Artem Khlebnikovon on the BIOSTER Technology Research Institute (http://www.bioaster.org/)

1. EU Project Informatics Alignment Workshop
Imperial College London
April 24th-25th
Nicolas Sapay & Artem Khlebnikov
BIOASTER

2. What is BIOASTER
• An independent technology research institute focused on infectious disease &
microbiota
– Multi-partner research projects
– Multi-technology data production capabilities resulting in clinical, phenotypic, organ, cellular
and molecular/omics data (single source or combination of multiple sources)
– Development of data integration and analysis tools for infectious disease and microbiota
research communities
• Funded by “Investment for the Future” program & private contributions
• Time frames : 9 years (2012 - 2020)
• Founders
Paris and Lyon-based
innovative companies
BIOASTER is supported
by the French
Government (up to
€180M over 9 years)
through its strategic
“Investment for the
Future” program and
the local authorities
(Grand Lyon, Région
Rhône Alpes) for its
facilities in Lyon.
3Public Research
Institutions
2Co-founding
leaders
3 Life science
companies
40+
SMEs

3. Data types collected by BIOASTER
Data Type1 Standards Platform Date
availability
Restricted
access 2,3
tranSMART
support
Clinical Not defined
(CDISC?)
• Electronic case
report form
July 2015 Yes Yes
Next
Generation
Sequencing
Fastq, Fastqc • Illumina
• Roche
• Life Technologies
Available Yes Yes
NMR Not defined • Brucker Available Yes Not yet
Mass
spectrometry
Not defined • Brucker
• Thermo Scientific
Available Yes Not yet
Cytometry Not defined • Fluidigm
• Miltenyi
Available Yes Not yet
Imaging Not defined Available Yes No ?
1 Molecular/omics data highlighted in blue
2 Possibility to release the restriction
3 Possibility to produce unrestricted access data

4. • Curation tools for miscellaneous data formats
• Loading and visualization of the molecular/omics data from human or
microorganisms
ex. genomics, transcriptomics, cytometry and metabolomics
• Loading and visualisation of multispecies data
ex. metatranscriptomics in microbiota…
• Integration or interfacing of tranSMART with in-house scripts
ex. R, Matlab…
• Support for legal and ethical issues in clinical data collection
N.B. Restricted access as a function of the project partern’s data ownership .
Specific needs for BIOASTER