20100623-hla-b1502

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20100623-hla-b1502

  1. 1. ! HLA-B*1502 F F F F F F 21 F F F F F F ( .) F F . . F F . . . . . F F F F F HLA-B*1502 F F F - F (carbamazepine) F F F F F F F F F F . . F F F F F F (Drughypersensitivity) F F F F F F F F F F F 2 F F F F , F F F F F (Stevens-Johnson syndrome F F SJS) F (toxic epidermal necrolysis F F TEN) F F F F F F F F F F F 2-7 1 F F 25-80% F F F F . F 0-2564-7000 F 1461,1462 e-mail : thaismc@nstda.or.th
  2. 2. F F F F F F F F F F F F F F F F F F F F F F F F F F F F F . F F F F . .2546 F F F F F F F F F F F F F F F F F F F F F F HLA Human Leukocyte Antigen HLA F F HLA F F F HLA F3 F 1. F F F F 2. F F F 3. F F F F F F F F F . F F HLA F F F F HLA HLA F F F F F F . F 0-2564-7000 F 1461,1462 e-mail : thaismc@nstda.or.th
  3. 3. F F F F F F F F F 200 F F 100 F F F A F F F 160 F G F 40 F C F F F F F F F A F F 50 F G F 150 F C F F F F G F F F F F F F F HLA-B F F F F F F HLA-B *1502 F F F HLA F F F F F F F F F F F F F F F F F F F F F F F ! HLA-B*1502 F F F F F F F F F . .2549 F F F F F F SJS/TEN 5 F F (Co-trimoxazole), F (carbamazepine), (allopurinol), (Phenytoin) (amoxicilin) WHO Uppsala Monitoring Center (WHO-UMC) F F SJS TEN F !! F F F F F F F SJS TEN F F F . F 0-2564-7000 F 1461,1462 e-mail : thaismc@nstda.or.th
  4. 4. HLA-B*1502 F F F F F F F F F F F F F F . . F F . . F F F F FF F F F HLA-B F F F F F F F F ( .) . . F F F HLA-B F SJS/TEN F F F F SJS/TEN F F F F F F F F F F F 42 F 37 ( 88.1%) HLA-B*1502 F F F F 42 5 ( 11.9%) F HLA-B*1502 F HLA-B*1502 F F SJS/TEN F F F 55 F (sensitivity) (specificity) F F HLA-B*1502 F 88.10% ( F F F Epilepsia, 2010; 51: 926-930) F F F F SJS/TEN (allopurinol) F F F F F F F 27 SJS/TEN F ( 100%) HLA-B*5801 7 54 ( 12.96%) F HLA-B*5801 F F F F F HLA-B*5801 SJS/TEN 348 F (sensitivity) (specificity) F F 100% 87%, ( F F Pharmacogenetic and Genomics, 2009 ;19:704-9) F F HLA-B F F F F SJS/TEN F F F F F F F F . F 0-2564-7000 F 1461,1462 e-mail : thaismc@nstda.or.th
  5. 5. F F FF F F F . . F F F F F F F F F F F F F F F F F F F F F F F F F F F F F F F F F F F F F http://pharmacology.md.kku.ac.th email pharmacogenomic.test.kku@gmail.com 23/06/53 /////////////////////////////////////////////// F . F 0-2564-7000 F 1461,1462 e-mail : thaismc@nstda.or.th

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