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 Vasopressor agent with direct and indirect effect on
the sympathetic system
 Indirect effect is by causing the release of
Noradrenaline
 Direct effect is by its action on β and α1 -
adrenoceptors
 Positive inotropic effect
 Constricts blood vessels
 Increases peripheral resistance
 Elevates systolic and diastolic...
 Over-dosage may cause severe hypertension, sinus
arrhythmias, myocardial infarction and cardiac arrest.
 Knights, K & Kathleen, B 2011, Pharmacology for
health professionals, Chapter 12, Elsevier,
Chatswood, Australia.
Metaraminol
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Metaraminol

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Metaraminol

  1. 1.  Vasopressor agent with direct and indirect effect on the sympathetic system
  2. 2.  Indirect effect is by causing the release of Noradrenaline  Direct effect is by its action on β and α1 - adrenoceptors
  3. 3.  Positive inotropic effect  Constricts blood vessels  Increases peripheral resistance  Elevates systolic and diastolic blood pressure  Improves cardiac contractility
  4. 4.  Over-dosage may cause severe hypertension, sinus arrhythmias, myocardial infarction and cardiac arrest.
  5. 5.  Knights, K & Kathleen, B 2011, Pharmacology for health professionals, Chapter 12, Elsevier, Chatswood, Australia.

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