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# Central dogma and transcription slides

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• http://www.mun.ca/biology/scarr/Fig13-02_eukaryotic.html
• ### Central dogma and transcription slides

1. 1. Central Dogma ofMolecular Biology And Transcription
2. 2. Warm-up: Try to figure out the letters corresponding to the code below:  CODE: 9-11-14-15-23-2-9-15 Use the same de-coding method to fill in the blank using CODE 2 and 3.  CODE 2: 3-5-14-20-18-1-12  CODE 3: 4-15-7-13-1  Today we will be learning about ___________ _________ How did you do that?! Other than because you’re so amazing!... Write down the mental steps you had to take to figure out that code.
3. 3. Code Breaking ActivityObjective: To break the code onto a sheet of paper as a group andtranslate the broken code to a series of pictures in order as fast as youcan. Turn this code in to Quanina to finish the activity.Guidelines:1. Everybody participates2. No talking; gestures and hand movements are okay3. 60 seconds to consult with team on roles and game plan before activity
4. 4. Code Breaking ActivityBreaking the code: Example: Code alternates between letter N-1-S-3-*-16 and number Corresponds to Letters and numbers correspond to a series of 3 letter words O-A-T-C-A-P If given a “letter” choose the next Which are the words letter in the alphabet. “oat” and “cap” If given a number choose the letter from the alphabet that NOTE: * means A corresponds to the number
5. 5. Code Breaking ActivityBreaking the code: Practice Problem: Code alternates between letter L 9W and number Letters and numbers correspond to a series of 3 letter words Practice Problem If given a “letter” choose the next Answer: letter in the alphabet. MIX If given a number choose the letter from the alphabet that corresponds to the number
6. 6. Code Breaking ActivityWrap-Up: Pass in the transcribed code along with the translatedpictures
7. 7. Central Dogma Notes DO NOT DRAW DIAGRAM
8. 8. TranscriptionDNA Transcription is the process of making a complementaryRNA copy of a sequence (section) of DNATranscription is similar to DNA replication except DNA is copiedto make more DNATranscription: DNA  RNA
9. 9. Video Transcription Basic: http://www.youtube.com/watch?v=5MfSYnItYvgMarkers
10. 10. Transcription In Eukaryotes: Eukaryotic transcription occurs in the nucleus Eukaryotic Transcription Step 1: Initiation Eukaryotic Transcription Step 2: Elongation Eukaryotic Transcription Step 3: Termination Eukaryotic Transcription Step 4: Post Transcriptional Modification
11. 11. Transcription In Eukaryotes:
12. 12. Transcription In Eukaryotes: InitiationGeneTemplate strand andCoding StrandPromoter region andTermination pointIntrons and Exons
13. 13. Transcription In Eukaryotes: InitiationStep 1a:Transcription factors(proteins) bindtogether on thepromoter region toform a transcriptioninitiation complex.Step 1b: RNApolymerase bindsthe transcriptioninitiation complex.
14. 14. Transcription In Eukaryotes: ElongationStep 2a: RNApolymerase startsmoving along thetemplate strand from 5’to 3’ adding free RNAto make mRNA.
15. 15. Transcription In Eukaryotes: TranscriptionStep 3a: RNApolymerase stops at atermination codon or apoly-A site.
16. 16. Transcription In Eukaryotes: Post- transcriptional ModificationSpliceosome cutsout introns5’ cap and Poly-Atail helps stabilizemRNA