Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

Chaskar CV


Published on

Chaskar CV

Published in: Science
  • Be the first to comment

  • Be the first to like this

Chaskar CV

  1. 1. Dr. Prasad Chaskar CONTACT DETAILS Avenue de Cour 126 1007 Lausanne, Switzerland Mobile: +41 78 922 38 66 E-mail: DATE OF BIRTH December 27, 1986 AVAILABILITY Immediately PERMIT Valid residence permit with rights to work in Switzerland. EDUCATION Ph.D. (March 2012 - February 2016) Swiss Institute of Bioinformatics and University of Lausanne, Switzerland M.Tech. (June 2009 - July 2010) Institute of Bioinformatics and Biotechnology, Pune, India M.Sc. (June 2004 - May 2009) Institute of Bioinformatics and Biotechnology, Pune, India WORK EXPERIENCE Data Scientist (March 2016 - Present) Philip Morris International, Neuchâtel, Switzerland • Established data fusion by matrix tri-factorization method for the integration of heterogeneous omics data. Researcher (March 2012 - February 2016) SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland • Developed a high-quality dataset of zinc and heme ligand-bound protein structures. • Successfully developed an on-the-fly quantum mechanical/molecular mechanical (QM/MM) docking algorithm and benchmarked it on diverse datasets. • Modeled the structure of an anticancer target MAP3K8 and performed virtual high-throughput screening (vHTS) of small molecules against it. Researcher (March 2011 - January 2012) National Center for Biological Sciences, Bangalore, India • Successfully investigated substrate recognition by DNA repair enzymes using computational chemistry methods. Junior Researcher (May 2007 - June 2009) National Center for Cell Sciences, Pune, India • Developed a computer application for transcription factor binding site prediction and analysis. • Established ChIP-on-chip assays to investigate role of epigenetics modifications and tran- scription factors in ovarian cancer progression. • Performed gene expression analysis and pathway analysis to identify bio-markers in ovarian cancer progression. EXPERTISE Technical skills: • Bioinformatics data analysis (e.g. sequence analysis, gene expression analysis, omics data integration), molecular modeling (e.g. homology modeling, molecular dynamics and QM/MM simulations), molecular and cell biology experiments (e.g. cell culture, ChIP-on-chip), scien- tific writing, presentation techniques. Computational tools: • Bioinformatics tools, R Studio, Gene Set Enrichment Analysis (GSEA), molecular modeling tools, Microsoft Office Excel.
  2. 2. Computer Programming: • Perl, UNIX shell scripting, R, Python, CHARMM. Operating Systems: • Linux and other UNIX variants, Microsoft Windows family. PUBLICATIONS 1. Chaskar, P.; Zoete, V.; Röhrig, U. F., On-the-Fly Quantum Mechanical/Molecular Mechani- cal (QM/MM) Docking with Attracting Cavities. (Submitted J. Chem Inf. Model-July2016) 2. Zoete, V.; Thierry, S.; Bovigny, C.; Daina, A.; Röhrig, U. F.; Chaskar, P.; Michielin, O. Attract- ing Cavities For Docking. Replacing The Rough Energy Landscape Of The Protein By A Smooth Attracting Landscape. J. Comput. Chem. 2016, 5, 437-47. doi:10.1002/jcc.24249 3. Chaskar, P.; Zoete, V.; Röhrig, U. F., Toward on-the-Fly Quantum Mechanical/Molecular Mechanical (QM/MM) Docking: Development and Benchmark of a Scoring Function. J. Chem Inf. Model. 2014, 54, 3137-3152. doi:10.1021/ci5004152 4. Kurrey, N. K.; Jalgaonkar, S. P.; Joglekar, A. V.; Ghanate, A. D.; Chaskar, P. D.; Doiphode, R. Y.; Bapat, S. A., Snail and Slug Mediate Radioresistance and Chemoresistance by An- tagonizing P53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Can- cer Cells. Stem Cells. 2009, 27, 2059-2068.doi:10.1002/stem.154 CONFERENCE POSTERS 1. Chaskar, Prasad; Zoete, Vincent; Michielin, Olivier; Röhrig, Ute. On-The-Fly Quantum Mechanical/ Molecular Mechanical (QM/MM) Docking. In: Computational Advances in Drug Discovery, Lausanne, Switzerland, September 22-25, 2015 2. Chaskar, Prasad; Zoete, Vincent; Michielin, Olivier; Röhrig, Ute. On-The-Fly Quantum Mechanical/ Molecular Mechanical (QM/MM) Docking. In: Basel Computational Biology Conference (BC2) 2015, Basel, Switzerland, June 7-10, 2015 3. Chaskar, Prasad; Puranik, Mrinalini. QM/MM Modeling and UVRR studies of DNA repair Enzymes. In: Innovative Approaches to Computational Drug Discovery, CECAM, EPFL, Lausanne, Switzerland, October 2-6, 2011 WORKSHOPS 1. Understanding Molecular Simulations, University of Amsterdam, Netherlands, January 7- 18, 2013 2. International Chemical Design and Discovery Course, Radboud University, Nimegen, Nether- lands, June 18-28, 2012 3. Advances in Biomolecular Modeling and Simulations using CHARMM, University College Dublin, Ireland, June 5-8, 2012 4. Computational Chemogenomics to understand Systems Biology and Computational Medic- inal Chemistry, University of Geneva, Switzerland, May 14-16, 2012 LANGUAGES • English (professional working proficiency) • Marathi (mother tongue) • Hindi (fluent) • French (beginner (A1 Level), taking lessons to improve French language skills).
  3. 3. REFERENCES 1. Prof. Olivier Michielin (MD-PhD) (Ph.D. supervisor at SIB-Lausanne) Department of Oncology, University of Lausanne and Centre Hospitalier Universitaire Vau- dois (CHUV), CH-1011 Lausanne, Switzerland Email: Phone: +41 21 314 01 85 2. Dr. Vincent Zoete (Ph.D. co-supervisor at SIB-Lausanne) Swiss Institute of Bioinformatics Unil, CIG - Quartier Sorge, bâtiment Genopode - 1015 Lausanne Email: Phone: +41 21 692 40 82 3. Dr. Ute Röhrig (Ph.D. co-supervisor at SIB-Lausanne) Swiss Institute of Bioinformatics Unil, CIG - Quartier Sorge, bâtiment Genopode - 1015 Lausanne Email: Phone: +41 21 692 40 86 4. Dr. Jay Siddharth (Mentor-microbiology at University of Pune, India) Nestle Institute of Health Sciences SA, EPFL Innovation Park, bâtiment H - 1015 Lausanne Email: Phone: +41 21 632 61 73 5. Dr. Björn Titz (Project supervisor at PMI-Neuchâtel) Philip Morris International, R&D Innovation Cube T1535 08 - 2000 Neuchâtel Email: Phone: +41 58 242 2312