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Pistoia 2011 Annual General Meeting


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Presentation delivered at the annual general meeting of Pistoia members. Describes the results of board member elections, the state of the Alliance's project portfolio, progress over the past year, and insights from new member Constellation Technologies about why they joined the Alliance.

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Pistoia 2011 Annual General Meeting

  1. 1. September 2011<br />The Pistoia AllianceAnnual General Meeting - 2011<br />
  2. 2. 2<br />Welcome<br />
  3. 3. 3<br />
  4. 4. Please mute your line unless you want to ask a question<br />
  5. 5. September 2011<br />The Pistoia AllianceMinutes of 2010 AGM<br />
  6. 6. Actions from 2010 Minutes<br />Action Items:<br />The board will work with the Operational Team to flesh out other ideas, and will talk reach out to the wider network to further explore these ideas. <br />Ashley to work with the people who proposed these projects to develop PowerPoint presentations that can be used to solicit input from board members to gauge interest. <br />6<br />
  7. 7. September 2011<br />The Pistoia AllianceBoard and Membership Update<br />
  8. 8. Core Board Member Change<br />10 Core companies<br />Bi-Annual rotation process<br />AstraZeneca, BMS, GSK, Lundbeck, Pfizer, Roche agreed to continue<br />1 Seat Vacant as Novartis kindly agreed to step down and<br />1 Candidate – Merck & Co<br />             <br />Decision:<br />Merck & Co are duly elected to Pistoia Alliance board until 2013 AGM.<br />8<br />
  9. 9. Participating Board Member Vote<br />Annual Rotation Process<br />14 Participating companies<br />6 Seats vacant (Infosys stepped down and normal rotation process)<br />7 candidates – we thank them all for standing<br />Candidates:<br />Frank Brown VP and CSO Accelrys<br />Joe Donahue  Senior Vice President, Global Sales at Thomson Reuters Life Sciences <br />Alex Drijver, CEO, ChemAxon<br />Sean Eakins, Collaborations Director, Collaborative Drug Discovery<br />Nicholas Lakin, Cognizant<br />Alex Scheer, Director, Informatics & Knowledge Management, Merck Serono<br />Michael Stapleton , General Manager, Informatics at PerkinElmer                <br />Decision: Frank, Joe, Alex D, Sean, Alex S, and Michael are duly elected to Pistoia Alliance board until 2012 AGM.<br />9<br />
  10. 10. Pistoia Governance<br />Ramesh Durvasula BMS<br />Alex DrijverChemAxon<br />Frank Brown Accelrys<br />Claus Stie KallesøeLundbeck<br />Bryn Roberts F. Hoffmann-La Roche<br />Alexander ScheerMerck Serono<br />Joe Donahue Thomson Reuters<br />Tom Flores GlaxoSmithKline<br />ChristophBrockel Pfizer<br />Jason Swift AstraZeneca<br />Ingrid AkerblomMerck & Co<br />Sean EakinsCDD<br />Michael StapletonPerkinElmer<br />BoD<br />Operational Team<br />Technical Committee Chair<br />Michael Braxenthaler Roche External Liaison<br />Ashley GeorgeGlaxoSmithKline Treasurer<br />John Wise Executive Director<br />Nick Lynch AstraZeneca President<br />Deborah Ausman Communications<br />Martyn Wilkins Company Secretary<br />Vacant <br />Supported by Working Group Chairs and Operational Team<br />Thanks to Pierre Menard for all his contributions to Pistoia as Technical Committee Chair<br />10<br />
  11. 11. Pistoia Alliance Membership<br />Sept 2011<br />
  12. 12. Member Summary<br />55 members<br />Targets for 2011/2012:<br /><ul><li>Biotechs & Life Science companies
  13. 13. Academics/NGOs
  14. 14. CROs
  15. 15. Wider Geographic coverage (Asia etc)</li></ul>Can you help with member recruitment?<br />12<br />
  16. 16. September 2011<br />The Pistoia AllianceProject Portfolio Review<br />
  17. 17. Sequence Services Phase 1<br />Status: <br /><ul><li>Phase 1 achieved
  18. 18. Phase 2 commenced</li></ul>Project lead: Simon Thornber GSK<br />Objective<br /><ul><li>Define standards for the provision of secure access to pre-competitive, shared, hosted, gene sequence databases and software tools.</li></ul>Timeline & Funding<br /><ul><li>£200,000
  19. 19. end April 2011</li></ul>Deliverables<br /><ul><li>Working prototype implementations demonstrated at the Pistoia Alliance User Conference April 2011
  20. 20. Phase 2 launched.
  21. 21. RFP published with enhanced user requirements including addressing NGS data.
  22. 22. RFP responses expected 23-Sep-11
  23. 23. Phase 2 PoC demonstrations at PA User Conference – April 2012</li></ul>Next steps<br />
  24. 24. Sequence Squeeze<br />Status: <br /><ul><li>On track</li></ul>Project lead: Simon Thornber GSK<br />Objective<br /><ul><li>Find a new algorithm/technique for compressing next-generation
  25. 25. sequencing data for use in the Sequenced Services project
  26. 26. £12,000 + VAT @ 20% to manage the prize
  27. 27. $15,000 prize money
  28. 28. April 2011 (ready for announcement at the Pistoia Alliance Users Conference)</li></ul>Timeline & Funding<br />Deliverables<br /><ul><li>Establish competition website:
  29. 29. Establish a judging panel
  30. 30. State-of-the-art gene sequence data compression tool
  31. 31. Project launch – start Q4 2011
  32. 32. Entries close end Q1 2012
  33. 33. Winners to be announced at the Pistoia Alliance Annual Conference on April 2012.</li></ul>Next steps<br />
  34. 34. SESL Phase 1<br />Status: <br /><ul><li>Phase 1 completion delayed
  35. 35. Phase 2 terminated</li></ul>Project Lead: Ian Harrow, (Pfizer), Wendy Filsell, Unilever<br />Objective<br /><ul><li>Provide a ‘push model’ for end-user access to biomedical knowledge stored in both published literature and biological database content. </li></ul>Timeline & Funding<br /><ul><li>£200,000
  36. 36. end June 2011</li></ul>Deliverables<br /><ul><li>A publicly accessible demonstrator
  37. 37. Two publications submitted end Q3 2011
  38. 38. Terminate project.
  39. 39. Complete demonstrator implementation
  40. 40. Submit publications
  41. 41. Transfer learnings to IMI Open PHACTS project</li></ul>Next steps<br />
  42. 42. ELN<br />Status: <br /><ul><li>Project terminated after Phase 2</li></ul>Project Lead: Richard Bolton<br />Objective<br /><ul><li>Provide a query standard to enable chemists to share information between – and to conduct searches across – different brands of ELNs without learning a plethora of search languages.</li></ul>Timeline & Funding<br /><ul><li>Phase 2 costs: $12,500
  43. 43. Phase 2 completed </li></ul>Deliverables<br /><ul><li>Identified and documented use cases
  44. 44. Elaborated an XML-based query standard – ready for testing
  45. 45. Find resource to write and publish a paper highlighting the opportunities and challenges of ELN Query standards.</li></ul>Next steps<br />
  46. 46. VSI<br />Status: <br /><ul><li>Phase 1 complete
  47. 47. Phase 2 waiting for resources</li></ul>Project Lead: Lee Harland (Pfizer), Ian Dix (AZ)<br /><ul><li>Provide a focus for vocabulary creators /consumers including publishers / Academia /Pharma and SMEs
  48. 48. Identify gaps in life sciences vocabulary standards space
  49. 49. Stimulate co-ordinated generation of new vocabularies in precompetitive space</li></ul>Objective<br />Timeline & Funding<br /><ul><li>December 2009 to June 2011</li></ul>Deliverables<br /><ul><li>Paper submitted to and accepted by Drug Discovery Today – June 2011
  50. 50. Identify and seek funding from interested parties to recruit a qualified consultancy to review vocabulary activities in the Life Sciences R&D domain.
  51. 51. Identify leaders across companies to maintain momentum
  52. 52. Identify areas for further vocabulary development, either specific initiatives, or as elements of other Pistoia activities
  53. 53. Assign priority to those areas</li></ul>Next steps<br />
  54. 54. (1) Recent Accomplishments<br />(3) Issues / Discussion Points<br />Sequence Services Phase II<br /><ul><li>RFP signed-off - available on PA public-domain web-site
  55. 55. RFP launch meeting completed: 22-Jul-11
  56. 56. Project Analyst – new contract agreed and signed : 29-Jul-11</li></ul>Sequence Squeeze<br /><ul><li>Gene Sequence Compression Prize – project named!
  57. 57. Appropriately qualified company appointed to run the prize
  58. 58. Contract signed</li></ul>SESL<br /><ul><li>Main papers in production – outlines concluded mid-July 2011</li></ul>VSI MDT Phase I<br /><ul><li>Paper accepted for publication (subject to changes) in “Drug Discovery Today” 28-Jun-11
  59. 59. Reviewer comments addressed 21-Jul-11</li></ul>Project Portfolio Questionnaire<br /><ul><li>Circulated end June 2011
  60. 60. Used at the 3rd Annual Lab Data Mgmt. Conf. London – June-11
  61. 61. 22 Responses collated and available in basecamp</li></ul>Information Ecosystem Workshop<br /><ul><li>Kick-off planning meeting Thursday 7-Jul-11
  62. 62. Draft agenda created
  63. 63. Delegates workshop planning meeting arranged 23-Aug-11</li></ul>Sequence Services Phase II<br /><ul><li>Project Analyst support is required going forward</li></ul>Sequence Squeeze<br /><ul><li>Awaiting kick-off meeting</li></ul>SESL<br /><ul><li>Develop relationship with IMI OpenPHACTS project?</li></ul>ELN – Project close<br /><ul><li>Resource for writing up ELN project</li></ul>VSI MDT Phase II<br /><ul><li>Resource required - Phase II consultant</li></ul>Project Portfolio Questionnaire<br /><ul><li>21 responses received – much follow-up required</li></ul>Information Ecosystem Workshop<br /><ul><li> 18 delegate places already signed up</li></ul>(4) Planned Activities<br />Sequence Services Phase II (NGS)<br /><ul><li>RFP response deadline: 23-Sep-11</li></ul>Sequence Squeeze<br /><ul><li>Compression Algorithm prize to be launched 1-Oct-11</li></ul>SESL<br /><ul><li>Main papers to be submitted by end Q3 2011
  64. 64. Demonstrator to be available by end Aug 2011
  65. 65. Article for autumn edition of the newsletter</li></ul>VSI MDT Phase II<br /><ul><li>Funding for consultant to provide background for business case
  66. 66. Generate and distribute RFP to qualified consultancies</li></ul>ELN<br /><ul><li>Publish the ELN project as a living document e.g. Source Forge</li></ul>Information Ecosystem Workshop<br /><ul><li>Monday 10-Oct-11 in Hanover, Germany </li></ul>(2) FY 11 - Projects in Development<br />
  67. 67. Reflections on Progress<br />
  68. 68. Pistoia Alliance Project Teams - Reflections<br />Slide 21<br />
  69. 69. Pistoia Alliance Publications <br />“The Pistoia Alliance - The Sequence Services Project” - Simon Thornber et al. - G.I.T. Laboratory Journal 1-2/2011<br />“Need for Collaborative Technologies in Drug Discovery” - Chris L. Waller et al. Book Chapter in “Collaborative Computational Technologies for Biomedical Research” – Edited by Sean Ekins et al. Wiley May 2011<br />“What are the obstacles to innovation in the Pharmaceutical Industry? The Pistoia Alliance responds” – The Pistoia Alliance – Drug Discovery World <br />“Empowering Industrial Research With Shared Biomedical Vocabularies” – Lee Harland et al - Drug Discovery Today in press<br />“ELNs - An Essential Productivity Tool – But Which One to Use” – John Wise - European Pharmaceutical Review - Issue 4, 2011<br />22<br />
  70. 70. September 2011<br />The Pistoia AllianceProject Portfolio Questionnaire Analysis<br />
  71. 71. Project Portfolio Questionnaire – Summary<br />
  72. 72. Open Question - 9<br />
  73. 73. September 2011<br />The Pistoia AllianceInformation Ecosystem Workshop (IES)<br />Overview<br />
  74. 74. IES Workshop: Logistics<br />
  75. 75. Agenda and Deliverables Outline<br />Morning session:<br />What is the IES? <br />Develop common understanding on what the IES should deliver (use cases)<br />Afternoon session:<br />How do we get there? <br />Develop a roadmap of projects and activities<br />White Paper:<br />The Key Concepts <br />of the Information Ecosystem<br />IES Roadmap:<br />Projects and<br />Follow-up activities<br />More info at<br />
  76. 76. September 2011<br />The Pistoia AllianceViews of a new member<br />
  77. 77. “Thoughts of a new member of the Pistoia Alliance”<br />Presentation to the Pistoia Alliance AGM<br />Nick Trigg, CEO <br />Constellation Technologies<br />13th Sept 2011<br />30<br />
  78. 78. Constellation Technologies<br />Involvement with Pistoia <br />contributing supplier since 2010<br />paid up “Participating” member since 2011<br />“Technology provider”<br />Technology provider with technology from CERN and UK particle physics programme specialising in providing “big data and bioinformatics” expertise to industrial customers.<br />Looking for partners with which to develop next generation products for bioinformatics<br />Delivered solution to Pistoia “Sequence Services Phase 1”<br />Partnership with Microsoft and STFC<br />Demonstrated solution at the Pistoia Users Conference, Boston, April 2011<br />31<br />
  79. 79. Pistoia -An alliance of interested parties <br />Pharmas<br />Large/medium/small<br />Biotechs<br />Academic institutions<br />Technology providers<br />Information providers<br />Infrastructure providers<br />32<br />Demand side<br />Supply side<br />
  80. 80. Objectives of Pistoia<br />Fundamentally<br />Make more money!<br />Solve complicated problems better/faster<br />How does it do that?<br />Access to customers/suppliers<br />Access to partners/collaborators<br />Latest thinking/trends<br />Opportunity to influence/direct<br />33<br />
  81. 81. How to increase value for members<br />More in = more out<br />Keep it relevant<br />Maintain momentum with innovative projects<br />Work efficiently<br />Same time as other events/Teleconferencing<br />Raise additional funding for projects from other sources<br />Government etc<br />34<br />
  82. 82. How to attract new members<br />It is unique<br />Added value of a special interest “club”<br />More customers or suppliers than normally possible<br />Leverage of everything<br />Money, ideas, technologies, etc<br />35<br />
  83. 83. Summary<br />Recognise that Pistoia is probably unique in the world<br />Keep it going!<br />Realise “failures” are not all bad<br />Manage back into your organisations<br />Don’t let it die slowly through expectation that it will die slowly<br />36<br />
  84. 84. September 2011<br />The Pistoia AllianceSummary<br />
  85. 85.
  86. 86. Thanks for your engagement in the coming year!<br />39<br />