Central dogma and transcription slides


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  • http://www.mun.ca/biology/scarr/Fig13-02_eukaryotic.html
  • Central dogma and transcription slides

    1. 1. Central Dogma ofMolecular Biology And Transcription
    2. 2. Warm-up: Try to figure out the letters corresponding to the code below:  CODE: 9-11-14-15-23-2-9-15 Use the same de-coding method to fill in the blank using CODE 2 and 3.  CODE 2: 3-5-14-20-18-1-12  CODE 3: 4-15-7-13-1  Today we will be learning about ___________ _________ How did you do that?! Other than because you’re so amazing!... Write down the mental steps you had to take to figure out that code.
    3. 3. Code Breaking ActivityObjective: To break the code onto a sheet of paper as a group andtranslate the broken code to a series of pictures in order as fast as youcan. Turn this code in to Quanina to finish the activity.Guidelines:1. Everybody participates2. No talking; gestures and hand movements are okay3. 60 seconds to consult with team on roles and game plan before activity
    4. 4. Code Breaking ActivityBreaking the code: Example: Code alternates between letter N-1-S-3-*-16 and number Corresponds to Letters and numbers correspond to a series of 3 letter words O-A-T-C-A-P If given a “letter” choose the next Which are the words letter in the alphabet. “oat” and “cap” If given a number choose the letter from the alphabet that NOTE: * means A corresponds to the number
    5. 5. Code Breaking ActivityBreaking the code: Practice Problem: Code alternates between letter L 9W and number Letters and numbers correspond to a series of 3 letter words Practice Problem If given a “letter” choose the next Answer: letter in the alphabet. MIX If given a number choose the letter from the alphabet that corresponds to the number
    6. 6. Code Breaking ActivityWrap-Up: Pass in the transcribed code along with the translatedpictures
    7. 7. Central Dogma Notes DO NOT DRAW DIAGRAM
    8. 8. TranscriptionDNA Transcription is the process of making a complementaryRNA copy of a sequence (section) of DNATranscription is similar to DNA replication except DNA is copiedto make more DNATranscription: DNA  RNA
    9. 9. Video Transcription Basic: http://www.youtube.com/watch?v=5MfSYnItYvgMarkers
    10. 10. Transcription In Eukaryotes: Eukaryotic transcription occurs in the nucleus Eukaryotic Transcription Step 1: Initiation Eukaryotic Transcription Step 2: Elongation Eukaryotic Transcription Step 3: Termination Eukaryotic Transcription Step 4: Post Transcriptional Modification
    11. 11. Transcription In Eukaryotes:
    12. 12. Transcription In Eukaryotes: InitiationGeneTemplate strand andCoding StrandPromoter region andTermination pointIntrons and Exons
    13. 13. Transcription In Eukaryotes: InitiationStep 1a:Transcription factors(proteins) bindtogether on thepromoter region toform a transcriptioninitiation complex.Step 1b: RNApolymerase bindsthe transcriptioninitiation complex.
    14. 14. Transcription In Eukaryotes: ElongationStep 2a: RNApolymerase startsmoving along thetemplate strand from 5’to 3’ adding free RNAto make mRNA.
    15. 15. Transcription In Eukaryotes: TranscriptionStep 3a: RNApolymerase stops at atermination codon or apoly-A site.
    16. 16. Transcription In Eukaryotes: Post- transcriptional ModificationSpliceosome cutsout introns5’ cap and Poly-Atail helps stabilizemRNA
    17. 17. Advanced Video Advanced Transcription: http://www.youtube.com/watch?v=SMtWvDbfHLo Simple to Understand: http://www.youtube.com/watch?v=WsofH466lqk
    18. 18. Transcription In Prokaryotes  Prokaryotic Transcription occurs in the cytoplasm
    19. 19. Transcription In Prokaryotes Prokaryotic Transcription Step 1: Initiation Prokaryotic Transcription Step 2: Elongation Prokaryotic Transcription Step 3: Termination
    20. 20. Transcription in Prokaryotes: InitiationA sigma factor (a type ofprotein) binds to RNApolymerase. This allowsRNA polymerase to bindto the promoter region.
    21. 21. Transcription In Prokaryotes: ElongationRNA polymerasestarts moving alongthe template strandfrom 5’ to 3’ addingfree RNA to makemRNA.mRNA is immediatelytranscribed to aprotein as mRNA ismade
    22. 22. Transcription In Prokaryotes: TerminationRNA polymerase stops at atermination codon orwhen a rho protein catchesup to RNA polymerase.