Adrenocotropic harmone

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Adrenocotropic harmone

  1. 1. ADRENOCOTROPIC HARMONE
  2. 2. <ul><li>It is a 39 amino acid single chain peptide, MW-4500 derived from proopio –melanocortin </li></ul>
  3. 3. Physiological function <ul><li>ACTH promote steroidogenesis in adrenal cortex . </li></ul><ul><li>Stimulate the cAMP formation in cortical cells & increase the availability of cholesterol for conversion into pregnenolone which is arate limiting step in production of mineralo & gluco steroids </li></ul>
  4. 4. <ul><li>it has trophic effect on adrenal cortex </li></ul><ul><li>High doses – hypertrophy & hyperplasia </li></ul><ul><li>Absence of ACTH – adrenal atrophy </li></ul>
  5. 5. Regulation of secretion <ul><li>Hypothalmus regulate ACTH release from pituitary by CRH receptors </li></ul><ul><li>Secretion of ACTH has circadian rhythm </li></ul><ul><li>Stressfull stimuli –pain, anxiety, fair </li></ul><ul><li>ADH enhance the ACTH release </li></ul>
  6. 6. <ul><li>Higher centres </li></ul><ul><li>Hypothalmus </li></ul><ul><li>Ant .pituitary </li></ul><ul><li>ACTH </li></ul><ul><li>Angiotensinogen </li></ul><ul><li>Angiotensin 1 </li></ul><ul><li>Angiotensin 2 </li></ul><ul><li>medulla cortex </li></ul><ul><li>adrenaline aldosterone </li></ul>stress
  7. 7. Pathological function <ul><li>Excess of ACTH – cushing’s syndrome </li></ul><ul><li>Low ACTH – hypocortism </li></ul>
  8. 8. uses <ul><li>For diagnosis of disorder of pituitary adrenal axis </li></ul><ul><li>Not adventagous, inconvinent & expensive </li></ul>

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