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Congenital Adrenal   HyperplasiaRenata O, Steyn F, Nathaly       M, Aileen j
What the disease is Congenital adrenal hyperplasia is a defect in the  adrenal glands when they lack enzyme. Two types o...
Classic CAH1. Salt wasting: body has trouble keeping the right    amount of salt. Causes weight loss &    dehydration in t...
Non-classic CAH Neither cortisol nor aldosterone is reduced No salt wasting Newborn girls usually have no abiguity
The target Both males and females are an easy target This disease affects 10,000-15,000 newborns  every year Severe for...
Areas of infection Affect the adrenal glands mainly Also affects the reproductive system of both  sexes
Causes Lack of enzyme needed by the adrenal gland to  make the hormones cortisol and aldosterone.    Cortisol: a steroid ...
Female Symptoms Abnormal menstrual cycles Deep voice Early appearance of pubic & armpit hair Ambiguous genitalia (geni...
Male Symptoms Early appearance of pubic & armpit hair Enlarged penis Small testes Early development of male characteri...
Exams and Tests Salt levels and urine tests X-ray for bone age High levels of serum DHEA sulfate    Dehydroepiandroster...
Treatments Treated with hormone replacement; generally  replaced with cortef and florinef. Take a form of cortisol daily...
Citation (idk if the way it’s cited is correct) The hormone foundation’s Patient Guide to  Congenital Adrenal Hyperplasia...
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  1. 1. Congenital Adrenal HyperplasiaRenata O, Steyn F, Nathaly M, Aileen j
  2. 2. What the disease is Congenital adrenal hyperplasia is a defect in the adrenal glands when they lack enzyme. Two types of CAH 1. Classic also has two forms: salt wasting (severe) & non-salt wasting (mild). 2. Non-classic
  3. 3. Classic CAH1. Salt wasting: body has trouble keeping the right amount of salt. Causes weight loss & dehydration in the first week of life for newborns.2. Non-salt wasting: levels of cortisol are reduced, no salt wasting. Causes ambiguous genitalia in female babies and virilization in both sexes before puberty.
  4. 4. Non-classic CAH Neither cortisol nor aldosterone is reduced No salt wasting Newborn girls usually have no abiguity
  5. 5. The target Both males and females are an easy target This disease affects 10,000-15,000 newborns every year Severe form affects mainly European Caucasians Mild form affects Ashkenazi-Jews
  6. 6. Areas of infection Affect the adrenal glands mainly Also affects the reproductive system of both sexes
  7. 7. Causes Lack of enzyme needed by the adrenal gland to make the hormones cortisol and aldosterone. Cortisol: a steroid hormone of the adrenal cortexAldosterone: hormone produced by the cortex of the adrenal gland
  8. 8. Female Symptoms Abnormal menstrual cycles Deep voice Early appearance of pubic & armpit hair Ambiguous genitalia (genitals that look both male and female)(picture maybe)
  9. 9. Male Symptoms Early appearance of pubic & armpit hair Enlarged penis Small testes Early development of male characteristics (e.g. deep voice, facial hair, etc.) (picture maybe)
  10. 10. Exams and Tests Salt levels and urine tests X-ray for bone age High levels of serum DHEA sulfate Dehydroepiandrosterone(DHEA)-sulfate- a weak male hormone produced in the adrenal glands in both males & females. Genetic test also help diagnose, confirm, & manage the disease.
  11. 11. Treatments Treated with hormone replacement; generally replaced with cortef and florinef. Take a form of cortisol daily (e.g. dexamethasone, fludrocortisone, or hydrocortisone)
  12. 12. Citation (idk if the way it’s cited is correct) The hormone foundation’s Patient Guide to Congenital Adrenal Hyperplasia. (n.d.). http://www.hormone.org/resources/up-adrenal- hyperplasia-patient-guide-083110-2.pdf Congenital Adrenal Hyperplasia-PubMed Health. National Center for biotechnology Information. http://ncbi.nlm.nih.gov/pubmed/health/ Congenital Adrenal Hyperplasia Medicine plus Medical Encyclopedia. National library of medicine-national institutes of health. http://nlm.nih.gov/medicineplus/encyla http://www.congenitaladrenalhyperplasia.org/

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