Three main topics are covered in this paper regarding Nb-Mo interactions in microalloyed steels. First, the synergetic behavior of Nb and Mo enhancing solute drag effects and modifying recrystallization and precipitation kinetics in austenite under hot working conditions are analyzed. Then, the effect of different microalloying additions on the final phase transformations will be exposed. In addition to composition and austenite conditioning effect on the phases formed and corresponding CCT diagrams, a quantitative study using EBSD technique has been performed in order to measure unit size distributions and homogeneity of complex microstructures. Finally, the contribution of different strengthening mechanisms to yield strength has been evaluated for different coiling temperatures and compositions.