Welcome to this demonstration of theBritish Pharmacopoeia 2000 on CD-ROM The screen views comprising this demo will change automatically There are 2 views of the BP on the CD: Index+: for intensive searching Acrobat PDF: for browsing
When you open the program you get the ‘Welcome’ screen:
Click ‘BP 2000’ to bring up the Index+ home screenFor the moment, note the PDF and BAN tabs; we’ll come back to them shortly. Click on‘British Pharmacopoeia Volume I’
This brings up a view of the sections in Volume I: Click on ‘Monographs: Medicinal and Pharmaceutical substances.
This brings up an A-Z list of the monographs in Volume I:Note from the tab that you are in ‘Browse’ mode. Scroll the list and click on amonograph title of interest, eg ‘Albendazole’
This brings up the Albendazole monograph. Scroll down to reveal all the textor click the ‘maximise’ icon to fill the screen. Note that most of the text is inred. This is to show that the text is either new to the BP 2000 or has beenrevised since BP 1999. Graphical elements such as structural formulae, tablesand equations are always black.
You now have a choice in the appearance of the text. Go theEdit menu and click ‘Options’. Click the Font tab.You have the choice of working with either a serif or sans serif font and with large or small text; small is recommended
Click the Proximity tab; this allows you to set your choice of values for the‘Near’ operator.Now click the View tab; this allows you to choose to have monograph titlesrepeated in the actual text, useful if you intend copying or exporting theentire text of a monograph.
In this version, 4.0, you can select text. Simply drag across any amount of text.The selected text can then be copied and pasted into other applications. If youprefer, you can export a monograph from Index+ as an RTF file by going toFile>Export RTF.
Place the cursor over the structural formula.Note it changes to a pointing hand. G G Now click.
This brings up an enlarged view of the structure.It can be saved as a bitmap (.bmp file) or copied to the clipboard.
Text in blue signifies a hypertext link to the cited text.For example, click on ‘octadecylsilyl silica gel for chromatography.
To retrace your steps click the ‘Browse’ button which returns you to the A-Zlist.To browse a different volume click on the rather small text at the top of thewindow ‘2000 British Pharmacopoeia CD-ROM’. This gets you back to thepoint where you can begin to browse the other volumes.
SearchingIndex+ provides a powerful search facility. Click the Searchtab.
This brings up a dialogue box in which you key the searchparameters.Let’s find all the capsules monographs with a dissolution test that useshydrochloric acid as the dissolution medium
We’ll do this progressively to see how you refine the query to get precisely theinformation you need.First we’ll search on ‘dissolution test’. Key in dissolution test in the text box andthen press the ‘Search’ button:
This brings up a Hit List showing 122 hits, meaning 122 monographs thatcontain the contiguous words ‘dissolution test’. Scrolling the list shows thatgeneral formulary and tablet monographs have been picked up.
Click the Search button to get back to where you were.Now we can refine the search by including the word ‘capsules’ in the ‘Title’box and pressing Search once more:
This time we only get 25 hits: Note that since the word ‘capsules’ is one of the search criteria it is highlighted in yellow.
Now we’ll include the words ‘hydrochloric acid’ by clicking the‘AND’ button. The words ‘AND’, ‘NOT’ and ‘OR’ are known as‘Boolean Operators’. They are an instruction to the search engineand not words on which to search.
This time we get 16 hits: Let’s take a look at the text of a hit monograph. Double-click on ‘Etodolac Capsules’.
This brings up the top of the Etodolac monograph.Click the down-arrow in the vertical scroll bar.
This takes us to the first or next occurrence of either of the searchwords, in this case ‘hydrochloric acid’. However….
…this result is not exactly what we’re after. The next 2occurrences of hydrochloric acid are nothing to do with thedissolution test. We need to refine the search further.We need to use the ‘NEAR’ operator. This allows you to set aproximity value - let’s say the words ‘hydrochloric acid’ should bewithin 20 words of ‘dissolution test’. Choosing an appropriatevalue does require a passing knowledge of BP phraseology.Click the Search button again.
Select the AND operator, click the NEAR button and change thedefault value to ‘20’: Now click the Search button again.
This time we only have 8 hits and Etodolac Capsules is not one ofthem.
Double-click on the first hit, Cefradine Capsules and then click on the down-arrow in the vertical scroll bar.The text jumps to the first occurrence of the search words. This time we’ve comeup trumps since hydrochloric acid is the dissolution medium!
Carry on clicking the down-arrow to scroll from one occurrenceof the search words to the next.You will find that each of the 8 hits correctly identifieshydrochloric acid as the dissolution medium.This search illustrates the power of Boolean operators to refinesearch criteria.
Before we take a look at the PDF view let’s go back to the Searchwindow and see what else is on offer.Notice there are 2 check boxes, one each for ‘British’ and‘European’. This simply allows searches to be confined to BP orEP monographs.
Secondly, there is an option to restrict searches to Volume I, Volume II or the BP(Vet)2000. If the ‘Restrict Search’ box is checked, the tabs referring to these volumesbecome live. By default all sections within these volumes will be searched but byunchecking the appropriate boxes the search can be confined to sections of yourchoice.
Thirdly, there’s tab labelled ‘BAN’. This allowsBritish Approved Names 1999 to be searched in exactly the sameway as the pharmacopoeial texts.
Now let’s take a look at the PDF view. This uses Adobe Acrobat™ as itsfoundation. The following views assume the reader is using Acrobat Reader4.0x. Click the PDF tab.The data has been structured into the 11 sections shown.
NoteThe slides that follow contain screenshots taken from the full version ofAcrobat 4.0. Not all the icons showing in the toolbars will be available inthe version of Acrobat Reader 4.0 supplied with the CD. They may also bein a different location.
Click on ‘Acacia to Liothyronine Sodium’.This brings up the first screenful of this range of monographs.Down the left side of the screen you see a bookmark list that allows you to navigatequickly to the monograph of interest
There are several zoom-in option buttons on the tool bar to aidlegibility.
There are conventional navigation buttons to pass toNext, Previous, First and Last page in the current set.
Text can be selected. Click the text icon on the tool bar. Thecursor changes to an I-bar when text can be selected by draggingin the usual way.
To select a graphic click and hold the Text icon and choose the Graphic selecttool from the fly-out selection. The cursor changes to cross-hairs. Drag acrossany graphic (includes tables and equations) to select it. It can now be copiedand pasted into most applications.
To search in PDF view, you must ensure the Index is loaded. Goto Edit>Search>Select indexes….
…ensure the ‘BP’ index box is checked, and click OK.
If ‘BP 2000 Index’ is not shown, click the ‘Add’ button,navigate to the Index folder and open the file‘BP Index.pdx’.
Now the Search button on the tool bar becomes live (it’s thesmaller of the 2 binoculars icons - the one with text behind).Click this button.
This brings up a somewhat primitive search dialogue:‘Match Case’ and ‘Proximity’ are self-explanatory but ‘Word Stemming’,Sounds Like’ and ‘Thesaurus’ are just beyond the scope of this demo.
Acrobat assumes the user knows about Boolean operators anddoes not provide any prompts towards their use in this dialogue.To find, for example, all uses of potassium bromide R and potassiumchloride R in infrared spectroscopy key the criteria in thefollowing way: Then click the Search button.
To show the hit-list click the hit-list button on the tool bar. Sincethe Acrobat version has not been fully indexed the hit-list simplytells you in which sections shown in the title screen a hit occurs.To view the text containing the first hit click ‘View’.
To scroll from hit-to-hit, click the Next and Previous hit scrollbuttons.
At all times, to get back to the title screen to begin browsing anew section of the BP, click the British Pharmacopoeia 2000button on the taskbar.
This completes this demonstration of BP 2000 on CD-ROM.To recap: The Index+ view provides a very powerful search facility. The PDF view gives an accurate, single-column representation of the text of the book from which the user can use to browse the publication. Together, these 2 views provide the user with the tools to explore the British Pharmacopoeia 2000 (which includes all the data from the 3rd Edition of the European Pharmacopoeia up to and including Supplement 2000), the BP (Veterinary) 2000 and British Approved Names 1999 to the fullest extent.