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Aâ¨tissueâ¨isâ¨anâ¨organizedâ¨aggregationâ¨ofâ¨cellsâ¨â¨orâ¨
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Tissuesâ¨combineâ¨toâ¨formâ¨largerâ¨functionalâ¨units,â¨
calledâ¨ORGANS.â¨â¨Thus,â¨theâ¨tissuesâ¨areâ¨theâ¨
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09.08.08: Epithelium
This document provides information about a course on medical histology from the University of Michigan Medical School. It discusses the copyright and terms of use for the course materials. The materials are made available under a Creative Commons license that allows for sharing and adapting with attribution. The document provides guidance on citing the materials and notes that some content may be graphic. It cautions that the materials are not meant as a replacement for medical advice.
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09.08.08: Epithelium
- 1. Author(s):â¨University of MichiganMedical School, Department of Cell and Developmental Biology ⨠⨠License:â¨Unless otherwise noted, the content of this course material is licensed under a Creative Commons Attribution Noncommercial Share Alike 3.0 License. http://creativecommons.org/licenses/by-nc-sa/3.0/ We have reviewed this material in accordance with U.S. Copyright Law and have tried to maximize your ability to use, share, and adapt it. The citation key on the following slide provides information about how you may share and adapt this material. Copyright holders of content included in this material should contact open.michigan@umich.edu with any questions, corrections, or clarification regarding the use of content. For more information about how to cite these materials visit http://open.umich.edu/education/about/terms-of-use. Any medical information in this material is intended to inform and educate and is not a tool for self-diagnosis or a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional. Please speak to your physician if you have questions about your medical condition. Viewer discretion is advised: Some medical content is graphic and may not be suitable for all viewers.
- 2. Citationâ¨Key⨠forâ¨moreâ¨informationâ¨see:â¨http://open.umich.edu/wiki/CitationPolicyâ¨â¨ Useâ¨+â¨Shareâ¨+â¨Adapt⨠⨠{â¨Contentâ¨theâ¨copyrightâ¨holder,â¨author,â¨orâ¨lawâ¨permitsâ¨youâ¨toâ¨use,â¨shareâ¨andâ¨adapt.â¨}⨠Publicâ¨Domainâ¨ââ¨Government:â¨Worksâ¨thatâ¨areâ¨producedâ¨byâ¨theâ¨U.S.â¨Government.â¨(17 USC §â¨105)⨠Publicâ¨Domainâ¨ââ¨Expired:â¨Worksâ¨thatâ¨areâ¨noâ¨longerâ¨protectedâ¨dueâ¨toâ¨anâ¨expiredâ¨copyrightâ¨term.⨠Publicâ¨Domainâ¨ââ¨Selfâ¨Dedicated:â¨Worksâ¨thatâ¨aâ¨copyrightâ¨holderâ¨hasâ¨dedicatedâ¨toâ¨theâ¨publicâ¨domain.⨠Creativeâ¨Commonsâ¨ââ¨Zeroâ¨Waiver⨠Creativeâ¨Commonsâ¨ââ¨Attributionâ¨Licenseâ¨â¨ Creativeâ¨Commonsâ¨ââ¨Attributionâ¨Shareâ¨Alikeâ¨License⨠Creativeâ¨Commonsâ¨ââ¨Attributionâ¨Noncommercialâ¨License⨠Creativeâ¨Commonsâ¨ââ¨Attributionâ¨Noncommercialâ¨Shareâ¨Alikeâ¨License ⨠GNUâ¨ââ¨Freeâ¨Documentationâ¨License⨠Makeâ¨Yourâ¨Ownâ¨Assessment⨠⨠{â¨Contentâ¨Open.Michiganâ¨believesâ¨canâ¨beâ¨used,â¨shared,â¨andâ¨adaptedâ¨becauseâ¨itâ¨isâ¨ineligibleâ¨forâ¨copyright.â¨}⨠Publicâ¨Domainâ¨ââ¨Ineligible:â¨Worksâ¨thatâ¨areâ¨ineligibleâ¨forâ¨copyrightâ¨protectionâ¨inâ¨theâ¨U.S.â¨(17 USCâ¨Â§â¨102(b))â¨*lawsâ¨in⨠yourâ¨jurisdictionâ¨mayâ¨differ⨠{â¨Contentâ¨Open.Michiganâ¨hasâ¨usedâ¨underâ¨aâ¨Fairâ¨Useâ¨determination.â¨}⨠Fairâ¨Use:â¨Useâ¨ofâ¨worksâ¨thatâ¨isâ¨determinedâ¨toâ¨beâ¨Fairâ¨consistentâ¨withâ¨theâ¨U.S.â¨Copyrightâ¨Act.â¨(17 USC § 107)â¨*lawsâ¨inâ¨your⨠jurisdictionâ¨mayâ¨differ⨠Ourâ¨determinationâ¨DOESâ¨NOTâ¨meanâ¨thatâ¨allâ¨usesâ¨ofâ¨thisâ¨3rd-partyâ¨contentâ¨areâ¨Fairâ¨Usesâ¨andâ¨weâ¨DOâ¨NOTâ¨guaranteeâ¨that⨠yourâ¨useâ¨ofâ¨theâ¨contentâ¨isâ¨Fair.⨠Toâ¨useâ¨thisâ¨contentâ¨youâ¨shouldâ¨doâ¨yourâ¨ownâ¨independentâ¨analysis toâ¨determineâ¨whetherâ¨orâ¨notâ¨yourâ¨useâ¨willâ¨beâ¨Fair.â¨â¨
- 3. ⨠Cellsâ¨andâ¨Tissuesâ¨Sequence ⨠Medicalâ¨Histology Epithelium⨠Fall,â¨2008⨠â¨
- 4. Tissues ⨠⨠⨠⨠[â¨Fr.â¨Tissu,â¨wovenâ¨;â¨â¨L.â¨texo,â¨toâ¨weaveâ¨] ⨠Aâ¨tissueâ¨isâ¨anâ¨organizedâ¨aggregationâ¨ofâ¨cellsâ¨â¨or⨠⨠groupsâ¨ofâ¨cellsâ¨thatâ¨functionâ¨inâ¨aâ¨coordinated⨠mannerâ¨toâ¨â¨performâ¨oneâ¨orâ¨moreâ¨specific⨠functions.⨠⨠Tissuesâ¨combineâ¨toâ¨formâ¨largerâ¨functionalâ¨units,⨠calledâ¨ORGANS.â¨â¨Thus,â¨theâ¨tissuesâ¨areâ¨the⨠basicâ¨functionalâ¨unitsâ¨responsibleâ¨for⨠maintainingâ¨bodyâ¨functions.â¨
- 5. BASICâ¨TISSUES⨠⨠⨠⨠â¨Epithelium⨠Connectiveâ¨tissue ⨠Muscle ⨠Nervousâ¨tissue ⨠Bloodâ¨
- 6. Epitheliumâ¨isâ¨aâ¨cohesiveâ¨sheetâ¨ofâ¨cellsâ¨that: ⨠1.â¨Coversâ¨theâ¨externalâ¨surfaceâ¨andâ¨linesâ¨theâ¨internal⨠surfaceâ¨ofâ¨theâ¨body.⨠â⯠Protectionâ¨(byâ¨withstandingâ¨wearâ¨andâ¨tear,â¨fromâ¨hydrationâ¨and⨠dehydration)⨠â⯠Transportâ¨â¨(i.e.â¨O2â¨andâ¨C02)⨠â⯠Selectiveâ¨Absorption:â¨(Controlâ¨theâ¨movementâ¨ofâ¨substancesâ¨between⨠theâ¨outsideâ¨environmentâ¨andâ¨theâ¨internalâ¨compartmentsâ¨inâ¨theâ¨body.)⨠â⯠Secretionâ¨â¨(secretoryâ¨cells)⨠⨠2.â¨Formsâ¨endocrineâ¨andâ¨exocrineâ¨secretoryâ¨glands.⨠⨠duct ⨠Secretory⨠portion⨠Junquueiraâ¨&â¨Carneiroâ¨10thâ¨Ed.â¨P.â¨82⨠Junqueira and Carnein 10th Ed. P. 82
- 7. â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨Epithelialâ¨liningâ¨cellsâ¨ofâ¨â¨ â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨Skinâ¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨Intestine⨠Michigan Medical School Histology Slide Collection Michigan Medical School Histology Slide Collection Multipleâ¨layersâ¨ofâ¨flatâ¨(squamous)â¨cells ⨠Singleâ¨layerâ¨ofâ¨tallâ¨(columnar)â¨cells â¨
- 8. Epithelialâ¨cells:⨠â¨â¨ 1. â¨Formâ¨avascularâ¨sheetsâ¨thatâ¨differâ¨inâ¨numberâ¨ofâ¨cellâ¨layers,â¨shapeâ¨ofâ¨theâ¨cells⨠andâ¨structuralâ¨specializationsâ¨ofâ¨theâ¨freeâ¨(apical)â¨cellâ¨surface,â¨dependingâ¨on⨠theâ¨tissueâ¨function(s).⨠2. â¨Areâ¨structurallyâ¨andâ¨functionallyâ¨polarized:â¨Haveâ¨apical,â¨lateralâ¨andâ¨basalâ¨domains.⨠3. â¨Areâ¨heldâ¨togetherâ¨byâ¨severalâ¨specializations,â¨knownâ¨asâ¨theâ¨intercellular⨠junctions,â¨andâ¨bindâ¨toâ¨theâ¨underlyingâ¨connectiveâ¨tissueâ¨viaâ¨theâ¨basement⨠membraneâ¨(LM)â¨orâ¨basalâ¨laminaâ¨(EM).â¨â¨ 4. â¨Areâ¨capableâ¨ofâ¨renewalâ¨andâ¨regeneration.⨠â¨â¨ â¨non-specializedâ¨epitheliumâ¨-â¨allâ¨cells⨠â¨â¨ â¨specializedâ¨epitheliumâ¨-â¨stemâ¨cells⨠⨠Ross/Romrell p. 52
- 9. Epithelialâ¨cells:⨠â¨â¨ 1. â¨Formâ¨avascularâ¨sheetsâ¨thatâ¨differâ¨inâ¨numberâ¨ofâ¨cellâ¨layers,â¨shapeâ¨ofâ¨theâ¨cells⨠andâ¨structuralâ¨specializationsâ¨ofâ¨theâ¨freeâ¨(apical)â¨cellâ¨surface,â¨dependingâ¨on⨠theâ¨tissueâ¨function(s).⨠2. â¨Areâ¨structurallyâ¨andâ¨functionallyâ¨polarized:â¨Haveâ¨apical,â¨lateralâ¨andâ¨basalâ¨domains.⨠3. â¨Areâ¨heldâ¨togetherâ¨byâ¨severalâ¨specializations,â¨knownâ¨asâ¨theâ¨intercellular⨠junctions,â¨andâ¨bindâ¨toâ¨theâ¨underlyingâ¨connectiveâ¨tissueâ¨viaâ¨theâ¨basement⨠membraneâ¨(LM)â¨orâ¨basalâ¨laminaâ¨(EM).â¨â¨ 4. â¨Areâ¨capableâ¨ofâ¨renewalâ¨andâ¨regeneration.⨠â¨â¨ â¨non-specializedâ¨epitheliumâ¨-â¨allâ¨cells⨠â¨â¨ â¨specializedâ¨epitheliumâ¨-â¨stemâ¨cells⨠⨠Ross/Romrell p. 52
- 10. Classificationâ¨ofâ¨Epithelium⨠(Pseudostratified) ⨠columnar ⨠(Respiratory) ⨠Ross/Romrell p. 53
- 11.
- 12. Simpleâ¨squamousâ¨epithelium:â¨â¨endotheliumâ¨andâ¨mesothelium ⨠Michigan Medical School Histology Slide School Kierszenbaum p.4
- 13. Endothelium/Mesothelium⨠⨠⨠(Simpleâ¨Squamousâ¨Epithelium) Source Undetermined
- 14. Simpleâ¨Cuboidalâ¨Epithelium⨠Michigan Medical SchoolHistology Slide School Kierszenbaum p.4
- 15. Simpleâ¨Columnarâ¨Epithelium⨠Source Undetermined Michigan Medical School Histology Slide School Kierszenbaum p.4
- 16. Simpleâ¨columnarâ¨epithelium ⨠⨠liningâ¨theâ¨gutâ¨lumen lumen⨠Twoâ¨layersâ¨of⨠smoothâ¨muscleâ¨on⨠Gray s Anatomy, wikimedia commons theâ¨wall ⨠Michigan Medical School Histology Slide School
- 17. Apicalâ¨Cellâ¨Surfaceâ¨Specializationsâ¨-â¨1â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨ Striatedâ¨Borderâ¨(Microvilli) ⨠G⨠G Sources Undetermined G:â¨â¨gobletâ¨cell â¨
- 18. Microvilli ⨠(Coreâ¨ofâ¨actinâ¨filaments) ⨠Darnell et al., Molecular Cell Biology p. 608 Source Undetermined
- 19. Apicalâ¨Cellâ¨Surfaceâ¨Specializationsâ¨ââ¨2â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨â¨ Ciliaâ¨â¨onâ¨theâ¨Respiratoryâ¨Epithelialâ¨Cells ⨠Verhey. Molecular Biology of the Cell, 4th Edition. Kierszenbaum p.6
- 20. Cilia⨠coreâ¨ofâ¨microtubulesâ¨inâ¨9+2â¨arrangementâ¨(axoneme) ⨠cilia⨠Gobletâ¨cells ⨠Basalâ¨bodies ⨠Respiratoryâ¨epithelium⨠Michigan Medical School Histology Slide Collection Source Undetermined
- 21. 9â¨+â¨2⨠(Axoneme) ⨠Ross
- 22. Dyneinâ¨isâ¨responsibleâ¨forâ¨the⨠sliding. ⨠Rossâ¨etâ¨al.,â¨4thâ¨ed.â¨P.â¨94⨠Alberts et. Al; p 648
- 23.
- 24. Microvilliâ¨andâ¨cilia⨠Microvilli ⨠Cilia⨠Sources Undetermined
- 25.
- 26. Stratifiedâ¨Squamousâ¨Epithelium⨠Non-keratinized⨠Keratinized⨠Michigan Medical School Histology Slide Collection Michigan Medical School Histology Slide Collection Linesâ¨esophagus,â¨oralâ¨cavity,â¨vaginaâŚâ¨ Linesâ¨thickâ¨andâ¨thinâ¨skinâ¨
- 27. Transitionalâ¨Epithelium⨠(urothelium) ⨠Kierszenbaum pg 6
- 28. Transitionalâ¨Epithelium⨠⨠(urothelium) Linesâ¨theâ¨urinaryâ¨tract,â¨ureter,⨠bladderâ¨andâ¨urethra ⨠Source Undetermined
- 29. Epithelialâ¨cells:⨠⨠1. â¨Formâ¨avascularâ¨sheetsâ¨thatâ¨differâ¨inâ¨numberâ¨ofâ¨cellâ¨layers,â¨shapeâ¨ofâ¨theâ¨cells⨠andâ¨structuralâ¨specializationsâ¨ofâ¨theâ¨freeâ¨(apical)â¨cellâ¨surface,â¨dependingâ¨on⨠theâ¨tissueâ¨function(s).⨠2. â¨Areâ¨structurallyâ¨andâ¨functionallyâ¨polarized:â¨Haveâ¨apical,â¨lateralâ¨andâ¨basalâ¨domains⨠3. â¨Areâ¨heldâ¨togetherâ¨byâ¨severalâ¨specializations,â¨knownâ¨asâ¨theâ¨intercellular⨠junctions,â¨andâ¨bindâ¨toâ¨theâ¨underlyingâ¨connectiveâ¨tissueâ¨viaâ¨theâ¨basement⨠membraneâ¨(LM)â¨orâ¨basalâ¨laminaâ¨(EM).â¨â¨ 4. â¨Areâ¨capableâ¨ofâ¨renewalâ¨andâ¨regeneration.⨠â¨â¨ â¨non-specializedâ¨epitheliumâ¨-â¨allâ¨cells⨠â¨â¨ â¨specializedâ¨epitheliumâ¨-â¨stemâ¨cells⨠⨠Ross/Romrell p. 52
- 30. Whatâ¨structuresâ¨holdâ¨theâ¨cells⨠togetherâ¨andâ¨attachesâ¨the⨠epitheliumâ¨toâ¨theâ¨connectiveâ¨tissue?⨠⨠Ans.â¨Intercellularâ¨junctions ⨠Basementâ¨membrane⨠(basalâ¨lamina)⨠Source Undetermined
- 31. Maculaâ¨adherensâ¨(desmosomes)⨠⨠andâ¨Intermediateâ¨Filaments ⨠⨠Source Undetermined
- 32. Maculaâ¨Adherensâ¨(desmosome) ⨠Adhesion⨠Cellâ¨1⨠Cellâ¨2⨠plaque⨠(plakoglobin, ⨠desmoplakins)⨠Tonofilaments ⨠(Keratin⨠Intermediate ⨠Filaments) ⨠Desmocollins⨠Intercellularâ¨Space⨠Cellâ¨Membranes⨠Boumphreyfr,â¨Wikimediaâ¨Commonsâ¨(adapted)⨠Source Undetermined
- 33. ⨠Desmosomesâ¨andâ¨Intermediateâ¨Filaments Desmosomesâ¨serveâ¨as: ⨠1.â¨â¨Spotâ¨attachmentâ¨sitesâ¨for⨠adjacentâ¨cellâ¨membranes.⨠⨠â¨2.â¨â¨Anchoringâ¨sitesâ¨for⨠intermediateâ¨filaments.⨠Alberts et al., p. 802 Verhey. Molecular Biology of the Cell, Garland Science 2008
- 34. Hemidesmosomesâ¨functionâ¨toâ¨anchor⨠epithelialâ¨cellsâ¨â¨toâ¨theâ¨connective⨠tissueâ¨viaâ¨basementâ¨membraneâ¨â¨ (basalâ¨â¨lamina).⨠Basement⨠membraneâ¨â¨ (basalâ¨lamina)⨠Michigan Medical School Histology Slide Collection Source Undetermined
- 35. Lossâ¨ofâ¨desmosomeâ¨functionsâ¨cause⨠⨠Blisteringâ¨Skinâ¨Disorders ⨠⨠Pemphigus:â¨â¨Separationâ¨of⨠epidermalâ¨cellsâ¨fromâ¨each⨠otherâ¨(acantholysis)â¨caused⨠byâ¨lossâ¨ofâ¨desmosome⨠functions.⨠⨠Bullousâ¨pemphigoid:â¨â¨ Separationâ¨ofâ¨epidermis⨠fromâ¨theâ¨dermisâ¨dueâ¨to⨠blisteringâ¨inâ¨theâ¨basement⨠membraneâ¨causedâ¨byâ¨loss⨠ofâ¨anchoringâ¨filamentsâ¨and⨠hemidesmosomes.⨠⨠Source Undetermined
- 36.
- 37. Zonulaâ¨adherensâ¨(intermediateâ¨junction) ⨠Darnell, et. al., p.608 Lady of Hats, Wikipedia
- 38. â¨â¨Zonulaâ¨adherensâ¨â¨â¨â¨â¨â¨â¨â¨Maculaâ¨adherens⨠⨠â˘âŻ Intermediateâ¨junction⨠â˘âŻ Desmosome⨠â˘âŻ Adheringâ¨junction⨠â˘âŻ Adheringâ¨junction⨠â˘âŻ Cadherins⨠â˘âŻ â¨Cadherins⨠â˘âŻ Linkedâ¨toâ¨actin⨠â˘âŻ Linkedâ¨toâ¨intermediate⨠filaments⨠filaments⨠â˘âŻ Adhesionâ¨belt⨠â˘âŻ Spotâ¨adheringâ¨junction⨠â¨
- 39. Zonulaâ¨Occludensâ¨(Tightâ¨Junction)â¨â¨â¨â¨â¨â¨â¨â¨ ⨠⨠servesâ¨â¨asâ¨a⨠Selective⨠Permeability⨠Barrier ⨠Junquueira & Carneiro 10th Ed. P. 82 ⨠Source Undetermined Lady of Hats, Wikipedia
- 40. Zonulaâ¨occludensâ¨(tightâ¨junction) ⨠Alberts et. Al, p. 794-5
- 41. Freeze-fractureâ¨preparation⨠Alberts et al.,p. 795 Bloomâ¨andâ¨Fawcettâ¨p.â¨67â¨
- 42. ⨠Nexusâ¨(gapâ¨Junction) -â¨communicatingâ¨junction ⨠Sixâ¨Connexinâ¨subunitsâ¨assembleâ¨toâ¨formâ¨aâ¨Connexon. ⨠Alberts et al., p. 802 Lady of Hats, Wikipedia
- 43.
- 44. Epithelialâ¨cells:⨠1. â¨Areâ¨structurallyâ¨andâ¨functionallyâ¨polarized:â¨Haveâ¨apical,â¨lateralâ¨andâ¨basalâ¨domainsâ¨â¨ 2. â¨Formâ¨avascularâ¨sheetsâ¨thatâ¨differâ¨inâ¨numberâ¨ofâ¨cellâ¨layers,â¨shapeâ¨ofâ¨theâ¨cells⨠andâ¨structuralâ¨specializationsâ¨ofâ¨theâ¨freeâ¨(apical)â¨cellâ¨surface,â¨dependingâ¨on⨠theâ¨tissueâ¨function(s).⨠3. â¨Areâ¨heldâ¨togetherâ¨byâ¨severalâ¨specializations,â¨knownâ¨asâ¨theâ¨intercellular⨠junctions,â¨andâ¨bindâ¨toâ¨theâ¨underlyingâ¨connectiveâ¨tissueâ¨viaâ¨theâ¨basement⨠membraneâ¨(LM)â¨orâ¨basalâ¨laminaâ¨(EM).â¨â¨ 4. â¨Areâ¨capableâ¨ofâ¨renewalâ¨andâ¨regeneration.⨠â¨â¨ â¨non-specializedâ¨epitheliumâ¨-â¨allâ¨cells⨠â¨â¨ â¨specializedâ¨epitheliumâ¨-â¨stemâ¨cells⨠⨠Ross/Romrell p.52
- 45. Epithelium⨠Typesâ¨-â¨simpleâ¨&â¨stratifiedâ¨(pseudostratified)⨠Apicalâ¨cellâ¨surfaceâ¨specializations⨠Microvilliâ¨-â¨actinâ¨filaments⨠Ciliaâ¨-â¨microtubulesâ¨(dyneins)⨠Intercellularâ¨junctions⨠â¨Zonulaâ¨occludensâ¨(tightâ¨junction)â¨-â¨ridgesâ¨andâ¨grooves,⨠⨠â¨sealâ¨intercellularâ¨spacesâ¨-â¨Selectiveâ¨permeabilityâ¨barrier⨠â¨Zonulaâ¨adherensâ¨-â¨actinâ¨filamentsâ¨-â¨cellâ¨toâ¨cellâ¨adhesion⨠â¨Maculaâ¨adherensâ¨(desmosome)â¨-â¨intermediateâ¨filaments⨠⨠â¨-â¨attachmentâ¨plaqueâ¨(spot)⨠â¨Hemidesmosomeâ¨-â¨attachesâ¨epitheliumâ¨toâ¨basalâ¨lamina⨠â¨Nexusâ¨(gapâ¨junction)â¨-â¨connexonsâ¨-â¨cellâ¨toâ¨cellâ¨â¨ ⨠⨠â¨communicationâ¨
- 46. Epithelialâ¨cellsâ¨formâ¨Secretoryâ¨â¨Glands ⨠Glands:â¨â¨Groupingsâ¨ofâ¨cellsâ¨specializedâ¨for⨠secretion⨠⨠Secretionâ¨isâ¨theâ¨processâ¨byâ¨whichâ¨smallâ¨molecules⨠areâ¨takenâ¨upâ¨andâ¨transformed,â¨byâ¨intracellular⨠biosynthesis,â¨intoâ¨aâ¨moreâ¨complexâ¨productâ¨thatâ¨is⨠thenâ¨activelyâ¨releasedâ¨fromâ¨theâ¨cell.⨠Exocrineâ¨(ducts)â¨andâ¨endocrineâ¨(ductless)â¨glandsâ¨
- 47. Secretoryâ¨Epithelialâ¨cells ⨠Source Undetermined
- 48. Developmentâ¨ofâ¨Endocrineâ¨andâ¨Exocrineâ¨Glands⨠⨠⨠⨠⨠⨠⨠⨠Junquiera and Carnein, 10th Ed. P. 82
- 49. ⨠Secretoryâ¨Unitsâ¨andâ¨Glandularâ¨â¨Cells Image of secretory unitsand glandular cells removed Kim, S.K.
- 50. Twoâ¨Secretoryâ¨Pathways ⨠Regulatedâ¨Secretion:â¨â¨Secretory⨠granulesâ¨accumulateâ¨inâ¨cellsâ¨and⨠theâ¨granuleâ¨contentâ¨isâ¨releasedâ¨by⨠exocytosisâ¨uponâ¨stimulation.⨠Exocytosis ⨠⨠Constitutiveâ¨Secretion:â¨â¨The⨠secretoryâ¨productâ¨isâ¨not⨠concentratedâ¨intoâ¨granulesâ¨butâ¨is⨠releasedâ¨continuouslyâ¨inâ¨small⨠vesicles.⨠Kim, S.K.
- 51. Learningâ¨Objectives ⨠Afterâ¨today sâ¨session,â¨theâ¨studentsâ¨areâ¨expectedâ¨to:⨠1. â¨Beâ¨ableâ¨toâ¨classifyâ¨epitheliaâ¨andâ¨identifyâ¨eachâ¨type.⨠2.⯠Recognizeâ¨fourâ¨typesâ¨ofâ¨intercellularâ¨junctionsâ¨and⨠hemidesmosomesâ¨atâ¨theâ¨electronâ¨microscopeâ¨levelâ¨and⨠knowâ¨theirâ¨functions.â¨â¨ 3.⯠Identifyâ¨theâ¨apicalâ¨specializationsâ¨andâ¨knowâ¨their⨠functions.⨠4. â¨Beâ¨ableâ¨toâ¨correlateâ¨differentâ¨typesâ¨ofâ¨epitheliaâ¨toâ¨their⨠functionsâ¨andâ¨knowâ¨whereâ¨inâ¨theâ¨bodyâ¨eachâ¨typeâ¨occurs.⨠5.⨠â¨Knowâ¨howâ¨specializedâ¨andâ¨non-specializedâ¨epithelialâ¨cells⨠areâ¨renewed.⨠6. â¨Knowâ¨howâ¨exocrineâ¨andâ¨endocrineâ¨glandsâ¨formâ¨andâ¨be⨠ableâ¨toâ¨recognizeâ¨secretoryâ¨cells.â¨
- 52. Additionalâ¨Sourceâ¨Information⨠forâ¨moreâ¨informationâ¨see:â¨http://open.umich.edu/wiki/CitationPolicyâ¨â¨ Slide 6: Junqueira and Carnein 10th Ed., pg 82 Slide 7: Michigan Medical School Histology Slide Collection Slide 8: Ross/Romrell p.52 Slide 9: Ross/Romrell p.52 Slide 10: Ross/Romrell p.53 Slide 11: Kierszenbaum p.6 Slide 12: Michigan Medical School Histology Slide Collection; Kierszenbaum p.4 Slide 13: Source Undetermined Slide 14: Michigan Medical School Histology Slide Collection; Kierszenbaum p.4 Slide 15: Source Undetermined; Michigan Medical School Histology Slide Collection; Kierszenbaum p.4 Slide 16: Michigan Medical School Histology Slide Collection; Grayâs Anatomy, Wikimedia Commons, http://commons.wikimedia.org/wiki/File:Gray1056.png Slide 17: Source Undetermined; Source Undetermined Slide 18: Darnell et al., Molecular Cell Biology p. 608; Source Undetermined Slide 19: Kierszenbaum p.6; K. Verhey Slide 20: Michigan Medical School Histology Slide Collection; Source Undetermined Slide 21: Ross Slide 22: Rossâ¨etâ¨al.,â¨4thâ¨ed.â¨P.â¨94;â¨Ross; Alberts et al., pg 648 Slide 23: Source Undetermined Slide 24: Source Undetermined; Source Undetermined Slide 25: Kierszenbaum; Kierszenbaum Slide 26: Michigan Medical School Histology Slide Collection Slide 27: Kierszenbaum, pg 6 Slide 28: Source Undetermined
- 53. Slide 29: Ross/Romrellp.52 Slide 30: Source Undetermined Slide 31: Source Undetermined Slide 32: Source Undetermined; CC BY Boumphreyfr, http://commons.wikimedia.org/wiki/File:Cell_junctions.png, CC:BY-SA 3.0, http://creativecommons.org/licenses/by-sa/3.0/ Slide 33: Verhey. Molecular Biology of the Cell, Garland Science 2008; Alberts et al., p. 802 Slide 34: Michigan Medical School Histology Slide Collection; Source Undetermined Slide 35: Source Undetermined Slide 36: Source Undetermined Slide 37: Lady of Hats, Wikipedia, http://commons.wikimedia.org/wiki/File:Adherens_Junctions_structural_proteins.svg; Darnell, et. al., p.608 Slide 39: Lady of Hats, Wikipedia, http://commons.wikimedia.org/wiki/File:Cellular_tight_junction_en.svg; Source Undetermined; Junquueira & Carneiro 10th Ed. P. 82 Slide 40:Alberts et. Al, p. 794-5; Slide 41: Alberts et al., p. 795; Bloom and Fawcett p. 67 Slide 42: Alberts et al., p. 802; Lady of Hats, Wikipedia, http://commons.wikimedia.org/wiki/File:Gap_cell_junction_en.svg Slide 43: Source Undetermined; Source Undetermined Slide 44: Ross/Romrell p.52 Slide 47: Source Undetermined Slide 48: Junquiera and Carnein, 10th Ed. P. 82 Slide 49: Sun-Kee Kim Slide 50: Sun-Kee Kim