1. What is the disease which improve pain & stiffness
with exercise & worsen with rest… ???
Dr. P. Ratan Khuman (PT)
M.P.T., (Orthopedic & Sports)
ANKYLOSING SPONDYLITIS
3. Contents
Definition
Serostatus
Introduction
Aetiology
Pathology
Clinical feature
Radiological features
Diagnosis & special test
Lab test
Differential diagnosis
Prognosis
Management
Pharmacological
Physical therapy
Well known people
References
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Ratankhuman (M.P.T., Ortho & Sports)
4. Definition
It is a seronegative, progressive inflammatory
disease presenting with pain & stiffness of
spine leading to bony ankylosis of the
sacroiliac & spinal joints. (Tidy’s, 12th ed, 1991)
It is an inflammatory systemic disease
predominantly affecting the axial skeleton in
genetically predisposed individuals. (Carol
David, 1999)
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5. Serostatus
It is a term used to refer to presence or absence of
specific substances in blood serum.
Test is looking for specific antibodies in an effort to
diagnose a particular disease.
A person's test results can be –
Sero-positive
Sero-negative
Indeterminate.
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6. Seronegative spondylarthropathy
It is a group of diseases involving the axial skeleton &
having a negative serostatus.
"Seronegative" refers to the fact that these diseases are
negative for rheumatoid factor, indicating a different
pathophysiological mechanism of disease than what is
commonly seen in RA.
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7. Conditions typically included within of
Seronegative Spondylarthropathies
Condition
% of people with
condition who are HLA-
B27 positive
Ankylosing Spondylitis
o Caucasians: 92%
o African-Americans:50%
Reactive arthritis (Reiter's syndrome) 60-80%
Enteropathic spondylitis or spondylitis
associated with inflammatory bowel &
ulcerative colitis (including Crohn’s disease)
60%
Psoriatic arthritis 60%
Isolated acute anterior uveitis 50%
Undifferentiated spondyloarthropathy 20-25%
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8. Common Characteristics
They are in relation to HLA-B27
Inflammatory arthritis, generally sacroiliitis & spondylitis
Oligoarthritis, generally with asymmetrical presentation
Enthesitis (inflammation of the sites where tendons or lig insert
into the bone.)
Familial aggregation occurs
Rheumatoid factor is not present
Extra-articular features, such as involvement of eyes, skin &
genitourinary tract
Overlap is likely between several of causative conditions12 December 2020Ratankhuman (M.P.T., Ortho & Sports)
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9. Introduction
Ankylosis spondylitis (AS) - Greek word
Ankylos = Bent = Stiffening = fusion.
When the joint loses its mobility & becomes stiff/fuse it is
said to be Ankylosed.
Spondylitis = inflammation of the spinal vertebrae
Spondylos = Vertebra
Itis = Inflammation
Describes as inflammation of the spine
which can lead to fusion of the bone.
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10. AS is 1st reported in medical literature by
“Bernard O’Connor”, an Irish Physician in
1666 – 1698
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11. Etiology
Age – adolescence & young adulthood, common between 15 to
40 years
Gender – Male > Female [3:1]
Incidence – 0.6% of adult male are affected
Heredity – occurs 30 time more in relative of patients than
general population
Tissue types – 95% of patient with AS are Human Leucocyte
Antigen (HLA-B27) positive
Associated conditions – sacroilitis associated with Ulcerative
colitis, Crohn’s disease or Reiter’s syndrome
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13. Who is At Risk?
Risk factors that predispose a person to AS include:
Positive HLA-B27 marker
A family history of AS
Frequent GIT infections
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14. Pathology
Synovitis of sacroiliac joints
Cellular infiltration of periosteum to ligament or muscle
junction (Entheses & Enthesiopathy).
Chronic inflammation leads to fibrosis which gradually
become calcified & ossified in spinal synovial & fibro-
cartilaginous joints.
Bony ridge form at periphery of IV joints leading to
ossification of annulus fibrosis & surrounding tissue (seen
in radiography & term as Syndesmophytes).
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18. Enthesitis
It is an inflammation at the insertion of
tendons, ligaments or capsules into bone
which is a frequent manifestation in AS
Occurred in 50% with long-standing AS &
39.4% with shorter disease duration.
Most frequently affected at insertion of
Achilles’ tendon &/or the plantar fascia at
the calcaneus.
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19. Enthesitis in peripheral joints
The sites affected can be both the synovium & the
insertion of tendons/ligaments at bone.
This implies that a peripheral joint might not be swollen,
only painful (especially pain on local pressure and, if
accessible, on movement).
Hip involvement was reported in 27%
Shoulder involvement was reported in 25%
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22. Clinical features
Articular features
Extra-articular features
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23. Articular features
Onsets – often insidious with mild pain & stiffness in
lower lumbar spine & SI joints
Morning stiffness – common in early stage
Fatigue – very common
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25. Articular features cont…
Lumbar Spinal features –
Pain & stiffness
Pain radiating down the back of leg
(Sciatica)
Peraspinal muscle spasm
Flattening of lumbar spine
All movt are affected
SLR is affected bilaterally
As disease progress, the same
feature are seen in thoracic &
cervical
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26. Articular features cont…
Thoracic spine features –
Diminished costovertebral & manubriosternal movt resulting
loss of thoracic expansion
Dependent on diaphragm for respiration
Reduction in vital capacity
Peripheral joints –
Pain & stiffness at shoulder, hip & knee
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35. Radiographic features
Sacroiliac joint –
Erosion & sclerosis of bone near the articular
surface
Ankylos later
Spine –
Apophyseal joint erosion
Squaring of the vertebral bodies with ossification of
disc margins
Syndesmophytes
“Bamboo Spine” due to calcification of longitudinal12 December 2020Ratankhuman (M.P.T., Ortho & Sports)
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37. 9 most significant physical problems rated by
patients with AS (Dziedzic 1998)
Difficulty sleeping on the stomach
Stiffness on waking
Difficulty in standing for longer periods
Difficulty in prolonged sitting
Difficulty in bending
Being a spectator rather than participating in activities
Pain increasing with higher levels of stress
Tiredness on waking
Limitation of leisure activities
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41. Diagnosis & Special Tests
Diagnosis criteria were first proposed by Kellgren et al. Rome,
1961 – 1963
Later in New York by Bennett & Burch, 1968
New York criteria have been modified by Cats et al., 1987
Secondary AS is Dx if it is coexists with psoriatic arthritis,
Reiter’s Syndrome & inflammatory bowel disease. (Calin,
1993)
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42. Diagnosis Criteria for AS
HISTORY EXAMINATION RADIOLOGY
SCREENING
TEST
Back pain:
1. Commences <40 years
2. Insidious onset
3. Persists 3>3 months
4. Associated morning stiffness
5. Improves with exercise
ROME
CRITERIA
1. LBP >3 months Not relieved
by rest
1. Limited motion of lumbar spine
Bilateral sacro-iliitis
2 limited chest expansion
2. Thoracic pain and stiffness
3. Iritis (past or present evidence)
3. Iritis (history)
NEW YORK
CRITERIA
1. Pain in lumbar spine
or at dorsolumbar junction
1. Limited movement of lumbar spine in 3 planes
1. Bilateral sacro-iliitis: grade 3-
4
2. unilateral sacro-iliitis: grade
3-4
Or bilateral sacro-iliitis: grade 2
2. Chest expansion <2.5 cm
MODIFIED
NEW YORK
CRITERIA
I. LBP 3>3 months, Improved
by exercise and not Relieved
by rest
1. Limitation of lumbar spine in Sagittal and
frontal planes
1. Bilateral sacro-iliitis: grade 2-
4 or
2. Limitation of Chest expansion relative to
normal values corrected for age & sex
2. Unilateral sacro-iliitis: grade
3-4
Rome criteria: AS if bilateral sacro-iliitis and any clinical criterion are present or four of five clinical criteria.
New York criteria: Definite AS if grade 3 or 4 bilateral sacro-iliitis with any clinical criterion or grade 2 bilateral or 3
or4 unilateral sacroiliitis with either clinical criterion 1 or both clinical criteria 2 and 3.
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43. Modified New York criteria for AS
Diagnosis –
1. Clinical criteria –
LBP & stiffness > 3 months which improves with ex, but not
relieved by rest.
Limitation of motion of the lumbar spine in both the sagittal &
frontal planes.
Limitation of chest expansion relative to normal values
corrected for age & gender.
2. Radiological criterion –
Sacroiliitis grade 2 bilaterally
Sacroiliitis grade 3–4 unilaterally.
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44. Modified New York criteria for AS
Grading –
Definite Ankylosing Spondylitis –
If the radiological criterion is associated with at least 1 clinical criterion.
Probably Ankylosing Spondylitis if –
Three clinical criteria are present.
The radiological criterion is present without any signs or symptoms
satisfying the clinical criteria (other causes of sacroiliitis should be
considered).
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46. Amor’s Classification Criteria for Spondyloarthritis (SpA)
1
Clinical symptoms or past history of Lumbar or dorsal pain at night or morning stiffness of lumbar
or dorsal pain
1
2 Asymmetrical oligoarthritis 2
3 Buttock pain 1
4 If alternate buttock pain 2
5 Sausage-like toe or digit 2
6 Heel pain or other well-defined enthesopathy 2
7 Iritis 1
8 Non-gonococcal urethritis or cervicitis within one month before the onset of arthritis 1
9 Acute diarrhea within one month before the onset of arthritis 1
10 Psoriasis, balanitis, or inflammatory bowel disease (ulcerative colitis or Crohn’s disease) 2
11 Radiological findings Sacroiliitis (bilateral grade 2 or unilateral grade 3) 3
12
Genetic background: Presence of HLA-B27 and/or family history of ankylosing spondylitis,
reactive arthritis, uveitis, psoriasis or inflammatory bowel disease
2
13
Response to treatment: Clear-cut improvement within 48 hr after NSAIDS intake or rapid relapse
of the pain after their discontinuation
2
Note: A patient is considered as suffering from SpA if the sums core is >612 December 2020Ratankhuman (M.P.T., Ortho & Sports)46
47. Domains and Instruments for All Three ASAS Core Sets
Domain Recommended instrument
Physical function
BASFI a patient oriented questionnaire of 10 questions that are averaged to
yield a score between 0 and 10. As an alternative the Dougados functional
index including 20 questions on a 5-point Likert scale (range 0–40) is
acceptable.
Pain
Two separate questions: (1) total pain in the spine due to AS, (2) pain at night
in the spine due to AS.
Patient global of
disease activity
Patient global-visual analogue scale ith 0 being no disease activity and 100
being severe disease activity
Spinal mobility
Four instruments: 1.Occiput to wall distance, 2. Chest expansion,
3. Modified schober index, 4. Lateral lumbar flexion or BASMIa
Inflammation (spinal
stiffness)
Average of morning stiffness duration and intensity (e.g., BASDAI questions 5
and 6) or duration of morning stiffness only
Fatigue Fatigue question from the BASDAI
Peripheral joints &
Entheses
Number of swollen joints (44 joint count) Validated entheses index (no
preferred instrument)
Acute phase reactants ESR
Radiographs of spine
and hips
X-pelvis (SI joints and hips) Lateral lumbar spine and lateral cervical spine
(mSASSS)
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48. Diagnostic Procedures of As
Symptoms
Positive family history of AS
Inflammatory back pain
Thoracic pain
Fractures of spine after minor trauma
Oligoarthritis
Anterior uveitis
Diarrhea
Shortness of breath
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50. Diagnostic Procedures of As
Laboratory tests
ESR or CRP
Blood count
HLA-B27 antigen (in case of doubtful diagnosis)
Urine: erythrocytes, protein?
Radiology
Pelvis: sacroiliitis, hip involvement?
Cervical, thoracic, lumbar spine
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51. Laboratory Tests
Elevated ESR or CRP
Platelet Count may be slightly elevated & mild normochromic,
normocytic anemia, due to a chronic disease
Positive RA factor & antinuclear antibodies (ANA) do not occur
HLA-B27 antigen present in majority of AS patients
Adolescent patients, radiographic confirmation of sacroiliitis can be
difficult, HLA-B27 testing could be helpful in Rx.
Raised levels of Alkaline Phosphatase, primarily derived from bone,
& serum immunoglobulin A (IgA)
Urine might show protein or erythrocytes in renal involvement.
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52. Radiology
The radiograph of pelvis show signs of sacroiliitis
Severity of sacroiliitis can be graded from 0 to IV of the SI
joints.
At early stages, sacroiliitis can be detected with CT &
MRI before the abnormalities at plain radiograph of pelvis
.
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53. Radiology cont...
Vertebral column often shows –
Bony sclerosis with squaring of vertebral bodies
Ossification of annulus fibrosis with syndesmophytes.
This might lead to fusion of vertebral column with a classical
“Bamboo Spine”.
Involvement of hip & shoulder joints –
Joint space narrowing can be detected by conventional X-rays.
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62. Differential Diagnosis
Other types of spondyloarthropathies
Psoriatic arthritis
Inflammatory bowel disease:
Ulcerative colitis or Crohn’s disease
Reactive arthritis
Juvenile spondyloarthropathy
Other types of arthritis
Rheumatoid arthritis
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63. Differential Diagnosis
Other causes of back pain
Non-inflammatory back pain
Fibromyalgia
Spine diseases: prolapsed intervertebral disc, spinal tumors,
bone tumors
Infections: tuberculosis, and others
Metabolic diseases
Diffuse idiopathic skeletal hyperosthosis (DISH or
Forestier’disease
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64. Differential Diagnosis
Other causes of sacroiliitis
Osteitis condensans ilii, septic sacroiliitis, paraplegia, paget’s
disease, dialysis associated
Spondylarthropathy, hyperparathyroidism, etc.
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65. Prognosis
Can range from mild to progressively debilitating & from
medically controlled to refractive.
Some have active inflammation followed by remission,
while others never have remission & have acute
inflammation & pain.
Unattended cases of AS accompanied by enthesitis,
especially when spine inflammation is not yet active, may
result in misdiagnosis of normal rheumatism.
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66. Prognosis …
In long-term undiagnosed –
Osteopenia or osteoporosis of spine may occur, causing
eventual compression fractures & back "hump".
Typical signs of progressed AS are –
Syndesmophytes formation on X-rays & abnormal bone
outgrowths similar to osteophytes affecting the spine.
In fusion of the vertebrae –
Paresthesia is a complication due to the inflammation of the
tissue surrounding nerves.
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67. Disease-specific Instruments
1) Bath AS disease activity index [BASDAI]
2) Bath AS functional index [BASFI]
3) Bath AS metrology index [BASMI]
4) Bath AS radiology index [BASRI]
5) Modified stroke AS spinal score [mSASSS]
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75. Management of as
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Education, Exercise,
Physical therapy,
Rehabilitation,
Patient Associations,
Self help group
NSAIDs
Axial Disease Peripheral Disease
TNF Blockers
Local Corticosteroid
DMARD (Sulfasalazine)
A
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77. Pharmacology Rx
The NSAIDs for AS –
Recommended as 1st Line Drug Rx for AS with pain & stiffness
Good anti-inflammatory capacity
Reducing pain & stiffness rapidly after 48–72 hours
With Gastrointestinal (GI) Risk, non-selective NSAIDs plus a gastro
protective agent, or a selective COX-2 inhibitor could be used.
Analgesics for AS –
Might be considered for pain control in whom NSAIDs are insufficient, C/I
& poorly tolerated.
E.g. Paracetamol & Opioids
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79. Pharmacology rx Cont…
Cortico-gluco-corticoid injections –
Directed to the local site of musculoskeletal inflammation may
be considered.
Disease-Modifying Anti-Rheumatic Drugs (DMARD)
The use of DMARDs for the Rx of axial disease in
spondyloarthritides (SpA) has been disappointing.
Sulfasalazine improves peripheral arthritis associated with SpA, but not
spinal pain.
Methotrexate is generally used in patients with RA to improve symptoms
& slow progression of erosive disease.
Bisphosphonates could be useful for spinal symptoms withAS12 December 2020Ratankhuman (M.P.T., Ortho & Sports)
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80. Pharmacology rx Cont…
Use of Biological Agents in AS –
Success of anti Tumour Necrosis Factor blockers (TNF) Rx in
SpA is probably class “A” effect.
Recommended drugs: e.g. Infliximab, Etanercept, Adalimumab
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81. Pharmacology rx Cont…
The following criteria should be fulfilled before initiating
biological agents:
A definitive diagnosis of AS
Presence of active disease for at least 4 weeks as defined by
both a sustained BASDAI of at least 4 (on a scale of 0-10) & an
expert opinion based on clinical features, acute phase
reactants & imaging modalities.
Presence of refractory disease defined by failure of at least two
NSAIDS during a 3-month period , failure of intra-articular
glucocorticoids if indicated & failure of sulfasalazine in patients
with peripheral arthritis. 12 December 2020Ratankhuman (M.P.T., Ortho & Sports)
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83. Physiotherapy Management
There are ample of evidence that Physiotherapy in the
form of exercises is effective (level A evidence) in
management of AS - SpA.
However, scientific evidence of long-term effectiveness is
not yet available.
But some suggested, ex should be continue life time.
Most AS feel too stiff to ex in morning, so taking a warm
bath before ex tends to ease this discomfort.
Choose a time of day that works best for patient.12 December 2020Ratankhuman (M.P.T., Ortho & Sports)
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84. Aims of Physio Rx
To educate the patient
To relieve pain & spasm
To maintain & improve mobility of the spine & peripheral
joints.
To strengthen the muscles of the trunk, the legs, the back
& the abdomen
To minimize deformities
To regain fitness
To relax the body 12 December 2020Ratankhuman (M.P.T., Ortho & Sports)
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85. Patient Education
Before starting an exercise program
Patient education plays a central role in successful
management of AS.
Soon after Dx of AS, patients should be explained about
possible progression of symptoms & other C/F, prognosis &
treatment.
Informing the patient about the possible occurrence of spinal
ankylosis will enhance compliance with proposed treatments.
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86. To Relieve Pain & Spasm
Heat therapy as a hot
pack can be applied
locally to the specific joint
& muscle affected.
Hold-relax technique are
best in relieving muscle
spasm after acute
inflammatory changes.
Hydrotherapy helps in
minimizing pain & spasm &
also restored mobility.
Recreational exercise –
Improves pain and stiffness &
improves function.
Exercise at least 30 min/day
Exercises at least 5
days/week
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Ratankhuman (M.P.T., Ortho & Sports)
87. Application of Heat
Warm shower or application of local heat promote
relaxation & help in stretching of tight muscles.
Should not apply local heat to an area >15min at a time
Avoid areas overlying artificial joints.
Keep the temperature of the heating pad at low or
medium level, never on high setting.
Do not lie on back with the heating, it increase the risk of
burn due to decreased blood circulation in the area by
pressure of body weight. 12 December 2020Ratankhuman (M.P.T., Ortho & Sports)
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88. Swimming
Swimming is an ideal exercise because it gently uses all
the muscles & is very relaxing.
It provides aerobic exercise to enhance general fitness &
enhance lung capacity.
Warm or even hot pool is generally most comfortable.
Heated swimming pool or spa helps to decrease pain and
stiffness.
Low-impact exercises in the water (swimming & water
aerobics) & stationary bicycling can help improve ex
capability, muscle strength & ROM.
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90. Swimming cont…
Regular free-style swimming is
considered to be one of the best
exercises for people with AS.
Using a snorkel may be helpful.
Careful not to slip on wet surfaces in
the pool area & it is also wise to avoid
diving.
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91. Spinal Extension & Deep Breathing Ex
Spinal extension exercises in prone lying
Hold time: 5 seconds and then relax
Repeat the exercise about 20 times.
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92. Spinal extension and deep
breathing exercises cont…
Chest Expansion Exercise in supine –
Clasping hands behind head & extending your elbows
outwards towards the bed while taking a deep breath.
Hold the breath for a count of 10 before exhaling and
relaxing for about 10 seconds.
Repeat the exercise about 20 times.
Give up smoking, in order to prevent its adverse
effects on the lungs and heart.
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93. Spinal extension and deep
breathing exercises cont…
Combine spinal extension & chest expansion
exs –
Performing corner push-ups
Take in a deep breath during this manoeuvre.
After a count of 10, exhale while returning.
Repeat exercise about 20 times thrice daily if
possible.
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94. Muscle-strengthening and
stretching exercises
Strengthening of back extensor & hip muscles to
keep the spine mobile & erect.
Try achieving functional ROM of hip & shoulder
joint
Daily stretching of involved joints to improve
mobility of the back, hips, shoulders, or other
involved joints.
Needs of Ex are –
To prevent stiffness
To regain muscle strength & prevent muscle wasting
& weakness. 12 December 2020Ratankhuman (M.P.T., Ortho & Sports)
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104. group exercise
Use of large Swiss balls & group exercise sessions that
include hydrotherapy are enjoyable and very helpful.
In some European countries, professionally supervised
special physiotherapy and hydrotherapy group sessions
for AS patients have been organized by AS patient
organizations.
Group physical therapy is cost-effective compared to
individualized therapy.
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105. Living with as: some hints
If you have physical limitations due to
advanced AS, there are devices to help
perform daily tasks:
Walking canes,
Special chairs and desks,
Special shoes, and
Devices that assist in putting on socks or
stockings and shoes, or for scratching or applying
soap on back, etc.
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106. Avoiding falls
Always wear a good pair of skid-resistant
shoes.
Use grab bars in the shower and toilets,
shower seats, raised toilet seats, and floor
lighting at night.
Avoid slippery surfaces and loose carpets.
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107. Posture
Sleep on a firm bed to maintain a good resting
posture at night.
Preferably make a habit of sleeping prone, to
prevent hip joints and the back flexion.
Avoid a pillow under knees because it increase
the tendency to muscle and tendon shortening.
Avoid a saggy mattress or a waterbed.
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108. Avoid using a pillow if possible, or use one just
thick enough to allow a horizontal position of
the face to prevent pain from overextension of
neck.
Practice lying prone
e.g. for 5 minutes or more before getting out of
the bed in the morning, and also before going to
bed at night.
People with AS need to practice good posture
habits at all times, and should be taught about
dynamic, resting, and occupational postures.12 December 2020Ratankhuman (M.P.T., Ortho & Sports)
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110. Dynamic posture
Be aware of standing posture & try to maintain
an erect posture, with the spine as straight as
possible.
Avoid any tendency to slump forward.
Splints, braces and corsets are generally not
helpful and are not advised.
Some form of bracing may be necessary on
rarely.
e.g. after injury to the back or neck
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111. Occupational posture
Analyse habitual and work
postures and modify working
positions to maintain a good
posture.
E.g, a drafting table with tilting
work surface may be better than
an ordinary office desk for writing
and reading & avoiding stress on
neck.
12 December 2020Ratankhuman (M.P.T., Ortho & Sports)
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112. Occupational posture cont…
Avoid physical activity that places prolonged
strain on back & neck muscles, and prolonged
stooping or bending.
Alternate between sitting and standing
positions to perform jobs that take a long time
to finish.
Maintain a good posture while sitting, and
avoid sitting for prolong periods, especially in
low soft sofas and chairs.
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113. Occupational posture cont…
During your mid-day break at work, lie flat for a
few minutes, and do some corner push-ups to
stretch the back.
A daily routine of deep breathing and spinal
motion/stretching exercises may minimize the
fusion, and at least preserve better posture.
Do deep breathing exercises at frequent
intervals during the day.
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114. Sports and recreational
activities
Sports and recreational activities that
encourage good posture & arching of the back
(extension) and rotation of the trunk are
recommended.
E.g. walking, hiking, swimming, tennis,
badminton, cross-country skiing, and archery.
Volleyball and basketball are excellent sports for
people however, not everyone can tolerate.
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115. Sports and recreational
activities cont…
Sports activities that require prolonged spinal
flexion may not be recommended.
E.g. golf, bowling & long distance cycling
Body contact sports (boxing, rugby, soccer,
American football & hockey) and downhill skiing,
are also not recommended due to greater
potential for injury.
Stationary cycle are good, but the handlebars
must be properly adjusted not to lean forward
while exercising.
12 December 2020Ratankhuman (M.P.T., Ortho & Sports)
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116. Sports & recreational activities
cont…
Cycling is good for general cardiovascular
conditioning, strengthening the leg muscles, and
exercising the hip and knee joints.
Aerobic exercises with machines that enhance
back, leg, and shoulder extension are helpful,
but should avoid undue stress on the neck.
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117. Well-known people with AS
Pope John Paul
Mötley Crüe's guitarist
Ed Sullivan , US
World Chess Champion
Vladimir Kramnik
England cricket captain
Mike Atherton
Australian cricketer
Michael Slater
Norwegian Prime Minister
Jens Stolenberg
Scottish snooker player
Chris Small
US Major League baseball
player Rico Brogna
Taiwanese musician Jay
Chou
Czech writer Karel Capek
Ian Woosnam British golfer
French tennis player
Tatiana Golovin
Lee Hurst comedian
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118. Pope John Paul
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126. Comedian - Lee Hurst
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127. Reference
Joachim Sieper, ankylosing spondylitis in clinical
practice, 2011
Barend J. Van Royen, ankylosing spondylitis
diagnosis and management, 2006
Karen Atkinson, Physiotherapy in Orthopaedics: A
problem-solving approach, 2005
Muhammad asim khan, Ankylosing Spondylitis: the
facts, 2002
Stuart Porter, Tidy Physiotherapy, 13th ed, 2003
Ann Thomson, Tidy Physiotherapy, 12th ed, 1995
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128. Reference cont…
Van Der Linden, Evaluation Of Diagnostic
Criteria for Ankylosing Spondylitis: A
Comparison of the Rome, New York & Modified
New York Criteria in Patients with a Positive
Clinical History Screening Test for Ankylosing
SpondylitiS, British Journal Of Rheumatology
1985;24:242-249
Joachim Sieper Ankylosing Spondylitis,
Seminar, Medical Department I, Rheumatology,
April 21, 2007
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129. Reference cont…
J Sieper et al., The Assessment of
SpondyloArthritis international Society (ASAS)
handbook: a guide to assess SpA, Ann Rheum
Dis 2009;68;ii1-ii44
AN Malaviya et al., Indian Rheumatology
Association consensus statement on the
diagnosis and treatment of axial SpA,
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