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The ZDSD Rat as a Translational Model for the Development of Drugs for Obesity, Metabolic Syndrome and Diabetes. This presentation describes the ZDSD rat. This rat is a model of obesity, metabolic syndrome and diabetes. In the pre-diabetic state it demonstrates all of the characteristics of human metabolic syndrome including obesity, glucose intolerance, insulin resistance, increased cardiovascular biomarkers and hypertension. In the diabetic state it expresses diabetic complications such as diabetic nephropathy, osteoporosis and delayed wound healing.