This handbook provides a glimpse into the complex world of major e-learning initiatives in post-secondary education and how many institutions are experimenting with what we call "virtual campuses. In particular, the handbook gathers the outcomes and experiences of the Re.ViCa project, which aimed to undertake a systematic and extensive review of virtual campuses in higher education. During the course of the project, we invited experts to relate their stories, experiences, thoughts and concerns; we met and shared our own visions at many international events, and read a great deal during our journey. What we learned and witnessed is without a doubt inspiring, hopeful, complex, and eye catching: the diversity of cultural understanding around a specific topic like virtual campuses, the creativity and range of applications of technology in education, the complex and changing landscape, and above all, the positive spirit of knowledge sharing.