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Ir presentation 062314


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Ir presentation 062314

  1. 1. Empowering Personalized Cancer Treatment Summer 2014 062314
  2. 2. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 2 Forward-Looking Statement This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements pertaining to future financial and/or operating results, future growth in research, technology, clinical development and potential opportunities for Cancer Genetics, Inc. products and services or Gentris, Inc. products and services., along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to, statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, risks of cancellation of customer contracts or discontinuance of trials, risks that we will not reach agreement on definitive acquisition agreements with Gentris, or that the Gentris and/or BioServe transactions will not close or, if either or both closes, will not realize the currently anticipated benefits, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, maintenance of intellectual property rights and other risks discussed in the Company's Form 10-K for the year ended December 31, 2013 and 10-Q for the quarter ended March 31, 2014 along with other filings with the Securities and Exchange Commission. These forward-looking statements speak only as of the date hereof. Cancer Genetics disclaims any obligation to update these forward-looking statements.
  3. 3. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 3 2013 Was a Year of Significant Progress and 2014 Shows Continued Success  54% full year revenue growth 2013 over 2012 and 45% growth Q1, 2014 over Q1, 2013.  Test volume grew 63% to 10,771 tests in 2013 over 2012 and 45% to 2,772 tests in Q1, 2014 over Q1, 2013.  Tripled Gross-Profit Margins to 26% in 2013.  Closed 2 follow-on offerings on NASDAQ totaling ~$60+ Million.  Launched 6 proprietary genomic-based diagnostic tests for lymphomas (CLL/SLL, DLBCL, FL, MCL), kidney cancer and cervical cancer.  Launched the CALR mutation analysis test targeting ~3 Million patients in the US with MPN.  Received 3 patent awards covering CGI’s diagnostics for hematologic and kidney cancers.  Expanded key biopharma relationships with Gilead and Roche driving adoption of CGI’s genomic tests nationally and internationally.  Progressive advancements to the management team and board of directors with experienced and seasoned industry leaders.  Expanded collaborations and partnerships with world-class institutions including J.V. with Mayo Clinic in Generation Sequencing: OncoSpire Genomics.
  4. 4. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 4 Molecular Diagnostics are Changing our Understanding of Cancer While Providing New Tools to Diagnose & Treat Patients Our unique focus & approach supports the entire cancer care continuum Personalize therapeutic plan and treatment options DIAGNOSIS PROGNOSIS THERANOSIS Assist in patient outcome and disease management What drug(s) to give, how much, and when? What are my survival prospects? Do I have cancer and what type? Use genomics to provide an accurate and definitive typing of the cancer Proprietary Products Focused Oncology Lab Comprehensive Report Integrated Molecular Diagnostic Testing Brings Benefits Across the Entire Oncology Ecosystem
  5. 5. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 5 CGI’s Mission is to Personalize and Improve the Success Rate in Cancer Treatment Integrating & Delivering Genomic Information About a Patient’s Cancer Can Improve Care & Reduce Cost Phenotypic & Physical Examination Morphologic & Pathological Analysis Large & Multiple Specimens Required Significant Delays to Treatment Traditional Approach Biomarkers and Companion Diagnostics Genomic Analysis & Proprietary Algorithms Reduced Size and Number of Specimens Improved Diagnoses & Treatment Plans Our Approach: Personalized Medicine Target For Tomorrow 25% Situation Today Source: Clinical Trends in Molecular Medicine, Vol. 7, Issue 5 100% Success Rate Target Success Rate
  6. 6. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 6 The Acquisitions of BioServe India and Gentris Corporation Provide Significant Market Upside & Improve CGI’s Competitive Position • Access to high-growth Indian diagnostics market – projected to grow at 15-20% per annum for the next decade. • Accelerates next-generation sequencing development and validation of targeted hot spot oncology panels. • Cost-effective expansion of genomic analysis & informatics capabilities with state of-the-art 14,000 sq. foot lab. BioServe India • Growth potential in integrating our oncology- focused testing capabilities with Gentris’ high-value contracts. • Expansion of Gentris’ capabilities and portfolio to include oncology-focused pharmacogenomics services. • 24,000 sq. foot lab space (CLIA/CAP/GLP) with NGS, genotyping, and gene expression test capabilities. Gentris Corporation
  7. 7. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 7 Unique, Scalable and Multifaceted Business Model With A Focus On Providing A Complete Solution Suite of Products and Services Provides Multiple Growth Drivers and Value to Multiple Parties: Clinical Community, Biopharma & Medtech CLINICAL SERVICES  Differentiated and complete disease-focused solutions  Superior turnaround times  World-class expertise in genomics and cytogenetics  Serving community hospitals and labs through unique Expand Dx™ program BIOPHARMA PARTNERSHIPS  Biomarker and companion diagnostic development  World-class genomics and bioinformatics  Drug-specific and cancer- specific assays  Comprehensive focus in hematologic and urogenital cancers PROPRIETARY PRODUCTS  Proprietary molecular diagnostics & FISH probes  Clinically validated  IP-protected  Sold globally  Probe manufacturing leverages low-cost, high scale facility in India
  8. 8. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 8 Our Target Markets in Oncology Testing Comprise Over 615,000 New Lives Annually in the U.S. Ability to Impact Over 615,000 New Lives Annually in the U.S. Source: American Cancer Society 156,420 2014 Estimated New Cases (U.S.) Death Rate 35% Hematological: Lymphoma, Leukemia, M. Myeloma 371,610 2014 Estimated New Cases (U.S.) Death Rate 16% Urogenital: Kidney, Bladder & Prostate 86,970 2014 Estimated New Cases (U.S.) Death Rate 31% Gynecological: Cervical, Endometrial & Ovarian 6 Products Launched in Target Segments Over $6Bn in Annual U.S. Spend on Lab Testing In These Categories
  9. 9. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 9 6 Proprietary Diagnostic Products Commercially Launched & In Market Incidence Indication Lymphoma & Leukemia Microarrays (MatBA®) 106,770 (Annual New Cases, Global) Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma 142,360 (Annual New Cases, Global) Diffuse Large B-Cell Lymphoma 62,300 (Annual New Cases, Global) Follicular Lymphoma 17,795 (Annual New Cases, Global) Mantle Cell Lymphoma Kidney Cancer Microarray (UroGenRA®) 274,000 (Annual New Cases, Global) Kidney Cancer Cervical Cancer DNA-FISH Probe (FHACT®) 1,750,000 (Annual New Cases, US) HPV+ Low Grade Cervical Lesions Over 2.3 Mn Combined Annual New Cases Globally
  10. 10. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 10 Product Pipeline Research & Discovery Clinical Development Commercial Development Launch & Market Entry Indication Development Stage Lymphoma & Leukemia Microarrays (MatBA®) Multiple Myeloma Bladder and Prostate Cancer Microarrays (UroGenRA®) Bladder Cancer Prostate Cancer HPV-Associated Cancer DNA-FISH Probe (FHACT®) Head & Neck Cancer Urogenital Cancer Microarrays (UGenRA™) Cervical Cancer Endometrial Cancer Ovarian Cancer
  11. 11. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 11 Despite Improved Cancer Care, Case Numbers for Hematologic Cancers are Still Rising Genomics-Based Tests like MatBA® are Critical and Improve the Management and Cost of Hematologic Cancers Source: Genzyme & Nature Source: National Cancer Institute, National Center for Health Statistics, SEER Dataset of Incidence & Mortality, FDA 1 2 5 12 89 100 80 60 30 2 Number of Years Ago 11.1 12.6 15.5 18.5 20.0 19.7 20.5 21.2 5.6 6.2 7.1 7.9 8.7 8.2 6.9 7.3 1975 1980 1985 1990 1995 2000 2005 2010 Incidence Rate Survival Rate Identified Leukemia & Lymphoma Subtypes Incidence & Survival Rates for NHLs (US Only, per 100,000)
  12. 12. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 12 MatBA®-CLL/SLL Improves Risk Stratification & Outcome Prediction  Validated in Collaboration w/ Dr. Kanti Rai & Dr. Nicholas Chiorazzi (NSLIJ); 2 Datasets, 322 specimens  Additional Validations being conducted w/ HUMC & Dana Farber; 2 Cohorts, 350+ specimens █ Favorable █ Intermediate █ Unfavorable █ Favorable/ Intermediate (no distinction) 38% of cases in our study have a favorable prognosis falling under "watch & wait" approach. 8% of cases with unfavorable prognosis missed by FISH and caught using MatBA®-CLL/SLL. Impact on therapy selection & clinical management of CLL patients. Genomic Aberrations Reported by FISH: 4 Genomic Aberrations Reported by MatBA®-CLL/SLL: 20 85% 15% FISH 23% 39% 38% (Current Method) (CGI Method)
  13. 13. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 13 MatBA® can Group Patients into Risk Groups & Prognostication Classes MatBA®- CLL / SLL is a diagnostic tool and prognostic indicator for patient stratification and improved patient management  Being actively used in clinical care, in clinical trials and in validation programs with Dana Farber, MSKCC and HUMC  20 key genetic events/sites classify CLL patients as having the potential for Poor outcome = High risk Intermediate outcome = Intermediate risk Good outcome = Low risk Detection of specific genomic imbalance in CLL/SLL by MatBA®-CLL/SLL correlates patient risk with time to first treatment (TTFT) and shorter overall survival (OS)  Patients classified as high risk showed a shorter TTFT compared to those classified as low or intermediate risk  Patients classified as high risk had significantly shorter OS times than those classified as low or intermediate risk  Provides additional risk stratification between low and intermediate risk patients, not currently available in other tests Time to First Treatment (TTFT) Time (months) Time (months) Proportion Surviving ProportionTreatment-Free –GOOD (n=74) –INTERMED (n=107) –POOR (n=47) –GOOD (n=74) –INTERMED (n=107) –POOR (n=47) P = 0.090 P = 0.001 P < 0.001 P = 0.010 Overall Survival (OS) Leukemia & Lymphoma – Houldsworth, et. al Sept. 18, 2013
  14. 14. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 14 UroGenRA®-Kidney Can Guide Management of Patients with Renal Masses and Appropriate Treatment Selection Clinical Benefits Include Reduction in Number of Highly Invasive Procedures and Time to Treatment Initiation, and Better Informed Treatment Selection Development of diagnostic algorithm  >600 RCC malignant subtypes (in-silico: SNP)  >100 malignant and benign renal neoplasms (in-house: aCGH & FISH) Retrospective in-house FFPE validation (n>190) CCF  100% diagnostic yield  97% diagnostic sensitivity to distinguish benign from malignant renal neoplasms  93% sensitivity to distinguish malignant RCC subtypes  C. Magi-Galluzzi and E. Klein (Cleveland Clinic) Prospective ongoing percutaneous core needle biopsy (n>50) MSKCC  Demonstrated ability to diagnose pathologically “unclassifiable” biopsies prior to surgical intervention  J. Coleman and J. Durack (MSKCC) PROBLEM Men and women with renal masses often undergo unnecessary nephrectomy for accurate diagnosis and experience delay in treatment SOLUTION UroGenRA® will detect genomic aberrations in a single assay permitting accurate diagnosis (benign vs malignant, and malignant subtype) guiding appropriate management and treatment strategies
  15. 15. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 15 FHACT® - A New Genomic Aid In The Screening & Management Of Cervical Cancer FHACT® Provides Critical Information Which Reduces Unnecessary and Costly Colposcopies Cervical cancer effects nearly 500,000 women globally each year with nearly 80% in developing countries. Today, all these women are referred for colposcopy. Women with abnormal or unclear Pap smears 55 Million Pap smears per year 3.5 Million Pap smears come back as unclear/abnormal 2 Million biopsies performed 12,000 cases of cervical cancer
  16. 16. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 16 FHACT® Provides Information for Developing Treatment Plans Potentially Reducing Healthcare Costs & Procedures FHACT® is the Only 4 Color FISH Probe that can be Used for Cervical Cancer Screening as Additional Testing Before Referral for Colposcopy Global Validation PartnersGenomic Amplification by Disease Category Source: P. Luhn, J. Houldsworth, et al., Gynecologic Oncology (2013) 5 10 19 20 0 20 40 60 80 ptrend = 0.01 6 9 9 20 0 20 40 60 80 ptrend = 0.02 6 9 7 12 0 20 40 60 80 ptrend = 0.03 3 8 12 12 0 20 40 60 ptrend = 0.001 <CIN2 & NLIM (n=11) <CIN2 & LSIL (n=20) CIN2 &/or HSIL (n=10) CIN3+ (n=7) <CIN2 & NLIM (n=11) <CIN2 & LSIL (n=20) CIN2 &/or HSIL (n=10) CIN3+ (n=7) FHACT® detects irreversible changes in cervical cells caused by HPV.
  17. 17. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 17 Large, Targeted Market Opportunities Target Markets Commercialization Strategy Community Hospitals Regional Cancer Centers Oncologists and Pathologists  Continue to growing sales force that calls on hospitals and regional laboratories  Plan development of national footprint through Expand Dx™ Biotechnology Companies Pharmaceutical Companies  Leverage clinical infrastructure and proprietary product portfolio for testing services that support clinical trials  Expand sales emphasis of Select One® Emerging Markets  Enhance distributor base in select emerging economies  Partner with leading local cancer care providers and hospitals to provide probes, arrays and clinical services  Collaborate to create and validate microarrays and other proprietary products  Accelerate launch of large scale studies Universities and Research Centers
  18. 18. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 18 Unique Service Offering Developed to Enable Community Hospitals to Improve Cancer Outcomes & Treat Patients Locally  Delivers better outcomes to community hospitals and laboratories  Enables community hospitals to bring “state-of-the-art” genomic testing to patients  Brings personalized medicine to the community hospital vs. just at academic and teaching hospitals  Allows community hospitals to keep patients and treat them locally  Improving care and quality is critical to maintaining reimbursement for community hospitals $600,000 - $800,000 USD in Testing Opportunity on Average per Hospital Expanding & Developing Cancer Care is a Top Priority for Hospital CEOs & CFOs 4,000 to 5,000 Community Hospitals & Laboratories in the U.S. 85% Of All U.S. Cancer Patients are Initially Diagnosed in Community Hospitals & Laboratories
  19. 19. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 19 Through Acquisition, Clinical Trial Services Show Strong Growth and Robust Pipeline Gentris Provides Pharmacogenomic Clinical Trial Services to Several Large Pharma Companies Including Merck, Novartis, Otsuka, Eisai and Bristol-Myers Squibb GROWTH IN CGI’s SELECT ONE® CONTRACTS ($000) 21% 55% ONCOLOGY DRUGS ASSOCIATED WITH BIOMARKER(S) $300 $2,700 $8,500 $14,200 2011 2012 2013 2014 Approximate value of contracts with biotech and pharma clients 2011 2016 Source: Company Analysis and Management Estimates
  20. 20. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 20 Over 6,800 Oncology Trials in the US Aligned with our Core Markets Number of Open Clinical Trials (U.S.) 1,439 1,453 2,178 1,765 Lymphoma Leukemia Urogenital HPV-Associated Source:
  21. 21. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 21 Gilead is Currently Using a Comprehensive Panel of CGI Services & Proprietary Products in National & International Trials for Hematologic Cancers The Gilead Relationship Exemplifies the Significant Upside Potential of CGI’s Select One® Offering Highlights  Comprehensive, biomarker-based patient profiling will help risk stratification and response monitoring  Improved patient profiling will result in improved trial efficacy for Gilead  Testing will occur across several methodologies, including flow cytometry, FISH, sequencing and mutation assays, and MatBA® microarrays  CGI provides biomarker driven insight regarding patient targeting and potential outcomes  Trials cover both national and international locations with all patient specimens being processed in Rutherford, New Jersey CGIX Press Release: Cancer Genetics, Inc. Selected By Gilead Sciences, Inc. to Provide Clinical Trial Services for International Trials in Chronic Lymphocytic Leukemia
  22. 22. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 22 Roche Partnership Expanding Market Presence Internationally “By expanding our relationship, we are strengthening our ability to provide patients the best service possible.” Alvaro Soto, Roche Servicios, Central America & Caribbean General Manager Highlights CGI provides genomic and biomarker testing services to 14 countries in Central America and the Caribbean.  CGI won a global RFP to help a strategic personalized medicine initiative for Roche Servicios (Latin America)  Roche sends all patient samples to the Rutherford facility where they are catalogued and processed  CGI interacts with both Roche and the hospital staff (pathologists, oncologists and nurses) and supports delivery of reports through an online HIPAA compliant portal  CGI and Roche expanded this relationship in 2013 and will begin developing workshops and training programs to drive adoption of biomarker-based cancer diagnostics throughout Central America and the Caribbean  CGI and Roche recently further expanded this relationship with an exclusive multi-year deal in which CGI will develop a center of excellence for lung cancer testing utilizing Roche’s FDA-Approved cobas® platform CGIX Press Release: Cancer Genetics, Inc. selected by Roche Servicios S.A. to provide services for the diagnosis and personalization of oncology treatment CGIX Press Release: Cancer Genetics, Inc. expands relationship with Roche Servicios S.A.
  23. 23. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 23 Collaborations with Premier Cancer Research Institutions Leading Differentiated Research & Driving Product Adoption Research Collaboration/ Licensing Clinical Services Partnership Highlights    Kidney Cancer, DLBCL, MCL & FL   Joint Venture Focused on Oncology & Next Generation Sequencing   Cervical Cancer   DLBCL    CLL    Cervical Cancer & DLBCL   Cervical Cancer   Kidney Cancer    DLBCL, Head & Neck Cancers    CLL
  24. 24. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 24 Mayo Clinic Joint Venture Investing in the Future – OncoSpire Genomics The Value and Focus of Next Generation Sequencing is Moving from Platforms to Clinically Relevant, Disease-Specific Applications Highlights  JV, based in Rochester, MN, will develop clinical diagnostic products and services on NGS platform(s) in areas of high clinical need  Three initial projects in key oncology categories selected by the SRC (Scientific Review Committee): Lung Cancer, Multiple Myeloma, Follicular Lymphoma  CGI commits up to $6 M over initial three year period (2013 to 2015-16 expected)  Mayo commits to “in-kind” services and support, use of facilities, NGS capabilities and access to biorepository  Joint Venture is exclusive in the project areas selected by CGI & Mayo  Important company update and analyst day held November 22, 2013 Next Generation Sequencing in Oncology
  25. 25. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 25 OncoSpire Genomics Projects are Unique and Have High Value 1.6 million new cases 200,000 new cases 20,920 new cases Informed Discovery Clinical Development Commercial Development Market Entry (with partners) Lung Cancer Multiple Myeloma Follicular Lymphoma Selected Projects Have Significant Clinical Value & May Yield Multiple Focused Panels to Become the Standard of Care in NGS-Based Oncology Management
  26. 26. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 26 Strong History of Growth CGI Revenue & Clinical Volume Trends (2009 – 2013) 54% Full Year 2013 Revenue Growth $1.67 $2.52 $3.02 $4.30 $6.61 2009 2010 2011 2012 2013 2,321 3,146 3,622 6,610 10,771 2009 2010 2011 2012 2013 Total Revenue ($Mn) Clinical Volume (Tests Processed)
  27. 27. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 27 Strong History of Growth - Revenue & Clinical Volume Trends (Q1 Comparison 2012-2014) $835 $1,219 $1,430 Q1, 2012 Q1, 2013 Q1, 2014 Total Revenue ($000) 1,610 1,911 2,772 Q1, 2012 Q1, 2013 Q1, 2014 Clinical Volume (Tests Processed)
  28. 28. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 28 Summary Statement of Operations (Q1 Comparison 2012-2014) Income Statement Item Q1, 2012 Q1, 2013 Q1, 2014 Revenue $835 $1,219 $1,430 Gross Profit 12 149 140 Gross Margin (%) 1.4% 12.2% 9.8% Research & Development (R&D) 524 491 597 Sales & Marketing (S&M) 340 396 749 General & Administrative (G&A) 936 1,571 2,731 Operating Profit (Loss) (1,788) (2,309) (3,937) Net Income (Loss) (1,072) 2,360 (2,486) $ in thousands Actual 03/31/14 Cash & Cash Equivalents $41,315 Stockholders’ Equity 43,635 $ in thousands Summary Balance Sheet
  29. 29. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 29 Consistent Focus on Gross Profit Improvements Additional Efforts Focused Operationally in US & India Gross Profit Margin Highlights of Initiatives (52%) (39%) (3%) 9% 26% (1,000) (800) (600) (400) (200) 0 200 400 600 800 2009 2010 2011 2012 2013 $inThousands  Decrease CGI Costs for Development & Services  Migrate DNA manufacture and NT Kits for CGI probes  Develop remove G-Band analysis capability  Develop remote FHACT® analysis capabilities  Move entire probe manufacturing & assembly
  30. 30. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 30 Multiple Customer Types Provide Diversified Revenue Mix With Covered Lives Already in Place Selected Payors Direct Bill Customer Types Biotechs Pharmas Academic Cancer Facilities Community & Regional Labs 72+ million covered lives through multiple payors: 13% 21% 58% 3% 5% Medicare 3rd Party InsuranceCompanies, Hospitals & Care Facilities Payor Revenue Mix 2013 Reimbursement Based Direct Bill / Pay Based 3rd Party Insurance Medicare Grants 2013 Probes Companies, Hospitals & Care Facilities
  31. 31. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 31 Experienced and Focused Management and Boards Scientific Advisory Board Andrea Califano, Ph.D. Chairman of the Columbia Initiative for Systems Biology Associate Director for Bioinformatics, Herbert Irving Comprehensive Cancer Center Timothy A. Chan, M.D., Ph.D. Principal Investigator, Human Oncology and Pathogenesis Program at Memorial Sloan-Kettering Cancer Center Riccardo Dalla-Favera, M.D. Director, Institute for Cancer Genetics at Columbia University Hans-Guido Wendel, M.D. Principal Investigator, Cancer Genetics Laboratory at Memorial Sloan-Kettering Cancer Center Vundavalli V. Murty, Ph.D. Director, Cancer Cytogenetic Laboratory and Molecular Pathology at Columbia University Andrew D. Zelenetz, M.D., Ph.D. Chief of Lymphoma Service and Head of Molecular Hemo-Oncology Laboratory, Department of Medicine at MSKCC Raju Chaganti, Ph.D., FACMG Founder • 35+ years in cancer research; 38 at MSKCC • Major discoveries in cancer genomics • Published 350+ articles, 4 patents Panna Sharma President & CEO • 15+ years as advisor to global life science & healthcare cos. • Founded TSG Partners • Chief Strategy Officer, iXL (IIXL) Edward J. Sitar Chief Financial Officer & Treasurer • 30+ yrs in finance & deal making in the healthcare industry • Healthagen, ActiveHealth Management, Cadent Holding, MIM Corporation (Bioscrip), Vital Signs, Zenith/Goldline Pharmaceutical, Coopers & Lybrand Jane Houldsworth, Ph.D. Vice President of R&D • 25+ years in translational oncology research • Published 50+ articles, 4 patents • NIH grantee Chairman of the Board, | Keith Brownlie, CPA | Edmund Cannon | Raju Chaganti, Ph.D. John Pappajohn | Franklyn Prendergast, M.D., Ph.D. | Paul Rothman, M.D. | Panna Sharma Board of Directors Officers & Management Team
  32. 32. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 32 Consistent Achievement of Milestones Expected in Coming Quarters  Increasing covered lives market access through additional payers & health care organizations  Launching multi-marker NGS panel for lymphoid malignancies  Additional international agreements with life science tools companies for DNA Probes and product distribution in key geographies  MatBA® – Next phase of data and results from Dana Farber and HUMC studies to help support value and reimbursement  Pursuing CE approval for IVDD use of FHACT® in E.U.  Additional news on biopharma partners & relationships  Pursuing additional indications for UroGenRA®- Kidney microarray  Portfolio and analyst update meeting (June)  Close of BioServe transaction (Q3, 2014)  Accelerating Market Traction – 54% growth during 2013 over 2012  Migrated DNA-FISH Probe Manufacturing to India reducing cost, increasing capacity and improving operational flexibility  Launched UroGenRA®-Kidney, a unique microarray for kidney cancer diagnosis in collaboration with MSKCC  Collaborative Study of UroGenRA®-Kidney with Cleveland Clinic demonstrated 93% diagnostic accuracy  Launched FHACT® outside the U.S. in collaboration with the National Cancer Institute research publication  Launched FHACT® as an LDT under CLIA in the U.S.  Received CLIA Approval for MatBA®-MCL (Mantle Cell Lymphoma)  Finalized Agreement with Multiplan and Three Rivers which gave us access to 72+ million covered lives  Launched OncoSpire Genomics – A Next Generation Sequencing Joint Venture with Mayo Clinic and announced initial set of projects (lung cancer, multiple myeloma & follicular lymphoma) Recent Accomplishments Upcoming Milestones and Value Drivers
  33. 33. For further information, please contact us at Cancer Genetics, Inc. Meadows Office Complex 201 Route 17 North Rutherford, NJ 07070 (201) 528-9200
  34. 34. Appendix
  35. 35. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 35 IP Position and Detailed Global Strategy  Strong and growing portfolio in molecular-focused patents for disease identification and stratification  IP-based on unique algorithms across a broad group of chromosomal regions  Validation of specific clinical endpoints that are associated with particular disease outcomes or decisions  Filing and maintenance of trademark portfolio Tool for Diagnosis and Prognosis of Mature B-Cell Neoplasms  US Issued Patent 8,580,713  US Issued Patent 8,557,747  Europe 10803548.6  India 6657/DELNP/2012  Canada 2,785,656 Methods of Analyzing Chromosomal Translocations Using Fluorescence In Situ Hybridization (FISH)  US Issued Patent 7,585,964  US Issued Patent 7,964,345  Canada 2,447,320 Panel for the Detection and Differentiation of Renal Cortical Neoplasms  US Issued Patent 8,603,948  US 14/078,726  Europe 08844570.5 Methods for Detecting Human Papilloma Virus-Associated Cancers  US 13/227,027  US 13/474,111  PCT/US2011/050681 Methods and Tools for the Diagnosis of Female Gynecological Cancers and Precancers  US 61/581,350
  36. 36. 2014 Cancer Genetics, Inc. | NASDAQ: CGIX | 36 BioServe India – Profile & Capabilities Cutting-Edge Genomic Services: Next Generation Sequencing, Genotyping & DNA Synthesis  Founded in 2002 and located in Hyderabad, Andhra Pradesh.  14,000 square foot NABL* accredited facility for its GMO services, equipped with NGS capabilities.  33 employees including 19 scientific staff members and 7 in sales.  Has developed next generation sequencing panels for oncology.  Infrastructure and scientific expertise required to integrate CGI’s DNA-FISH probe manufacturing and proprietary FHACT® business into the Indian biotech market that accounts for >25% of global cervical cancer deaths.  Current customers include Center for Cellular and Molecular Biology, Center for DNA Finger Printing and Diagnostics and Dr. Reddy's labs.  Backed by VenturEast, a pioneering healthcare-focused venture capital fund manager based in India with ~$300 Million under management. $65 Bn $100 Bn 2013 2015 Indian Healthcare Sector Dx & Medical Equipment $3.3 Bn $5 Bn 2013 2015 15-20% Growth Source: PM Live Pharmaceutical Industry News & KPMG *NABL: National Accreditation Board for Testing and Calibration Laboratories (equivalent to CLIA).