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Questions for knowledge creators

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University of Miami's Clinical and Translational Sciences Institute (CTSI) runs a bootcamp course for medical residents & fellows and postdocs. This is my 2012 version of "Questions for knowledge creators" lecture.

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Questions for knowledge creators

  1. 1. Questions for knowledge creatorsrichard j. bookmanrbookman@miami.edu2012 Bootcamp Courseuniversity of miami12 September 2012
  2. 2. disclosures• I have no financial interest in any of the content presented today.• I have no direct experience in translational or clinical research
  3. 3. objectivesleave you with questions
  4. 4. How do you pick a problem?
  5. 5. Research is a human activity
  6. 6. http://www.stanford.edu/group/vista/cgi-bin/FOV/wp-content/uploads/2012/02/tables1.png
  7. 7. Which offer do you want?
  8. 8. Which offer do you want?
  9. 9. results 68% 16% 32% 84% Dan Ariely, Predictably Irrational
  10. 10. Hypothesis-driven vs. discovery-driven research
  11. 11. Let’s play a game
  12. 12. basic applied
  13. 13. fundamental useful? D.E. Stokes, Pasteur’s Quadrant, 1997
  14. 14. fundamental useful
  15. 15. From G. Dyson, Turing’s Cathedral, 2012
  16. 16. the internet of things big bang
  17. 17. everythe internet of things ^ big data
  18. 18. http://doi.ieeecomputersociety.org/10.1109/MIS.2009.36
  19. 19. research 3.0
  20. 20. how are these trendsplaying out in clinicalresearch ??
  21. 21. http://www.patientslikeme.com
  22. 22. http://www.pnas.org/content/105/6/2052
  23. 23. Methods http://www.pnas.org/content/105/6/2052
  24. 24. http://www.nature.com/nbt/journal/v29/n5/full/nbt.1837.html
  25. 25. AbstractPatients with serious diseases may experiment with drugsthat have not received regulatory approval. Online patientcommunities structured around quantitative outcome datahave the potential to provide an observational environmentto monitor such drug usage and its consequences. Herewe describe an analysis of data reported on the websitePatientsLikeMe by patients with amyotrophic lateral sclerosis (ALS)who experimented with lithium carbonate treatment.To reduce potential bias owing to lack of randomization, wedeveloped an algorithm to match 149 treated patients to multiplecontrols (447 total) based on the progression of their disease course.At 12 months after treatment, we found no effect of lithium ondisease progression. Although observational studies using unblindeddata are not a substitute for double- blind randomized control trials,this study reached the same conclusion as subsequent randomizedtrials, http://www.nature.com/nbt/journal/v29/n5/pdf/nbt.1837.pdf
  26. 26. http://artisopensource.net/cure/
  27. 27. Salvatore IaconesiFounder, Art is open source
  28. 28. “Patient engagement is theblockbuster drug of the 21st century” Leonard Kish http://www.hl7standards.com/blog/2012/08/28/drug-of-the-century/
  29. 29. summaryWhat problem do you want to work on?How does your own brain limit your ability to reason?Have you fallen in love with your own ideas?Are you looking for black swans?In a digitally enabled world, can you think of better ways tocreate useful knowledge?How can you empower patients so as to accelerate discovery?

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