The Standards Landscape

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Slide deck prepared by Suzanne Sansone to support breakout discussion during the Pistoia Alliance Information Ecosystem Workshop in October 2011

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The Standards Landscape

  1. 1. AM 5: The Standards Landscape (Susanna Sansone)1 David Klatte2 Ingrid Schmid3 Jesus Del Valle4 Parthiban Srinivasan5 Paul Bradley6 Peter Boogard8. Joseph Donahue9 Susanna SansoneTypes of standards- Terminologies- File format (combined with the terminology),- Minimal requirements (also called referred to as ‘business rules’ whencontracting out a CROs certain defining what information/level of details areexpected back)Standards as enablers:- enterprise search, find info within an organization;- data federation, link data across disparate resource;- data entry/curation, identify and record unambiguously the information;- data storage and reuse.…etc…
  2. 2. Unhelpful wealth of ‘standards’- A consequent mountain of technical frameworks needed to achieve datainteroperability; a laborious (and often ambiguous) cross-referencing/mappingexercises;, done internally;- Lots of time spent in “plumbing”;- Gaps and overlaps in coverage; different methods, practices and protocols usedto build them.E.g. Varity of tests’ results - small molecules- animal models- clinical samples (CDISC is not sufficient)- cell lines- new types of data (e.g. omics)- biological networks=> received in a variety of formats from different sources, mapped to an ‘internalstandard’; but ideally those should be mapped to a set of common standards
  3. 3. Biological network space – example of domain:- BioPax http://co.mbine.org/ (community-driven standards: format+ontology)- BEL http://belframework.org (Selventa-driven in response to BioPax being toocumbersome but also missing information/elements)Potential roles for Pistoia1. A common catalogue, with selected, rubber-stamped standards (extractedfrom a raw lists, created collaboratively) - to proactively monitor the changing standards landscape: monitor usability (pragmatism), maturity, coverage - to (ultimately) facilitate wide adoption, by pharmas, vendors, KM providers and academia2. Stimulating interactions (informed by 1) - Proactive role for Pistoia (via WG? VSI extending its scope?) - Identify low hanging fruits (e.g. BEL and BioPax)

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