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Transdermal Delivery


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A brief presentation on the novel method of transdemal delivery.

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Transdermal Delivery

  1. 1. trans - dermal delivery rahul.gulrajani
  2. 3. introduction <ul><li>in a broad sense, the term trans dermal delivery system includes all topically administered drug formulations intended to deliver the active ingredient into the general circulation </li></ul><ul><li>a trans dermal patch or skin patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream </li></ul><ul><li>trans dermal patches currently available include the nicotine patch, and Fentanyl, an analgesic for severe pain , patches administering oestrogen for menopause, angina, pain relievers for shingles (herpes zoster), for pain from acute injuries and chronic pain </li></ul><ul><li>recent developments expanded their use to the delivery of hormonal contraceptives, anti depressants and even pain killers and stimulants for Attention Deficit Hyperactivity Disorder/ADHD </li></ul>
  3. 4. advantages of trans dermal delivery
  4. 5. components
  5. 6. components <ul><li>liner – it protects the patch during storage, and is removed prior to use </li></ul><ul><li>drug - drug solution is in direct contact with the release liner </li></ul><ul><li>adhesive - serves to adhere the components of the patch together along with adhering the patch to the skin </li></ul><ul><li>membrane - controls the release of the drug from the reservoir and multi-layer patches </li></ul><ul><li>backing - protects the patch from the outer environment </li></ul>
  6. 7. types of trans dermal patches
  7. 8. single-layer drug-in-adhesive <ul><li>the adhesive layer of this system also contains the drug </li></ul><ul><li>in this type of patch the adhesive layer not only serves to adhere the various layers together, along with the entire system to the skin, but is also responsible for the releasing of the drug </li></ul><ul><li>the adhesive layer is surrounded by a temporary liner and a backing </li></ul>
  8. 9. multi-layer drug-in-adhesive <ul><li>it is similar to the single-layer system in that both adhesive layers are also responsible for the releasing of the drug </li></ul><ul><li>one of the layers is for immediate release of the drug and other layer is for control release of drug from the reservoir </li></ul><ul><li>the multi-layer system is different however that it adds another layer of drug-in-adhesive, usually separated by a membrane (but not in all cases) </li></ul><ul><li>this patch also has a temporary liner layer and a permanent backing </li></ul>
  9. 10. reservoir <ul><li>unlike the single-layer and multi-layer-drug-in-adhesive systems the reservoir trans dermal system has a separate drug layer </li></ul><ul><li>the drug layer is a liquid compartment containing a drug solution or suspension separated by the adhesive layer </li></ul><ul><li>this patch is also backed by the backing layer </li></ul><ul><li>in this type of system the rate of release is zero order, i.e. constant rate </li></ul>
  10. 11. matrix <ul><li>the matrix system has a drug layer of a semisolid matrix containing a drug solution or suspension </li></ul><ul><li>the adhesive layer in this patch surrounds the drug layer partially overlaying it </li></ul>
  11. 12. vapour <ul><li>in this type of patch the adhesive layer not only serves to adhere the various layers together but also to release vapour </li></ul><ul><li>the vapour patches release essential oils and are used in cases of decongestion mainly </li></ul><ul><li>other vapour patches on the market are controller vapour patches that improve the quality of sleep </li></ul>
  12. 13. rate of absorption
  13. 14. factors affecting bio availability
  14. 15. mechanism of action <ul><li>the application of the trans dermal patch and the flow of the active drug constituent from the patch to the circulatory system via skin occur through various methods </li></ul>
  15. 16. action aiding mechanisms
  16. 17. iontophoresis <ul><li>iontophoresis passes a current to an area of skin, through the electrode placed in contact with the formulation, which facilitates drug delivery across the barrier </li></ul><ul><li>mainly used for pilocarpine delivery to induce sweating as part of cystic fibrosis diagnostic test </li></ul><ul><li>iontophoretic delivery of lidocaine appears to be a promising approach for rapid onset of anaesthesia </li></ul>
  17. 18. electroporation <ul><li>electroporation is a method of application of short, high-voltage electrical pulses to the skin. </li></ul><ul><li>after electroporation, the permeability of the skin for diffusion of drugs is increased by 4 orders of magnitude </li></ul><ul><li>the electrical pulses are believed to form transient aqueous pores in the stratum corneum, through which drug transport occurs </li></ul><ul><li>it is safe and the electrical pulses can be administered painlessly using closely spaced electrodes to constrain the electric field within the nerve-free stratum corneum </li></ul>
  18. 19. ultrasound <ul><li>application of ultrasound, particularly low frequency ultrasound, has been shown to enhance trans dermal transport of various drugs including macromolecules </li></ul><ul><li>it is also known as sonophoresis </li></ul>
  19. 20. microscopic projections <ul><li>trans dermal patches with microscopic projections called micro needles are used to facilitate trans dermal drug transport </li></ul><ul><li>needles ranging from approximately 10-100 µm in length are arranged in arrays </li></ul><ul><li>when pressed into the skin, the arrays make microscopic punctures that are large enough to deliver macromolecules, but small enough that the patient does not feel the penetration or pain </li></ul><ul><li>the drug is surface coated on the micro needles to aid in rapid absorption </li></ul><ul><li>they are used in development of cutaneous vaccines for tetanus and influenza </li></ul>
  20. 21. thank you