H ms cs_capabilities_competitive_analysis_ 7-11-12

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Presentation of Capabilities and Competitive Advantage of Neuromics' umbilical derived human stem cells and MSCGro high performance growth and differentiation media.

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H ms cs_capabilities_competitive_analysis_ 7-11-12

  1. 1. Potent Human Mesenchymal Stem Cells and Media Capabilities and Competitive Analysis www.neuromics.com
  2. 2. STEM CELL PRODUCTS Focus on Mesenchymal Stem Cells-Why MSCs?• Numerous Clinical Uses: Joint disease & injury, autoimmunity, stroke, organ failure (heart, liver, kidney & lung), MS, promotion of HSC engraftment, regenerative medicine, cancer, hearing loss, etc.• Readily Available: Blood, adipose (fat) tissue, bone marrow, teeth, etc
  3. 3. GFP-Expressing Human MSCs Catalog Number SC00A4 Image: FITC of Single Human MSC GFP-Expressing Human MSCs express label in the cytoplasm.Illustrates morphological detail of human mesenchymal stem cells.
  4. 4. GFP-Expressing Human MSCsFITC Image FITC + PC showing selection
  5. 5. Red Fluorescent Human Mesenchymal Stem Cells Self-Renewal Transfer of label to chondrocyte (25 mM PGE2)
  6. 6. MSC Growth in Low Serum MSCGro™ Compared to Lonza MSC-GM MSCGroTM at Day 3 MSCGroTM at Day 4 Lonza at Day 3 Lonza at Day 4
  7. 7. Human MSC Growth in MSCGroTM vs Competitors Media:MSCGroTM results in faster growth & 2-3-fold greater cell recovery
  8. 8. 160 Real Time Stability of MSCGro 140 Compared to Competitors Medium 120Doubling Time (Hrs) 100 MSCGro at 5% O2 MSCM-ScienCell at 5% O2 80 MSCGro at 20% O2 60 (Adipose MSCs by third party) 40 20 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 o Months at 2-8 C
  9. 9. Humanized Complete & Humanized Powder MSCGro™
  10. 10. Differentiation of Human MSCs Cultured in MSC-GroTM MediumChondrocyte Stained Adipocytes Stained with Osteoblast Stained with Alcian Blue Oil Red with Alizarin Red
  11. 11. Competitive Advantages of MSCGroTM• MSC growth rate/cell recovery > Lonza, InVitrogen, Stem Cell Technologies, ScienCell & ZenBio media.• MSC quality/potency (Lumenesc™) > Lonza, InVitrogen and Stem Cell Technologies media.• Vastly improved real time stability.• Medium function unaffected by freezing.• Out-performs competitors at both reduced & ambient O2• Supports self-renewal of human, rat & mouse MSCs• Also supports primary cultures: fibroblasts (human & rat); rat cardiomyocytes & possibly hepatocytes• Provided complete & ready to use as is.

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