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Implementing Blockchain applications in healthcare

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Blockchain technology can revolutionise the way information is exchanged between parties by bringing an unprecedented level of security and trust to these transactions. The technology is finding its way into multiple use cases but we are yet to see full adoption and real-world business implementation in the Healthcare industry.
In this webinar we will explore the main challenges and considerations for the implementation of Blockchain technology in Healthcare use cases. This is the third webinar in our Blockchain Education series.

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Implementing Blockchain applications in healthcare

  1. 1. 11 October, 2019 IMPLEMENTING BLOCKCHAIN APPLICATIONS IN HEALTHCARE Speakers: • Richard Shute, Consultant, Curlew Research • Benoît Marchal, Senior IT Project Manager, Roche • Sebastian Coates, CEO & Co-founder, Immuto • Robert Chu, Founder, Embleema Moderator: Richard Norman, Project Manager, Pistoia Alliance Blockchain Initiative
  2. 2. This webinar is being recorded
  3. 3. Speakers
  4. 4. ©PistoiaAlliance Introduction to the speakers Pistoia Alliance Blockchain Community of Interest Webinar: Implementing blockchain applications in Healthcare 411 October, 2019 Richard Shute Consultant, Curlew Research •IS/IT/Ix strategic business relationship, account and portfolio manager; medicinal chemist; blockchain blogger. •Has presented extensively on the role of blockchain tech in life sciences. •Was project manager for the Pistoia Alliance work on “Blockchain Applications to Life Sciences R&D” from March-December 2018. Benoît Marchal Senior IT Project Manager, Roche •15 years IT project management at Roche to support Pharma Development. •Project Owner of the blockchain project PEPS. •Roche lead in IMI industry collaboration EHR4CR. •Founder of NovaXon. Sebastian Coates CEO & Co-founder, Immuto •Background in Computer Science & Mathematics from Tufts and Oxford Universities. •Worked on blockchain projects at Bank of America and Vertex Pharmaceuticals. •Focus on making it easy to build scalable blockchain-based applications. Robert Chu Founder, Embleema •Founded Embleema in 2017 •Distinguished career at IBM and IMS Health (now IQVIA). •At IQVIA he was Senior VP Global Technology Solutions, responsible for USD 800M, delivering SaaS real world data solutions for the Healthcare and Life Sciences industries globally.
  5. 5. ©PistoiaAlliance Poll Question 1 511 October, 2019 What is your familiarity with blockchain? A. I am using blockchain B. I am experimenting with blockchain C. I am aware of blockchain D. I know next to nothing about blockchain Pistoia Alliance Blockchain Community of Interest Webinar: Implementing blockchain applications in Healthcare
  6. 6. ©PistoiaAlliance Poll Question 2 611 October, 2019 What is your organisations’ familiarity with blockchain? A. Actively using blockchain B. Experimenting with blockchain C. Aware of blockchain D. Not sure about my organisation Pistoia Alliance Blockchain Community of Interest Webinar: Implementing blockchain applications in Healthcare
  7. 7. ©PistoiaAlliance Poll Question 3 711 October, 2019 In your opinion, what will be the main future application of blockchain in Healthcare? A. Enhancing secure sharing of patient data B. Enhancing monetisation of patient data C. Securing drug supply chains D. Enhancing patient consent management in clinical trials Pistoia Alliance Blockchain Community of Interest Webinar: Implementing blockchain applications in Healthcare
  8. 8. Implementing Blockchain Applications in Healthcare: An Introduction Richard Shute Curlew Research www.curlewresearch.com
  9. 9. ©PistoiaAlliance • What is Blockchain and Distributed Ledger Technology (DLT)? (briefly!) • Why Blockchain vs. other technologies? – What are the benefits of, and how does DLT differ from other databasing technologies? • How is blockchain tech being used in Healthcare now and in the future? – the key use cases • How can we demonstrate and measure the value of Blockchain? – The big challenge! Posing questions – but not necessarily providing answers!
  10. 10. ©PistoiaAlliance • What is Blockchain and Distributed Ledger Technology (DLT)? (briefly!) • Why Blockchain vs. other technologies? – What are the benefits of, and how does DLT differ from other databasing technologies? • How is blockchain tech being used in Healthcare now and in the future? – the key use cases • How can we demonstrate and measure the value of Blockchain? – The big challenge! Posing questions – but not necessarily providing answers! NB: I tend to use the term “DLT” synonymously with “blockchain tech”. Strictly speaking this is incorrect!* * https://medium.com/nakamo-to/whats-the- difference-between-blockchain-and-dlt- e4b9312c75dd 11 October, 2019 Pistoia Alliance Blockchain Community of Interest Webinar: Implementing blockchain applications in Healthcare
  11. 11. ©PistoiaAlliance So what is “blockchain” technology? What is blockchain? https://www.youtube.com/watch?v=3xGLc-zz9cA How does a blockchain work? https://www.youtube.com/watch?v=SSo_EIwHSd4 11 October, 2019 Pistoia Alliance Blockchain Community of Interest Webinar: Implementing blockchain applications in Healthcare
  12. 12. ©PistoiaAlliance A blockchain is ... in short • DISTRIBUTED • VISIBLE, OPEN & TRANSPARENT • CONSENSUS • IMMUTABLE • AUDITABLE “... a digital, distributed transaction ledger, with identical copies maintained on multiple computer systems controlled by different entities. • Anyone participating in a blockchain can review the entries in it. • Users can update the blockchain only by consensus of a majority of participants • Once entered into a blockchain, information can never be erased • Ideally, a blockchain contains an accurate and verifiable record of every transaction ever made.” http://deloitte.wsj.com/cfo/2016/02/26/beyond-bitcoin-blockchain-is-coming-to-disrupt-your-industry-weekend-reading/
  13. 13. ©PistoiaAlliance What is a blockchain not?
  14. 14. ©PistoiaAlliance Why DLT and not a more traditional databasing technology? http://www.multichain.com/blog/2016/03/blockchains-vs-centralized-databases/
  15. 15. ©PistoiaAlliance Disintermediation Transaction Mgmt Confidentiality Performance https://www.enterprisetimes.co.uk/2018/12/28/high-performance-blockchain-and-blockchain-tools- 2018-and-2019/ Distributed vs Centralized Blockchain Traditional Tech Database
  16. 16. ©PistoiaAlliance Consensus Building Methods Openness versus Performance
  17. 17. ©PistoiaAlliance What are the current and future key use-cases for blockchain tech in healthcare? Halamka, J.D. et al (2019), Blockchain in Healthcare Today, Volume 2 https://blockchainhealthcaretoday.com/index.php/journal/article/view/106/111
  18. 18. ©PistoiaAlliance Blockchain Use-Cases in Healthcare
  19. 19. ©PistoiaAlliance • What is Blockchain and Distributed Ledger Technology (DLT)? (briefly!) • Why Blockchain vs. other technologies? – What are the benefits of, and how does DLT differ from other databasing technologies? • How is blockchain tech being used in Healthcare now and in the future? – the key use cases • How can we demonstrate and measure the value of Blockchain? – The big challenge! Posing questions – but not necessarily providing answers!
  20. 20. ©PistoiaAlliance Blockchain tech’s high level value Transparency All blockchain participants are able to view data added to the chain, while the chain improves data integrity by being the single source of truth Auditability/ Immutability Blockchain data is immutable and everlasting, creating an exhaustive means of record keeping Trust Blockchain’s connected data blocks, and distributed validation structure establish trust between participants without them having to know one another Disintermediation By enabling transparency and trust, the blockchain can fulfil the roles that intermediaries traditionally provide
  21. 21. ©PistoiaAlliance Blockchain tech’s high level value Transparency All blockchain participants are able to view data added to the chain, while the chain improves data integrity by being the single source of truth Auditability/ Immutability Blockchain data is immutable and everlasting, creating an exhaustive means of record keeping Trust Blockchain’s connected data blocks, and distributed validation structure establish trust between participants without them having to know one another Disintermediation By enabling transparency and trust, the blockchain can fulfil the roles that intermediaries traditionally provide
  22. 22. ©PistoiaAlliance From 2016: https://www.coindesk.com/blockchain-innovation-trust-money
  23. 23. ©PistoiaAlliance Poll Question 4 23 In your opinion, what is stalling blockchain adoption? A. Cost B. Lack of relevant skills C. Lack of upper management buy-in D. Regulatory/Audit/Compliance/Governance concerns and demands E. Unsure how to start 11 October, 2019 Pistoia Alliance Blockchain Community of Interest Webinar: Implementing blockchain applications in Healthcare
  24. 24. Patient Empowered, Privacy Secured (PEPS) project Benoît Marchal Roche
  25. 25. ©PistoiaAlliance Disclaimer 2511 October, 2019 • The views and opinion expressed in this presentation are solely those of the presenter and do not represent an official statement from Roche or its affiliates. • These slides are not intended for wider distribution outside the intended purpose without presenter approval. • The content of this slide deck is accurate to the best of the presenter’s knowledge at the time of production. • Mention of companies, services or tools is purely illustrative and does not imply endorsement. • The presentation does not contain any proprietary brand / specific disease state related information and information contained herein is illustrative only.
  26. 26. ©PistoiaAlliance Sharing data, yes but not all I want to know what my data is used for I really do not want my employer or my bank to know about my condition I want to help research, if it does not help me it will help somebody else I would like to be asked Patient Empowered Privacy Protected The simplest is often to INFORM & ASK patients PEPS Project: IT Sponsor: XXX Business Sponsor: YYYY PEPS Solution Through Data Use Transparency Build Patient Trust
  27. 27. ©PistoiaAlliance Data linkage and patient privacy: The impossible balance New Discovery Privacy “Methods will need to be developed to address duplication of patient information in different data sources and to enable linking data about a single patient across data sources while protecting patient privacy” Framework for FDA’s Real-World Evidence Program – Dec 2018
  28. 28. ©PistoiaAlliance Why a Blockchain solution? ● Modern? ● Secure? ● Open source? ● Trust without central authority?
  29. 29. ©PistoiaAlliance Why a Blockchain solution? ● Modern ● Secure ● Open source ● Trust without central authority Fake ID Real ID jsK85hGF98 Marcel Dupont uiZT8FV6cg Peter Smith
  30. 30. ©PistoiaAlliance Blockchain and Consortium
  31. 31. Implementing blockchain in the Life Sciences Sebastian Coates Immuto sebass@immuto.io
  32. 32. ©PistoiaAlliance Background: • Blockchain POC for tracking patient consent without a CRO. • Built on Quorum blockchain Privacy: • Only stored hashes of data on-chain; sensitive information stored off-chain • Consortium Model Benefits: • Data immutability, time-stamping, authorship verification Đocumen
  33. 33. ©PistoiaAlliance Challenges Faced & Learnings Private vs. Consortium vs. Public • Private chain is just a database • Consortium has difficulty gaining traction • Public network has unpredictable cost Privacy is Paramount • Everything stored on- chain is public, forever • Hashes and electronic signatures allow for verification while preserving data privacy 1 2 Enterprise Value Proposition • Immutability • Tamper-proofing data • Proof of existence / proof of ownership • Robust audit trails 3
  34. 34. ©PistoiaAlliance 01 02 03 Public-Chain Security • Leverages Ethereum Mainnet for true immutability guarantees • Custom scaling solution to support high throughput Privacy-Focused • Only store hashes of data on- chain • Users own their data Easy-to-Integrate • RESTful API with open-source libraries • Data agnostic • Cloud-based infrastructure abstracts complexities Current Work
  35. 35. Implementing blockchain in the Life Sciences Robert Chu Embleema
  36. 36. ©PistoiaAlliance Note: (1) HIVE: High Performance Integrated Virtual Environment ; WHISE: Wellness & Health Information Secure Exchange Simonyan V and Mazumder R. High-performance Integrated Virtual Environment (HIVE) Tools and Applications for Big Data Analysis. Genes, 2014 Sep 30;5(4): 957-981. PMID: 25271953. Simonyan V, Chumakov K, Dingerdissen H, Faison W, Goldweber S, Golikov A, Gulzar N, Karagiannis K, Vinh Nguyen Lam P, Maudru T, Muravitskaja O, Osipova E, Pan Y, Pschenichov A, Rostovtsev A, Santana-Quintero L, Smith K, Thompson EE, Tkachenko V, Torcivia-Rodriguez J, Voskanian A, Wan Q, Wang J, Wu TJ, Wilson C, Mazumder R. High-performance integrated virtual environment (HIVE): a robust infrastructure for next-generation sequence data analysis. Database (Oxford). 2016;2016:baw022. PMID: 26989153. Striped & encrypted data shipped across nodes Interercommunication into distributed architecture, with WHISE hosted by pharma, research & FDA Data collected from patients & ingested in Embleema HIVE RWE Patient Data HIVE1 EMR Genomics PGHD Clinical TrialsProteomics DataIngestionLayer PRO - Marketplace - Patient Data Index - Data Contractual Terms Data ExchangeHIVE Network (WHISE) Patient Consent Data Flow Traceability Stripe Engineering Metadata (SEM) TokensBLOCKCHAIN Real World Data Exchange Platform
  37. 37. ©PistoiaAlliance Striped & encrypted data shipped across nodes Interercommunication into distributed architecture, with WHISE hosted by pharma, research & FDA Data collected from patients & ingested in Embleema HIVE RWE Patient Data HIVE1 EMR Genomics PGHD Clinical TrialsProteomics DataIngestionLayer PRO Data ExchangeHIVE Network (WHISE) Patient Consent Data Flow Traceability Stripe Engineering Metadata (SEM) TokensBLOCKCHAIN Is it Production-Level ? Queuing Transaction Error Handling Security
  38. 38. ©PistoiaAlliance Patient Consent Data Flow Traceability Stripe Engineering Metadata (SEM) TokensBLOCKCHAIN Is it Production-Level ? Queuing Transaction Error Handling Security
  39. 39. ©PistoiaAlliance Striped & encrypted data shipped across nodes Interercommunication into distributed architecture, with WHISE hosted by pharma, research & FDA Data collected from patients & ingested in Embleema HIVE RWE Patient Data HIVE1 EMR Genomics PGHD Clinical TrialsProteomics DataIngestionLayer PRO Data ExchangeHIVE Network (WHISE) Stripe Engineering Metadata (SEM) TokensBLOCKCHAIN Standards and Compliance No PHI HIPAA GDPR
  40. 40. Question and Answer Session
  41. 41. info@pistoiaalliance.org @pistoiaalliance www.pistoiaalliance.org Thank you to our speakers and our audience

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