1 B Actino

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1 B Actino

  1. 1. Actinomycetes Page 3
  2. 2. Actinomycetes (order) <ul><li>Three genera </li></ul><ul><li>Actinomyces species </li></ul><ul><li>Nocardia species </li></ul><ul><li>Streptomyces species </li></ul>
  3. 3. Gram Positive Filamentous Bacteria no YES aerobe Streptomyces PARTIALLY sometime aerobe Nocardia no YES ANAEROBE Actinomyces yes no aerobe Mycobacteria ACIDFAST GRANULE OXYGEN GENUS
  4. 5. Actinomycosis A chronic suppurative and granulomatous disease of the cervico-facial, thoracic or abdominal areas
  5. 6. Actinomycosis Actinomyces israelii
  6. 7. Ecological Niche Actinomyces Endogenous (man and animals)
  7. 9. CLINICAL SPECIMENS Actinomyces <ul><li>Pus </li></ul>
  8. 10. Sulphur granules
  9. 12. Drug of Choice <ul><li>Penicillin </li></ul><ul><li>(large doses) </li></ul>
  10. 13. Serological Test <ul><li>None available </li></ul>
  11. 15. Nocardiosis <ul><li>Subcutaneous infections, pulmonary infections, and brain abscesses </li></ul>
  12. 16. Ecological Association Soil Endogenous ?
  13. 17. Geographic Distribution <ul><li>World wide </li></ul>
  14. 18. Nocardiosis <ul><li>N. asteroides – Pulmonary </li></ul><ul><li>N. brasiliensis - Abscesses </li></ul>
  15. 21. Clinical Specimens <ul><li>Sputum </li></ul><ul><li>Pus </li></ul><ul><li>Biopsy tissue </li></ul>
  16. 23. Serological Test <ul><li>None available </li></ul>
  17. 24. Drug of Choice Sulfamethoxazole-Trimethoprim
  18. 25. STREPTOMYCOSIS Streptomyces species
  19. 26. Mycetoma <ul><li>Streptomyces species </li></ul>
  20. 27. Ecological Association Soil
  21. 29. Streptomyces may invade bone
  22. 30. Clinical specimens Pus Biopsy material
  23. 33. Serological Test None available
  24. 34. Treatment <ul><li>Surgical debridement </li></ul><ul><li>Sulfa drugs </li></ul><ul><li>Amphotericin B </li></ul>

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