Private and ConfidentialMiHealth ForumBarcelona, SpainMay 2012 Neuroelectrics Barcelona S.L. “Living Science” Ana Maiques Chief Executive Officer
How can we make a difference in…Chronic Neuropathic Pain Post Stroke Rehabilitation• Common chronic pain: • Type of disabilities: • back (55%), • motor control • joint pain (46%) • sensory disturbances • neck pain (34%). • aphasia• 27% of individuals suffered in silence without seeking medical • problems with thinking and memory assistance, from which 38% were in daily pain.• High % intolerance and refractory to pain medication. • emotional disturbances • Highest effectiveness during the first year post event.Yearly incidence rate: ~10M patients Yearly incidence rate: ~400K patientsBurden on Society: Burden on Society: €300 bn (~1.5-3% GDP) €26 bn (~0.2% GDP) $635 bn (~4% GDP) $43 bn (~0.3% GDP) 2
Potential applications ofTranscrainial Direct Current Stimulation (tDCS) Definition: tDCS is a form of neurostimulation which uses constant, low current delivered directly to the brain area of interest via small electrodes. When these electrodes are placed in the region of interest, the current induces intracerebral current flow, which can either increase or decrease the neuronal excitability in the specific area in order to alter brain functioning. Possible applications tDCS-related clinical studies published per annum (Pubmed) • ALS (Amytrophic Lateral Sclerosis) • Alzheimer’s disease • Ataxia140 262 • Eating disorders, alcohol abuse, craving or deception 123 studies • Epilepsy120 in less • Migraine100 than 3 • Motor cortex / Stroke years • Movement disorders 80 70 69 • Pain / Fibromyalgia 60 Total: • Parkinson’s disease 50 402 • Psychological disorders (depression or anxiety) 40 26 studies • Tinnitus 22 20 16 • Working memory and language 8 10 2 3 3 • Visual cortex / Parietal cortex 0 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 4
StarStim– Wireless tDCS Neuro-StimulatorAbout usWe are an IT medical device provider specializing in non-invasiveneuromodulation and electrophysiology reading (EEG).Our technologyDefinition: TRANSCRANIAL DIRECT CURRENT STIMULATION (tDCS) isapplying low electrical currents through minimum two electrodes, anode and cathode. A non-invasive neuro-stimulation.Product Features Regulatory approvals Easy to use • CE mark : May, 2012 • Medical device manufacturing High-resolution non-invasive stimulation license (ISO 13485) Physiological feedback and recording Efficacy of tDCS (EEG) • 30 Pain studies with statistically significant improvement in pain levels vs. control arm. • 41 post-Stroke studies conducted to date with statistically significant improvement in rehab vs. Precise & repeatable electrode placement control arm. • All studies were conducted with competitor devices.
StarStim presents a: Treatment Innovation & Business Model Innovation LEGEND Physic flow Monetary flow Channel: InternetChannel: Physical visit Prescribes Home StarStim CLINIC/HOSPITAL PATIENT Attendance - Supervision PAIN AND STROKE REHABILITATION DEPARTMENTS Channel: Internet 6
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