FDA warns against“Sex Plus”P.Naina MohamedPharmacologist
IntroductionThe Food and Drug Administration (FDA) isadvising consumers not to purchase oruse “Sex Plus,” a product promot...
Possible Mechanism of ActionSex PlusContains undeclared sildenafil, tadalafil, sulfosildenafil anddimethylacetildenafilInh...
Interaction with NitratesUndeclared ingredients(sildenafil, tadalafil, sulfosildenafil anddimethylacetildenafil)Interact w...
Other InteractionsUndeclared ingredients(sildenafil, tadalafil, sulfosildenafil anddimethylacetildenafil)Interacts with Al...
ConclusionFDA warns the Consumers should stop using this productimmediately and throw it away.FDA advises the Consumers wh...
References http://www.fda.gov/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSafely/MedicationHealthFraud/ucm349414.h...
References http://www.nlm.nih.gov/medlineplus/druginfo/meds/a604008.html http://www.rxlist.com/cialis-tadalafil/drug-2.h...
Upcoming SlideShare
Loading in …5
×

FDA warns against Sex plus

56,213 views

Published on

FDA gave warning against the use of Sex plus containing sildenafil and tadalafil which interact with nitrates and reduces blood pressure in dangerous levels, on 25th April 2013.

Published in: Health & Medicine, Business
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
56,213
On SlideShare
0
From Embeds
0
Number of Embeds
4
Actions
Shares
0
Downloads
2
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

FDA warns against Sex plus

  1. 1. FDA warns against“Sex Plus”P.Naina MohamedPharmacologist
  2. 2. IntroductionThe Food and Drug Administration (FDA) isadvising consumers not to purchase oruse “Sex Plus,” a product promoted andsold for sexual enhancement on variouswebsites and in some retail stores on 25thApril 2013.FDA laboratory analysis confirmed that “SexPlus” contains undeclared sildenafil,tadalafil, sulfosildenafil anddimethylacetildenafil.
  3. 3. Possible Mechanism of ActionSex PlusContains undeclared sildenafil, tadalafil, sulfosildenafil anddimethylacetildenafilInhibition of Phosphodiesterase 5 (PDE 5)Inhibition of Breakdown of cGMPIncrease the concentration of cGMP in smooth muscle of corpuscavernosum and penile arteriesSmooth muscle relaxationIncrease the blood flow to corpus cavernosumPenile Erection
  4. 4. Interaction with NitratesUndeclared ingredients(sildenafil, tadalafil, sulfosildenafil anddimethylacetildenafil)Interact with prescription drugs like nitrates(Nitroglycerin)Excessive dilation of smooth muscle of blood vesselsLower blood pressure to dangerous levelsHypotensionHeart Attack
  5. 5. Other InteractionsUndeclared ingredients(sildenafil, tadalafil, sulfosildenafil anddimethylacetildenafil)Interacts with Alpha adrenergic blockers, otherantihypertensives or CYP3A4 enzyme inhibitorslike Ketoconazole, Erythromycin, RitonavirLower blood pressure to dangerous levelsHypotension
  6. 6. ConclusionFDA warns the Consumers should stop using this productimmediately and throw it away.FDA advises the Consumers who have experienced any negativeside effects should consult a health care professional as soonas possible.FDA announces to the public of a growing trend of dietarysupplements or conventional foods with hidden drugs andchemicals. These products are typically promoted for sexualenhancement, weight loss, and body building, and are oftenrepresented as being “all natural.”FDA claims that they are unable to test and identify all productsmarketed as dietary supplements on the market that havepotentially harmful hidden ingredients.FDA advises the Consumers to exercise caution before purchasingany product in the above categories.
  7. 7. References http://www.fda.gov/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSafely/MedicationHealthFraud/ucm349414.htm Goodman & Gilmans The Pharmacological Basis ofTherapeutics, 12eLaurence L. Brunton, Bruce A. Chabner, Björn C. Knollmann Harrisons OnlineFeaturing the complete contents of Harrisons Principles ofInternal Medicine, 18eDan L. Longo, Anthony S. Fauci, Dennis L. Kasper, Stephen L.Hauser, J. Larry Jameson, Joseph Loscalzo, Eds. Hursts The Heart, 13eValentin Fuster, Richard A. Walsh, Robert A. Harrington Basic & Clinical Pharmacology, 12eBertram G. Katzung, Susan B. Masters, Anthony J. Trevor Clinicians Pocket Reference, 11eLeonard G. Gomella, Steven A. Haist
  8. 8. References http://www.nlm.nih.gov/medlineplus/druginfo/meds/a604008.html http://www.rxlist.com/cialis-tadalafil/drug-2.htm http://www.medicinenet.com/tadalafil/article.htm http://www.drugs.com/tadalafil.html

×