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7.expectorants and emetics

PCI syllabus, MSBTE, Pharmaceutical chemistry-I, Pharmaceutics, Inorganic chemistry, Diploma in Pharmacy, expectorants and emetics, topical agents

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7.expectorants and emetics

  1. 1. Expectorant s and Emetics Pankaj Kusum Ramdas Khuspe M. Pharmacy (Pharmaceutics)
  2. 2. Expectorants “Remove sputum from respiratory tract.” E.g.: Potassium chloride
  3. 3. Types A.Depend upon mechanism of action: 1.Sedative: Ammonium chloride 2.Stimulant: Lemon
  4. 4. B. Depend upon mechanism of action: 1.Volatile oils: Eucalyptus oil 2.Iodides: Potassium iodide 3.Ammonium salts: Ammonium chloride 4. Misc. : Vasicine
  5. 5. Emetics “Induce vomiting” E.g.: Antimony potassium tartrate
  6. 6. Types Depending upon mechanism of action: A.By stimulating CTZ: Morphine B. By acting peripherally: Ammonium chloride
  7. 7. Ammonium chloride NH4Cl Syn: Ammonium muriate MOP: From ammonia and hydrochloric acid. NH3 + HCl NH4Cl
  8. 8. Physical Properties: 1. White crystalline powder 2. Odourless 3. Ammonical taste 4. Very soluble in water 5. Soluble in glycerin 6. Soluble in alcohol 7. Insoluble in acetone and ether 8. Hygroscopic in nature
  9. 9. Uses 1.Mild expectorants 2.To maintain acid base balance in body. 3.In cough preparation.
  10. 10. Storage “ It should be stored in well closed container at a cool place.”
  11. 11. Incompatibility Incompatible with alkalis, carbonates, lead and silver salts.
  12. 12. Potassium Iodide MOP: By using iodine, ferric salts and potassium carbonate.
  13. 13. Physical Properties: 1. White crystalline powder 2. Odourless 3. Bitter taste 4. Soluble in water 5. Soluble in glycerin 6. Soluble in alcohol.
  14. 14. Uses 1. Mild expectorants 2. To treatment of hypo- thyroidism. 3. Used as a source of iodine. 4. In cough preparation. 5. To stabilize in preparation of solutions of iodine.
  15. 15. Storage “ It should be stored in well closed container at a cool place.”
  16. 16. Incompatibility Incompatible with salts of mercury, bismuth, lead, iron, oxidizing agent and dilute hydrochloric acid.
  17. 17. Antimony Potassium tartrate [ KOOC-CHOH-CHOH-COO-SbO ] Or C4H4KO7Sb. Syn: Tartar of emetics, tartar emetic
  18. 18. MOP By mixing antimony trioxide (5 parts) with potassium acid tartrate (6 parts).
  19. 19. Physical Properties: • Colorless powder. • Odourless. • Sweet taste. • Soluble in water. • Insoluble in alcohol. • Aqueous solution is acidic in nature.
  20. 20. Uses 1.As a emetics. 2.As a expectorants. 3.As a anti microbial agent.
  21. 21. Storage “ It should be stored in well closed container at a cool place.”
  22. 22. Incompatibility Incompatible with acid salts, heavy metals, albumin and soap solution.
  23. 23. Thank you

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PCI syllabus, MSBTE, Pharmaceutical chemistry-I, Pharmaceutics, Inorganic chemistry, Diploma in Pharmacy, expectorants and emetics, topical agents

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