Curriculum Vitae                                 Bryon E. Petersen, Ph.D.Business Address:Dept. of Pathology, Immunology, ...
Byron E. Petersen, Ph.D.1994-present         American Association for the Advancement of Science, (AAAS)1993-present      ...
Byron E. Petersen, Ph.D.4. Piscaglia AC, Shupe TD, Gasbarrini A, Petersen BE. Microarray RNA/DNA in Different    Stem Cell...
Byron E. Petersen, Ph.D.20. ATP Cassette transporter gene expression in rat liver progenitor cells. Jenny E. Ros, Tania   ...
Byron E. Petersen, Ph.D.37. Hepatic oval cell activation in response to injury following chemically induced periportal or ...
Byron E. Petersen, Ph.D.       microenvironment. Eds Greenbeger JS and Keadding AM. In press, Cambridge University       P...
Byron E. Petersen, Ph.D.Youngmi Jung, 2002-2006: Dissertation Title: "Role of Somatostatin in Migration of Hepatic Oval   ...
Byron E. Petersen, Ph.D.                      Agency for Science, Technology and Researchs (A*STAR), Singapore.           ...
Byron E. Petersen, Ph.D.Invited Speaker: Cell Biotechnology Seminar, Arizona State University, Tempe, Arizona, Oct.       ...
Byron E. Petersen, Ph.D.Invited Speaker "Hepatic Stem Cell" meeting. NIH, Dec., 1996.’97,’98,’99                          ...
Byron E. Petersen, Ph.D.           Period October 1, 2001-September 30, 2003: Direct indirect costs: $289,000           Th...
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Curriculum Vitae

  1. 1. Curriculum Vitae Bryon E. Petersen, Ph.D.Business Address:Dept. of Pathology, Immunology, and Experimental Medicine Phone: (352) 392 - 6261College of Medicine, University of Florida FAX: (352) 392 - 6249P.O. Box 100275, Gainesville, FL 32610-0275, e-mail: petersen@pathology.ufl.edufor : Courier Service, add: 1600 S. W. Archer Rd., Room M-649, MSB: Education and TrainingUndergraduateDates Attended Institution Degree Major Subject1995-1990 University of Iowa B.A. Biology/BotanyGraduateDates Attended Institution Degree Major Advisor/Discipline1992-1995 University of Pittsburgh M.S. Dr. Billy Day/Toxicology1995-1996 University of Pittsburgh Ph.D. Dr. Day/Mole.Toxicology Appointments and PositionsAcademicDates Institution/Organization Rank/Title2006-present University of Florida Associate Professor2000-2006 University of Florida Assistant Professor1999-2000 University of Pittsburgh Res. Asst. Professor1997-1999 University of Pittsburgh Research Associate1991-1996 University of Pittsburgh Research Specialist 41990-1991 Duke University Research Technician MembershipsDates2000-present American Association for the Study of Liver Diseases, (AASLD) Basic Science Education Committee, 2006-present1993-present American Association for Cancer Research, (AACR). Elected to National Associate Member Council, 1997-2000 Grant Writing Workshop Committee Member, Annual AACR meeting, New Orleans, 1998 Chair, Writing Workshop Committee given at the Annual AACR meeting, Philadelphia, 1999 Elected Chair of Associate Member Council 1999-2000 Membership Development Committee, 2003-present1995-present American Society of Investigative Pathology, (ASIP) Member Liver Pathobiology sub-section, since 1995
  2. 2. Byron E. Petersen, Ph.D.1994-present American Association for the Advancement of Science, (AAAS)1993-present Allegheny-Eire Chapter, Society of Toxicology, (A-E SOT).2001.2002 Society of Regenerative Medicine and Stem Cell Biology, Inc.; Founder and Board of Directors.2003-present International Society for Stem Cell Research (ISSCR). HonorsExemplary Teaching Award: University of Florida, College of Medicine, 2007.Doctoral Dissertation Advisor and Mentoring Award: University of Florida, College of Medicine, 2007.Distinguished Lecturer 22nd Annual Meeting of the Korean Society of Endocrinology, Seoul Korea, April 30, 2004.Keynote Lecturer, “Frontiers In Hepatology,” University of Navarra, Pamplona, Spain, December 13-14, 2001Distinguished Lecturer, “Asian Science Seminar on Animal Cell Technology 2001”, Nagoya University, Nagoya, Japan, Nov. 7-11, 2001Distinguished Lecturer, "13th Annual Seminars in Liver Regeneration", Japanese Hepatology Society, February 8, 2000, Tokyo, JapanPh.D. Dissertation nominated and selected as best written communication, Ph.D. level. Graduate School of Public Health, Dept. of Environmental, Occupational Health andToxicology. University of Pittsburgh, 1997Ph.D. dissertation nominated & selected as best written communication, Ph.D., Science entry. University of Pittsburgh, 1997Outstanding Student Award for academic excellence. Graduate School Public Health, Univ. Pittsburgh, 19971st place award, 7th Annual Dept of Pathology Research Presentations, Univ. of Pittsburgh, Medicine 1996National Student Research Travel Award from American Society of Investigative Pathologist (ASIP) for the Experimental Biology Meeting, 1995.Honorable mention, 2nd place, Allegheny-Erie Region Society of Toxicology Student Research Award, 1994.Honorable mention, 2nd place, University of Iowa Electron-Microscopy Society, Senior Research Project, 1990. Publications1. Granulocyte-Colony Stimulating Factor Promotes Liver Repair and Induces Oval Cell Migration and Proliferation in Rats. Anna C. Piscaglia, Thomas D. Shupe, Seh-Hoon Oh, Antonio Gasbarrini, Bryon E. Petersen. Gastroenterology. In Press.2. Piscaglia AC, Shupe TD, Petersen BE, Gasbarrini A. Stem Cells, Cancer, Liver, and Liver Cancer Stem Cells: Finding a Way out of the Labyrinth. Current Cancer Drug Targets. In press.3. Bone marrow derived hepatic oval cells differentiate into hepatocytes in 2AAF/PHx induced liver regeneration. She-Hoon Oh, Rafal Witek, SiHyun Bae, Donghang Zheng, Youngmi Jung, Anna C. Picaglia and Bryon E. Petersen. Gastroenterology, 2007, 132:1077-1087.Curriculum Vitae 2 Date: May9, 2007
  3. 3. Byron E. Petersen, Ph.D.4. Piscaglia AC, Shupe TD, Gasbarrini A, Petersen BE. Microarray RNA/DNA in Different Stem Cell Lines. Current Pharmaceutical Biotechnology, 2007, 8:1-9.5. Human hepatic progenitor cells express vasoactive intestinal peptide receptor type-2 and receive nerve ending. David Cassiman, Nicoletta Sinelli, Ilse Bockx, Sara Vander Borght, Bryon Petersen, Rita De Vos, Jos van Pelt, Frederik Nevens, Louis Libbrecht, Tania Roskams. Liver International, 2007, ISSN 1478-3223:324-328.6. Oval Cell Response in 2AAF/PHx Rat is Attenuated by siRNA Targeted to SDF-1. Donghang Zheng, Seh-hoon Oh, Youngmi Jung and Bryon E. Petersen. AJP, 169(6): 2066-2074.7. Breast cancer resistance protein (BCRP/ABCG2) is expressed by progenitor cells/reactive ductules and hepatocytes and its expression pattern is influenced by disease etiology and species type: possible functional consequences. (2006)Vander Borght S, Libbrecht L, Katoonizadeh A, van Pelt J, Cassiman D, Nevens F, Van Lommel A, Petersen BE, Fevery J, Jansen PL, Roskams TA. J Histochem Cytochem. 2006 Sep;54(9):1051-9.8. A potential role of somatostatin and its receptor SSTR4 in the migration of hepatic oval cells. (2006) Jung Y, Oh SH, Zheng D, Shupe TD, Witek RP, Petersen BE. Lab Invest. 2006 86(5):477-89.9. Mesenchymal stem cells spontaneously express neural proteins in culture and are neurogenic after transplantation. (2006) Deng J, Petersen BE, Steindler DA, Jorgensen ML, Laywell ED. Stem Cells, 24(4):1054-64.10. Evidence Regarding a Stem Cell Origin of Hepatocellular Carcinoma. (2006) Thomas Shupe and Bryon Petersen. Stem Cell Reviews 3:261-264.11. Stem-cell therapy for hepatobillary pancreatic disease. Takahsa Fujikawa, Seh-hoon Oh, Tom Shupe and Bryon E. Petersen. (2005) J Hepatobiliary Pancreat Surg. 12: 190-195.12. Teratoma Formation Leads to Failure of Treatment for Type I Diabetes Using Embryonic Stem Cell-Derived Insulin-Producing Cells. Takahisa Fujikawa, Seh-Hoon Oh, Liya Pi, Heather M Hatch, Tom Shupe, and Bryon E Petersen. (2005) American Journal of Pathology 166(6): 1781-1791.13. The Role of Connective Tissue Growth Factor in Oval Cell Response During Liver Regeneration Following 2-AAF/PHx in Rats. Liya Pi, Seh-Hoon Oh, Thomas Shupe and Bryon E. Petersen. (2005) Gastroenterology 128: 2077-2088.14. Monocrotaline, an Alternative to Retrorsine Based Hepatocyte Transplantation. Rafel Witek, Samantha H. Fisher and Bryon E. Petersen. (2005) Journal of Cell Transplantation 14: 41-4715. Ex vivo transduced liver stem cells as a platform for gene therapy Sihong Song, Rafal P. Witek, Yuanqing, Lu, Young-Kook Choi, Donghang Zheng, Marda Jorgensen, Chenwei Li, Terence R. Flotte, Bryon E. Petersen (2004) Hepatology 40:918-924.16. Adult Bone Marrow-Derived Cells Trans-differentiating into Insulin-Producing Cells for the Treatment of Type I Diabetes. Seh-Hoon Oh, Toni. M. Muzzonigro, Si-Hyun Bae, Jennifer M. LaPlante, Heather M. Hatch, and Bryon E. Petersen, Laboratory Investigation 84; 607-617.17. Signal Transduction Determining the Fate of Stem Cells. Lynn E. Heasley and Bryon E. Petersen (2004) EMBO Reports 5 (March): 241-244.18. Primer on Stem Cells, Part I: Stem Cell Biology, Christopher R. Cogle, Ronald C. Sanders, Edward W. Scott, and Bryon E. Petersen (2003) Mayo Clinic Proceedings, 78:993-100319. Primer on Stem Cells, Part II: Ethical and Regulatory Issues. Christopher R. Cogle, Steven M. Guthrie, Bill Allen, Edward W. Scott and Bryon E. Petersen (2003) Mayo Clinic Proceedings, 78:993-1003.Curriculum Vitae 3 Date: May9, 2007
  4. 4. Byron E. Petersen, Ph.D.20. ATP Cassette transporter gene expression in rat liver progenitor cells. Jenny E. Ros, Tania AD Roskams, Mariska Geuken, Rick Havinga, Patrick Splinter, Bryon E. Petersen, Nicholas F. LaRusso, Han Moshage, Folkert Kuipers, Klaas Nico Faber, Michael Müller, and Peter L.M. Jansen. (2003) Gut, 52:1060-1067.21. Neural Trans-differentiation Potential of Hepatic Oval Cells in the Neonatal Mouse Brain. Jie Deng, Eric D. Laywell, Dennis A. Steindler, Bryon E. Petersen (2003) Experimental Neurology, 182: 373-382.22. Mouse Hepatic Oval Cells Express the Hematopoietic Stem Cell Markers Sca-1 and CD-34. Bryon E. Petersen, Brian Grossbard, Heather Hatch, Edward Scott. (2003) Hepatology, 37(3): 632-640.23. Hepatic oval "stem" cell in liver regeneration. Seh-Hoon OH, Heather M. Hatch, and Bryon E. Petersen. (2002) Seminars in Cell and Developmental Biology, 13: 405-409.24. SDF-1/CXCR4: A Possible Mechanism for Bone Marrow Derived Hepatic Oval Cell Recruitment to the Rat Liver. Hatch H, Zhang D, Jorgensen MS. and Petersen BE. (2002) Cloning and Stem Cells 4(4): 339-352.25. In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone- producing cells. Lijun Yang, Shiwu Li, Heather Hatch, Kim Ahrens, Janet G. Cornelius, Ammon B. Peck and Bryon E. Petersen. (2002) PNAS 99: 8078.26. Stem cells in adult tissue. Sharon C. Presnell, Bryon E. Petersen and Mohammad Heidaran. (2002) Seminars in Cell and Developmental Biology, 13: 369-376.27. Bone Marrow Cells Adopt Phenotype of Other Cells by Spontaneous Cell Fusion. Naohiro Terada, Takashi Hamazaki, Masahiro Oka, Masanori Hoki, Diana M. Mastalerz, Yuka Nakano, Edwin M. Meyer, Laurence Morel, Bryon E. Petersen & Edward W. Scott, (2002) Nature 416: 542.28. Hepatic oval (stem) cell expression of EDG receptors for lysophosphatidic acid in mouse chronic liver injury. Yuri Y. Sautin, Marda Jorgensen, Bryon E. Petersen, Jean S. Saulnier- Blache, James M. Crawford, Stanislav I. Svetlov. (2002) Journal of Hematotherapy & Stem Cell Research 11:643-649.29. The processing and Utilization of Hepatocyte Growth Factor/Scatter Factor Following Partial Hepatectomy in the Rat. Pediaditakis P, Lopez-Talavera JC, Petersen BE, Monga SPS, Michalopoulos GK. Hepatology 34(4): 688-697.30. Hepatic Stem Cells: Coming full circle. Petersen BE. Journal Blood Cells, Molecules and Disease May/June 590-600.31. Stem Cells: A Journey into a New Frontier. Petersen BE and Terada N. (2001) Journal of Nephrology 12(8): 1773-1780.32. Hepatic Oval Cells: Knocking on Forbidden Doors. Petersen BE (2000) Journal of Regenerative Medicine 1:59-6433. Adrenergic stimulation of Hepatocyte Growth Factor expression. Broten J. Michalopoulos GK, Petersen BE, and Cruise J. (1999) BBRC 262(1): 7634. Hepatocyte growth factor (HGF) and receptor (c-met) in normal and malignant astrocytic cells. Welsh WC, Komblith PL, Michalopoulos GK, Petersen BE, Beedle A, Gollin SM and Golgfarb RH. Anticancer Research 19(3A): 165.35. Growth factor signal transduction immediately following two-thirds partial hepatectomy in the rate. Stolz D-B, Mars WM, Petersen BE, Kim T-Y, and Michalopoulos GK. Cancer Research 59: 3954-3960.36. Bone marrow as a potential source for hepatic oval cells. Petersen BE, Bowen WC, Mars WM, Patrene KD, Boggs SS, Sullivan AK, Greenberger JS, and Goff JP. (1999) Science 284:1168-1170.Curriculum Vitae 4 Date: May9, 2007
  5. 5. Byron E. Petersen, Ph.D.37. Hepatic oval cell activation in response to injury following chemically induced periportal or pericentral damage. Petersen BE, Zajac VF, and Michalopoulos GK. (1998) Hepatology 27(4): 1030-1038.38. Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat. Petersen BE, Goff JP, Greenberger JS and Michalopoulos GK. (1998) Hepatology 27(2): 433-445.39. Bile ductular damage induced by Methylene Dianiline inhibits oval cell activation. Petersen BE, Zajac VF, and Michalopoulos GK. (1997) American Journal of Pathology 151(4): 905-910.40. Extracellular matrix remodeling at the early stages of liver regeneration. Kim T-Y, Mars WM, Stolz DB, Petersen BE and Michalopoulos GK. (1997) Hepatology 26(4): 896-904.41. Expression of HGF and cMet in the developing and adult brain. Achim CL, Katyal S, Wiley CA, Shiratori M, Wang G, Oshika E, Petersen BE, Li J-M, and Michalopoulos GK. (1997) Development Brain Research 102(2): 299-303.42. Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF-∀ in a chemically defined (HGM) medium. Block GD, Locker J, Bowen WC, Petersen BE, Katyal S, Strom SC, Riley T, Howard TA and Michalopoulos GK. (1996) Journal of Cell Biology 132: 1133-1149.43. Synergistic effects of hepatocyte growth factor on human cord blood CD34+ progenitor cells are the result of c-met receptor expression on the stem cell. Goff JP, Shields DS, Petersen BE, Zajac VF, Michalopoulos GK and Greenberger JS. (1996) Stem Cell 14(5): 592-602.44. Distinct morphological and mito-inhibitory effects induced by TGF-β1,, HGF and EGF on mouse, rat and human hepatocytes. Petersen BE, Yee CJ, Bowen W, Zarnegar R, and Michalopoulos GK, (1994) Cell bio and Tox 10: 219.45. Expression and characterization of biologically active human hepatocyte growth factor (HGF) by insect cell infected with HGF-recombinant baclovirus. Yee CJ, DeFrances MC, Bell A, Bowen W, Petersen BE, Michalopoulos GK, and Zarnegar R. (1993) Biochem 32(31): 7922.46. Localization of Hepatocyte Growth Factor (HGF) gene one human chromosome 7. Zarnegar R, Petersen BE, DeFrances MC, Michalopoulos GK. (1992) Genomic January 12:147-150 Book ChaptersSomatic Cell Therapy, Past, Present and Future, Chapter One. Jennifer Williams and Bryon E. Petersen. In “Cell Therapy” edited by Damian Garcia-Olma, Jose Manuel Garcia- Verdugo, Jorge Alemany, Manuel A Gonzalez and Jose A Gutierrez-Fuentez. Publisher Humana Press. Due January, 2007Isolation and Characterization of Hepatic Stem Cells, or “Oval Cells”, from Rat Livers. In “Stem Cells in Regenerative Medicine”. Anna C. Piscaglia1, Thomas Shupe, and Bryon E. Petersen. Editors: Julie Audet and Bill Stanford, Publisher Humana Press. October, 2006Turning Blood to Liver. Bryon E. Petersen and Neil D. Theise. (2003) In Stem Cell Therapy for Autoimmune Disease. Ed. Richard K. Burt. Landes Bioscience/ Eurekah Press, Austin, TX. Chapter 4.Liver Stem Cells. Petersen BE, Hatch H (2002) in Methods of Tissue Engineering. Eds. Atala A, Lanza P. , Academic Press. San Diego, CA. Chapter 35, pages 429-437.Effects of Hepatocyte Growth Factor and IL-11 on Human Cord Blood CD34 + Progenitor Cells. Goff JP., Shields DS., Petersen BE., Michalopoulos GK. and Greenberger JS. In: Proceedings of Keystone Symposium; Molecular and Cellular Biology: The hematopoieticCurriculum Vitae 5 Date: May9, 2007
  6. 6. Byron E. Petersen, Ph.D. microenvironment. Eds Greenbeger JS and Keadding AM. In press, Cambridge University Press. PatentsBone Marrow Stem Cells in Treating Diabetes and Other Pancreatic Disorders”. US Patent Number: US7,169,608 B2, January 30, 2007. FiledApplication in progress for “Bone Marrow Transplantation for Hepatic Regeneration/Repair”, United States and International patent rights filed, University of Pittsburgh.Application in progress for “Isolation of Hepatic Oval “Stem” Cells Using Thy-1 Antibody and FACS Analysis”, United States and International patent rights filed, University of Pittsburgh.Application in progress for "SDF-1 as a Potential Protein for Recruitment of HSCs to the Liver" Provisional patent filed University of Florida.Application in progress for "Trans-differentiation of Adult Liver Stem cells into Pancreatic Islet, insulin producing cells". Provisional patent filed University of Florida.Application in progress for “Long-term Culture Medium for Liver Stem Cells”. Provisional patent filed University of Florida.Application in progress for “Liver Stem Cells Potential for Neuronal Tissue”. Provisional patent filed University of Florida.Application in progress for “Small Animal Model for the study of Hepatitis C Virus (HCV). Provisional patent filed University of Florida. TeachingIDP Director for the Molecular Cell Biology Program, Medical Graduate School, University of Florida (2001-2005)Course Director for MCB Journal Club, University of Florida (2001-2005).Course Instructor: Stem Cell Biology, University of Florida. Cellular and Molecular Basis of Liver DiseaseFounding Member of the Stem Cell Program, University of Florida Shands Cancer Center.Graduate Faculty Status, Medical Graduate School, University of FloridaOrgan Systems Toxicology, Graduate School of Public Health, University of Pittsburgh. Team- taught course, section of Hepatic Growth and Regeneration. Past Students and TraineesStudents: (Doctoral and Masters)Jie Deng, 2001-2005: Dissertation Title: “Neurogenesis of Adult Stem Cells.”Rafel Witek, 2002-2005: Dissertation Title: “Novel Application of Gene Therapy and Somatic Stem Cells in Treating Metaboloic Liver Disorders.”Liya Pi, 2001-2005: Dissertation Title: “The Role of Connective Tissue Growth Factor in Oval Cell Aided Liver Regeneration in the 2AAF/PHx Model.”Curriculum Vitae 6 Date: May9, 2007
  7. 7. Byron E. Petersen, Ph.D.Youngmi Jung, 2002-2006: Dissertation Title: "Role of Somatostatin in Migration of Hepatic Oval Cells in Injured Liver Model of Rats." Donghang Zheng, 2001-2006: Dissertation Title: “Stromal Cell Derived Factor-1 (SDF-1) in Oval Cell Activation and Migration.”Jennifer Williams, 2003-2007: Dissertation Title: The role of Wnt signaling in oval cell activation and differentiation in the rat 2AAF/PHx model.Heather Hatch, 2003-2005: MS Thesis: “Notch and Jagged Role in Oval Cell Activation in the 2AAF/PHx model.”Fellows:Dr. Shey-hue Bae, 2002-2004: Post-doctoral Fellow; Assistant Professor Korean Catholic University, Seoul, KoreaDr. Takashita Fujikawa, 2002-2004: Post-doctoral Fellow; Transplant Surgery Fellow, University of Florida, Gainesville, FL. ServiceServing member of the AASLD Basic Science Educational Committee, appointed May 2006- presentServing member of the AACR Membership Development Committee, appointed June 2001-presentChaired Maxi-symposium on Adult Stem Cells: EB/ASIP Annual Meeting, Orlando FL, March 31-April 4, 2001Co-chaired workshop "Gene Therapy as a Platform for Liver Diseases", EB/ASIP AnnualMeeting, Orlando FL, March 31-April 4, 2001Editorial Board member for the journals: Cloning and Stem Cells (Associate Editor) Organogenesis Stem Cell Reviews Regenerative Medicine: Stem Cell Biology section (no longer in publication)Reviewer for journals: Hepatology American Journal of Pathology Journal of Cell Biology Experimental Medicine Experimental Hematology FASEB Journal Cancer Research Gastroenterology NatureGrant reviewer for: NIH/NIA (adhoc study sections dealing with stem cell RFAs) NIH.NIDDK (ad-hoc HBPP and TME) Permanent Member HPBB: 2007-2010. NIH.NIBIB (study section Tissue Engineering) NASA DOD, Life Sciences Division, U.S. Army Research Office Italian Ministry of Health Wellcome Trust Foundation Netherlands Review Organization German Scientific AgencyCurriculum Vitae 7 Date: May9, 2007
  8. 8. Byron E. Petersen, Ph.D. Agency for Science, Technology and Researchs (A*STAR), Singapore. Scottish Hospital Endowment Research Trust (SHERT)Serving member of the Board of Directors (Vice President) Regenerative Medicine and Stem Cell Biology Society, 2001-2003Elected to National Associate Member Council (AACR), 1997-2000 Grant Writing Workshop Committee Member given at the Annual AACR meeting, New Orleans, 1998 Chair, Writing Workshop Committee, Annual AACR meeting, Philadelphia, 1999 Elected Chair of Associate Member Council 1999-2000 Past-Chair of Associate Member Council 2000-2001 Serving committee member Membership Development Committee (2001-present)University of Pittsburgh Technology and Transfer Office; Application Review Committee MemberScientific Advisor Board Member: Indiana University/Prude University-Indianapolis Regenerative Medicine and Stem Cell ProgramInternational Advisor to the Catholic University of Korea Adult Stem Cell program. Speaking InvitationsInvited Speaker, University of Pittsburgh, Dept. of Pathology, Grand-rounds. December 6-7, 2006.Invited Speaker, Cure Glycogen Storage Disease Foundation Annual Retreat. October 15-16, 2006. Cheshire, CT.Invited Speaker, FASEB summer research conferences "Liver Growth, Development and Disease." July 22-27, 2006 Snowmass CO.Invited Speaker, Diabetes Summit, Cleveland Clinics, May 17-18, 2006, Cleveland, OhioInvited Speaker, University of Birmingham, Dept of Cell Sciences, October 18 2005, Birmingham, England.Invited Speaker, GSD-1 Symposium, October 14-15, 2005, Milton Keynes, EnglandInvited Speaker, GSD-1 Symposium, September 15-16, 2005, Calgary, CanadaInvited Speaker GSD-1 Workshop, Alexicon Pharmaceuticals, May 23, 2005, Cheshire, CT.Invited Speaker Johnson and Johnson, Betalogics Division, June 8, 2004, Princeton, NJ.Invited Speaker Catholic University of Korea 50th Anniversary, May 1, 2004 Seoul Korea (2 lectures; General session and breakout session).Keynote Speaker Korean Society of Endocrinology April 30, 2004, Seoul KoreaInvited Speaker: University of Texas, Institute of Molecular Medicine Houston, TX, October 2003.Invited Speaker: European Association for the Study of Liver (ESAL), Venice, Italy, Sept. 24-27, 2003Invited Speaker: University of Texas, Institute of Molecular Medicine, Houston, TX, June. 25-26, 2003Invited Speaker: Cirgle-Najjar Foundation 3rd Annual Meeting and Support Group, Lancaster, PA. June 11-13, 2003Invited Speaker: JDRF Research Center, University of Pittsburgh, Children’s Hospital, Pittsburgh, PA May 1,2003Invited Speaker: Int’l Congress of the Cell Transplant Society, Emory University, Atlanta, Mar. 3-5, 2003Invited Speaker: MD Anderson Cancer Center, University of Texas, Houston, TX, Jan. 21-23, 2003Curriculum Vitae 8 Date: May9, 2007
  9. 9. Byron E. Petersen, Ph.D.Invited Speaker: Cell Biotechnology Seminar, Arizona State University, Tempe, Arizona, Oct. 16-17, 2002Invited Speaker: Mayo Clinic National Conference on Medicine and the Media, at the Mayo Clinic, Rochester, Minnesota, Sept. 20-22, 2002Invited Discussion Leader: The Gordon Research Conference on Signal Transduction by Engineered Extracellular Matrices, Connecticut College Conference Center, New London, CT, June23-27, 2002Invited Speaker: Stem Cell Therapy and Autoimmune Diseases Conference, sponsored by the Leucadia National Corporation, at Snowbird Conference Center, Snowbird, Utah, June 6- 9, 2002Invited Speaker: International Conference on Emerging Trends in Biotechnology: Stem Cells- Technology, Potential and Trends. Hyderdad, India, May 2-4, 2002Invited Speaker: Alpha-1 Foundation, Critical Issues: Stem Cell Therapies in Reparative Medicine, Miami, FL, April 19-22, 2002Invited Speaker: Frontiers In Hepatology, University of Navarra, Pamplona, Spain, Dec. 13-14, 2001Invited Speaker: Asian Science Seminar on Animal Cell Technology (ASSACT2001), Nagoya University, Nagoya, Japan, Nov. 8—10, 2001Invited Speaker: Conference: Stability and Reversal of the Differentiated State, The Banbury Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, Oct. 28—31, 2001Invited Speaker “Stem Cells: New Frontiers in Biomedicine” Teaching Course, Universidad Complutenese de Madrid. El Escorial, Spain, September 3-7, 2001Invited Speaker: Stem Cell Research Workshop, sponsored by Microban Canada, Inc., Montreal, Canada, Aug. 28-29, 2001Invited Speaker: University of Montreal, 2d International Symposium on Pediatric Gastroenterology and Nutrition, Montreal, QC, Canada, June, 2001Invited Speaker: Stem Cell Plasticity Workshop, sponsored by the Leukemia and Lymphoma Society, Four Seasons Biltmore, Santa Barbara, CA, May 4-6, 2001Invited Speaker: Brigham Young University, Iowa, Dept of Zoology, April, 2001Invited Speaker: University of Iowa, Dept. Anatomy & Cell Biology, January, 2001Invited Speaker: The Next Regeneration: World Conference Stem Cell Biology, Oct. 2000, Orlando FLInvited Speaker: The New Stem Cell Workshop, September 2000, Leiden, The NetherlandsInvited Speaker: “Mechanisms of Liver Growth and Differentiation in Health and Disease” FASEB Summer Research Conference, Snowmass Village, Colorado, July-Aug. 2000Invited Speaker: “Signal Transduction by Engineered Extracellular Matrices” The First Gordon Research Conference, New Hampshire, June 25-29, 2000Invited Speaker: Public Forum: Progress and New Hope in the Fight Against Cancer. AACR 91st Annual Meeting, San Francisco, CA, April 1-5, 2000.Invited Speaker Japan Science and Technology Forum, Medicine and Biology of Stem Cells, Kanagawa, Japan, February 9-15, 2000Invited Speaker C.H.I. Conference Stem Cell Biology, Oct. 3-5, 1999Invited Speaker Falk Symposium, Regensburg, Germany, Sept. 15-18, 1999Invited Speaker Martin Luther University, Halle, Germany, Sept. 14, 1999Invited Speaker Osiris Therapeutics Inc., Baltimore MD. Aug. 24, 1999Invited Speaker Duke University, Cancer Institute, Aug. 5, 1999Invited Speaker University of North Carolina, Dept of Pathology, July 30, 1999Invited Speaker Cedars-Sinai Medical Center, Dept of Surgery, July 15, 1999Curriculum Vitae 9 Date: May9, 2007
  10. 10. Byron E. Petersen, Ph.D.Invited Speaker "Hepatic Stem Cell" meeting. NIH, Dec., 1996.’97,’98,’99 Grants:Funded Agency: NIH/NIDDK Type: RO1 (DK58614-05) competing renewal proposal. “Mechanisms of oval cell activation, proliferation and differentiation” Principle Investigator: Bryon E. Petersen, Ph.D. Percent effort: 30% Period: December 1 2005-November 30, 2009. Direct and indirect costs: $1,450,000.00 This grant examines three potential mechanisms in oval cell biology. Agency: NIH/NIDDK Type: RO1(DK65096) “Fusion and Plasticity in Stem Cell Aided Liver Regeneration” Principle Investigator: Bryon E. Petersen, Ph.D. Percent effort: 30% Period: July 1 2005-June 30, 2010. Direct and indirect costs: $1,750,000.00 This grant examines fusion events in different stem cell aided liver regeneration models as well as homing properties of SDF-1 and the plasticity of oval cells . Agency: The Children’s Fund for GSD-1. Foundation support for the treatment of glycogen storage disease. “Gene/Stem Cell Therapy for the treatment of GSD-1.” Principle Investigator: Bryon E. Petersen, Ph.D. Percent effort: 10% Period: August 1 2006-July 31, 2007. Direct and indirect costs: $154,000.00 This grant examines the potential to treat GSD-1 utilizing gene and stem cell technologies as a potential clinical tool. Agency: NIH.NIDDK Type: PO1 (competing renewal) “Gene therapy approaches in the treatment of alpha-1 Antitrypsin (AAT) disorder.” Principle Investigator: Terry Flotte: Co-I project number 2, Percent effort: 15% Period: September 1, 2005-August 31, 2010. Direct and indirect costs: $15,000,000.00 (Project #2: $200,000/yr direct cost) This grant examines the potential to treat AAT disorder utilizing gene and stem cell technologies as a potential clinical tool. Agency: NIH-NIDDK Type: R21 Name of Agency: NIH/NIDDK (R21 AI064357) Principle Investigator: Chen Liu: Co-I, Percent effort 5% Dates: 04/01/2005-03/31/2007 Direct Costs: $250,000 This grant examines the development of a humanized mouse liver for the investigation of immune responses against HCV infection.Completed: Agency: NIH/NCI Type: R21 Pilot grant (DK60015-01) 7/01/02-6/30/04 “Bone Marrow as a Source for Pancreatic Stem Cells in the rat model” Principle Investigator: Bryon E. Petersen, Ph.D. Percent effort: 10%Curriculum Vitae 10 Date: May9, 2007
  11. 11. Byron E. Petersen, Ph.D. Period October 1, 2001-September 30, 2003: Direct indirect costs: $289,000 This grant examines the potential role of bone marrow stem cells as a source for pancreatic regeneration and the pheno-type the bone marrow sub-population capable of becoming pancreatic cells. Agency: Children’s Miracle- Network pilot grant. 3/1/04-2/28/05 PI-Petersen, BE “Adult Bone Marrow Stem Cell Plasticity in the Treatment of Diabetes”, Funded $20,000 Agency: NIH/NIDDK Type: RO1 (DK58614-01) Last year of funding cycle. “Bone Marrow Derived Stem Cells for Liver Regeneration” Principle Investigator: Bryon E. Petersen, Ph.D. Percent effort: 30% Period: December 1, 2005-November 30, 2009: Direct and indirect costs: $1,125,000 This grant examines the potential role of bone marrow stem cells as a source for hepatocyte regeneration and explores the chemokine homing protein SDF-1 involvement in stem-cell-aided liver regeneration. Agency: NIH /NIDDK 3/31/03 – 2/01/05 “EDG receptor signaling during hepatic stem cell activation” Svetlov, S. (P.I.) Petersen, B (Co-I.) 5% Direct and indirect cost $290,000 The goals of this project are (i) to explore the expression profile of the EDG receptors for LPA in human liver in normal conditions, during fibrogenesis and in its final stage, cirrhosis, and (ii) to characterize their potential pathogenic and prognostic values. Agency: NIH /NIDDK 07/31/03 – 06/30/05 Characterization & therapeutic efficacy of insulin-producing cells generated in vitro from adult human stem cells L. Yang (P.I.) Petersen, B. (Co-PI) 10% Direct and indirect cost $260,000 To define the signals involved in stem cell trans-differentiation into insulin-producing pancreatic cells. Howard Hughes Medical Institute Research Award for New Faculty. $50,000 Community Service:USA-Swimming Official (stroke and turn) and Starter, National Level Certified.FHSAA Swimming OfficialNCAA-Certified Swim OfficialMerit Badge Counselor Boy Scout of AmericaCurriculum Vitae 11 Date: May9, 2007

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