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  1. 1. Template provided by: “” TRADITIONAL USES Shilajit is an important drug of ancient Hindu materia medica and extensively used in a variety of diseases.It is classified as a panacea,and has been used historically for general physical strengthening, anti-aging , blood sugar stabilizing, libido, injury healing, enhanced brain functioning potency, support immune system, arthris management, hypertension, obesity , leprosy etc. It is also used in parasitic disease of skin and as antiphlogistic. According to Ayurveda, Shilajit arrests the process of aging and produces rejuvenation MODERN MEDICINAL USES Shilajit shows huge pharmacological actions: Analgesic, nootropic, ant anxiety or adaptogenic, antiulcer , anti-inflammatory ,antiviral activity, antimicrobial, immune modulator, spermatogenic and ovogenic effects, anthelmintic, antidiabetic, antispasmodic, bronchodilator etc. INTRODUCTION REFERENCES SHILAJIT:A potent herbo-mineral drug Sunita Maka (2011 Batch) Central Institute of Science and Technology Sangam Chowk, New Baneshwor, Kathmandu, Nepal Logo Here NOMENCLATURE Botanical Name: Asphaltum panjabanium, Black asphaltum Common names: Shilajit (Nepali), Shilajita (Sanskirt), Asphalt (Enlgish) Shilajit is a precious product of nature in herbal medicine. ‘Shila’ means stone and ‘jit’ means exudate. Shilajit is a natural blackish brown exudate found to be exposed between the cracks in the layers of rocks during the summer. It is a herbo-mineral with humic acids that are considered natures own best medicine for plants, animals, human, and the earth itself. ORIGIN It is found in altitudes between 1000 to 5000 meters in high Himalayan cliffs of Nepal and also been found in similar mountain range in India, Afghanistan , Bhutan, China, Pakistan, Tibet, Norway, and Russia. It is believed to be latex gum resin of plants like Styrax officinalis Linn and/or Euphorbia royleana Boiss, and bryophytes (Barbula, fissidens, Marchantia etc.) which became trapped and preserved in tallest mountains during movement of continents. COLLECTION collected in May-June or June-July ORGANOLEPTIC PARAMETERS Colour : Laccifer Lacca (dark red or blackish brown) Odor : Smells like cow’s urine Taste : Salty and bitter in taste Texture : Soft, slimy to the touch, and heavy IDENTIFICATION AND PROCESSING Ancient Ayurveda Acharyas (sage) Charak and Susruta have characteristically differentiated shilajit into four and six types .They are: Gold(red variety)-Sauvarna, Silver(white variety)-Rajat, Copper(blue variety)-Tamra and Iron(blakish brown variety)-Lauha. Lauha shilajit is common and supposed to be superior. Susruta samhita includes two more minerals: lead and zinc. Method of purification: Dissolved in water, filtered and dried. Reverse osmosis and freeze drying are used by manufacturers to remove free radicals, mycotoxins and fungal toxins. Silajit purity test: Pliability: Melts in hands becoming gooey and sticky, very hard when placed in fridge. Solubility: Dissolves completely in warm water or milk creating black gold or reddish black liquid. Flame: Will not light on fire or get burned. It will bubble and produce an ash that emanates outward.  Bhattacharyya et al., Pharmacology online 2 : 690-698 (2009) SHILAJIT DIBENZO - ALPHA – PYRONES : MITOCHONDRIA TARGETED ANTIOXIDANTS  Carlos Carrasco – Gallardo , Review Article Shilajit : A natural Phytocomplex with Potential Precognitive Activity, International Journal of Alzheimer’s Disease Volume 2012, Article ID 674142, 4 pages( )  Mohd. Aamir Mirza1, Shilajit: An Ancient Panacea, International Journal of Current Pharmaceutical Review and Research ,Volume 1, Issue 1, May 2010 – July 2010, Page 2-11  Kishor Pant, Bimala Singh, Nagendra Thakur Shilajit: A Humic Matter Panacea for Cancer International Journal of Toxicological and Pharmacological Research 2012; 4(2): 17-25  Mittal P.1*, Kaushik D.1, Gupta V. 2, Bansal P.2, Khokra S.1 Therapeutic Potentials of “Shilajit Rasayana”-A Review ,International Journal of Pharmaceutical and Clinical Research 2009; 1(2): 47-49 Euphorbia royleana Raw shilajit STANDARDIZATION Side effects may be seen with unpurified Shilajit which include generalized burning sensation, peripheral neuritis, syncope, vertigo, bleeding tendencies, indigestation etc. Possible contradictions : are hypoglycemia, gout, with heavy foods Charak Samhita : Contraindicated with Kulthi (Dolichus biflorus) that is used in treatment of renal calculi. Toxicity : Crude unprocessed Shilajit may be toxic if they contain mycotoxins from fungus like Aspergillus niger, A. ochraceous , Trichothecium roseum and free radicals. Shilajit contains more than 85 minerals in ionic form. The constituents are: Ozokerite and Alum earth are substance that look like similar to shilajit and may be used as counterfeit products. Some others include:  Sand, gum, feces of goat and bitumen  Mixed with gum of Vanjha  Momia resembling Shilajit is obtained from some of the mountains in Arabia and Persia Substances used as Shilajit in Nepal, Bihar and Bengal in 1844 which on analysis was found to be Aluminium sulphate. Shilajit rock, Neem , Guduchi, Vasa , Bhringaraj , Ghritakumari , Indrayava, Triphala, Gomutra, Karpura Shilajatu, mud of pond and some other substances are mixed together and sold as Shilajit. USE DESCRIPTION Anti-Alzheimer holds a potential in the treatment of the apparently untreatable and incurable Alzheimer’s disease Enlarge Prostate It help maintain the balanced flow of testosterone & help maintain the urine’s flow. Anti- ulcerogenic Ability to decrease gastric acid secretion and peptic output Urinary problems Effective in treating burning urine, incontinence of urine due to enlarged prostate or stone in the bladder or kidney. Cognition Enhancer Nootropic activity,augment learning acquisition and memory retrieval. Aphrodisiac Increases core energy responsible for sexual and spiritual power. Diabetes Used for the prevention and treatment of diabetes in Ayurvedic medicine. Antioxidant A powerful antioxidant that has the added benefit of being able to cross the blood-brain barrier. Anti- inflammatory Shown to reduce acute chemically induced edema by 77%. Anemia Good source of trace minerals and contains iron. Arthritis The antioxidant and anti-inflammatory properties help to decrease and relieve joint inflammation and pain. Cholesterol Lowers serum cholesterol, liver cholesterol, serum triglycerides and serum phospholipids S. No. ORGANIC CONSTITUENTS CRUDE SHILAJATU(%) PURIFIED SHILAJATU(%) 1. Moisture 12.54 29.03 2. Benzoic acid 06.82 08.58 3. Dibenzo alpha pyrones 0.4-1 - 4. Hippuric acid 05.53 06.13 5. Fulvic acid 3-5 - 6. Fatty acids 02.01 01.30 7. Resin and waxy matter 03.28 02.44 8. Gums 15.59 17.32 9. Albuminoids 19.61 16.12 INORGANIC CONSTITUENTS 10. Ash 22.88 18.34 11. Silica 4.60 02.69 12. Iron (Fe2O3) 00.51 00.64 13. Alumina (Al2O3) 02.26 02.61 14. Lime(CaO) 06.83 04.82 15. Magnesia (MgO) 01.20 01.20 16. Potash (K2O) 04.60 03.81 17. Sulphuric acid 00.64 00.97 18. Chloride 00.26 00.57 19. Phosphoric acid 00.28 00.24 20. Nitrogen 03.64 03.36 HO OH OH HOOC O O N OH O O O N COOH R O NH HN R O O O O CHO O OH HO OH HO HOOC COOH HO HO O O O Humic Acid OH HOOC HOOC COOH OH O COOH COOH CH2OH COOH Fulvic Acid O OH N H O O HO Hippuric acid O HO Benzoic acid O O OH 3-OH,DBP O O OH OH 3,8-(OH)2-DBP O O OH OH 3,8-(OH) 2-DBP-Semiquinone O O O O 3,8-(OH)2-DBP-Quinone Dibenzo alpha pyrones CHEMICAL CONSTITUENTS USES SIDE EFFECTS AND SAFETY MEASURES ADULTERANTS / SUBSTITUENTS A well standardized shilajit contains fulvic acid 60-70% Table: 50g shilajit tab. formulation MARKETED FORMULATIONS PARAMETERS RESULTS LOD 105 c %w/w 1.613+_0.336 Total ash (%w/w) 5.765+-0.3385 Acid insoluble ash(%w/v) 0.927+-0.131 Fig : Shilajit capsules Fig : Shilajit powders

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  • PranjalPatel15

    Apr. 19, 2021

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