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OLEA25®HYDROXYTYROSOL- Health Benefits from Olive Leaf


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OLEA25®HYDROXYTYROSOL is organic biotransformed technology at 25% from Olive Leaf. A Polyphenol of Mediterranean Diet with Benefits of Mitochondrial Biogenesis, Anti-Inflammation, Anti-toxicity, Strong Anti-Oxidant for Heart Health, Neurodegenerative Disease, Bone & Joint Health and Diabetes protection. Inquire with interests for Your Healthcare Practice and Health. Olea25 is your natural nutraceutical choice for the aging process.
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OLEA25®HYDROXYTYROSOL- Health Benefits from Olive Leaf

  2. 2. Olea25® Hydroxytyrosol Bioactive Polyphenol of Olive Leaf & Mediterranean Diet PurificationTechnology Biotransformation Process BAUERHEALTHACTION.COM Hydroxytyrosol (3,4-dihydroxyphenylethanol; DOPET)
  3. 3. BAUERHEALTHACTION.COM Olea25® 25% Hydroxytyrosol Heart Disease & Diabetes Cellular Function & Protection Skin Health and UV Protection Joint & Bone Health Neuroprotective
  5. 5. H E A L T H C A R E P R O F E S S I O N A L W H O L E S A L E I N T E R E S T R E T A I L I N Q U I R I E S . BAUERHEALTHACTION.COM Request Information
  6. 6. BAUERHEALTHACTION.COM Scientific-basednutraceuticalforyourclients. OliveLeafextractutilizingbotanical extractiontechnology. Olea25®ismanufacturedunderGMPand ISOCertificationsandthequalitycontrol systemguaranteeseachitemonthe certificateofanalysisandthetraceability fromrawmaterialtofinalextract. Olea25 Hydroxytyrosol 25%
  7. 7. OLEA25®HYDROXYTYROSOL Anti-Inflammatory Roles Reduces Acute and Chronic Inflammatory Biomarkers Heart Disease Hyperglycemia and Metabolic Syndrome Osteoarthritis and Rheumatoid Arthritis Cancer Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD.Pirozzi, Claudio et al. Journal of Nutritional Biochemistry , Volume 30 , 108 - 115 BAUERHEALTHACTION.COM
  8. 8. OLEA25®HYDROXYTYROSOL Anti-Inflammatory Roles BAUERHEALTHACTION.COMBiol Pharm Bull (2009) 32:578–82.10.1248/bpb.32.578 Decreased Cytokines Decreased Chemokines Reduced expression of Cyclooxygenase-2(COX-2) and inducible Nitric Oxide Synthase (iNOS) more 60%
  9. 9. OLEA25®HYDROXYTYROSOL Anti-Inflammatory Roles Reduces Inflammatory Biomarkers Hydroxytyrosol ability to reduce NF-κB activation(NF-κB is a regulator of inflammation, activating genes): Pro-inflammatory cytokines Immunoregulatory BAUERHEALTHACTION.COM
  10. 10. OLEA25®HYDROXYTYROSOL Anti-Inflammatory Roles Inhibits the production of Pro-Inflammatory Cytokines in an in vitro model of Neuroinflammation. Impacts Neuroinflammation in Parkinson’s and other Neurodegenerative diseases. BAUERHEALTHACTION.COM
  11. 11. OLEA25®HYDROXYTYROSOL Cellular Aging Chronological Lifespan Quiescent cells exhibit age-dependent loss in regenerative capacity. Manganese Superoxide Dismutase(MnSOD) extends Chronological Lifespan(CLS) Presence of Telomere-Independent pathways influence CLS BAUERHEALTHACTION.COM
  12. 12. OLEA25®HYDROXYTYROSOL Cellular Aging Chronological Lifespan Hydroxytyrosol Increases MnSOD Inhibits Age-Associated increase in Mitochondrial Reaction Oxygen Species(ROS) Extends CLS of normal Human Skin Fibroblasts BAUERHEALTHACTION.COM
  13. 13. OLEA25®HYDROXYTYROSOL Metabolic Syndrome & Diabetes Olive leaf extract may represent an effective adjunct therapy that normalizes glucose homeostasis in individuals with diabetes. Julio Wainstein, Tali Ganz, Mona Boaz, Yosefa Bar Dayan, Eran Dolev, Zohar Kerem, and Zecharia Madar. Journal of Medicinal Food. June 2012, 15(7): 605-610. doi:10.1089/jmf.2011.0243. Olive Leaf Extract as a Hypoglycemic Agent in Both Human Diabetic Subjects and in Rats BAUERHEALTHACTION.COM
  14. 14. Hydroxytyrosol Improves glucose homestasis(HbA1c) Improves plasma insulin levels Improves insulin sensitivity Improves pancreatic β-cell secretion BAUERHEALTHACTION.COM
  15. 15. M e c h a n i s m b y w h i c h O A ( O l e i c A c i d ) a n d H T p r e v e n t T N F - α - i n d u c e d i m p a i r m e n t i n a d i p o n e c t i n e x p r e s s i o n Scoditti, Egeria et al. “Additive Regulation of Adiponectin Expression by the Mediterranean Diet Olive Oil Components Oleic Acid and Hydroxytyrosol in Human Adipocytes.” Ed. Salvatore Papa. PLoS ONE 10.6 (2015): e0128218. PMC. Web. 17 July 2016. BAUERHEALTHACTION.COM
  16. 16. OLEA25®HYDROXYTYROSOL Joint & Bone Health Hydroxytyrosol Prevents Increase of Osteoarthritis(OA) Marker in Human Chondrocytes Treated with Hydrogen Peroxide or Growth- Related Oncogene Facchini A, Cetrullo S, D’Adamo S, Guidotti S, Minguzzi M, et al. (2014) Hydroxytyrosol Prevents Increase of Osteoarthritis Markers in Human Chondrocytes Treated with Hydrogen Peroxide or Growth-Related Oncogene a. PLoS ONE 9(10): e109724. doi:10.1371/journal.pone.0109724 BAUERHEALTHACTION.COM
  17. 17. OLEA25®HYDROXYTYROSOL Joint & Bone Health Hydroxytyrosol Prevents or Reduces Increases In OA Pathogenic Stimuli(Facchini, et al) Cell death Activation of Executive Caspases DNA Damage Expression of Pro-Inflammatory Genes (COX-2, iNOS) Expression of Genes Driving Condrocyte Terminal Differentiation BAUERHEALTHACTION.COM
  18. 18. HT potential as a chondroprotective nutraceutical compound against OA, not merely for its antioxidant ability, but as an autophagy and SIRT-1 inducer as well. Cetrullo, Silvia, et al. "Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and-independent mechanisms." Biochimica et Biophysica Acta (BBA)-General Subjects 1860.6 (2016): 1181-1191. BAUERHEALTHACTION.COM
  19. 19. Hydroxytyrosol Acts directly on DNA to reduce expression of inflammatory mediators or inhibit their biosynthesis pathways through a similar mechanism of glucocorticoids and/or NSAIDs. BAUERHEALTHACTION.COM
  20. 20. Hydroxytyrosol Results obtained after 2 months of supplementation demonstrate for the first time the potential therapeutic effect of olive tree extract with high polyphenols content against inflammation and associated pain in RA. Effect of rich polyphenols olive tree extract on inflammation and pain in patients with rheumatoid arthritis: a 8-week randomized, double-blind, placebo-controlled clinical trial. Ghanam J. et al BAUERHEALTHACTION.COM
  21. 21. OLEA25®HYDROXYTYROSOL Potent Anti-Cancer Properties Cell death/Autophagy Anti-Inflammatory Down Regulates TERT (subunit of Telomerase) Radioprotective Upregulates numerous anti-oxidant proteins and enzymes Alters transcription factors Rafehi, Haloom et al. “Investigation into the Biological Properties of the Olive Polyphenol, Hydroxytyrosol: Mechanistic Insights by Genome-Wide mRNA-Seq Analysis.” Genes & Nutrition 7.2 (2012): 343–355. PMC. Web. 19 July 2016. BAUERHEALTHACTION.COM
  22. 22. Kathrin Pallauf, Katrin Giller, Patricia Huebbe, and Gerald Rimbach, “Nutrition and Healthy Ageing: Calorie Restriction or Polyphenol-Rich “MediterrAsian” Diet?,” Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 707421, 14 pages, 2013. doi:10.1155/2013/707421 Polyphenols and Caloric Restriction BAUERHEALTHACTION.COM
  23. 23. BAUERHEALTHACTION.COM Regulation of Sirtuins activities are, together with AMPK activity and PGC-1α-dependent pathways, at the centre of the response to CR. López-Lluch, G. and Navas, P. (2016), Calorie restriction as an intervention in ageing. J Physiol, 594: 2043–2060. Sirtuins and Caloric Restriction Sirtuins play a pivotal role in the response to Caloric Restriction. Sirtuins are shown to be involved in the regulation of lifespan and metabolism in different organisms.
  24. 24. Sirt-1 Guardian against Cellular Oxidative Stress and DNA damage metabolism stress resistance cellular survival cellular senescence/aging Regulates inflammation-immune function endothelial functions circadian rhythms BAUERHEALTHACTION.COM
  25. 25. Hydroxytyrosol Sirt-Food Polyphenol Hydroxytyrosol Sirt-1 Food Contributes to the Health Benefits of the Mediterranean Diet BAUERHEALTHACTION.COM
  26. 26. BAUERHEALTHACTION.COM Olea25® Hydroxytyrosol 25% Scientific-based nutraceutical for your clients. Olive Leaf extract utilizing botanical extraction technology OLEA25® is manufactured under GMP and ISO Certifications and the quality control system guarantees each item on the certificate of analysis and the traceability from raw material to final extract.
  27. 27. BAUERHEALTHACTION.COM Olea25® Hydroxytyrosol 25% Contact Information Randall Bauer Questions Call: 949-872-2488 Request Information Click Here