Diabetic Retinopathy I. Complications of Diabetes for both :       Type I       Type II II. Blood Glucose levels increases...
What causes Diabetic Retinopathy ?Hyperglycemia (Diabetes)                   High Blood Sugar           Changes Blood vess...
Symptoms:Patients complain of spots or floatersCentral vision may become blurred or goin and out of focusPatients may c...
Stages:Mild non-proliferativeModerate non-proliferativeSevere non-proliferativeProliferative
Diabetic Neuropathy Affect nerves throughout the body (most commonly affects nerves in feet and legs) Types of Diabetic Ne...
Symptoms of NeuropathyNumbness, “pins and needles” sensation in feet, legs or armsNeuropathy can lead to muscle weakness i...
Oxidative Stress and Alpha-lipoic acid                         Hyperglycemia      Polyol              Glucose auto-     Pa...
Methylcobalamin   Neurologically active form of Vit.B12 Provoke re-generation of nerves without side-effects Vit.B12 an...
Benfothiamine Lipid soluble form of Thiamine(Vit.B12) Effective precursor of active Thiamine Used in treatment of alcoh...
Vitamin B6 (Pyridoxal phosphate):   Water soluble Vitamin   Acts as a cofactor in many reactions of amino acid     metab...
Biotin (Vit.H):Symptoms of overt biotin deficiency include: Hair loss (alopecia) Conjunctivitis Dermatitis in the form ...
Say NO to  Diabetes and YES to     LifeThank You
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Presentation on diabetes complications and treatment

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Harsh Raghav

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Presentation on diabetes complications and treatment

  1. 1. Diabetic Retinopathy I. Complications of Diabetes for both : Type I Type II II. Blood Glucose levels increases for a long ,changes occur in tiny blood vessels that supply blood to retina III. Person notices: Blotch Blurriness Dark spots
  2. 2. What causes Diabetic Retinopathy ?Hyperglycemia (Diabetes) High Blood Sugar Changes Blood vessels of Retina Blood vessels (Retina) swell and leak fluid Fluid leaks into “Macula” Blurred Vision
  3. 3. Symptoms:Patients complain of spots or floatersCentral vision may become blurred or goin and out of focusPatients may complain of blockage ofvisionOthers may notice difficulty seeing atnightRisk Factors:DiabetesPregnancyHigh Blood PressureHigh Cholesterol
  4. 4. Stages:Mild non-proliferativeModerate non-proliferativeSevere non-proliferativeProliferative
  5. 5. Diabetic Neuropathy Affect nerves throughout the body (most commonly affects nerves in feet and legs) Types of Diabetic Neuropathy  Peripheral neuropathy  Autonomic neuropathy  Focal neuropathy  Proximal NeuropathyWhat causes Neuropathy ?  Lifestyle factors-smoking,alcohol consumption  Metabolic factors (duration of diabetes)  Nerve and blood vessel factors (damage to blood vessels)  Nerve injury such as Carpal tunnel syndrome
  6. 6. Symptoms of NeuropathyNumbness, “pins and needles” sensation in feet, legs or armsNeuropathy can lead to muscle weakness in affected areasDiabetes : A leading cause of peripheral neuropathy, 60-70% people with Diabetes have mild to severe forms of nervous system damageKidney disorders : High amounts of toxic substances in the blood can damage nerve tissue, patients requiring dialysis may develop polyneuropathyVit. Deficiency : Vitamins deficiencies particularly (E,B1,B6,B12) are essential to healthy nerve function. Thiamine deficiency can cause painful neuropathy of extremities
  7. 7. Oxidative Stress and Alpha-lipoic acid Hyperglycemia Polyol Glucose auto- Pathway oxidation AGE formation Oxidative Stress X Nerve Ischemia ALA increases Glutathione (GSH), which is an important anti- oxidant. ALA acts as powerful lipophilic, free radical scavenger
  8. 8. Methylcobalamin Neurologically active form of Vit.B12 Provoke re-generation of nerves without side-effects Vit.B12 and Folate (Folic acid) worksynergistically Have role in methylation (process for themaintenance of brain chemistry and nerves andplays role in synthesis of Dopamine)
  9. 9. Benfothiamine Lipid soluble form of Thiamine(Vit.B12) Effective precursor of active Thiamine Used in treatment of alcohol neuritis Used in General nervehealth, Fibromyalgia
  10. 10. Vitamin B6 (Pyridoxal phosphate):  Water soluble Vitamin  Acts as a cofactor in many reactions of amino acid metabolism  Also necessary for enzymatic reaction governing the release of glucose from glycogen  Neurotransmitter synthesis  Hemoglobin synthesis and function
  11. 11. Biotin (Vit.H):Symptoms of overt biotin deficiency include: Hair loss (alopecia) Conjunctivitis Dermatitis in the form of a scaly red rash around the eyes,nose, mouth, and genital area. Neurological symptoms in adults such as depression, lethargy, hallucination, and numbness and tingling of the extremities
  12. 12. Say NO to Diabetes and YES to LifeThank You

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