Dengue control


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Dengue control

  1. 1. Controlling Dengue Rafi ur Rahman M. Phil (Biotechnology and Genetic Engineer)
  2. 2. Introduction: Dengue Causative Agent, The Virus Transmission The Mosquito Control
  3. 3. The Dengue Fever  Is an acute fever producing infectious disease  Mostly found in the tropics  Pronounce DEN-ghee  Complications can be fatal  It is also known as Dengue fever , break- bone fever.  Complicated forms are DHF and DSS
  4. 4. Causative Agent: The Virus  RNA Virus  Genus Flavivirus.  Family Flaviviridae.  11000bp which encodes a single large poly protein.  Other relatives: West-Nile virus, Yellow fever virus, hepatitis C virus.  Four Serotypes: DEN1-4. 60-80% sequence homology and also Surface Protein Homology
  5. 5. Transmission:  Aedes Aegypti: Cosmopolitan.  Ae. Albopictus: South-East Asia.  Biting around the ankles and knees close to the ground in the daytime  Distinct Physical Features.  Life cycle.
  6. 6. The Mosquito:  Dengue cases usually increase during the rainy season  The spread of the mosquito is attributed to poor environmental sanitation  When it rains the water gets stored in any place such as discarded tires, broken bottles, and even shoes  Other examples are soda cans, birdbaths, rain gutters, toys, pool covers, tree stumps, and garbage cans.
  7. 7. More About the Causative Agent:  Male feeds on plant nectar  Female feeds on blood (Human, Animals, Birds, Monkeys).  Life Span: 14-21 days.  Lays 300 eggs during her life span.  The mosquito can travel up to 10 km.
  8. 8. Control:  No specific vaccine or drug invented.  Can be controlled by limiting  1) Eliminating the Mosquito vector and/or  2) Interrupting Human-vector Contact. THAT’S WHY;  Clothing, that minimize skin exposure must be used.  Mosquito repellents.  Mosquito nets.  Don’t let clear water un-covered for more than 1 day.  Put the cover on water container along with cloth.
  9. 9. Contdd..  If the larvae are seen any where, put some detergent(surf), wait for some time and then discard.  Do not leave any source into the water tanks(over-flow, air source), if left however, cover with some sort of net or long pipe.  Focus on neglected areas like water pots in bird cages etc..  Turn over all unused water containers.
  10. 10. Control:  Control of Immature stages:  Vector control: 1. Larviciding with insecticides. 2. Elimination of breeding sites  Only Temephos, Permethrin, Bti, and Pyriproxyfen are approved by WHO for use in drinking-water.  Bti Toxins: Bacillus thuringiensis var. israelensis (Bti), Bacillus Sphaericus (Bs).  High larvicidal activity in mosquitoes.  Should be used in Combinations: [BTi + Insecticide], [BTi + Copepods]: Excellent results.  Commercial Preparations: Liquid/Granular Preps are available.
  11. 11. References:  Akram, W., (n.d.). Aedes as a vector of Dengue: a possible threat to our lives. Khwarzimig Science Society. University of Agriculture, Faisalabad. Retrieved April 19, 2010 from  Bauman, R., (2006). Microbiology disease by systems. San Francisco , CA: Pearson Benjamin Cumming Publisher  Center for Disease Control and Prevention, (2009)Dengue epidemiology. Retrieved April 22, 2010 from  Center for Disease Control and Prevention, (2009). Other infectious disease related to travel, dengue fever (DF) and dengue hemorrhagic fever (DHF). Retrieved April 19, 2010 from dengue-hemorrhagic-fever.aspx  Center for Disease Control and Prevention, (2009). About CDC’s dengue branch. Retrieved April24, 2010 from  Gubler, D.J., Clark, G.G., (1995)Dengue/dengue hemorrhagic fever: The emergence of a global health problem. Retrieved April 19, 2010 from  Gubler, D., (1998). Dengue and dengue hemorrhagic fever . Clinical Microbiology Reviews, July 1998, p.480-496. Retrieved April 24, 2010 from http:/  World Health Organization, (2009). Dengue and Dengue haemorrhagic fever. Retrieved April 19, 2010 from
  12. 12. Recommended Sources :