14. II. Genomic Instability Gene mutation Chromosomal aberration Cell death Mitotic failure-aneuploidy Micronuclei
15. Genomic Instability and 2 nd cancers? … As nearly one in 10 cancer diagnoses are second (or higher) malignancies, it is important to understand the contribution of radiotherapy to second cancer induction and pursue well-coordinated efforts to determine the role of induced genomic instability
21. Bystander-mediated Genomic instability ... 35 y.o. Male. Nuclear power plant accident. Total body neutron dose of 5.4 Gy, plus 8.5–13 Gy γ rays. B lood stem cell transplant from his sister ( HLA identity ). Good initial recovery. Chromosomal damage was then observed in the offspring of the donor (sister) cells, hinting at a bystander effect . Decesased 82 days after the accident due to multi-organ failure .