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Systems Biology Modeling of the Brain in Health & Disease

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www.drbrowncares.com

Introducing the Spinocerebellar Ataxia Modeling Suite, which integrates a variety of molecules, proteins, ion channels, and ions, along with their associated reaction-diffusion and signaling pathways. This modeling suite is a prime example of using computational biology for translational, precision, and systems medicine. Health and disease are both simulated in these publicly available models. References are provided for each paper that describes model development and results.

@drbrowncares

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Systems Biology Modeling of the Brain in Health & Disease

  1. 1. Systems Biology Modeling ofSystems Biology Modeling of the Brain in Virtual Cellthe Brain in Virtual Cell Sherry-Ann Brown, MD, PhD @drbrowncares, drbrowncares@gmail.com
  2. 2. Modeling in Virtual CellModeling in Virtual Cell @drbrowncares drbrowncares@gmail.com Brown & Loew, Frontiers in Neuroscience 2015-1
  3. 3. Modeling in Virtual CellModeling in Virtual Cell @drbrowncares drbrowncares@gmail.com Brown & Loew, Frontiers in Neuroscience 2015-1
  4. 4. Modeling in Virtual CellModeling in Virtual Cell @drbrowncares drbrowncares@gmail.com Brown & Loew, Frontiers in Neuroscience 2015-1
  5. 5. Hernjak et al, Biophysical Journal 2005 Parallel fiber stimulus Climbing fiber stimulus @drbrowncares drbrowncares@gmail.com Calcium Pathways In The Cell
  6. 6. Modeling in Virtual Cell @drbrowncares drbrowncares@gmail.com Max 8120 1400 Min Brown et al, Biophysical Journal 2008
  7. 7. Modeling in Virtual CellModeling in Virtual Cell Max 8120 1400 Min @drbrowncares drbrowncares@gmail.com Brown et al, Biophysical Journal 2008
  8. 8. @drbrowncares drbrowncares@gmail.com Brown et al, Frontiers in Neuroscience 2015-2
  9. 9. @drbrowncares drbrowncares@gmail.com Brown et al, Frontiers in Neuroscience 2015-2
  10. 10. @drbrowncares drbrowncares@gmail.com Brown et al, Frontiers in Neuroscience 2015-2
  11. 11. Modeling in Virtual CellModeling in Virtual Cell @drbrowncares drbrowncares@gmail.com Brown & Loew, Frontiers in Neuroscience 2015-1
  12. 12. Modeling in Virtual CellModeling in Virtual Cell @drbrowncares drbrowncares@gmail.com Brown et al, Frontiers in Neuroscience 2015-2
  13. 13. Modeling in Virtual CellModeling in Virtual Cell @drbrowncares drbrowncares@gmail.comBrown et al, Frontiers in Neuroscience 2015-2
  14. 14. Modeling in Virtual CellModeling in Virtual Cell @drbrowncares drbrowncares@gmail.comBrown & Loew, Frontiers in Neuroscience 2015-1
  15. 15. @drbrowncares drbrowncares@gmail.comBrown & Loew, Frontiers in Neuroscience 2015-1
  16. 16. @drbrowncares drbrowncares@gmail.comBrown & Loew, Frontiers in Neuroscience 2015-1
  17. 17. Citations Textbooks (11) + Journal articles (34) @drbrowncares drbrowncares@gmail.com
  18. 18. @drbrowncares drbrowncares@gmail.com
  19. 19. Systems Biology Modeling ofSystems Biology Modeling of the Brain in Virtual Cellthe Brain in Virtual Cell Sherry-Ann Brown, MD, PhD @drbrowncares, drbrowncares@gmail.com

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