGIESTable 32 : DNA SEQUENCING END USER MARKET SEGMENTSTable 33 : MAJOR SEQUENCING CENTERSTable 34 : EXAMPLES OF LARGE CORE SEQUENCING CENTERSTable 35 : DNA SEQUENCING KEY GROWTH DRIVING FORCESTable 36 : GLOBAL VALUE OF GENETIC ANALYSIS MARKET, BY ANALYSIS TYPE, THROUGH2013Table 37 : GLOBAL VALUE OF DNA SEQUENCING MARKET, BY PRODUCT TYPE, THROUGH2013Table 38 : GLOBAL VALUE OF DNA SEQUENCING INSTRUMENTS, BY SANGER AND NEXTGENERATION FORMATS, THROUGH 2013Table 39 : GLOBAL VALUE OF DNA SEQUENCING CONSUMABLES MARKET, BY SANGER ANDNEXT GENERATION FORMATS, THROUGH 2013Table 40 : GLOBAL VALUE OF DNA SEQUENCING, BY CUSTOMER, THROUGH 2013Table 41 : GLOBAL VALUE OF SANGER SEQUENCING, BY CUSTOMER, THROUGH 2013Table 42 : GLOBAL VALUE OF NEXT GENERATION SEQUENCING, BY CUSTOMER, THROUGH2013Table 43 : GLOBAL VALUE OF DNA SEQUENCING MARKET, BY TECHNOLOGY, THROUGH2013Table 44 : GLOBAL VALUE OF DNA SEQUENCING, BY END USE APPLICATION, THROUGH2013Table 45 : GLOBAL VALUE OF NEXT GENERATION SEQUENCING, BY END USE APPLICATION,THROUGH 2013Table 46 : GLOBAL VALUE OF SANGER SEQUENCING, BY END-USE APPLICATION, THROUGH2013Table 47 : GLOBAL VALUE OF SEQUENCING, BY GENOME, THROUGH 2013
  7. 7. Table 48 : GLOBAL VALUE OF DNA SEQUENCING, BY ANALYSIS TYPE, THROUGH 2013Table 49 : GLOBAL VALUE OF NEXT GENERATION SEQUENCING, BY ANALYSIS TYPE,THROUGH 2013Table 50 : GLOBAL VALUE OF SANGER SEQUENCING, BY ANALYSIS TYPE, THROUGH 2013Table 51 : GLOBAL VALUE OF DNA SEQUENCING PRODUCTS, BY GEOGRAPHICAL MARKET,THROUGH 2013Table 52 : GLOBAL VALUE OF SANGER SEQUENCING PRODUCTS, BY GEOGRAPHICALMARKET, THROUGH 2013Table 53 : GLOBAL VALUE OF NEXT GENERATION SEQUENCING PRODUCTS, BYGEOGRAPHICAL MARKET, THROUGH 2013Table 54 : RECENT ACTIVITY IN NEXT GENERATION SEQUENCING PATENTSTable 55 : SEQUENCING IP LITIGATION STATUSList of FiguresSummary Figure : GLOBAL VALUE OF DNA SEQUENCING, BY END USE APPLICATION, 2006-2013Figure 1 : DNA, MRNA AND GENETIC VARIATIONFigure 2 : SEQUENCING THROUGHPUT TRENDFigure 3 : HUMAN GENOME SEQUENCING COST TRENDFigure 4 : $1,000 GENOME PRODUCT SPACEFigure 5 : KEY DNA SEQUENCING TECHNOLOGIESFigure 6 : DNA SEQUENCING PLATFORM WORKFLOW STEPSFigure 7 : DDNTP CHEMICAL STRUCTUREFigure 8 : SANGER SEQUENCING WORKFLOWFigure 9 : COST BREAKDOWN FOR SEQUENCING A SINGLE HUMAN GENOME, USING 2005SANGER SEQUENCER TECHNOLOGYFigure 10 : NEXT GENERATION SEQUENCING TECHNOLOGIESFigure 11 : SCHEMATIC COMPARISON OF SBS AND SBL SEQUENCING PLATFORMSFigure 12 : SEQUENCING BY SYNTHESIS: REVERSIBLE TERMINATOR REACTIONFigure 13 : SEQUENCING BY SYNTHESIS: PYROSEQUENCING REACTIONFigure 14 : SCHEMATIC OF SOLID SEQUENCING BY LIGATIONFigure 15 : DECODING SOLID COLOR DATAFigure 16 : SINGLE MOLECULE SEQUENCING BY SYNTHESISFigure 17 : NANOPORE SEQUENCING WORKFLOW AND TECHNOLOGY APPROACHESFigure 18 : GLOBAL CUMULATIVE INSTALLED BASE OF DNA SEQUENCERS, THROUGH 2008Figure 19 : SEQUENCING COMPETITIVE MARKET SPACEFigure 20 : SINGLE SEQUENCER, WHOLE GENOME THROUGHPUT TRENDS 1975-2015Figure 21 : GENETIC ANALYSIS COST/INFORMATION CONTENT TRENDSFigure 22 : NHGRI $100,000 AND $1,000 GENOME PROJECT CUMULATIVE FUNDING BYTECHNOLOGY, 2004-2007 ($98.7 MILLION)Figure 23 : NHGRI ANNUAL FUNDING BY TECHNOLOGY, 2004-2007Figure 24 : NHGRI FUNDING OF $100,000 AND $1,000 PROGRAMS, 2004-2007Figure 26 : GROWTH IN BASE PAIRS DEPOSITIED IN GENBANK, 1986-2006Figure 27 : DNA SEQUENCING INDUSTRY STRUCTURE, 1995-2005Figure 28 : DNA SEQUENCING INDUSTRY STRUCTURE, POST 2005Figure 29 : 2008 ESTIMATED COMPETITOR MARKET SHARE: SEQUENCING INSTRUMENTSAND REAGENTS (TOTAL MARKET: $862.4 MILLION)Figure 30 : 2008 ESTIMATED COMPETITOR MARKET SHARE: SANGER SEQUENCINGINSTRUMENTS AND REAGENTS (TOTAL MARKET: $557.1 MILLION)
  8. 8. Figure 31 : 2008 ESTIMATED COMPETITOR MARKET SHARE: NEXT GENERATIONSEQUENCING INSTRUMENTS AND REAGENTS (TOTAL MARKET $305.3 MILLION)Figure 32 : PERSONAL GENOMICS COMPETITIVE POSITIONINGFigure 33 : MAJOR SEQUENCING CENTER’S SHARE OF THE GENOME SEQUENCINGPROJECTS MARKET, 2008Figure 34 : WASHINGTON UNIVERSITY ADOPTION OF NEXT GENERATION SEQUENCERS,2007 AND 2008Figure 35 : 2008 SEQUENCING FUNDING BY AGENCYFigure 36 : EUKARYOTIC SEQUENCING PARADIGMFigure 37 : SNP GENOTYPING MARKETFigure 38 : WORLDWIDE SEQUENCING PATENT APPLICATIONS BY COMPANY, 2001 TOPRESENTFigure 39 : WORLDWIDE NEXT GENERATION SEQUENCING PATENT APPLICATIONS, BYTECHNOLOGY, 2001-2008Figure 40 : WORLDWIDE SEQUENCING-RELATED PATENT APPLICATIONS, BY GEOGRAPHY,2001-2008Latest Market Research Reports: Synthetic Biology: Emerging Global Markets Labeling and Linkage Agents for Immunoassays and Gene Probes Advanced Drug Delivery Systems: Technologies and Global Markets Global Market for Catalyst Regeneration Markets for Advanced Wound Care Technologies Wireless Sensors: Technologies and Global Markets Remote Sensing Technologies and Global MarketsAbout Us:ReportsnReports is an online library of over 75,000 market research reports and in-depthmarket research studies & analysis of over 5000 micro markets. We provide 24/7 online andoffline support to our customers. Get in touch with us for your needs of market researchreports.Follow us on Twitter: http://twitter.com/marketsreportsOur Facebook Page: http://www.facebook.com/pages/ReportsnReports/191441427571689Contact:Mr. Priyank7557 Rambler road,Suite 727, Dallas, TX 75231Tel: + 1 888 391 5441E-mail: sales@reportsandreports.comhttp://www.reportsnreports.comVisit Our Blog: Market Research Reports

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