Identification: Specimen of Trivalent Polio vaccine.
Type: A live attenuated vaccine.
VVM stage – 4
Constituents : attenuated polio virus(sabin)
Type- 1 > 106 CCID50
Type- 2 > 105 CCID50
Type -3 > 105.8 CCID50
PRESERVATIVE: Neomycin- 15mcg
STABILIZED with: Mgcl3
Stored at 4
Dose: 2drops (0.1ml) orally at birth (0 dose)
and 6wks – 10wks – 14wks & booster at 16-24month.
Efficacy & Protection rate: 90-95% for life long
Contraindication: acute illness, diarrhoea, leukemia & those on steroid.
Public health importance: used for active immunization against polio
INACTIVATED (Salk) POLIO VACCINE
ORAL (Sabin) POLIO VACCINE
Given s.c or i.m
Provides only systemic immunity.
Prevents only paralysis (CNS invasion).
Not useful in controlling epidemics.
Dosing: 4 doses.
Both systemic and local immunity.
Prevents both paralysis and intestinal
Useful in controlling epidemic.
Dosing: 0 – 6 – 10 - 14 wks – 16 to 24month
total 5 doses.