Graduate Students Workshop

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Library Research: Tips, Tricks & Time Savers for graduate Students

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Graduate Students Workshop

  1. 1. Library Research: Tips, Tricks & Time Savers for graduate StudentsNazi TorabiAllyn & Betty Taylor LibraryFall 2012http://www.slideshare.net/ntorabi 1
  2. 2. Content Navigating library website Information in Multiple Places –Databases Structured Search Strategies - PubMed Web of Knowledge Citation tracking o Backward tracking o Forward tracking RefWorks 2
  3. 3. 3
  4. 4. From Program Guide pages or databases page Bookmark PubMed from here Bookmark Google Scholar from here
  5. 5. Title search in the librarycatalogue Springer Protocols Current Protocols 5
  6. 6. 6
  7. 7. Subject search in librarycatalogue 7
  8. 8. Browse Library Tutorials Library tutorial page is available athttp://www.lib.uwo.ca/tutorials/browse  How To Find Dissertations  Introduction to RefWorks  How to Find An Impact Factor  How to Import Citations from PubMed into RefWorks 8
  9. 9. Which Resources (Databases)? Points to consider:  1) Does it cover the desired subject area?  2) Does it contain the key resources?  3) What is the time span for coverage?  4) What types of resources does it cover?  5) Overlap with other resources, unique content?  Program Guide Pages 9
  10. 10. Search Strategies 10
  11. 11. Structured Search Methodology1. Have a research topic in the form of question2. Isolate the concepts3. Search concepts separately (Using OR)4. Combine concept sets (Using AND)5. Evaluate results and refine6. Apply limits if necessary 11
  12. 12. Sample articleZheng F, Zhan C-G. (2012). Modeling ofPharmacokinetics of Cocaine in Human Reveals theFeasibility for Development of Enzyme Therapiesfor Drugs of Abuse. PLoS Comput Biol,DOI: 10.1371/journal.pcbi.1002610 12
  13. 13. Abstract " A promising strategy for drug abuse treatment is to accelerate the drug metabolism by administration of a drug-metabolizing enzyme. The question is how effectively an enzyme can actually prevent the drug from entering brain and producing physiological effects. In the present study, we have developed a pharmacokinetic model through a combined use of in vitro kinetic parameters and positron emission tomography data in human to examine the effects of a cocaine-metabolizing enzyme in plasma on the time course of cocaine in plasma and brain of human. …It has been demonstrated that administration of a cocaine hydrolase/esterase (CocH/CocE) can considerably decrease the cocaine half-lives in both brain and plasma, ….The estimated maximum cocaine plasma concentration which a given concentration of drug-metabolizing enzyme can effectively prevent from entering brain and producing physiological effects can be used to guide future preclinical/clinical studies on cocaine-metabolizing enzymes. ….” 13
  14. 14. What is the Question?What is the role of drug metabolising enzymes in the treatment of cocaine abuse? Identify the main keywords drug-metabolizing enzyme cocaine abuse 14
  15. 15. Simple Search in Google Scholar  drug-metabolizing enzyme AND cocaine abuse  How many hits? 15
  16. 16. Simple Search in PubMed drug-metabolizing enzyme AND cocaine abuse drug metabolism AND enzyme ANDcocaine abuse Not about enzyme therapy thought! 16
  17. 17. Search Strategies  Pearl methodology framework (Sandieson, 2006)  Subject headings  Citation tracking  Backward tracking  Forward tracking
  18. 18. Pearl methodology framework Step 1: Choosing a Representative Sample of Articles Step 2: Extracting the Relevant Search Keywords and expanding on them Step 3: Refining the List of Search Keywords Step 4: Validating the Search Keywords (Sandienson, 2011) 18
  19. 19. Synonyms, related terms, variant spellings, truncation and wildcards When designing a search strategy, in order to be as comprehensive as possible, it is necessary to include a wide range of keyword terms for each of the concepts selected. For example:  synonyms:  related terms:  variant spellings:  truncation and wildcards:  truncation: random* (for random or randomised or randomized or randomly, etc); and  wildcard: behavio?r (for behaviour or behavior).
  20. 20. Searching Using Subject Headingshttp://youtu.be/wlrZPaIDDwg 20
  21. 21. Databases• Search syntax varies across interfaces.• Subject heading varies across databases. – Subject heading = MeSH= Descriptors = Control vocabulary = ...• Search strategy has to be tailored for each database. – *Tip: For further details refer to the “Help” files for the database in question. Developing a search strategy is an iterative process!
  22. 22. Structured Search Methodology1. Have a research topic in the form of question2. Isolate the concepts3. Search concepts separately (Using OR)4. Combine concept sets (Using AND)5. Evaluate results and refine6. Apply limits if necessary 22
  23. 23. What is the Question?What is the role of drug metabolising enzymes in the treatment of cocaine abuse? Identify the main concepts Enzyme therapy Drug addiction Metabolism Cocaine 23
  24. 24. 24
  25. 25. Search Each Concept SeparatelyDrug Addiction enzyme therapySubstance-Related Disorders drug abusecocaine esterase Substance Abusedrug overdose pharmacogeneticsEnzymotherapy cocaine hydrolasePharmacokinetics pharmacologyDrug Dependence 25
  26. 26. Concept Map Concept 1 Concept 2 Concept 3 Concept 4Drug cocaine Enzymotherapy PharmacokineticsAddiction hydrolasedrug abuse cocaine enzyme therapy metabolism esterasedrug overdose Cocaine Drug therapy pharmacogeneticsDrug pharmacologyDependenceSubstanceAbuse Substance- Related Disorders 26
  27. 27. 27
  28. 28. 28
  29. 29. Searching using subheadings 29
  30. 30. MeSH 30
  31. 31. Using broader term 31
  32. 32.  Designing a good search strategy is like playing chess well. 32
  33. 33. My NCBI Customize PubMed display Save collections (sharing) Save search strategies Set up alerts Need to register for My NCBI
  34. 34. Web of Knowledge Online environment which allows searching of  BIOSIS Previews  Web of Science  Medline  Zoological Record  Journal Citation Reports Cross searching Cross database navigation 34
  35. 35. Web of Science Consists of 5 databases:  Science Citation Index Expanded (1945-present)  Social Sciences Citation Index (1898-present)  Arts & Humanities Citation Index (1975-present)  Conference Proceedings Citation Index- Science (1990-present) Multidisciplinary subject coverage Citation searching capability Coverage back to 1955 online In print back to 1945 Create citation report 35
  36. 36. Journal Citation Reports Determine the relative importance of journals within subject categories Look up Impact Factor as well as other indices for journals Various editions – science & social science 36
  37. 37. WOS Run the same search in WOS What is the most cited articles in your result list? 37
  38. 38. Concept Map Concept 1 Concept 2 Concept 3 Concept 4Drug cocaine Enzymotherapy PharmacokineticsAddiction hydrolasedrug abuse cocaine enzyme therapy metabolism esterasedrug overdose Cocaine Drug therapy pharmacologyDrugDependenceSubstanceAbuse Substance- Related Disorders 38
  39. 39. WOS Search#3 Topic=("Drug therapy" OR Enzymotherapy OR "enzyme therapy")# 2 Topic=("cocaine hydrolase" OR "cocaine esterase" OR cocaine)# 1 Topic=("Drug Addiction" OR "drug abuse" OR "drug overdose" OR"Drug Dependence" OR "Substance Abuse" OR "Substance RelatedDisorders")Limit by: Research Areas=( BIOCHEMISTRY MOLECULAR BIOLOGY ) AND Document Types=(ARTICLE OR REVIEW ) AND Languages=( ENGLISH ) 39
  40. 40. 40
  41. 41. Cited ReferenceUsing Google Scholar and Web of Science, please identify how many times this article has been cited.Hardman A. E. The influence of exercise on postprandial triacylglycerol metabolism. ATHEROSCLEROSIS 141: S93- S100 Suppl. 1 DEC 1998 41
  42. 42. Using Scopus 42
  43. 43. Locating ArticlesGroup 1Lenhard K, Bommer GT, Asutay S, Schauer R, Brabletz T, Goke B, Lamerz R, Kolligs FT. Analysis of promoter methylation in stool: a novel method for the detection of colorectal cancer. Clin Gastroenterol Hepatol. 2005 Feb;3(2):142-9. PMID: 15704048 [PubMed - indexed for MEDLINE]Group 2Herlyn M, Sears HF, Verrill H, Koprowski H. Increased sensitivity in detecting tumor-associated antigens in sera of patients with colorectal carcinoma. J Immunol Methods. 1984 Dec 14;75(1):15-21. PMID: 6512262 [PubMed - indexed for MEDLINE]
  44. 44. Introduction to RefWorks
  45. 45. What is RefWorks? Personal bibliographic citation managers Save citations as you search Organize your research, Include citations while you write your paper Import references from many data sources including databases, the UWO catalogue, even from web pages Create bibliographies Share citations with friends, colleagues, students, etc.
  46. 46. Why Use RefWorks? free to all UWO faculty, staff, and students web-based so available anywhere and anytime data is stored on a server in Toronto data is backed up every night so you will not lose your data
  47. 47. Create a FolderReferences organization by default: o Last imported folder o References not in a folder o Deleted references (deleted references will store here for 30 days) 47
  48. 48. Create a Folder
  49. 49. Editing References Duplicates Upload attachments
  50. 50. Direct import This will automatically launch RefWorks and store the citations in your "Last Imported" folder. Direct export functionality is available from most database providers. e.g. SCOPUS Tutorial available at:http://www.lib.uwo.ca/taylor/grad/intro_refworks_import.shtml
  51. 51. Indirect Import References have to be imported into RefWorks from a text file (txt.) created by saving references from a wide variety of online services and other bibliographic management programs. Text file will be imported into RefWorks via specific filters. e.g. PubMed Video Tutorial available at:http://www.lib.uwo.ca/tutorials/refworksimportingcitationsfrompubme d
  52. 52. Create a bibliography Output Style Format a Bibliography from a List of References
  53. 53. Using Write-N-CiteEnables you to incorporate citations into your paper while you write. Automatically generates a bibliography when youre done. Please watch the following video Write- N- cite From north California State University Libraries
  54. 54. RefWorks off campus access 1) Visit www.lib.uwo.ca 2) Login to off-Campus Access (connect to proxy) 3) Then, sign into RefWorks 1 2
  55. 55. Online Help for RefWorks Taylor Support for RefWorks Scholars Portal help guide
  56. 56. Thank You for Your Attention! Need library help. Please feel free to contact:Nazi Torabi519-661-2111 ext 88992 Taylor Service Desk ntorabi@uwo.ca 519-661-3168 tayref@uwo.ca 56

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