Fox Chase Cancer Center                                          Curriculum Vitae                                         ...
Specialty Certification:                   1992    American Board of Internal Medicine (IM)                   1993    Amer...
2003-date Associate Editor, Cancer Research                  2005-date Associate Editor, BMC Cell DivisionAcademic Committ...
Nov. 2001   S and G2 phase roles for Cdk2 in the human cell cycle- Fox Chase            Cancer Center, Philadelphia, PAFeb...
Mar. 2006    Colon carcinoma and the professional tumor suppressor p16Ink4a-                                 Presbyterian ...
LH.: A family of human cdc2-related protein kinases. EMBO Journal 11(8):       2909-17, Aug 1992.Koh J., Enders GH., Dynla...
cells. Molecular & Cellular Biology 21(8): 2755-66, Apr 2001.Gibson S.L., Dai C.Y., Lee H.W., DePinho R.A., Gee M.S., Lee ...
Dews M., Homayouni A., Yu D., Murphy D., Wentzel E., Sevignani C., Wentzel E.,         Furth E., Lee W.M., Enders G.H., Me...
tumor progression and angiogenesis by p16Ink4a, Digestive Disease Week,           Los Angeles, CA, (poster) May 2006.   Li...
Books:                     [none]Alternative Media:   El Deiry W.S., Enders, G.H.: Colon polyps. Emedicine Bhutani, M.S., ...
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  1. 1. Fox Chase Cancer Center Curriculum Vitae Date: Dec 2008 Gregory H. Enders, MD, Ph.DOffice Address: Fox Chase Cancer Center 333 Cottman Avenue Philadelphia, PA 19111If you are not a U.S. citizen or holder of a permanent visa, please indicate the type of visa you have: none (U.S. citizen)Education: 1980 AB Harvard College (Biology) 1987 Ph.D. University of California at San Francisco (Genetics) 1988 M.D. University of California at San Francisco (Medicine) 1988 National Institutes of Health Medical Scientist Training Program, University of California, San FranciscoPostgraduate Training and Fellowship Appointments: 1988-1990 Resident in Medicine, Brigham and Women’s Hospital, 1988-1991 Clinical Fellow in Medicine, Harvard Medical School 1990-1993 Fellow in Gastroenterology, Massachusetts General Hospital, Boston 1991-1993 Research Fellow in Medicine, Harvard Medical SchoolMilitary Service: NoneFaculty Appointments: 1993-1996 Instructor in Medicine, Harvard Medical School 1996 Lecturer C in Medicine, Department of Medicine, University of Pennsylvania School of Medicine 1996-2006 Assistant Professor of Medicine, University of Pennsylvania School of Medicine 1998-2005 Assistant Professor of Genetics (secondary appointment), University of Pennsylvania School of Medicine 2006-date Member, Fox Chase Cancer CenterHospital and/or Administrative Appointments: 1993-1996 Clinical Assistant in Medicine, Massachusetts General Hospital
  2. 2. Specialty Certification: 1992 American Board of Internal Medicine (IM) 1993 American Board of Internal Medicine (Gastroenterology) 2003 American Board of Internal Medicine (Gastroenterology) recertifiedLicensure: 1988-1997 Massachusetts 1996-date PennsylvaniaAwards, Honors and Membership in Honorary Societies: 1980 Magna Cum Laude in Biology, Harvard College 1993 Clinical Investigator Award, National Cancer Institute 1997 Barra Foundation New Research Initiative Award, University of Pennsylvania, Department of Medicine 1999 Research Scholar Award, American Cancer Society 2000 Department of Medicine Measey Award, University of Pennsylvania 2001 Miles and Shirley Fiterman Basic Research Award, American Digestive Health FoundationMemberships in Professional and Scientific Societies: American Association for Cancer Research (2001-) American Association for the Advancement of Science (1996-) American Gastroenterological Association (1990-) American Medical Association (1988-1995) American Society of Microbiology (1998-2003) Dutch National Cancer Society Review Group, reviewer (2002) Massachusetts Medical Society (1995-1996) NIH SPORE in Pancreatic Cancer Review Group, member (2003) U.S. Army Breast Cancer Program Cell Biology Review Group, member (2000) Wellcome Trust (London), International Biomedical Programme Review Group, reviewer (2003) Reviewer, Digestive Disease Week national meeting (2003-present) NIH Digestive Disease Research Core Centers Review Group, member (2004) Oxford Radiobiology Research Review Group, member (2005) NIH Cell Signaling and Dynamics Study Section, ad hoc member (2005-6) Reviewer, Vanderbilt University NIEHS Center internal grants program (2008)Editorial Positions: 1996-date Ad hoc reviewer for the following journals: British Journal of Cancer, Cancer Research, Clinical Cancer Research, DNA and Cell Biology, EMBO Journal, EMBO Reports, Gastroenterology, Journal of Biological Chemistry, Journal of Clinical Investigation, Molecular and Cellular Biology, Oncogene 2001-date Editorial Board Member, Cancer Biology and Therapy 2
  3. 3. 2003-date Associate Editor, Cancer Research 2005-date Associate Editor, BMC Cell DivisionAcademic Committees: University of Pennsylvania 2001 Cancer Biology Theme Group, Dean’s Research Coordinating Council, member 2001-2002 Combined Degree Program Admissions Committee, member 2003-date Physician Scientist Program, council member 2005-date Cell and Molecular Biology Graduate Group, Cell Growth and Cancer curriculum committee member Fox Chase Cancer Center: 2007 Postdoctoral symposium committee 2007-date Institutional Animal Care and Use Committee 2008-date Imaging Facility Faculty Advisory Board 2008-date Director, Gastroenterology Journal ClubMajor Teaching and Clinical Responsibilities University of Pennsylvania and affiliated Hospitals: 1997-date Attending Physician, Gastrointestinal Fellows Clinic 1997-date Cell and Molecular Biology Program Thesis Committee Member 1998-1999 Instructor, Genetics course for medical students 1998-2002 Co-director, The Cell Cycle and Cancer graduate course (CMB 530), Cell and Molecular Biology Graduate Group 1998-2003 Attending Physician, Internal Medicine Service 2003-2006 Director, Morphology Core Facility, NIH Center for Molecular Studies in Digestive and Liver Diseases 2004-2006 Guest faculty, The Cell Cycle and Cancer graduate course (CMB 530), Cell and Molecular Biology Graduate Group 2005-2006 Lecturer, Genetic Medicine medical student course 2006-2006 Guest faculty, Principles of Cancer Signaling and Therapeutics (Phrm 560, CMB), Pharmacology and Cell and Molecular Biology Graduate Groups Fox Chase Cancer Center: 2006-date Staff Consult, Gastrointestinal inpatient service 2007-date Attending Physician, Gastrointestinal endoscopy serviceLectures by Invitation: June 2000 Tumor suppression in the upper GI tract by p16INK4a- Center for Molecular Studies in Digestive and Liver Disorders, University of Pennsylvania, symposium: Upper Gastrointestinal Tract: Biology and Genetic Oct. 2000 The Rb-E2F pathway- Wistar Institute, Philadelphia, PA, Cancer Biology graduate course Oct. 2001 p16: an emergency brake for cell proliferation- American Cancer Society, Delaware Valley Chapter Fundraiser, Philadelphia, PA 3
  4. 4. Nov. 2001 S and G2 phase roles for Cdk2 in the human cell cycle- Fox Chase Cancer Center, Philadelphia, PAFeb. 2002 Dissecting Cdk2 function in the human cell cycle- Children’s Hospital of Philadelphia, University of Pennsylvania Cancer Center Cancer Genetics Seminar SeriesMay 2002 Inhibition of colon tumor progression by the INK4a/ARF locus- Marie Lowe Center for Comparative Oncology Seminar Series, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PAJan. 2003 Inhibition of colon tumor progression by the INK4a/ARF locus- Mount Sinai School of Medicine, New York City, Liver and Gastroenterology seminar seriesOct. 2003 Inhibition of colon tumor progression by the Ink4a/Arf locus- Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NCOct. 2003 Inhibition of colon tumor progression by the Ink4a/Arf locus- University of Massachusetts Medical Center, Worcester, MAApr. 2004 Inhibition of colon tumor progression by the Ink4a/Arf locus- Vanderbilt University, Nashville, TNMay 2004 GI oncology literature review. Annual meeting of the American Gastroenterological Association, New Orleans, LAAug. 2004 Cdk inhibition in human cells compromises Chk1 function and induces a DNA damage response- Cancer Genetics and Tumor Suppressor Genes meeting, Cold Spring Harbor Laboratory, Cold Spring Harbor, NYOct. 2004 Cdk2: Dispensable master regulator of the mammalian cell cycle- Fels Institute for Cancer Research and Molecular Biology, Philadelphia, PANov. 2004 The Rb-E2F checkpoint pathway- Wistar Institute, Philadelphia, PA, Cancer Biology graduate courseOct. 2005 The tumor biology of p16 in colon cancer- The Dana Farber Cancer Institute, Boston, MANov. 2005 The Rb-E2F checkpoint pathway- Wistar Institute, Philadelphia, PA, Cancer Biology graduate courseNov. 2005 Inhibition of colon tumor progression and angiogenesis by p16Ink4a- Georgetown University, Washington, D.C.Nov. 2005 Colon carcinoma and the professional tumor suppressor p16Ink4a- Columbia College of Physicians and Surgeons, New York, NYNov. 2005 Colon carcinoma and the professional tumor suppressor p16Ink4a- Memorial Sloan Kettering Cancer Center, New York, NYJan. 2006 The tumor biology of p16 in colon cancer- Johns Hopkins University, Baltimore, MD 4
  5. 5. Mar. 2006 Colon carcinoma and the professional tumor suppressor p16Ink4a- Presbyterian Hospital, New York Weill Cornell Medical Center, New York, NY Apr. 2006 Colon cancer and the professional tumor suppressor p16Ink4a- Emory University, Atlanta, GA May, 2006 Cell cycle regulation and GI cancer- Digestive Disease Week meeting, Los Angeles, CA June 2006 The tumor biology of p16Ink4a in colon cancer- Tufts-New England Medical Center, Boston, MA July 2006 The tumor biology of p16Ink4a in colon cancer- Fox Chase Cancer Center, Philadelphia, PA Aug. 2006 The tumor biology of p16Ink4a in colon cancer- Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA Dec 2008 Cell cycle in the balance: reciprocal regulation by Wee1 and Cdks, Department of Medicine, Temple University School of Medicine, Philadelphia, PAOrganizing Roles in Scientific Meetings: Apr. 2001 Co-Chair, Cell Cycle Checkpoints and Tumor Development mini- symposium, American Association for Cancer Research annual meeting, 4/01, New OrleansBibliography: Research Publications, peer reviewed (print or other media): Hornick CA., Hamilton RL., Spaziani E., Enders GH., Havel RJ.: Isolation and characterization of multivesicular bodies from rat hepatocytes: an organelle distinct from secretory vesicles of the Golgi apparatus. Journal of Cell Biology 100(5): 1558-69, May 1985. Enders GH., Ganem D., Varmus H.: Mapping the major transcripts of ground squirrel hepatitis virus: the presumptive template for reverse transcriptase is terminally redundant. Cell 42(1): 297-308, Aug 1985. Enders GH., Ganem D., Varmus HE.: 5-terminal sequences influence the segregation of ground squirrel hepatitis virus RNAs into polyribosomes and viral core particles. Journal of Virology 61(1): 35-41, Jan 1987. Chang, C., Enders, G.H., Sprengel, R., Peters, N., Varmus, H.E., Ganem, D.: Expression of the pre-core region of an avian hepatitis virus is not required for viral replication. Journal of Virology Vol. 61: 3322-3325, 1987. Ridker PM., Enders GH., Lifton RP.: False positive mononucleosis screening test results associated with Klebsiella hepatic abscess. American Journal of Clinical Pathology 94(2): 222-3, Aug 1990. Meyerson M., Enders GH., Wu CL., Su LK., Gorka C., Nelson C., Harlow E., Tsai 5
  6. 6. LH.: A family of human cdc2-related protein kinases. EMBO Journal 11(8): 2909-17, Aug 1992.Koh J., Enders GH., Dynlacht BD., Harlow E.: Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature 375(6531): 506-10, Jun 8 1995.Zhu, L., Enders, G.H., Lees, J.A., Beijersbergen, R.L., Bernards, R, Harlow, E.: The pRb-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes. EMBO Journal Vol. 14: 1904-1913, 1995.Enders GH., Koh J., Missero C., Rustgi AK., Harlow E.: p16 inhibition of transformed and primary squamous epithelial cells. Oncogene 12(6): 1239-45, Mar 21 1996.Mitra J., Dai C.Y., Somasundaram K., El-Deiry W.S., Satyamoorthy K., Herlyn M., Enders G.H.: Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a). Molecular & Cellular Biology 19(5): 3916-28, May 1999.Prabhu NS., Somasundaram K., Tian H., Enders GH., Satyamoorthy K., Herlyn M., El-Deiry WS.: The administration schedule of cyclin-dependent kinase inhibitor gene therapy and etoposide chemotherapy is a major determinant of cytotoxicity. International Journal of Oncology 15(2): 209-16, Aug 1999.Dai C.Y., Enders G.H.: p16 INK4a can initiate an autonomous senescence program. Oncogene 19(13): 1613-22, Mar 23 2000.Dai C.Y., Furth E.E., Mick R., Koh J., Takayama T., Niitsu Y., Enders G.H.: p16(INK4a) expression begins early in human colon neoplasia and correlates inversely with markers of cell proliferation. Gastroenterology 119(4): 929-42, Oct 2000.Steppan C.M., Brown E.J., Wright C.M., Bhat S., Banerjee R.R., Dai C.Y., Enders G.H., Silberg DG., Wen X., Wu GD., Lazar MA.: A family of tissue-specific resistin-like molecules. Proceedings of the National Academy of Sciences of the United States of America 98(2): 502-6, Jan 16 2001.Krauthauser C.M., Hall L.A., Wexler R.S., Slee A.M., Mitra J., Enders G.H., Kerr J.S.: Regulation of gene expression and cell growth in vivo by tetracycline using the hollow fiber assay. Anticancer Research 21(2A): 869-72, Mar-Apr 2001.Hu B., Mitra J., van den Heuvel S., Enders G.H.: S and G2 phase roles for Cdk2 revealed by inducible expression of a dominant-negative mutant in human 6
  7. 7. cells. Molecular & Cellular Biology 21(8): 2755-66, Apr 2001.Gibson S.L., Dai C.Y., Lee H.W., DePinho R.A., Gee M.S., Lee W.M., Furth E.E., Brensinger C., Enders G.H.: Inhibition of colon tumor progression and angiogenesis by the Ink4a/Arf locus. Cancer Research 63(4): 742-6, Feb 15 2003.Kalabis J., Patterson M.J., Enders G.H., Marian B., Iozzo R.V., Rogler G., Gimotty P.A., Herlyn M.: Stimulation of human colonic epithelial cells by leukemia inhibitory factor is dependent on collagen-embedded fibroblasts in organotypic culture. FASEB Journal 17(9): 1115-7, Jun 2003.Harada, H., Nakagawa, H., Oyama, K., Takaoka, T., Jacobmeier, B., Enders, G.H., Opitz, O., Rustgi, A.: Telomerase induces immortalization of human esophageal keratinocytes without p16Ink4a inactivation. Molecular Cancer Research 1: 729-38, Aug 2003.Mitra, J., Enders, G.H.: Cyclin A/Cdk2 complexes regulate activation of Cdk1 and Cdc25 phosphatases in human cells. Oncogene 23: 3361-7, Apr 21 2004.Takaoka, M., Harada, H., Deramaudt, T.B., Oyama, K., Andl, C.D., Johnstone, C.N., Rhoades, B., Opitz, O.G., Enders, G.H., Nakagawa, H. Ha-RasG12V induces senescence in primary and immortalized human esophageal keratinocytes with p53 dysfunction. Oncogene 23:6760-8, Sep 2 2004.Maude, S.L., Enders, G.H. Cdk inhibition in human cells compromises Chk1 function and activates a DNA damage response. Cancer Research 65:780-786, Feb 1, 2005.Gibson, S.L., Boquoi, A., Chen, T., Sharpless, N.E., Brensigner, C., Enders, G.H. p16Ink4a inhibits histologic progression and angiogenic signaling in Min colon tumors. Cancer Biology and Therapy 4:1389-1395, Dec 2005.Enders, G.H., Maude, S.L. Traffic safety for the cell: influence of cyclin-dependent kinase activity on genomic stability. Gene 371:1-6, Feb 2006.Mitra J., Enders G.H., Azizkhan-Clifford J., Lengel K.L: Dual regulation of the Anaphase promoting complex in human cells by cyclin A-Cdk2 and cyclin A-Cdk1 complexes. Cell Cycle 5:661-6, Mar 2006.Furth E.E., Gustafson K.S., Dai C.Y., Gibson S.L., Menard-Katcher P., Chen T., Koh J., Enders G.H.: Induction of p16Ink4a within regenerative epithelial crypts in ulcerative colitis. Neoplasia 8:429-436, Jun 2006. 7
  8. 8. Dews M., Homayouni A., Yu D., Murphy D., Wentzel E., Sevignani C., Wentzel E., Furth E., Lee W.M., Enders G.H., Mendell J.T., Thomas-Tikhonenko T.: Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nature Genetics 38:1060-65, Sep 2006. Boquoi A, Jover R, Chen T, Pennings M, Enders G. Transgenic expression of VEGF in intestinal epithelium drives mesenchymal cell interactions and epithelial neoplasia. Gastroenterology, epub Nov 1, 2008.Contributions to peer-reviewed clinical research publications, participation cited but notby authorship: [none]Research Publications, non-peer reviewed: [none]Abstracts: Dai, C.Y., Gibson, S.L., Gee, M.S., Lee, W.F., Lee, H.-L., DePinho, R.A., Enders, G.H.: Suppression of mouse colon tumor angiogenesis by the INK4a/ARF locus. Digestive Disease Week, Atlanta, GA (poster) May 2001. Dai, Y.C., Gibson, S.L., Gee, M.S., Lee, W.F., Brensinger, C., Furth, E.E.,Lee, H.- W., DePinho, R.A., Enders, G.H.: Suppression of colon tumor progression and angiogenesis by the INK4a/ARF locus. Digestive Disease Week, San Francisco, CA (poster) May 2002. Mitra, J., Enders, G.H.: Specific functions of Cdk2 and Cdk1 required for timely progression through G2 phase in human cells. Cold Spring Harbor Laboratory Protein Phosphorylation and Cell Signaling meeting (poster) May 2003. Takaoka, M., Harada, H., Rhoades, B., Deramault, T., Opitz, O., Enders, G.H., Nakagawa, H.: Oncogenic RAS induces a senescence-like phenotype in human esophageal epithelial cells. American Association of Gastroenterology digestive Disease Week meeting, Orlando, Florida (oral) May 2003. Kalabis, J., Enders, G.H., Herlyn, J.: Leukemia inhibitory factor (LIF) is a critical factor for maintaining intestinal homeostasis by stimulating proliferation of normal human epithelial cells. American Association for Cancer Research annual meeting Washington, D.C. (poster) July 2003. Maude, S., Enders, G.H.: Cdk inhibition in human cells compromises Chk1 function and activates a DNA damage response. DNA Replication and Genome Integrity Meeting, The Salk Institute, San Diego, CA (oral) August 2004. Boquoi, A, Gibson, S.L., Chen. T., Furth, E.E., Enders, G.H.: Inhibition of colon 8
  9. 9. tumor progression and angiogenesis by p16Ink4a, Digestive Disease Week, Los Angeles, CA, (poster) May 2006. Li, C.C., Enders, G.H.: A new regulatory element in human cell mediating its inactivation by cyclin A/Cdk2, The Cell Cycle, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, (poster) May 2008.Editorials, Reviews, Chapters, including participation in committee reports (print orother media): Zhu L., Enders G.H., Wu C.L., Starz M.A., Moberg K.H., Lees J.A., Dyson N., Harlow E.: Growth suppression by members of the retinoblastoma protein family. [Review] [67 refs] Cold Spring Harbor Symposia on Quantitative Biology Vol. 59: 75-84, 1994. Enders G.H.: Book review: Redesigning cancer therapy. Cancer Biology and Therapy 1 Vol. 1: 195-196, 2002. Enders G.H.: Cyclins in breast cancer: too much of a good thing. Breast Cancer Research 4(4): 145-147, 2002. Enders G.H.: The INK4a/ARF locus and human cancer. [Review] [98 refs] Methods in Molecular Biology Vol. 222: 197-209, 2003. Enders G.H.: Colon cancer metastasis: is E2F-1 a driving force? Cancer Biology and Therapy 3: 400-1, Apr 2004. Enders G.H., Maude S.L.: Traffic safety for the cell: influence of cyclin dependent kinase activity on genomic stability. Gene 371:1-6, Apr 12, 2006. Enders G.H., Boquoi A.: Ubiquitination of Myc: flipping the switch. Cancer Biology and Therapy 5: 907-8, Aug 2006. Enders G.H.: The Ink4a locus: beyond the cell cycle. In Cancer genome and tumor microenvironment. Springer Science and Business Media, in press. Boquoi A., Enders G.H.: Adenomatous polyposis coli mutations in colon cancer: slipping off the brake and onto the gas pedal. Cancer Biology and Therapy 7:485-7, Apr 2008 Enders G.H.: Expanded roles for Chk1 in genome maintenance. J Biol Chem 283: 17749-52 Jun 2008 Adams, P.D., Enders, G.H. Wnt signaling and senescence: a tug of war in early neoplasia? Cancer Biol. Ther 7: 1706-11 Nov 2008 9
  10. 10. Books: [none]Alternative Media: El Deiry W.S., Enders, G.H.: Colon polyps. Emedicine Bhutani, M.S., Talavera, F., Anand, B.S., Mechaber, A.J., and Katz, J. (Ed.s). 3(3), March 5 2002 Notes: Online. www.emedicine.com/med/topic414.htm. Enders G.H., El Deiry, WS.: Colon polyps. Emedicine Bhutani, M.S., Talavera, F., Anand, B.S., Mechaber, A.J., and Katz, J. (Ed.s), Sept, 2005. Notes: Online. www.emedicine.com/med Enders G.H.: Colonic polyps. Emedicine Bhutani, M.S., Talavera, F., Anand, B.S., Mechaber, A.J., and Katz, J. (Ed.s), in press. Notes: Online. www.emedicine.com/med.Patents: [none] 10

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