The information for this report was gathered using both primary and secondary research including comprehensive research of secondary sources such as company literature, databases, investment reports, and medical and business journals.

1. Cell Culture: The World Market for Media, Sera and Reagents, 3rd. Edition
Published: October 2011
No. of Pages: 155
Price: $ 3500
Several cell culture-derived biopharmaceutical drugs were launched in the US and European
markets in 2010. Biopharmaceuticals (recombinant proteins, monoclonal antibody and
nucleic acid-based products) represent the fastest growing sector in the pharmaceutical
industry. Driving the extraordinary interest in biopharmaceuticals is the ability of these large
proteins to target diseases in a very specific manner, thus maximizing efficacy while
minimizing side effects.
Growth in the development and production of biopharmaceuticals is the most significant
driver of the cell culture market. Biological products are developed from large and
complex protein molecules, which require equally complex manufacturing methods and an
array of analytical techniques. Protein-based biopharmaceuticals are invariably produced by
an initial cell culture step (upstream processing), followed by product recovery, purification
and formulation into final product format (downstream processing).
This report analyzes the world market for the cell cultures used in these steps and the
major trends driving this market. Forecasts and current market sizing are provided in three
specific segments:
• Media,
• Sera, and
• Reagents
Browse All: Biotechnology Market Research
In addition to a thorough discussion of the technologies and techniques currently employed
and emerging in the cell culture area, the Kalorama's exhaustive report provides specific
information on:
• Market Size, growth, and forecasts of the segments through 2015
• Competitive Market Share by leading supplier as of 2010.

2. • Estimated Market Share by Region (North America, Europe, U.S.)
• Key Market Drivers and Restraints for suppliers, including discussions of biopharmaceutical
pipelines, biomedical R&D directions, and the future of transgenic plant and animal
production.
• Review of the various expression systems (Bacteria, Yeast, Insect, and Mammal) and the
biopharmaceutical product manufactured by these systems
• Discussion of the preferences in media types vying for dominance in the market, including
the following:
ADCF - animal derived component free media
CD - chemically defined media
CSFM - complete serum free medium
PF - protein free media
SF - serum free media
SFM - serum free medium
• Major Trends Impacting the Market stem cell research (including plans of major
companies)cell culture-based vaccine Production and generic bipharmaceuticals
• Profiles of Leading Suppliers and information about M&A activities in recent years
The information for this report Cell Culture: The World Market for Media, Sera and
Reagents, 3rd. Edition was gathered using both primary and secondary research including
comprehensive research of secondary sources such as company literature, databases,
investment reports, and medical and business journals. Telephone interviews and email
correspondence were the primary method of gathering information. For the purpose of this
study Kalorama Information conducted interviews with key industry officials, consultants,
and government personnel. These sources were the primary basis in gathering information
specifically relating to revenue and market share data presented in this report. Specific
interviews with pharmaceutical company and cell culture supply company representatives
included marketing directors, division managers, and product representatives.
All Kalorama reports advertise the single user price, which limits access to one user. We
also feature department and global pricing for reports that will be utilized by more than one
user at your company. Please ask your sales representative or select the correct license on
our website.

3. Table Of Contents
CHAPTER ONE: EXECUTIVE SUMMARY
Scope and Methodology
Cells for Biopharmaceutical Production
Bacteria and Yeasts Systems
Animal Cell Systems
Insect Cell Systems
Cell Lines and Cell Banks
Fermentors and Bioreactors
Stirred-Tank Reactors
Airlift Fermentors
Packed Bed Reactors
Hollow-Fiber Reactor
Disposable Systems
Fermentation Processes
Batch and Fed-Batch Fermentation
Suspended vs. Anchored Cells
Microencapsulation
Cell Culture Environmen
Functions and Components of Basal Media
pH and Osmotic Pressure
Energy Sources
Nutrients
Cell Culture Media
Lysogeny broth (LB)
Classical Media
Serum-free Media
Protein-Free Media
Chemically Defined Media
Specialty Media
Sera
Reagents
Shifting Towards Non-animal Derived Reagents
Addressing Reagent Safety Issues
World Cell Culture Market
Cell Culture Market and Forecast
Current and Future Trends
CHAPTER TWO: GENETICALLY MODIFIED CELLS FOR BIOPHARMACEUTICAL
DEVELOPMENT
Growing Demand for Biopharmaceuticals
Biopharmaceutical Market
Development of Biopharmaceuticals
Biopharmaceutical Product Approvals
Biopharmaceutical Growth Increases Demand for Cell Culture Products
A Brief History of Biotechnology
Science of Genetic Manipulation
From Petri Dish to Biopharmaceutical Upstream Bioprocessing: Cell Culture Expression
Systems
Cells for Biopharmaceutical Production

4. Bacteria and Yeasts Systems
Animal Cell System
Insect Cell Systems
Advantages/Disadvantages of Cell Culture Systems
Cell Lines and Cell Banks
Biopharmaceuticals Produced from Cell Culture
Cell Culture Practices and Regulatory Guidelines
Validation of Facilities
Maintaining Sterilization Standards
CHAPTER THREE: CELL CULTURE TECHNOLOGY
Introduction and Overview
Milestones in Cell Culture Development
Cell Lines for Bioproduction
Predominant Cell Lines
Chinese Hamster Ovary (CHO)
SP / , and NS
HEK and PER. C
Fermentors and Bioreactors
Types of Bioreactors/Fermentors
Stirred-tank Reactors
Airlift Fermentors
Packed Bed Reactors
Hollow-fiber Reactor
Disposable Systems
Fermentation Processes
Batch and Fed-Batch Fermentation
Suspended vs. Anchored Cells
Microencapsulation
Cell Culture Environment
Functions and Components of Basal Media
pH and Osmotic Pressure
Energy Sources
Nutrients
Cell Culture Media
Types of Media
Lysogeny broth (LB)
Classical Media
Serum-free Media
Protein-free Media
Chemically Defined Media
Specialty Media
Sera
Sources of Sera
Bovine Serum Safety Issues and Regulations
Shift to Serum-free Media
Reagents
Major Types of Biologic Reagents
Amino Acids
Growth Factors and Cytokines
Albumin

5. Transferrin
Thrombin
Growth Supplements
Protease Inhibitor
Attachment Factors
Shifting Towards Non-animal Derived Reagents
Addressing Reagent Safety Issues
CHAPTER FOUR: CELL CULTURE MARKET; CURRENT AND FUTURE TRENDS
Overview
Cell Culture Market
Market Drivers
Cell Culture Market Forecast
Segment Analysis
Media
Sera
Reagents
Cell Culture Suppliers’ Market Share
current and future trends
Shift to Serum-free and Animal Product-free Media
Concomitant Need for Animal-derived Media
Cell Culture-based Vaccine Production
Cell Culture-based Vaccine on Market
Stem Cell Research Driving Cell Culture Market
Life Technologies
Sigma-Aldrich
ThermoFisher Scientific
Lonza Bioscience
EMD Millipore
BD Bioscience
Impact of Generic Biopharmaceuticals on Cell Culture Market
Impact of Transgenic Animals and Plants on the Cell Culture Market
CHAPTER FIVE: COMPANY PROFILES
Advanced Biotechnologies, Inc.
History and Lines of Business
Cell Culture Products and Services
Affymetrix, Inc.
History and Lines of Business
Cell Culture Products
Molecular Biology Enzymes
Molecular Biology Kits and Reagents
Purification
Biochemicals
PCR Reagents
Financial Information
AMRESCO, Inc.
History and Lines of Business
Cell Culture Products
Analytical Biological Services Inc.
History and Lines of Business

6. Cell Culture Products
Mammalian Cell Culture
Cell in Microtiter Plates for HTS
Primary Cultures
Insect Cell Culture
Athena Enzyme Services
History and Lines of Buiness
Cell Culture Products
Atlanta Biologicals, Inc.
History and Lines of Business
Cell Culture Products
Animal & Human Sera
Media & Balanced Salts
Supplements & Reagents
Cell Separation Products
BD Biosciences
History and Lines of Business
Cell Culture Products
Financial Information
BIOCHROM AG
History and Lines of Business
Cell Culture Products
Bioreclamation Inc
History and Lines of Business
Cell Culture Products
Cell Essentials, Inc.
History and Lines of Business
Cell Culture Products
CellGenix Technologie Transfer GmbH
History and Lines of Business
Cell Culture Products and Services
ClonTech Laboratories, inc.
History and Lines of Business
Cell Culture Products
EMD Millipore
History and Lines of Business
Cell Culture Products
Financial Information
Gemini Bio-Products
History and Lines of Business
Cell Culture Products
Cell Culture Sera
Human Sera
Specialized Media
Irvine Scientific
History and Lines of Business
Cell Culture Products
Cell Culture Products
Custom Media Program
Express Media Service

7. R&D Development Program
Invitria
History and Lines of Business
Cell Culture Products
Cellastim
Lacromin
Optiferrin
ITSE Animal-free
Zap-CHO
Zap-Hybridoma
J R Scientific, Inc.
History and Development
Cell Culture Products
Life Technologies Corporation
History and Lines of Business
Cell Culture Products
Financial Information
Lonza Bioscience
History and Lines of Business
Cell Culture Products and Services
Culture Media Development
Cell Line Creation
Cell Banking
Financial Information
Mediatech, Inc.
History and Lines of Business
Cell Culture Products
MP Biomedicals
History and Lines of Business
Cell Culture Products
Novozymes Biopharma US Inc
History and Lines of Business
Cell Culture Products
rAlbumin
Albucult
Albufuse and Albufuse Flex
Yeast Expression Technology
Growth Factors
Bacillus-derived Hyaluronic Acid
Purification Ligands
Recombinant Tansferrin
PAA labORATORIES, Inc.
History and Lines of Business
Cell Culture Products
PromoCell GmbH
History and Lines of Business
Cell Culture Products
Quality Biological, Inc.
History and Lines of Business
Cell Culture Products

8. R&D Systems, Inc.
History and Lines of Business
Cell Culture Products
SAFC Biosciences
History and Lines of Business
Cell Culture Products
Financial Information
SBH Sciences
History and Lines of Business
Cell Culture Products
Selexis SA
History and Lines of Business
Cell Culture Products
SeraCare Life Sciences, Inc.
History and Lines of Business
Cell Culture Products
Financial Information
Sera Laboratories International Ltd
History and Lines of Business
Cell Culture Products
Product Categories
Thermo Fisher Scientific, Inc.
History and Lines of Business
Cell Culture Products
Financial Information
Wisent, Inc.
History and Lines of Business
Cell Culture Products
LIST OF EXHIBITS
CHAPTER ONE: EXECUTIVE SUMMARY
Exhibit 1-1 : Worldwide Cell Culture Market
Exhibit 1-2 : Cell Culture World Market Share, by Region, 2010
CHAPTER TWO: GENETICALLY MODIFIED CELLS FOR BIOPHARMACEUTICAL DEVELOPMENT
Exhibit 2-1 : Biopharmaceutical Development by General Indication and Development
Activity (Phase III through Registration)
Exhibit 2-2 : Biopharmaceuticals Approved in the US and/or the EU, 2010
Exhibit 2-3 : Approximate times from Introduced Gene to Protein Production at Useable
Levels
Exhibit 2-4 : Disadvantages/Advantages of Cell Culture Systems
Exhibit 2-5 : Selected Biopharmaceuticals Produced from Bacteria, Yeast and Mammalian
Cells
CHAPTER THREE: CELL CULTURE TECHNOLOGY
Exhibit 3-1 : Selected Products/Companies Offering Alternatives to Animal Sera Products
for Hybridoma, Myeloma and CHO cell lines
CHAPTER FOUR: CELL CULTURE MARKET; CURRENT AND FUTURE TRENDS
Exhibit 4-1 : Worldwide Cell Culture Market, 2005-2015
Exhibit 4-2 : Cell Culture World Market Share, by Region, 2010
Exhibit 4-3 : World Cell Culture Market by Segment: Media, Sera and Reagents, 2005-

9. 2015
Exhibit 4-4 : Cell Culture Market Share, 2010
Exhibit 4-5 : Selected Transgenic Products in Clinical Trials
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