INTRODUCTION TO AUTONOMIC PHARMACOLOGY Part II - Anatomy of

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INTRODUCTION TO AUTONOMIC PHARMACOLOGY Part II - Anatomy of

  1. 1. INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part II Anatomy of peripheral nervous system
  2. 2. Skeletal Muscle Peripheral Nervous System Somatic Nervous System Autonomic Nervous System Parasympathetic Nervous System Sympathetic Nervous System Selective Activation Diffuse Activation Glands, Smooth Muscle & Cardiac Muscle
  3. 3. Controls skeletal muscle Controls smooth & cardiac muscle & glands Peripheral Nervous System Somatic Nervous System Autonomic Nervous System One Neuron Efferent Limb Two Neuron Efferent Limb
  4. 4. Ach Ach Ach Ach NE Ach EPI/NE Ach Ach Somatic Sympathetic Sympathetic Sympathetic Para- sympathetic Postganglionic Fiber; Adrenergic Postganglionic Fiber; Cholinergic Adrenal Gland Motor Fiber Sweat Glands Smooth Muscle Cardiac Cells Gland Cells Smooth Muscle Cardiac Cells Gland Cells Skeletal Muscle Preganglionic Fiber; Cholinergic Ganglion Ganglion Ganglion
  5. 5. Radial Muscle of Iris Ciliary Muscle SA & AV Nodes His-Purkinje System Myocardium Bronchi/Bronchial Glands Stomach Kidneys Intestines Bladder//Genitalia Sublingual/Submaxillary & Parotid Gland Pilomotor Muscles Sweat Glands Blood Vessels Sympathetic Nervous System (Thoracolumbar Outflow) Paravertebral Ganglia Prevertebral Ganglia
  6. 6. Ventral Root White Ramus Communicans Paravertebral Ganglion Prevertebral Ganglion Gray Ramus Communicans Autonomic Nerve Spinal Nerve
  7. 7. Epinephrine (+) Fatty Acid Release (-) Intestinal Motility (+) Glycogenolysis (+) ACTH & TSH (+) Mental Alertness (+) Muscle Contraction & Efficiency (+) Dilates Airways (+) Cardiac Output ADRENAL MEDULLA Chromaffin Cells
  8. 8. Parasympathetic Nervous System (Craniosacral Outflow) Genitalia Bladder Large Intestines Kidney Bile Ducts Gallbladder Small Intestines Stomach Bronchi/Bronchial Glands SA & AV Node Sphincter Muscle of Iris Ciliary Muscle Lacrimal Gland Submaxillary & Sublingual Glands Parotid Gland
  9. 10. Most organs receive dual sympathetic and parasympathetic innervation. However, some organs only receive sympathetic innervation: Spleen Sweat Glands Piloerector Muscles Most Blood Vessels

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