AIMS & SCOPEHepatology International is the official journal of the Asian Pacific Association for the Study ofthe Liver (APASL). This is a peer-reviewed journal featuring articles written by clinicians,clinical researchers, and medical professionals and is dedicated to research and patient careissues in hepatology. The quarterly journal will focus on new and emerging technologies andadvances in liver and biliary disorders.Types of articles published: Original Research Articles related to clinical care and basic research Review Articles Guidelines Selected Author Summaries Video Submissions Case ReportsINSTRUCTIONS FOR AUTHORSMANUSCRIPT SUBMISSIONManuscript submissions must be made electronically via e-mail or through electronic media,(e.g., CD Rom) until Editorial Manager, a web-based handling system is made available. Pleaseinclude a cover letter listing the corresponding author’s full name, mailing address, telephone, fax,and correct e-mail address.Please submit your manuscript and all supporting documents to one of the following threeEditors: Dr. Yun-Fan Liaw, who handles HBV (Clinical & Basic), can be reached at firstname.lastname@example.org; Dr. Masao Omata, who handles HCV and Hepatocellular Cardinoma, can be reachedat email@example.com; Dr. Shiv Sarin, who handles NASH (NAFLD) PHT, and HepaticFailure, can be reached at firstname.lastname@example.org. Manuscripts that fall under any other categoriescan be submitted to Dr. Yun-Fan Liaw.For postal submissions of CD ROM’s only: Dr. Masao Omata, Professor and Chair, Departmentof Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo,Bunkyo-ku, Tokyo 113-8655, JapanCOPYRIGHT AND FINANCIAL DISCLOSURECopyright on all accepted manuscripts will be held by APASL. It is necessary that a copyrighttransfer statement be signed by the corresponding author, who shall sign on behalf of all authors,expressly transferring copyright to APASL in the event the manuscript is accepted for publicationin the Journal.A copyright transfer statement signed by all authors must be included with the manuscriptsubmission. Submissions received without a signed copyright transfer statement cannot besent out for peer-review.MANUSCRIPT ORGANIZATIONPlease number manuscript pages consecutively and organize the manuscript in the orderindicated below.
Title Page: On the first page of the manuscript, include the title of the article, as well as the firstand last names for each contributing author [first name, middle initial(s), surname, degree(s)].For all contributing authors, indicate the departmental and institutional affiliation(s) and thecomplete street or mailing address for each affiliation, including the city, state or province, andcountry where the work was performed. Also on the title page, include a short title (not to exceed30 characters in length, including spaces between words) for use as a running head. At thebottom of the title page, indicate any acknowledgments of grant support.Structured Abstract of not more than 250 words in the order of Purpose, Methods, Results, andConclusions. The structured abstract should state the purpose of the study or investigation, basicprocedures (study subjects or experimental animals and observational and analytical methods),main findings (give specific data and their statistical significance, if possible), and the principalconclusions. The first time an abbreviated term is used, spell it out in full and follow with theabbreviation in parentheses – for example: ultrasound (US).Text: Organize the text into an introductory section that conveys the background and purpose ofthe report, and then into sections titled “Materials and Methods,” “Results,” and “Discussion.”When required by the nature of the report, manuscripts that do not follow this specific format maybe accepted.Acknowledgments: Individuals, other than authors, who were of direct help in the reported workshould be acknowledged by a brief statement on a separate page immediately following the text.References: Please type references double-spaced and number them in order of their firstappearance in the text (not alphabetically). Once a reference is cited, all subsequent citationsshould be to the original number. References may not appear in your Reference List unless theyhave been cited in the text or tables. Papers that have been accepted for publication or are inpress may be listed as references, but the Journal does not reference unpublished data andpersonal communications. Use the form for references adopted by the U.S. National Library ofMedicine, as in Index Medicus. For each reference, show inclusive page ranges (e.g., 7-19).In references to journal articles, please include (1) surname and initials (without periods) of allauthors, (2) article title, (3) abbreviated journal name, (4) year, (5) volume number, and (6)inclusive page numbers, in that order. An example follows: 1. Maeda K, Rahman M, Fukui T, et al. Japan’s contribution to clinical research in gastroenterology and hepatology. J Gastroenterol 2003;38:1153-4In references to books, please include (1) surname and initials (without periods) of the first threeauthors and et al. for all others, (2) chapter title, if any, (3) editor(s), if any, (4) title of book, (5) cityof publication, (6) publisher, (7) year, and (8) inclusive page numbers. Volume and editionnumbers, and name of translator should be included when appropriate. Examples follow: 1. Krishnamurthy G, Krishnamurthy S. Nuclear Hepatology: A Text Book of Hepatobiliary Disease, New York, Springer-Verlag, 2002; 6-12 2. Jones MC, Smith RB. Treatment of gastric cancer. In Ford TL, editor, Cancer of the Digestive System, Berlin, Springer-Verlag, 1999;140-154Tables: Each table should appear on a separate sheet of 21.5 x 28 cm. (8½ x 11 in.) paper, andinclude a brief heading/title at the top. Number the tables in order of their first appearance in thetext (e.g., Table 1, Table 2, etc.). All tables must be cited in the text.Figures (Illustrations): Please make sure that illustrations are professionally drawn. Symbols,letters, and numbers should be of sufficient size to be clearly recognizable when the figure isreduced to publication size. Decimals should be written in North American format. Photographs in
which a person is identifiable must either have the face masked out, or be accompanied bywritten permission for publication from the individual in the photograph.Electronic Figures (Illustrations): See Guidelines for Electronically Produced Figures below foracceptable figure formats. Please label each figure (e.g., Fig. 1) and include a caption or legendon the bottom of each figure.Publication of Color Figures: Color figures may be used without charge for the electronicversion of the journal that is published online via SpringerLink. However, color figures will appearin the print version of the Journal at the authors expense at $1,150 per article.GUIDELINES FOR ELECTRONICALLY PRODUCED FIGURES AND ILLUSTRATIONSFor production of the figures and illustrations of an accepted manuscript, the Springer productiondepartment requires electronically produced figures to be saved in either EPS (EncapsulatedPostScript) or TIFF (Tag Image File Format) format. Most drawing programs (e.g. AdobeIllustrator, Deneba Canvas, CorelDraw) have a save-as-EPS option in their Save dialog box.Other information about EPS can be found at the Adobe website.GENERAL Upload figures and illustrations separately from the text (i.e. files should not be integrated with the text files). Unless the authors have specified they wish to pay for color, color figures and illustrations will be converted to grey scale for the print edition.VECTOR (LINE) GRAPHICS Vector graphics exported from a drawing program should be stored in EPS format only. Suitable drawing program: Adobe Illustrator. For simple line art the following drawing programs are also acceptable: Corel Draw, Freehand, Canvas. No rules narrower than .25 pt. No grey screens paler than 15% or darker than 60%. Screens meant to be differentiated from one another must differ by at least 15%.SPREADSHEET/PRESENTATION GRAPHICSMost presentation programs (Excel, PowerPoint, Freelance) produce data that cannot be storedin an EPS or TIFF format. Therefore graphics produced by these programs cannot be used forreproduction.HALFTONE ILLUSTRATIONS Black & white and color figures and illustrations should be saved in EPS or TIFF format. Figures and Illustrations should be created using Adobe Photoshop whenever possible.SCANS Scanned reproductions of black and white photographs should be provided as 300 ppi EPS or TIFF files. Scanned color illustrations should be provided as EPS or TIFF files scanned at a minimum of 300 ppi with a 24-bit color depth. Line art should be provided as EPS or TIFF files at 600 ppi.MULTIMEDIA ARTICLE AND DYNAMIC MANUSCRIPT SUBMISSION REQUIREMENTS(I.E. STREAMING VIDEOS)Multimedia articles are papers where the heart of the article is the video and, generally, only anabstract and references are included. Dynamic articles are regular articles with video(s) includedas electronically supplementary material.
Upon submission of multimedia or dynamic articles, the author(s) will be required to submit thevideo in the following format:• For multimedia articles, video clips should not exceed 9 minutes. For dynamic articles, video clips should not exceed 3 minutes and each manuscript should not contain more than 3 video clips.• Multimedia file for review and submission: MPEG-1 file with the largest frame size (usually 320 x 240 pixels) that will fit on a CD and will be playable on a Windows-based computer.• The content of these files must be identical to that reviewed and accepted by the Editor of the Journal.• All narration should be in English.• There should be a “manuscript” submitted with the video that includes a title page, abstract and key words, as well as references if needed.