BOS-Bio-Programming environment

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BOS-Biological Operating System - Looking for funding to create the first of its kind - Biological Visual programming Environment which will be easy to use by biologists who are not computer savvy/ NOT programming savvy but are driven by biological research queries.

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BOS-Bio-Programming environment

  1. 1. Helix Genomics HELIX GENOMICS
  2. 2. BOS – Biological Operating System Helix Genomics Prasad Burra, Ph.D Founder, MD & CTO programming life Helix Genomics
  3. 3. protein DNA mutant Drug Discovery phase (5-7Y) 8-1 $1.3B Helix Genomics HELIX GENOMICS Market pain Science
  4. 4. Market pain : Software <ul><li>Not 'systems biology' ready </li></ul><ul><li>One algorithm – one tool </li></ul><ul><li>Tools not scalable, extensible </li></ul><ul><li>Tools are scattered </li></ul><ul><li>No flowchart or process automation </li></ul><ul><li>Enormous unproductive time – searching , learning, customizing, benchmarking </li></ul><ul><li>No standardization </li></ul><ul><li>No integration </li></ul><ul><li>Data Redundancy </li></ul>Restrictive Helix Genomics
  5. 5. Novel BOS paradigm The Researcher Custom data Best Results Output <ul><li>'systems biology' ready </li></ul><ul><li>One-language solution </li></ul><ul><li>Biological design & intuitive </li></ul><ul><li>Customizable, extensible and flexible </li></ul><ul><li>Flowchart or process automation </li></ul><ul><li>On-the-fly biological programming – no compilation, no linking </li></ul><ul><li>Rich source of reusable and tested biological objects </li></ul><ul><li>Easy testing, validation and benchmarking </li></ul><ul><li>Cuts cost and time by ~55% </li></ul><ul><li>Scientific exploration & inquiry </li></ul><ul><li>Faster & alternative solutions </li></ul><ul><li>Process / Flowchart implementation </li></ul><ul><li>Reliable, Reusable & Consistent </li></ul><ul><li>Application Frameworks </li></ul>Helix Genomics Our Solution:'a must have'
  6. 6. ...The analytical software segment .. posting .. fastest growth rate... Global Bioinformatics Market Outlook, Research Report, Sept 2007 Evolving bioinformatics software Competitive Matrix Helix Genomics 1 st Gen 2 nt Gen 3 ed Gen 4 th Gen 1970- -- 1980-- 2000- -- 2002- -- Functions ( Sequence Comparison) Tools Like Blast Accelrys Bio perl / Bipjava Helix Genomics / Bos Integration / Visualization 0 10 10 10 programming & Automation 0 10 3 8 ( customization, scripting, extensibility) 0 0 6 10 Biological design implementatin 0 0 1 10
  7. 7. BOS – one-stop, one-language solution <ul><ul><li>Standardization is possible with BOS which is mentioned as a major challenge in recent market reports </li></ul></ul>GBMO, Research Report, Sept 2007 Integration / Visualization Biological Design Programming & Automation Biological Functions Helix Genomics
  8. 8. Market size <ul><li>Bioinformatics tools - market size: </li></ul><ul><li>The bioinformatics market is forecast to grow at a CACR of 23% to $4.5bn by 2011 </li></ul><ul><li>Market segmentation </li></ul><ul><ul><li>Database providers – 45% (2006) - $US 0.8b </li></ul></ul><ul><ul><li>Drug Discovery research – 55% - $US 1.0b </li></ul></ul><ul><li>Genomics – 60% </li></ul><ul><li>Proteomics – 40% </li></ul>Helix Genomics GBMO, Research Report, Sept 2007
  9. 9. Market growth ...it is the analytical software segment that is posting the fastest growth rate ... ( Global Bioinformatics Market Outlook, RNCOS, Sept 2007) ‏ Helix Genomics Market Category 1980 2002 2005 Data Suppliers 49% 38% 30% Analytical Software Providers 39% 43% 55% Enterprise System Providers (Accelrys etc…) ‏ 12% 19% 15%
  10. 10. Target market <ul><li>Drug Discovery research Co's </li></ul><ul><ul><li>Pharmaceutical </li></ul></ul><ul><ul><li>Biotech </li></ul></ul><ul><ul><li>Life Science </li></ul></ul>Academia Helix Genomics Source: Nature Biotechnology, 2000
  11. 11. Target size <ul><li>Bioinformatics R&D and Educational Establishments* </li></ul>Helix Genomics *Estimates based on 'Growing the Nation's Bioscience sector:, BIO, April 2006 USA Europe India Total Degree Colleges/ Post Graduate Centers 1250 1070 2000 4670 Engineering Colleges/Universities/Depts. 350 Research Institutes/Labs 2050 1850 75 3975 Biotech /Life Science Cos 1120 990 20 2130 Pharma Cos/CROs 1580 1320 30 2930 Total 6000 2530 2475 13705
  12. 12. Technology Licensing Contract Services <ul><ul><li>Contract Research Service and Outsourcing </li></ul></ul><ul><ul><ul><li>Custom biological databases </li></ul></ul></ul><ul><ul><ul><li>Custom algorithms, </li></ul></ul></ul><ul><ul><ul><li>custom software tools </li></ul></ul></ul>Drug discovery, genomic, proteomic & HT data analysis Product Service Online bioinformatics lab Helix Genomics Revenue models
  13. 13. Current Status Helix Genomics HELIX GENOMICS
  14. 14. Growth & Sustainability Patent Protected Technology Exploitation Product Road Map BioVPE ‏ BOS Client/Server BOS Online Bio SDK ‏ Helix Genomics BOS on Cloud Computing/ GRID/ Mobile / Parallel
  15. 15. Exit strategy Helix Genomics HELIX GENOMICS
  16. 16. BOS – Biological Operating System programming life Helix Genomics <ul><ul><li>Goal : BOS on every PC (in 10 years) ‏ </li></ul></ul><ul><ul><ul><li>Google of Bioinformatics (Internet market) ‏ </li></ul></ul></ul><ul><ul><ul><li>Microsoft of Bioinformatics (PC market) ‏ </li></ul></ul></ul>
  17. 17. Helix Genomics Additional Slides
  18. 18. BOS –Data curation through analysis to publishing <ul><li>500 Biological Objects </li></ul><ul><li>15000 methods/functions </li></ul><ul><li>25 Algorithm Implementation </li></ul><ul><li>15 Database Input formats </li></ul><ul><li>3 Output formats </li></ul><ul><li>7 Biological Libraries </li></ul><ul><li>Several Sequence and Structure </li></ul><ul><li>specific objects </li></ul><ul><li>Statistics and Matrix functions </li></ul><ul><li>300,000 lines of Code </li></ul><ul><li>Dynamic Intelli Help </li></ul><ul><li>Programmatic interface for connecting </li></ul><ul><li>to databases </li></ul>Protein Prediction Algorithms Protein Homology modeling Genome wide analysis Helix Genomics HELIX GENOMICS Encouraging Innovation, Enabling Expression of Biological Intuition
  19. 19. Technically me <ul><li>2.5 years in Web Designing – </li></ul><ul><li>Wikis, Web CMSs using AJAX – [X|D]HTML, CSS, Javascript, MySQL, PHP </li></ul><ul><li>4 years of teaching & training in Bioinformatics & Computational Biology </li></ul><ul><li>6 years of entrepreneurial activity – </li></ul><ul><li>Director / Founder / CEO / CTO </li></ul><ul><li>12 years of research into Bioinformatics, Bio-software, Genomics, Proteomics, Systems Biology </li></ul><ul><li>15 years of Programming – </li></ul><ul><ul><li>C++ / Shell Scripting / *nix OS / </li></ul></ul>Helix Genomics
  20. 20. Excerpts supporting BOS timing <ul><li>...it is the analytical software segment that is posting the fastest growth rate...( Sept 2007) ‏ </li></ul><ul><li>...lack of standardization remain the biggest challenge for the bioinformatics industry...(Sept 2007) </li></ul><ul><li>... outsourcing is expected to emerge as a definitive trend in the bioinformatics industry, according to a new report by Frost & Sullivan(Sep, 06) </li></ul><ul><li>...if the tools are put in the hands of the actual users , the entire user base will increase , making it an attractive proposition for the bioinformatics companies...(Aug 05) ‏ </li></ul><ul><li>it is necessary to capture the student/academic community first...(Oct, 05) ‏ </li></ul><ul><li>the market for bioinformatics isn't large enough to support a company built around one or two high-cost software programs targeted to a relatively small user group...(Nov, 04) </li></ul>Helix Genomics
  21. 21. BOS programming guide : Helix Genomics BOS programming guide:
  22. 22. Life Cycle of Biological Query <ul><li>Data Generation (Experimental)‏ </li></ul><ul><li>Data Processing Tools </li></ul><ul><li>Data Reduction Tools </li></ul><ul><li>Data Annotation Tools </li></ul><ul><li>Data Mining Tools </li></ul><ul><li>Data Analysis Tools </li></ul><ul><li>Data Representation Tools </li></ul><ul><li>Data Publishing Tools </li></ul>Domain of a Computational Biologist With BOS one can accomplish all these computational tasks and queries Helix Genomics
  23. 23. BOS Algorithms – Generic Object Oriented Biological Algorithms - GOOBA Self Repeat Algo. Helix Genomics Encouraging Innovation, Enabling Expression of Biological Intuition.

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