Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

Ca supplements increase mi meta analysis

1,632 views

Published on

This meta-analysis show that calcium supplements may increase the risk of heart attack

Published in: Health & Medicine
  • Slim Down in Just 1 Minute? ■■■ https://url.cn/5ouhNaM
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • If you have a few spare minutes per day, we have some very exciting news for you! ◆◆◆ https://t.cn/A6Z4MmPB
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • Be the first to like this

Ca supplements increase mi meta analysis

  1. 1. www.pronutritionist.net Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta- analysis. Bolland MJ et al. BMJ 2010;341:c3691 Page 1 Bolland MJ et al. BMJ 2010;341:c3691
  2. 2. Page 2 Background • Sufficient intake of calcium is essential for bone health • Calcium and vitamin D are considered as basic treatments in fracture prevention among both osteopenic and osteoporotic patients • Previous observational studies have demonstrated positive association between high calcium intake and cardiovascular health • In some recent studies high calcium intake as supplements has been linked to increased risk of cardiovascular events in renal failure • High intake of calcium is also associated to increased incidence of prostate cancer www.pronutritionist.netBolland MJ et al. BMJ 2010;341:c3691
  3. 3. Methods • n=11 921,meta-analysis of randomized placebo controlled trials. Patients were overwhelmingly female, typically osteoporotic seniors • None of the trials included was designed (and powered) for cardiovascular outcomes (mainly fracture prevention studies). • Intervention: minimum 500 mg of calcium daily without concurrent vitamin D • Follow up: ≈ 4 years • End points: MI, stroke, sudden death and their composite end point 3 www.pronutritionist.netBolland MJ et al. BMJ 2010;341:c3691
  4. 4. Results, myocardial infarctions (#) 4 Bolland MJ et al. BMJ 2010;341:c3691 www.pronutritionist.net +27 %
  5. 5. Results, other CV endpoints • No difference in strokes (1.20, 0.96 to 1.50, P=0.11) • No difference in deaths (1.09, 0.96 to 1.23, P=0.18) • No difference in composite end point (1.18, 1.00 to 1.39, P=0.057) 5 Bolland MJ et al. BMJ 2010;341:c3691 www.pronutritionist.net
  6. 6. Discussion • Results of the meta-analysis are in contrast to observational studies, and raise concern about the safety of large scale use of calcium supplementation • As the included studies were not designed to explore cardiovascular events, they are subject to bias • Renal failure is common among elderly females, this meta-analysis and previous studies in renal failure throw doubt on the recommendation of routine calcium supplementation in elderly osteopenia and osteoporosis • Mechanism behind the phenomenon is unknown, vascular calcification is suggested • Authors conclude that reassessment of osteoporosis guidelines is warranted 6 www.pronutritionist.netBolland MJ et al. BMJ 2010;341:c3691
  7. 7. Discussion • Results of the meta-analysis are in contrast to observational studies, and raise concern about the safety of large scale use of calcium supplementation • As the included studies were not designed to explore cardiovascular events, they are subject to bias • Renal failure is common among elderly females, this meta-analysis and previous studies in renal failure throw doubt on the recommendation of routine calcium supplementation in elderly osteopenia and osteoporosis • Mechanism behind the phenomenon is unknown, vascular calcification is suggested • Authors conclude that reassessment of osteoporosis guidelines is warranted 6 www.pronutritionist.netBolland MJ et al. BMJ 2010;341:c3691

×