Current Problems in Pediatric and Adolescent Health CareVolume 37, Issue 10, November-December 2007, Pages 374-399 <br />d...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...
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November-December 2007, Pages 374-399 doi:10.1016/j.cppeds.2007.09 ...

  1. 1. Current Problems in Pediatric and Adolescent Health CareVolume 37, Issue 10, November-December 2007, Pages 374-399 <br />doi:10.1016/j.cppeds.2007.09.001 | How to Cite or Link Using DOICopyright © 2007 Mosby, Inc. All rights reserved.   Permissions & Reprints<br />Infant Feeding: Initiation, Problems, Approaches <br />John Nicholas Udall Jr MD, PhDa<br />aDepartment of Pediatrics; WVUHSC-Charleston, Women and Children’s Hospital, Charleston, WV.<br />Available online 28 November 2007. <br />Article Outline<br /> HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "sec1" Section I: Developmental Aspects of Swallowing and Feeding in Infants and Young Children ( <br />http://www.nature.com/gimo/contents/pt1/full/gimo17.html)<br />Incidence and Prevalence of Feeding and Swallowing Disorders in Pediatrics <br />Development of Feeding and Swallowing Skills <br />Prenatal Swallowing and Sucking<br />Infant Feeding and Swallowing<br />Transition Feeding<br />Critical and Sensitive Periods with Implications for Behavioral and Sensory-based Feeding Problems<br />Effects When Oral Feeding Is Not Possible in the Newborn Period<br />Taste and Smell in Oral Feeding of Infants and Young Children <br />Clinical Assessment of Pediatric Swallowing and Feeding Disorders for Primary Care Physicians <br />Principles of Clinical Feeding Evaluation<br />Categories of Causes of Swallowing and Feeding Disorders<br />Caregiver Perceptions of Feeding Problems<br />Interdisciplinary Team Approach<br />Instrumental Examination of Swallowing <br />Management of Feeding and Swallowing Problems in Pediatrics<br />Section II: Gut Motility and Enteral Feeding Tolerance with an Emphasis on Premature Infants<br />Gastrointestinal Motility <br />Esophagus<br />Stomach and Small Intestine<br />Postprandial Small Intestinal Motility<br />Interdigestive Small Intestinal Motility<br />Colon<br />Developmental Aspects <br />Mouth and Esophagus<br />Stomach<br />Small Intestine<br />Feeding Recommendations for Premature Infants<br />Section III: Behavioral Treatment of Feeding Disorders<br />Classification <br />Evaluating Feeding Problems <br />Treatment <br />Appetite Manipulation<br />Behavioral Contingency Techniques<br />Section IV: Feeding Issues in the Disabled Child<br />Magnitude of the Problem <br />Nutritional Needs <br />Inadequate Intake<br />Increased Losses<br />Energy Requirements<br />Assessment <br />Medical History<br />Nutritional History<br />Physical Examination<br />Anthropometrics<br />Laboratory Evaluation<br />Recommendations <br />Other Considerations<br />References<br />The impetus for this issue comes from a Topic Symposium entitled, “Infant Feeding: Initiation, Problems, Approaches” held at the Pediatric Academic Societies meeting in Toronto May 6, 2007. The symposium focused on four aspects of feeding infants and young children. Each aspect was discussed by an authority in the field.<br />One presentation concerned the developmental aspects of swallowing and feeding infants and young children. Another addressed the development of gut motility in the premature infant and its relationship to enteral feeding. The third topic concerned the behavioral treatment of feeding disorders in toddlers and finally, feeding issues related to neurologically impaired children were reviewed.<br />Feeding premature and full-term infants through the first few years of life has become an area of interest and study over the past two decades. The realization that some infants and children are not fed easily or may develop feeding problems resistant to traditional approaches has led to the institution of feeding teams at larger pediatric centers. Hopefully, information presented at the Topic Symposium and contained within this issue will be shared with others as we follow emerging research concerning the optimal feeding of normal infants and children, and those with feeding disorders.<br />Section I: Developmental Aspects of Swallowing and Feeding in Infants and Young Children (http://www.nature.com/gimo/contents/pt1/full/gimo17.html)<br />Adequate respiration and nutrition are essential throughout a lifetime. Breathing usually does not require active effort by infants except for those with complicating factors, for example, bronchopulmonary dysplasia, upper airway obstruction as in Pierre Robin sequence, other craniofacial anomalies, and severe laryngotracheomalacia. Eating, on the other hand, requires active effort by infants who must have exquisite timing and coordination of simultaneous breathing, sucking, and swallowing. Adequate growth, defined by weight gain in early infancy and for the first few years of life, is the primary measure of successful feeding. Breathing, sucking, and swallowing are activities that occur in the upper aerodigestive tract and are orchestrated by cranial nerves and specific areas in the brain. Successful oral feeding requires that children have functional oral sensorimotor and swallowing skills, adequate pulmonary and gastrointestinal function, central nervous system integration, and normal musculoskeletal tone. A breakdown in coordination of swallowing and breathing can result in aspiration. Aspiration may present with coughing and choking, usually during feeding, and is indicative of compromised airway protective reflexes. If laryngotracheal sensation is also affected, aspiration may be silent without overt manifestations.<br />Normal feeding patterns reflect the early developmental pathways that are the basis for later communication skills. The interrelationships between feeding (in all living beings) and complex verbal communication (unique to humans) are multifactorial and in need of continued research. The study of comparative anatomy and its implications for human communication are well described. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib1" 1<br />Professionals who examine and treat infants and children who have feeding and swallowing problems must have a thorough understanding of embryologic and developmental anatomy of the upper aerodigestive tract and the physiology of deglutition. Research in the past 30 years has added to the understanding of the orderly development of feeding and swallowing in utero through infancy.<br />Incidence and Prevalence of Feeding and Swallowing Disorders in Pediatrics<br />Feeding and swallowing disorders are relatively common in early infancy and in some instances may be markers for significant health implications that do not become obvious until later. As many as 35% of infants exhibit food selectivity and refusal, as revealed by parent interviews in general population surveys. Feeding problems are relatively common in various infant populations, including, but not limited to, preterm “at-risk” infants, infants with congenital heart disease following open-heart surgery, infants diagnosed with nonorganic failure to thrive, and children with cerebral palsy (CP). Prevalence rates of dysphagia range from 57 to 92% varying by type of CP. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib2" 2 Children with CP and dysphagia are found to have a higher incidence of undernutrition, growth failure, and poor health than those children without swallowing problems. Children with more severe forms of CP and dysphagia have higher mortality rates than other groups.<br />This review provides an overview of (1) the development of feeding and swallowing skills, including critical/sensitive periods with implications for behavioral and sensory based feeding problems; (2) taste and smell, and their impact on oral feeding; (3) clinical assessment; (4) instrumental examination of pediatric swallowing disorders; and (5) management of pediatric feeding and swallowing disorders.<br />Development of Feeding and Swallowing Skills<br />Prenatal Swallowing and Sucking<br />In utero studies of fetuses have documented the early development of swallowing and oral-motor function HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib3" 3 ( HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "tbl1" Table 1). In utero swallowing is important for the regulation of amniotic fluid volume and composition, recirculation of solutes from the fetal environment, and the maturation of the fetal gastrointestinal tract. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib4" 4 The pharyngeal swallow, one of the first motor responses in the pharynx, has been observed between 10 and 14 weeks’ gestation. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib5" 5 Recent studies have demonstrated swallowing in most fetuses by 15 weeks’ gestation and consistent swallowing by 22 to 24 weeks’ gestation.3<br />TABLE 1. <br />Gestational ages for swallowing and sucking<br />Swallowing functionGestational age (wk)Pharyngeal swallow10-14True suckling18-24Tongue cupping28Sustained total oral nutrition34-37<br />Full-size table<br />View Within Article<br />True suckling begins around the 18th to 24th week and is characterized by a distinct backward and forward movement of the tongue. The frequency of suckling motions can be altered by taste. Taste buds are evident at 7 weeks’ gestation. By 12 weeks’ gestation, distinctively mature receptors are noted. Self oral-facial stimulation usually precedes suckling and swallowing. Tongue cupping is seen by 28 weeks’ gestation.<br />This backward and forward movement of the tongue in suckling is all that can be expected because the tongue fills the oral cavity at this stage of development. Backward movement appears more pronounced than forward movement. Tongue protrusion does not extend beyond the border of the lips. Serial ultrasound images have shown that suckling motions increase in frequency in the later months of fetal life.3 By 34 weeks’ gestation, a healthy preterm infant likely suckles and swallows well enough to sustain nutrition strictly through oral feedings. Some healthy preterm infants may be ready to begin oral feeding by 32 to 33 weeks’ gestation.<br />It has been estimated that the near-term human fetus swallows 500 to 1000 mL/d of amniotic fluid. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib4" 4 Earlier reports had indicated that the fetus swallows about 450 to 500 mL of amniotic fluid per day (of the total 850 mL) and excretes about the same amount in urine. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib6" 6 Decreased rates of fetal suckling are associated with digestive tract obstruction or neurologic damage. Intrauterine growth retardation may be a manifestation of neurologic damage. Lack of regular swallowing by the fetus should lead one to suspect problems that may be related primarily to the preterm infant or primarily to the mother. Maternal polyhydramnios characterized by excessive amniotic fluid in the uterus may result from multiple fetal and maternal etiologies. Severe polyhydramnios is more strongly associated with congenital malformations than mild or moderate polyhydramnios. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib7" 7<br />Infant Feeding and Swallowing<br />Oral feeding that requires suckling, swallowing, and breathing coordination is the most complex sensorimotor process the newborn infant undertakes. Premature infant patterns differ from those of full-term infants. Lau and coworkers describe five primary developmental stages of sucking that characterize the maturational process ( HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "tbl2" Table 2). HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib8" 8 Sucking patterns in infants born at less than 30 weeks’ gestation were monitored from the time they were introduced to oral feeding until they reached full oral feeding. The five-stage scale demonstrates the relationship between the development of sucking and oral feeding performance of preterm infants. A high interobserver reliability was observed on 50 bottle-feeding assessments. The authors suggest that there is no significant in utero maturation of sucking occurring between 26 and 29 weeks’ gestation, or they had insufficient statistical power to detect a difference over this developmental period. A significant correlation between the level of maturity of an infant’s sucking and gestational age was found. Feeding performance correlated with progression of oral feeding. These authors suggest that developmental scales can be used clinically for the identification and characterization of the oral sensorimotor skills of preterm infants at any point in their development as they progress in their individual oral feeding schedule. Objective and quantitative evaluations of infants’ nonnutritive and nutritive sucking would be helpful in evaluating strength and coordination. One proposal includes a finger pressure device to allow for quantification of specific measures of nonnutritive sucking in combination with a nipple/bottle system developed for monitoring nutritive sucking. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib9" 9 However, there is no standardized quantifiable procedure available currently.<br />TABLE 2. <br />Five primary stages of sucking in preterm infants<br />StageDescription1aNo suction; arrhythmic expression1bArrhythmic alternation of suction and expression2aNo suction; rhythmic expression2bArrhythmic alternation of suction and expression; sucking bursts noted3aNo suction; rhythmic expression3bRhythmic suction and expression; suction amplitude increases, wide amplitude range, prolonged sucking bursts4Rhythmic suction and expression; well-defined suction, amplitude range decreased5Rhythmic, well-defined suction and expression; increasing suction amplitude; sucking pattern similar to term infant<br />Full-size table<br />Adapted from Lau et al. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib8" 8<br />View Within Article<br />Term infants typically show food-seeking behavior through rooting for a breast or bottle. Preterm infants gradually achieve skills for rooting, suckling, and swallowing for functional oral feeding as they mature. Important early developmental milestones and feeding skills from birth to 36 months are shown in HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "tbl3" Table 3. Children older than 36 months typically are eating regular table food and drinking from an open cup. They continue to refine their skills but do not attain new skills.<br />TABLE 3. <br />Developmental milestones and feeding skills birth to 36 months<br />Age (mo)Development/postureFeeding/oral sensorimotorBirth to 4-6Neck and trunk with balanced flexor and extensor toneVisual fixation and trackingLearning to control body against gravitySitting with support near 6 monthsRolling overBrings hands to mouthNipple feeding, breast, or bottleHand on bottle during feeding (2-4 months)Maintains semiflexed posture during feedingPromotion of infant–parent interaction6-9 (transition feeding)Sitting independently for a short timeSelf-oral stimulation (mouthing hands and toys)Extended reach with pincer graspVisual interest in small objectsObject permanenceStranger anxietyCrawling on belly, creeping on all foursFeeding more in upright positionSpoon feeding thin, pureed foodsSuckle pattern initially suckle ->suckBoth hands to hold bottleFinger feeding introducedVertical munching of easily dissolvable solidsPreference for parents to feed9-12Pulling to standCruising along furnitureFirst steps by 12 monthsAssisting with spoon; some become independentRefining pincer graspCup drinkingEats lumpy, mashed foodFinger feeding for easily dissolvable solidsChewing includes rotary jaw action12-18Refining all gross and fine motor skillsWalking independentlyClimbing stairsRunningGrasping and releasing with precisionSelf-feeding: grasps spoon with whole handHolding cup with two handsDrinking with 4-5 consecutive swallowsHolding and tipping bottle>18-24Improving equilibrium with refinement of upper extremity coordinationIncreasing attention and persistence in play activitiesParallel or imitative playIndependence from parentsUsing toolsSwallowing with lip closureSelf-feeding predominatesChewing broad range of foodUp–down tongue movements precise24-36Refining skillsJumping in placePedaling tricycleUsing scissorsCirculatory jaw rotationsChewing with lips closedOne-handed cup holding and open cupdrinking with no spillingUsing fingers to fill spoonEating wide range of solid foodTotal self-feeding, using fork<br />Full-size table<br />Adapted from Arvedson and Brodsky HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib10" 10 (pp. 62-7).<br />View Within Article<br />The development of independent, socially acceptable, feeding processes begins at birth and progresses throughout the first few years of childhood. Oral sensorimotor skills improve within general neurodevelopment, acquisition of muscle control that includes posture and tone, cognition, and language, and psychosocial skills (Table 3).10<br />Feeding and swallowing skill development parallels psychosocial milestones of homeostasis, attachment, and separation/individuation ( HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "tbl4" Table 4). HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib11" 11 Infants during the first 2 to 3 months of life strive toward homeostasis with the environment. Goals include sleep regulation, regular feeding schedules, and awake states that are developmentally advantageous in the development of emotional attachment to primary caregivers. Successful pleasurable feeding experiences foster efficient nipple control, reaching, smiling, and social play. Thus, feeding gradually becomes a social event. Caregivers should not interpret pauses between sucking bursts as a need for burping or early satiety. Once caregivers interrupt feeding, some infants do not resume sucking readily. Caregivers then may perceive that an infant is full or too tired to continue, so they stop the feeding. If this pattern becomes habitual, the infant is likely to gain weight slowly or not at all, which results in undernutrition or failure to thrive. If the interactions between infant and caregiver fail to develop appropriately, the infant may indicate lack of pleasure, loss of appetite, and, in severe forms, vomiting and rumination. Significant feeding problems can evolve out of a mismatch between infants’ cues and caregivers’ interpretations of the cues.<br />TABLE 4. <br />Feeding-related psychosocial milestone: birth to 36 months<br />StagePsychosocial milestonesBirth to 3 months (homeostasis)Cues for feeding: arousal, cry, rooting, suckingCaregiver responds to cues (leads to self-regulation)Infant quiets to voiceHunger–satiety pattern developsInfant smile promotes interaction with primary caregiverPleasurable feeding experiences -> greater environmental interaction3-6 months (attachment)Primary interactions—“falling in love”↑Reciprocity of positive infant and caregiver interactionsConsistent cuesAnticipation of feedingPauses likely socialization, not necessarily for burping or to indicate satietySmiling, laughing, social, alertPreferred feeders are parentsCalls for attention by 6 months6-36 months (separation/individuation)Responds to “no”Imitates movements, and gradually imitation of speechPlay activity to explore environment (7-9 months)Facial expression used to indicate likes and dislikesFollows simple directionsSelf-feeding emergesMealtimes become more predictableSpeech becomes importantDirection following—gradually 2- to 3-step commandsMealtimes become part of whole family scheduleRapid increase in language 24-36 monthsIndependent feeding by end of period<br />Full-size table<br />Adapted from Chatoor et al.11<br />View Within Article<br />Transition Feeding<br />Infants show readiness for the transitional feeding period that usually begins around 4 to 6 months in typically developing infants, which also is the period of attachment for psychosocial milestones ( HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "tbl4" Table 4). HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib11" 11 Transition feeding describes the readiness for and initiation of spoon feeding, usually with thin cereal mixed into breast milk or formula for most infants. Infant developmental skills that indicate readiness for spoon feeding include, but are not limited to, upright sitting with minimal support, midline head position maintained for several minutes without support, hand-to-mouth motor skills, dissociation of lip and tongue motions, and anatomic changes resulting in more space for the tongue within the oral cavity that allow for vertical motion of the tongue in addition to the previously restricted movements of “in and out” suckling. Over the next several months, infants gain oral sensorimotor skills for accepting thicker and lumpier food by spoon. Then, they move into a period of greater independence noted by finger feeding of easily dissolvable solid food. They gradually become more precise in picking up small pieces of food (or other objects), as they attain a pincer grasp with thumb and forefinger, which is expected by 10 to 12 months.<br />Critical and Sensitive Periods with Implications for Behavioral and Sensory-based Feeding Problems<br />The concept of critical and sensitive time periods in overall human development is well documented in some areas of development and in animal research. Lorenz HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib12" 12 interpreted findings from animal embryologic studies to imply that there is a period during early development when the organism is primed to receive and perhaps permanently encode important environmental information. These interpretations do not mean that later learning cannot occur or that it is not important, but they do emphasize the possible significance of these early experiences.<br />Critical and sensitive periods are believed to exist in the development of normal feeding behavior. Descriptions of these critical periods typically focus on the introduction of chewable textures ( HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "tbl3" Table 3). Children develop oral side preferences for chewing that relate to hand preferences in many instances. Chewing skills vary with textures. Children develop mature chewing skills for solid foods earlier than for viscous and pureed foods. However, it is common for children who have not mastered the timing and coordination for swallowing purees and other smooth food to be kept on those textures because caregivers may believe that these children are not ready for introduction of chewable food, which is not necessarily true. Children need to be introduced to solid foods at the most appropriate times. Children may reject solids on initial presentation if they are introduced after the critical periods. The longer the delay in the introduction of solids, the more difficult it is for many children to accept chewable food. Withholding solids at a time when a child should be able to chew (6 to 7 months developmental level) can result in food refusal and even vomiting, HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib13" 13 which in turn may have a significant negative effect on nutrition and hydration status.<br />Studies in mice reveal that those fed a soft-feed (powdered) diet after weaning reduced synaptic formation in the cerebral cortex and impaired the ability of spatial learning (radial maze) in adulthood when compared with mice fed a hard-feed (pelleted) diet. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib14" 14 Similar deficits may result from lack of experience and exposure to age-appropriate foods in humans, providing a conceptual framework to explain clinical observations of the challenges encountered in the learning of oral sensorimotor and other skills in children not fed during critical/sensitive periods for oral skill development. Perhaps when children have not been introduced to solid foods within the critical sensitive periods, broad aspects of development may be affected negatively. One may assume that these children missed not only this critical period for chewing, but also the underlying skills, which include trunk stability, head control, mobility of limbs, and mouthing experiences involving hands, fingers, and toys. Physiologic processes that are underpinnings for oral sensorimotor and swallowing skills, such as respiratory control, also have critical periods that can impact the feeding process.<br />Psychosocial development, personality, and environment are additional factors that must be considered for children with feeding issues. Some children may respond in aversive ways when presented with certain textures, tastes, or temperatures of food and liquid. These same children may be hypersensitive to tight clothes or tags on their clothes. They may not like to wear shoes. They may get upset when their hands get dirty, so they refuse to do finger painting and will not put their fingers into pudding or other pureed food.<br />Critical and sensitive periods may apply to the mother, with effects related to the potential for efficient feeding and global development of an infant. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib15" 15 Maternal early contact with both preterm and term infants has been found to have a positive effect on the mother’s attachment behavior and ultimately enhanced development of the infant.<br />Effects When Oral Feeding Is Not Possible in the Newborn Period<br />When infants with major physical and physiologic problems are prevented from initiating oral feeding in the same timeframes as their more typically developing peers, many demonstrate prolonged delays and significant difficulty with oral feeding. In addition, significant variations are found in the form and function of the ingestive systems of age-matched healthy infants and at-risk infants. Ultrasounds revealed that fetal swallowing occurred most commonly in the presence of oral-facial stimulation. Hands were touching face and mouth. In some instances, fingers or thumbs were seen in the mouth. Perhaps some infants miss critical periods while still in the womb. Miller and colleagues HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib3" 3 postulate that prenatal development indices of emerging aerodigestive skills may guide postnatal decisions for feeding readiness and, ultimately, advance the care of medically fragile neonates. Clinicians must have knowledge regarding normal development to appreciate and understand the implications of differences in infants and young children with feeding and swallowing problems, which are likely to be just one or two pieces of a much larger and more complex puzzle. All aspects must be delineated to plan management strategies that will permit adequate nutrition without pulmonary issues and without stress to the child as well as to the caregiver.<br />Taste and Smell in Oral Feeding of Infants and Young Children<br />Understanding an infant’s awareness of taste and smell, along with responses to textures and temperature, is fundamental for clinicians of any discipline to determine the potential for acceptance of new foods. Physicians, dietitians, nurses, and therapists who guide parents when children are failing to thrive, or have limited range of foods in the diet, must examine the broad parameters that can impact on a child’s feeding status. These experiences occur much earlier than many professionals would expect. Initial experiences with flavors occur before birth, because the flavor of amniotic fluid changes as a function of the dietary choices of the mother. Flavors from the mother’s diet during pregnancy are transmitted to amniotic fluid, which are not only perceived by the fetus but also enhance the acceptance and enjoyment of that flavor in a food during weaning from the breast. The ability to detect additional tastes and flavors develops after birth. Thus, it is clear the early sensory experiences have an impact on the acceptance of flavors and foods during infancy and childhood. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib16" 16<br />It has long been shown that human infants are born with a preference for sweet. Their sensory apparatus can detect sweet tastes. Tatzer and colleagues HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib17" 17 found that preterm infants fed exclusively via gastric tubes exhibited more nonnutritive sucking in response to minute amounts of glucose than to water solutions presented intraorally. Infants produced more frequent and stronger sucking responses when offered a sucrose-sweetened nipple compared with a latex nipple. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib18" 18<br />Exposure to flavors in breast milk may serve to heighten preferences for these flavors and facilitate the weaning process. Some breastfed infants are more willing to accept a novel vegetable on first presentation than are formula-fed infants. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib19" 19 Children who have been breastfed for at least 6 months are also less likely to become picky eaters. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib20" 20<br />The ability to detect and prefer a salt taste does not appear until infants are about 4 months of age. Animal model studies demonstrate that this developmental change may reflect postnatal maturation of central and peripheral mechanisms underlying salt taste perception. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib21" 21 The preference that emerges at this age appears to be largely unlearned.<br />An example of the importance of early exposure to flavors is found in the acceptance of protein hydrolysate formulas by 7-month-old infants who had readily accepted this kind of formula when compared with their regular milk- or soy-based formula in the first couple months of life. These formulas are known by a variety of names depending on the company that produces and distributes them in the United States and in other countries throughout the world. A sensitive period in early infancy is suggested as at least one important factor, as shown by the finding that those infants 7 months and older avidly accept these formulas if they have experienced them during the first months of life. However, in marked contrast, 7- to 8-month-old infants who had no previous experience with hydrolysate formulas strongly rejected them and displayed extreme and immediate facial grimaces, similar to those observed in newborns in response to bitter and sour tastes. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib22" 22<br />Professionals who make decisions regarding feeding of infants and young children have to consider multiple variables. Differences in flavor acceptance that occur from breastfed to bottle-fed infants and that likely change over time reflect complex interactions of sensory and motor factors.<br />Clinical Assessment of Pediatric Swallowing and Feeding Disorders for Primary Care Physicians<br />There are four key questions that physicians and nurses in primary care can ask parents when an infant or young child presents at the office or clinic with parental concerns related to feeding. The answers help determine if a comprehensive clinical feeding and swallowing assessment is needed, even though the answers do not necessarily define the problem: <br />• How long do mealtimes typically take? If more than about 30 minutes on any regular basis, there is a problem. Prolonged feeding times are major red flags pointing to the need for further investigation. <br />• Are mealtimes stressful? Regardless of descriptions of factors that underlie the stress, further investigation is needed. It is very common for parents to state that they “just dread mealtimes.”<br />• Does the child show any signs of respiratory stress? Signs may include rapid breathing, gurgly voice quality, nasal congestion that increases as the meal progresses, and panting by an infant with nipple feeding. Recent upper respiratory illness may be a sign of aspiration with oral feeds, although there may be other causes.<br />• Has the child not gained weight in the past 2 to 3 months? Steady appropriate weight gain is particularly important in the first 2 years of life for brain development as well as overall growth. A lack of weight gain in a young child is like weight loss in an older child or adult.<br />Principles of Clinical Feeding Evaluation<br />The clinical evaluation of an infant or child with complex issues related to feeding and swallowing includes a thorough history, physical examination, and feeding observation. Instrumental assessments of swallowing may be needed following the clinical evaluation when concerns are noted regarding pharyngeal phase physiology and risks for aspiration with oral feeding. Most children are best served in the context of an interdisciplinary team. Unfortunately, such teams are available only in a limited number of medical centers in the United States and in other countries throughout the world. Information is provided that should be useful for physicians, dietitians/nutritionists, and other professionals who do not have an interdisciplinary team available. All professionals who work with these infants and children are urged to collaborate with appropriate colleagues and to develop an interdisciplinary team to whatever extent is possible. Particular attention is paid to factors that are likely to interfere with adequate nutrition and hydration, because the most fundamental goals for all children relate to optimal status of nutrition and hydration.<br />Categories of Causes of Swallowing and Feeding Disorders<br />A careful reading of the medical, developmental, and feeding history is the first step that is critical to decision-making. Swallowing and feeding disorders in infants and children are complex and can have multiple causes in various categories of disorders including, but are not limited to the following: <br />• Disorders that affect hunger/appetite, food-seeking behavior, and ingestion <br />• Anatomic abnormalities of the oropharynx<br />• Anatomic/congenital abnormalities of the larynx and trachea<br />• Anatomic abnormalities of the esophagus<br />• Disorders affecting suck-swallow-breathing coordination<br />• Disorders affecting neuromuscular coordination of swallowing<br />• Disorders affecting esophageal peristalsis<br />• Mucosal infections and inflammatory disorders causing dysphagia<br />• Other miscellaneous disorders associated with feeding and swallowing difficulties, for example, xerostomia, hypothyroidism, trisomy 18 and 21, Prader–Willi syndrome, allergies, lipid and lipoprotein metabolism disorders, and a variety of craniofacial syndromes.<br />Link and Rudolph HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib23" 23 have a detailed list of specific causes within each of the above categories.<br />Caregiver Perceptions of Feeding Problems<br />Each person involved with feeding and caring for a child is likely to have perceptions of the feeding status and problems that differ from other caregivers and professionals. Information is needed from more than one caregiver or professional involved with the child. Questions are formulated to delineate the feeding status as clearly as possible. The following questions go beyond the screening questions suggested earlier. A discussion of each of these questions can be found at http://www.nature.com/gimo/contents/pt1/full/gimo17.html. <br />How long does it take to feed the child? <br />Is the child independent for feeding or dependent on others to a greater degree than would be expected for age and overall developmental status?<br />Is the child a total oral feeder?<br />Do differences in food textures, temperatures, or tastes change the child’s response at mealtime?<br />Does the feeding problem change throughout the course of the meal?<br />Does the feeding problem vary by time of day or by feeder?<br />Does the child maintain a midline neutral position of the trunk, neck, and head without requiring added support?<br />Are there signs of breathing difficulties during feeding?<br />Does the child have emesis regularly?<br />Does the child refuse food?<br />Does the child get irritable or sleepy and lethargic during mealtimes?<br />How do the child and caregiver interact? Are there signs of forced feeding?<br />Interdisciplinary Team Approach<br />An interdisciplinary team approach offers the benefit of coordinated consultation and problem-solving for multiple interrelated problems. Effective management of these medically complex children depends on the expertise of many specialists, who may work independently and as a team ( HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "tbl5" Table 5). Case coordination is often a critical component that is intensive and needed to optimize the child’s health and development along with the family’s ability to cope with multiple issues and sometimes disparate opinions and recommendations. An interdisciplinary approach is recommended at institutions where professionals evaluate and treat children with complex feeding and swallowing problems. Success factors include the following: <br />• Collegial interaction among relevant specialists <br />• Shared group philosophy related to diagnostic approaches and management protocols<br />• Team leadership with organization for evaluation and sharing of information<br />• Willingness to engage in creative problem-solving and research<br />• Time commitment for the labor-intensive work that is required<br />TABLE 5. <br />Feeding/swallowing team members and their functions<br />Team memberFunctionParentsPrimary caregiver and decision-maker for childPhysicianMedical leader(gastroenterologist, developmental pediatrician, or pediatric physiatrist)Team co-leaderPediatric health and neurodevelopmental diagnosisMedical and health monitoring within specialty areaSpeech-language pathologistTeam co-leader (active in feeding clinic and coordinates programmatic activities)Clinic and inpatient feeding and swallowing evaluationVideofluoroscopic swallow study (VFSS) with radiologistFlexible endoscopic examination of swallowing (FEES) with otolaryngologistOral sensorimotor intervention programNurseLeads preclinic planningReviews records and parent informationCoordinates patient follow-upChanges gastrostomy tubesDietitian/nutritionistAssesses past and current dietsDetermines nutrition needsMonitors nutrition statusPsychologistIdentifies and treats psychological and behavioral feeding problemsGuides parents for behavior modification strategiesDirects inpatient behavioral feeding programOccupational therapistEvaluates and treats children with problems related to posture, tone, and sensory issuesSocial workerAssists families for community resources in a variety of waysActs as advocate for the childAdditional specialists OtolaryngologistPhysical examination of upper aerodigestive tractDetailed airway assessmentFEES with speech-language pathologistMedical and surgical treatment of airway problems PulmonologistLower airway disease—evaluation and management RadiologistVFSS with speech-language pathologistComputed tomography (CT) scan of chestVaried radiographic diagnostic studies Pediatric surgeonSurgical management of gastrointestinal disease Cardiovascular surgeonSurgical management of cardiac disease Neurologist/neurosurgeonMedical and surgical management of neurologic problems Physical therapistSeating evaluations and modifications to seating systems<br />Full-size table<br />Adapted from Arvedson and Brodsky HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib10" 10 (pp. 6-7).<br />View Within Article<br />Depending on the expertise and interest in different institutions, team members may be drawn from different disciplines. The functions should cover those described ( HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "tbl5" Table 5). Not all disciplines will be needed for all children. It is important to determine which disciplines can best serve the child and family so that patient care can be both efficient and efficacious. Specific discipline involvement may change over time as the child’s needs change.<br />Instrumental Examination of Swallowing<br />Instrumental examinations may be needed for infants and children particularly when the pharyngeal and esophageal physiology needs to be delineated objectively to answer specific questions related to the safety and efficiency for oral feeding. However, a full discussion of this is beyond the scope of this article and the reader is referred to http://www.nature.com/gimo/contents/pt1/full/gimo17.html.<br />Management of Feeding and Swallowing Problems in Pediatrics<br />Management decisions are made in light of the total child with consideration for medical/surgical, nutrition, oral sensorimotor, behavioral, and psychosocial factors. Intervention strategies are focused on primary problem areas of deficit. Evidence-based practice guidelines are needed. Airway stability and adequate nutrition/hydration status are prerequisites for all oral sensorimotor and behavioral approaches to increase the volume of oral feeding or to improve oral skills to expand food textures and to increase efficiency. Initial efforts to improve caloric intake may include increasing caloric density of food, as per the dietitian and physician, along with making adjustments of food textures to improve efficiency and safety or oral feeding. Adequate fluid intake is critical to meet hydration needs and to minimize potential of constipation, which can be a major complicating factor in facilitating hunger, appetite, and interest in feeding.<br />Oral sensorimotor intervention involves strategies related to the function of oral structures for bolus formation and oral transit that are under voluntary neurologic control, that is, the jaw, lips, cheeks, tongue, and palate. Techniques vary widely among therapists with little evidence of efficacy, efficiency, and outcomes. Some children appear to improve oral function when foods vary on the basis of texture, tastes, and temperature. Other children show significantly improved oral skills and timing of swallowing with posture and position changes. Frequently used strategies include tapping or stroking the face and using a “Nuk®” brush or other kinds of stimulation. Parents and therapists report that this kind of stimulation will “wake up the system” and then the child will swallow more quickly and more firmly. However, data are sorely lacking. Goals of specific exercises usually relate to improved strength and coordination, but without defined objective measures of outcomes.<br />Professionals and parents do not disagree about the importance of adequate nutrition/hydration. However, there is more likely to be disagreement regarding the need for a gastrostomy tube (GT). It is not unusual for parents to need some time, at least a few weeks or even months, before they agree to a GT. A nasogastric tube may be used for a few weeks as a test to determine if the child tolerates needed volume of liquid per feeding without discomfort or emesis. The nasogastric tube feeds also provide an opportunity to monitor weight gain. If nonoral feeds are likely to be required for longer than several weeks, not necessarily for total oral feeding but perhaps just to meet fluid requirements or for medications, a GT should be considered. A feeding GT often relieves stress on the caregivers by allowing freedom from fear of malnutrition. More efficient caloric delivery also frees time for other more pleasurable interactions with the child. Some oral therapy should continue at appropriate levels to ensure the continued experience and maximal development of oral skills over time. Speech-language pathologists can train parents, who can then take advantage of offering tastes during several brief “practice” sessions each day. Duration of each session should be only about 5 to 10 minutes in these circumstances. When a child is on bolus feeds, optimal timing for “pleasurable practice” is likely to be shortly before the start of the tube feeding, providing the child does not show aversive reactions to the tube feedings.<br />Data on evidence-based research are needed. All therapeutic approaches have a primary goal for each child to experience healthy, safe, and pleasurable oral feeding, whether the child is a total oral feeder or gets just limited quantities and types of food for practice and pleasure. Pulmonary stability and nutritional well-being are always the primary goals for all infants and children.<br />Section II: Gut Motility and Enteral Feeding Tolerance with an Emphasis on Premature Infants<br />The gastrointestinal tract is a complex organ that starts at the mouth and ends at the anus. Its functions include mastication of food, digestion and absorption of nutrients, elimination of waste, and protection of the host from infectious organisms and toxins. Normal intestinal motility is important for each of these functions. When normal motility is absent or impeded a variety of diseases and/or disorders may occur.<br />Much information now exists concerning gastrointestinal motility in adults. However, we are just beginning to understand the developmental aspect and the importance of motility in premature and term infants.<br />Gastrointestinal Motility<br />When considering motility in adults and children, the intestine may be divided into segments that are separated by sphincters. Food introduced into the mouth is masticated, mixed with fluid, electrolytes, immunoglobulins, and enzymes. The mixture is delivered to the esophagus, propelled distally through the gastroesophageal sphincter and into the stomach where it is churned with additional fluid, electrolytes, acid, and enzymes. The mixture then transits the pylorus and empties into the small intestine. Long-chain fats and triglycerides present in the mixture empty slowly from the stomach. Liquids low in fat have a more rapid transit into the small intestine where digestion continues and where nutrients are absorbed as they move fairly rapidly through the small intestine. Ingested material not digested and absorbed is delivered to the colon through the ileocecal valve. Transit slows as the colon reabsorbs water, and the liquid chyme is propelled by peristalsis into the transverse and descending colon. By the time waste reaches the sigmoid colon and rectum, much of the water has been reabsorbed. The fecal mass is then compact and ready for elimination.<br />Esophagus<br />Motility in each of the gastrointestinal segments is unique to that part of the intestine. The esophagus can be divided into three functional regions: upper esophageal sphincter (UES), esophageal body, and lower esophageal sphincter (LES). The coordinated motor pattern of the esophagus, or primary peristalsis, is initiated by the act of swallowing. A rapidly progressing pharyngeal contraction transfers the bolus through a relaxed UES into the esophagus (Fig 1). As a swallow is initiated, there is laryngeal elevation as the swallow-bolus passes from the pharynx, across the UES, and into the proximal esophagus. As the UES closes, a progressive circular contraction begins in the upper esophagus and proceeds distally along the length of the esophageal body to propel the bolus through a relaxed LES. The LES is not an anatomically discrete sphincter but a high-pressure zone (Fig 1). Secondary peristalsis is a progressive contraction in the esophageal body that is not induced by a swallow, but rather by stimulation of sensory receptors in the esophageal body. This type of peristalsis is usually induced in two ways: by luminal distention from refluxed gastric contents or following incomplete clearing of esophageal contents by primary peristalsis.<br />Full-size image (345K)<br />FIG 1. Esophageal motor events in response to a swallow. The UES relaxes when the swallow-bolus moves from the pharynx into the proximal esophagus. The contraction wave moves down the esophagus and as it approaches the LES there is relaxation of that high pressure zone. *While every effort has been made to locate the copyright owner of this work, Academy Professional Information Services, we have been unable to do so and obtain permission for the reproduction of this figure. Given its scientific value, we have taken the step of reproducing it here and invite anyone with a claim to the copyright of this work to contact us at 212-633-3957.<br />View Within Article<br />Physiologically, the LES in children is a 2- to 3-cm-long segment of tonically contracted smooth muscle at the distal end of the esophagus. Intraabdominal pressure, gastric distention, peptides, hormones, various foods, and many drugs modify the LES pressure. When swallowing, LES relaxation is mediated via preganglionic, cholinergic vagal fibers in addition to postganglionic, noncholinergic, nonadrenergic nerves. However, the LES can also transiently relax independent of swallowing, and an increased proportion of this type of inappropriate relaxation has been reported in children with gastroesophageal reflux. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib24" [24] and HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib25" [25]<br />Stomach and Small Intestine<br />The stomach mixes the food-bolus with additional fluid, electrolytes, and enzymes and propels the chyme toward the pylorus. The mixture is emptied into the proximal small intestine. Two distinctive patterns of motility may occur in the small intestine: postprandial and interdigestive.<br />Postprandial Small Intestinal Motility<br />Following a meal, there can be segmentation contractions of the stomach and small intestine that chop, mix, and roll chyme, and/or peristalsis, which propels the chyme toward the large intestine.<br />Interdigestive Small Intestinal Motility<br />This pattern of motility is seen between meals when the stomach and small intestine are devoid to a large extent of food and chyme. During this period, so-called housekeeping contractions originate in the gastric pacemaker or proximal small intestine and propagate down the small intestine, sweeping it clean of debris. This pattern is called the migrating motor complex. The migrating motor complex consists of three distinctive contraction patterns or phases (Fig 2). Phase 1 is a motor quiescent period, which follows phase 3 and precedes phase 2. Phase 2 is a period of irregular contractions, varying in amplitude and periodicity. Phase 3 is a distinctive pattern of regular, high-amplitude contractions repeating at a maximal rate for several minutes. Each phase migrates proximal to distal. The term migrating motor complex best describes the entire cycle, although it has been occasionally used interchangeably with phase 3.<br />Full-size image (128K)<br />FIG 2. Gastrointestinal motility pattern in a healthy adult. Note the cyclic occurrence of each phase of the migrating motor complex. The most recognizable motor pattern is phase 3 (asterisks), which is distinguished by a band of repetitive contractions. It is followed by phase 1, motor quiescence, and then phase 2, which is characterized by periodic irregular contractions. Phase 3 starts either in the stomach or in the proximal small intestine. *While every effort has been made to locate the copyright owner of this work, Academy Professional Information Services, we have been unable to do so and obtain permission for the reproduction of this figure. Given its scientific value, we have taken the step of reproducing it here and invite anyone with a claim to the copyright of this work to contact us at 212-633-3957.<br />View Within Article<br />Motility in the small intestine, as in all parts of the digestive tube, is controlled by excitatory and inhibitory signals from the enteric nervous system with input from the central nervous system. In addition, a number of gastrointestinal hormones affect gastrointestinal motility. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib26" 26<br />Colon<br />Three prominent patterns of motility are observed in the colon: (1) segmentated contractions; (2) antiperistalic contractions which tend to propel fecal debris toward the cecum; and (3) mass movements. In periods between meals, the colon is generally quiescent. Following a meal, colonic motility increases significantly due in part to gastrocolic and duodenocolic reflexes. Several times each day mass movements push feces into the rectum. When rectal volume increases to the appropriate threshold, the internal anal sphincter relaxes. When this is followed by voluntary relaxation of the external anal sphincter, defecation occurs. Figure 3 shows the sequence of pressure changes in the normal colon.26<br />Full-size image (159K)<br />FIG 3. This colonic motility pattern is characterized by high-amplitude propagated contractions (HAPCs) starting in the descending colon and migrating both proximally and distally. *While every effort has been made to locate the copyright owner of this work, Academy Professional Information Services, we have been unable to do so and obtain permission for the reproduction of this figure. Given its scientific value, we have taken the step of reproducing it here and invite anyone with a claim to the copyright of this work to contact us at 212-633-3957.<br />View Within Article<br />This complex and coordinated mechanism which moves ingested nutrients and fluid through the gastrointestinal tract is immature at birth. It is common to see this immaturity manifest as gastroesophageal reflux, abdominal distention, or sometimes diarrhea and/or constipation. We have recently gained a better understanding of the development of gastrointestinal motility. Hopefully, as we continue to explore this new area of research, improved methods for feeding premature and full-term newborns will be developed.<br />Developmental Aspects<br />Mouth and Esophagus<br />The gastrointestinal tract is essentially fully formed by 11 weeks of gestation, when swallowing of amniotic fluid begins. By 18 to 20 weeks sucking movements appear, and at 37 weeks’ gestation a normal fetus can swallow and process nearly 500 mL. of amniotic fluid a day. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib26" 26 As early as 1983, Bernbaum and colleagues studied nonnutritive sucking during the gavage feedings of 30 premature infants with birth weights less than 1500 g. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib27" 27 All feedings were performed using oral-gastric feeding tubes. The control group (n = 15) was fed a standard formula using set amounts of formula. The experimental group of 15 premature infants was fed the same formula and amount. However, in the experimental group the oral-gastric tube was inserted through a central aperture in a nipple that the infant sucked while being fed via the oral-gastric tube. This was defined as nonnutritive sucking (NNS). The investigators found that NNS decreased intestinal transit time (increased motility) and caused a more rapid weight gain despite comparable caloric intake, resulting in a shortened hospital stay. They concluded that, although the physiologic mechanisms resulting from the NNS were not elucidated, NNS may be an important factor to consider when feeding premature infants. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib27" 27<br />More recently Pinelli and Symington reviewed the literature and set out to determine whether NNS in preterm infants influences: (a) weight gain; (b) energy intake; (c) heart rate; (d) oxygen saturation; (e) length of hospital stay; (f) intestinal transit time; (g) age at full oral feeds; or (h) any other clinically relevant outcomes. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib28" 28 Several data bases were searched including The Cochrane Central Register of Controlled Trials. After a comprehensive search, the authors found that there was a significant decrease in length of stay of premature infants receiving a NNS intervention. Other positive clinical outcomes of NNS were a more rapid transition from tube to bottle feeding and better bottle-feeding performance. No negative outcomes were noted. However, the review did not reveal a consistent benefit of NNS with respect to other major clinical variables (weight gain, energy intake, heart rate, oxygen saturation, intestinal transit time, age at full oral feeds, and behavioral state). Based on available evidence, the authors concluded that NNS in preterm infants appeared to have some clinical benefit and did not have short-term negative effects. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib28" 28<br />Primary esophageal peristalsis, induced by swallowing, begins during early fetal life. One aspect of esophageal motility that has been studied in infants is the laryngeal chemoreflex. This collective response to stimulation of the pharynx or larynx includes startle, rapid swallowing, apnea, laryngeal constriction, hypertension, and bradycardia—mechanisms that protect the fetus living in an aqueous environment from amniotic fluid aspiration. The development of these mechanisms prepare the fetus for postnatal adaptation. The chemoreflex can be studied in infants by stimulating the pharynx with saline or water. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib29" 29 In some infants, laryngeal chemoreflexes may be ineffective, leading to aspiration, or they may be overly effective, resulting in apnea. However, in infants born extremely premature, or with congenital anomalies or hypoxic/ischemic encephalopathy, feeding difficulties may precede the diagnosis of delayed neurologic development.<br />There is not much evidence of esophageal defense mechanisms against gastroesophageal reflux (GER) in infants, although a wealth of information exists from adult studies. Using new techniques, Jadcherla and colleagues have characterized esophageal protective phenomena in developing infants.29 Their study apparatus consists of a water-perfusion manometry system with a specially designed manometric catheter. The researchers infuse varying volumes of air, water, or apple juice into the mid-esophagus and note responses of the upper gastrointestinal tract to these stimuli. They have identified three responses to the stimuli: (a) occurrence of esophageal peristalsis unrelated to a swallow (secondary peristalsis); (b) increase in UES pressure; and (c) occurrence of primary peristalsis. These protective reflexes were elicited reliably and safely. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib29" 29<br />With this new technology, we may be able to study feeding techniques and nutrient formulations that minimize recruitment of these protective mechanisms. Perhaps this information will lead to infant formulas that are better tolerated and associated with less GER.<br />Stomach<br />It is common practice to check gastric residuals (GR) before feeding very low birth weight infants. The gastric residual volume (GRV) is regarded as an objective parameter for feeding intolerance in premature and term infants. Increased pregavage residuals are regarded as one of the gastrointestinal manifestations of stage I (suspected) necrotizing enterocolitis. The definition of increased GR, however, and its relation to feeding intolerance has never been studied in a systematic manner during enteral feeding of extremely low birth weight infants (ELBW: <1000g). Furthermore, the presence of gastric fluid, which is green, suggests poor emptying or reflux of bile into the stomach and may prompt the suspension of feedings or the initiation of diagnostic procedures. However, the significance of green GR and its impact on feeding intolerance has not been studied in ELBW infants. Mihatsch and coworkers in Germany studied 99 ELBW premature infants in regards to GR volume and green gastric aspirate. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib30" 30 Using a standardized protocol, premature infants were evaluated from day 3 to day 14 of life. At 48 hours of age, milk feedings were started at 12 mL/kg/d, divided over 12 feeding periods each day. When GR were checked before each feeding, a GRV of 2 mL or less was tolerated by infants who weighed <750 g at birth and a gastric residual volume up to 3 mL was tolerated by infants weighing >750 g at birth. When GRV increased markedly, feedings were reduced or withheld. The color of the GR was also assessed. The investigators found that the median volume of formula tolerated by infants at 14 days of life was 103 mL/kg/d. The mean GRV for infants in the study did not correlate with the amount that was taken on the 14th day. Furthermore, green GR did not correlate with the feeding volume, which could be tolerated on day 14. The authors concluded that GRV below 2 and 3 mL, respectively, for the two weight groups (<750 and >750 g) and a green color of the residual should not slow down the advancement of feeding volumes. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib30" 30<br />Gastric emptying has also been studied in older infants. Tolia and coworkers designed a prospective study using gastric scintigraphy to assess gastric emptying and the frequency of GER when three different formulas were fed infants. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib31" 31 Twenty-eight infants under 1 year of age with GER were studied. They were given three different formulas using the same volume per single feeding: a casein-predominant formula, a soy formula, and a whey-hydrolysate formula were all given in randomized order. A significant difference (P < 0.05) in GER episodes was noted when comparing the casein-predominant and whey hydrolysate feedings. Gastric emptying was more rapid with the whey-hydrolysate formula compared with the casein-based formula. The presumption is that casein-based formulas curdle in the stomach and slow gastric emptying, whereas whey-based formulas do not curdle and clear the stomach more rapidly. The curdling predisposes the infant to GER. The authors suggest “that formula selection may be important in the treatment of conditions associated with delayed gastric emptying.” HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib31" 31 Others have noted similar findings when comparing whey-based and casein-formula feedings in spastic quadriplegic children. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib32" 32<br />Small Intestine<br />As survival of preterm infants has increased, so has morbidity related to immaturity of the gastrointestinal tract. Although a variety of enteral feeding regimens are used for feeding preterm infants, few studies have tested the efficacy of these regimens, because no direct measure of intestinal motility has been available. However, experience suggests that preterm infants may tolerate enteral feedings well using special formulas designed for premature infants if they are fed in a carefully prescribed regimen. Physical characteristics of the nutrients, such as caloric content, osmotic load, pH, fat content, and fiber content, may all affect gastric emptying and gastrointestinal motility in infants as they do in adults.<br />Jadcherla and others recently developed a technique to record small intestinal motility in preterm and term infants. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib33" [33] and HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib34" [34] As in the adult, intestinal motor activity in the neonate changes in response to enteral feeding. When slow-infusion feedings are given to preterm or term infants, duodenal motor activity significantly increases postprandially compared with that seen during fasting. This “fed response” may be altered by the rate of infusion and the concentration of the formula. Using a low-compliance, continuous perfusion manometry system, motor activity responses to different formulas can be assessed in preterm and term infants. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib33" [33] and [34]<br />Jadcherla and his group studied two commercially available formulas of different nutrient densities: Similac 20 (20 cal/oz) and Similac Special Care (24 cal/oz).34 Infants in a very controlled fashion received both formulas at different times. Motor responses during the feeding of the two formulas differed significantly. When the preterm infants were fed for the first time, their motor activity increased when they were fed the lower calorie-dense formula, Similac 20. Motor activity decreased when fed the higher calorie-dense formula. However, these differences in motor responses to the two formulas were not present 10 days later when the infants were restudied using both formulas. The inhibition of motor responses to the calorically denser formula early on may underlie the feeding intolerance infants experience when they are first fed formula. However, this inhibitory response diminishes with age, suggesting that denser formulas can be introduced later to preterm infants. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib34" 34<br />Feeding Recommendations for Premature Infants<br />Although we are just beginning to appreciate the complexity of gastrointestinal motility in premature and full-term infants and understand how formulas and feeding may influence gastrointestinal motility, recommendations based on current evidence is available. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib35" 35<br />Optimal nutrition is critical in the management of small, preterm infants. However, no standard has been set for the precise nutritional needs of infants born prematurely. Present recommendations are designed to provide nutrients to approximate the rate of growth and composition of weight gain for a normal fetus of the same postmenstrual age and to maintain normal concentrations of blood and tissue nutrients. Generally, intrauterine growth rate can eventually be achieved, but it is not obtained until well after the time of birth. Nearly all ELBW infants experience significant growth retardation during their stay in the neonatal intensive care unit. This is largely a result of the management of acute neonatal illnesses and gradual advancement of feeding to minimize the risk of feeding-related complications, such as necrotizing enterocolitis.35<br />The quality of postnatal growth depends on the type, quantity, and quality of the feedings consumed. Preterm infants fed standard infant formulas gain a higher percentage of their weight as fat when compared with a fetus of the same maturity. The use of specially formulated preterm infant formulas and preterm human milk fortifiers results in a composition of weight gain and bone mineralization closer to that of the reference fetus.35<br />Randomized prospective trials of ELBW infants fed specially formulated preterm formulas ( HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "tbl6" Table 6) have shown significant improvements in growth and cognitive development when compared with feeding of standard formulas for full-term infants. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib36" 36<br />TABLE 6. <br />Nutrient data/liter for formulas used to feed low-birth-weight and prematurely born infants<br />Similac Special Care 24 Enfamil Premature Lipil 24 Neosure Advance 22 cal Enfacare 22 cal Liquid (Ross Laboratories Columbus, OH)Liquid (Mead Johnson, Evansville, IN)Liquid (Ross Laboratories, Columbus, OH)Liquid (Mead Johnson, Evansville, IN)Energy, kcal806810746740Protein, g222419.421Fat, g43.8414139Polyunsaturated, g8.310.3——Monounsaturated, g3.54.5——Saturated, g3226.2——Linoleic acid, g5.78.55.67.1Carbohydrate, g86.19076.979<br />Full-size table<br />Reproduced from reference HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib35" 35> with permission.<br />View Within Article<br />Recent findings concerning gastrointestinal motility and formula composition underscore the need for the clinician to carefully plan and monitor the nutritional care of preterm infants during hospitalization and after discharge. A consensus recommendation of nutrition experts on specific nutrient requirements in preterm infants summarizes available data and recommendations and should be referred to for more detailed information. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib37" [37], HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib38" [38] and HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib39" [39]<br />Hopefully, with a better understanding of gastrointestinal function, intestinal motility, and formula composition, we will be able to design more appropriate formulas for premature and term infants.<br />Section III: Behavioral Treatment of Feeding Disorders<br />Feeding is an important part of the everyday life of infants and young children, and much parent–child interaction occurs during feeding. About 25 to 40% of infants and toddlers are reported by their caregivers to have feeding problems, mainly colic, vomiting, slow feeding, and refusal to eat. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib40" 40 Severe feeding problems are prevalent in 40 to 70% of children with developmental disabilities and chronic medical conditions.[40] and HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib41" [41] It has been suggested that many feeding disorders develop as a result of an organic condition but are maintained over time by behavioral factors.41 Because of the prevalence of feeding disorders, busy pediatricians will have ample opportunity during their careers to come in contact with these challenging problems. They must be prepared to handle them and have a strategy as to how to approach the simple uncomplicated problems and know when to refer more complicated patients to a tertiary center that has a feeding team in place.<br />Classification<br />A review of the literature reveals several attempts to classify pediatric feeding disorders. Earlier, physicians and investigators focused on failure to thrive as a diagnostic label. This diagnosis was made when an infant’s or child’s weight and height measurements fell below the 5th percentile on growth standards or a patient’s established growth curve decelerated across two major percentiles over time. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib42" 42 The most frequently cited classification of failure to thrive was that of organic or nonorganic. Organic failure to thrive included problems related to structural or anatomic abnormalities involved with feeding (eg, defects of the palate, tongue, and esophagus), neuromuscular problems (eg, cerebral palsy, paralysis), or other known physiological reasons (eg, esophagitis, gastroesophageal reflux). In contrast, nonorganic failure to thrive had origins based in disruptive social and environmental influences, which adversely influenced or contributed to the problem.41 It has been suggested that the vast majority of childhood undernutrition in the United States in the past has been attributable to the so-called nonorganic causes. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib43" 43 The organic–nonorganic classification was rigid and failed to account for feeding problems, which may have a combination of physiological, environmental, and/or behavioral components. In most instances there are several reasons or causes for a feeding disorder.41<br />In 1998 Burklow and her colleagues at Cincinnati Children’s Hospital Medical Center suggested an alternative classification.41 Their Interdisciplinary Feeding Team (IFT) reported a classification system that allowed them to categorize 103 children (64 males and 39 females) with feeding disorders. The children were referred to the IFT for concerns related to poor oral intake and problems with sustained growth. Disciples represented on the team included Pediatric Gastroenterology, Nursing, Nutrition, Occupational Therapy, Psychology, and Speech Pathology. Intake evaluations were reviewed on each consecutive child seen from September 1992 to September 1995. The IFT identified five categories that reflected the nature of the complex feeding disorders in these infants and children: (1) structural abnormalities; (2) neurological conditions; (3) behavioral issues; (4) cardiorespiratory problems; and (5) metabolic dysfunction.<br />Developmental delay or mental retardation was reported in 74% (n = 76) of all subjects. Thirty-eight percent (n = 39) of the subjects were born prematurely (range, 24-36 weeks). There were no significant gender differences for prematurity, developmental delay, or categorization of feeding problems. The percentage occurrence of categories and clusters of categories are shown in Figure 4. It is of note that 85% of subjects were categorized as having a behavioral component to their feeding disorder. Neurological conditions were identified in 73% of the sample: structural abnormalities in 57% of the sample; cardiorespiratory problems in 7%; and metabolic dysfunction in 5% of the sample.41<br />Full-size image (10K)<br />FIG 4. Percent of subjects assigned to each category (alone or in combination). Bar 1: behavioral issues, n = 88 (85%); Bar 2: neurological conditions, n = 75 (73%); Bar 3: structural abnormalities, n = 59 (57%); Bar 4: cardiorespiratory problems, n = 7 (7%); Bar 5: metabolic dysfunction, n = 5 (5%). *Reproduced from reference 41 with permission.<br />View Within Article<br />The authors note that a majority of the feeding disorder patients had a combination of organic and nonorganic problems. They therefore suggest that no attempt be made to force a choice between organic and nonorganic characterization of feeding problems. They conclude that children referred to their team represent those with the most complex types of feeding disorders, including structural anomalies, who have been unresponsive to initial treatment efforts in the community by a single discipline such as Occupational Therapy or Speech Pathology. Their report underscores the point that behavior plays an important role in children with feeding problems. HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "bib41" 41<br />More recently, an alternative classification of feeding disorders has been suggested by Bernard-Bonnin.40 She suggests that early feeding disorders be classified according to the following: (1) structural abnormalities; (2) neurodevelopmental disabilities; and (3) behavioral-feeding disorders ( HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "tbl7" Table 7). Like Burklow and her group, she suggests that there is often overlap. The first category, that of structural abnormalities, includes three anatomic areas: the naso-oropharynx, the larynx and trachea, and the esophagus. The second category, neurodevelopmental disabilities, is composed of conditions that disrupt the process of learning to eat and result in oral-hypersensitivity and oral-motor dysfunction. The third category, behavioral feeding disorders, includes six types of disorders ( HYPERLINK "http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7584-4R7HW8C-6&_user=789722&_coverDate=12%2F31%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000043357&_version=1&_urlVersion=0&_userid=789722&md5=1cc9165649dbe9865102ba648ed88776&searchtype=a" l "tbl7" Table 7). It is not clear if pica should be considered in this group since it is common for infants and children before 24 months of age to mouth and occasionally eat nonnutritive substances. Pica should be considered only when the behavior persists for longer than 1 month and is judged inappropriate for the developmental level of the child.42<br />TABLE 7. <br />Classification of feeding disorders<br />Structural abnormalities • Abnormalities of the naso-oropharynx: choanal atresia, cleft lip or palate, Pierre Robin sequence, macroglossia, ankyloglossia • Abnormalities o

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