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Everything You Ever Wanted To Know About EphB4, Informatically-Speaking

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Everything You Ever Wanted To Know About EphB4, Informatically-Speaking

  1. 1. Everything You Ever Wanted to Know About EphB4, Informatically-Speaking Ben Ferguson 7/30/07
  2. 2. <ul><li>E rythropoietin- p roducing h epatoma </li></ul><ul><li>Largest family of RTKs; A and B subclasses </li></ul><ul><li>Chr. 7q22, negative strand </li></ul><ul><li>Previously known as HTK ( H epatocellular T ransmembrane K inase), Mdk2 ( M ouse d evelopmental k inase 2, Tyro11, Myk1 </li></ul><ul><li>108.27 kDa </li></ul>The Basics
  3. 3. The Basics <ul><li>Interacts with its ligand, ephrin-B2, on adjacent cells as heterodimer and heterotetramer; also with NMDA receptors, syndecan 3 </li></ul><ul><li>May also interact with Src, FAK, Rac, Rho, Ras, others </li></ul>
  4. 4. <ul><li>ttccagcgcagctcagcccctgcccggcccggcccgcccggctccgcgccgcagtctccctccctcccgctccgtccccgctcgggctcccaccatccccgcccgcgaggagagcactcggcccggcggcgcgagcagagccactccagggagggggggagaccgcgagcggccggctcagcccccgccacccggggcgggaccccgaggccccggagggaccccaactccagccacgtcttgctgcgcgcccgcccggcgcggccactgccagcacgctccgggcccgccgcccgcgcgcgcggcacagacgcggggccacacttggcgccgccgcccggtgccccgcacgctcgcatgggcccgcgctgagggccccgacgaggagtcccgcgcggagtatcggcgtccacccgcccagggagagtcagacctgggggggcgagggccccccaaactcagttcggatcctacccgagtgaggcggcgccatggagctccgggtgctgctctgctgggcttcgttggccgcagctttggaaggtgagtttccttgcgggggggggcgcaccccgtcactcctgggacctcccccccaacatctgggcctcggagtggaggggccggcctctgactacccctacccgggcactgcagtcccaaacacttcggaccgatagtgctggaacgggaggggggcggggaagaggcgcccgacgggtagtggagttttcttttgtttgggaaagagatggagtctggctacgacccgggacattcccctgcccgggctccccgaactctcactgctgattacatacgcccctggctgcctttcctttcctccctaccccactattcaaaactatctgcaaagtttctgtcccagtcccacctcccgccgtacatgagggaaggtttctggagaagcaacagcagacaaggcacaacttttcgtgctaggccctaaaacgacccccagcgccaattccttagcgatcacaccttgatcctccagttccacactcctgcaacaggatggcctcctttgcattcacacagcaaacccccaaaccgctctcccgcccactgctcctgcccctggtatagggtggctccttggtttctacaggctgcaccccatccctttaaatgcggtctagaccccggccccaggtgagtcccgggcttcccttgagacctaggagcgggtagaaactgacctacacagcccccaggtagaaactgacctacacagcccccacatcgccctaactaacccagtctatctcccacctcctggtctctccaagcatttctttggccatggatcgctgtccctcctggtcccctaaagggggagccaagagccctagaaactctcctgtgtccctaatgtcctttcagtgagctgccaacacccccctttctctgtctggtatgaaagtggttatggggcggtaggctatgagggactcccaaagggaaggattcagcggcgttagaaaaaccctctccccctggctgggcaggactgccctgggctggggatcaaaggctaggtgtggggttgggagtgaggggaggcttgcccagctcagagaacggagaagggggaacaaaaaccatgaacgaggggaagaggaaggccaaaggggtggaaaaaccacgaggacgaggtgtggtgagaaggaaagacgcaaagaggaaatggtgattgtgacacctattacctgagtgtttccaagcaccaggcctgtgctgagcgccttacaaatattaatttcacccatccagcaacgctaagggtggtgctattattgcccccatttttcagatgaggaggctggggcttagttaaggttaagtagtttatccaaggccctgtgccgcgaggaacagcgagaagtggaggccgaaagcgaaggagagatagtgactgtcagaaagagaaacggaggtggacagagagtggaggagagataggtgagagacatgcgaactgacagatcaaagcgtggctgcagctgagctgggacgcagaaagggagcctgcgcttgctctgggctgcggacagcccgaggcagagacagtgtgtaaattggagacaggaaaacactatcccggctggaacaatggagggtggagacggcagcctctatccacccccttcccagaacccgggcatcctgtccccagtgagcagggctgtctcttgccacccatggggaccttgcgcctctcacctcaggctggctggcttcccatctgacccctagctggaggacatcatttggtccccaggaagaggctgcctcacccaccctctttctcttctctcctgcagctcccatggggtgggagccaggtgttctggctcccctctccacccttcccagcgcccaatgccccccacattgccggcccccgaggggattcctgtaccctccctcctccactctccactgccaggggctgtgcagtttttcctaatccccccccttcctccagtgcctgtcccctcccccgatgatccgagccaagccaggtgtgttcacccctcccattcataccgccccccagaatctcctcccctctgccttcccataaccaaatccagatgtgaggcctcggcgggagcctgggaaccctagcatcccgacctccagtgcttcctgatcagggcactcgtggggagggaggtactgggatgggggccagggctatgccccaggcacggagcgctcccttcaaggagggaaggacggggtgtttggtctgaaagcagagaggggtcttggacagggaatgaaattgtggggtagagaggctgattctgggacttaggggaggaaacgtggaggctgagacaagaggttcccctcccacaccagcagcctctgctcgtgggggtcaggaccagggcgcagctctcattttaaccctttctgagctgccgccccttctccccgtacattttgatctccctccctcctccagggaggcctagatctggggtatcccaagggagccccatgcctaccagatgttgggggtggggttggcacttagcagaagaggccagaaatcaggcgggtgcagagggcagggcttgctcccctcttggccccccaactcctctagctcagagctaagaggatccacctgcctcggttcccagggatctggtcttcctgacctccctcccccaccccaggcactgactctgtctctctgtctgtctcagagaccctgctgaacacaaaattggaaactgctgatctgaagtgggtgacattccctcaggtggacgggcaggtgagagctgcacccaggagctggagctctggagggaaactgagggaggagagggcgcctgtgccgcctgctttctgtgtgccactcctctcccctgtccccccagatgacagcagccccagcagtgtcgtctgagcccttctcagaggcgccctcctcgcagtaccagcagcccccctttctcagtccctctcactttataggattcaccccatgcagccctctccctggcggctccccagcccccttgctgacctccttctctgcacagtgggaggaactgagcggcctggatgaggaacagcacagcgtgcgcacctacgaagtgtgtgacgtgcagcgtgccccgggccaggcccactggcttcgcacaggttgggtcccacggcggggcgccgtccacgtgtacgccacgctgcgcttcaccatgctcgagtgcctgtccctgcctcgggctgggcgctcctgcaaggagaccttcaccgtcttctactatgagagcgatgcggacacggccacggccctcacgccagcctggatggagaacccctacatcaaggtacctgggtgcccccagggctcagccacagccaaggtgggattccagccagcaggcccgtggcctggagggcagccgatgtagttgcgaggcctctggcccgcgcgctgggggctggaagcaggaggcttaggtctggggagggaagggggtgatcttctgggcggaggagcagaatatacgggggctgcctggcccggcccccagggaggcccaagggtcaggcttctcctccagtcacctcaaccaccctaccccactgtgctccagccacactgagtttctcccattccctgactgcacctggctggtttccagctcaagactttgcagcggtgatgtctccacctgggggcctctctgcctctcacacccctacttgtcttcggagttccagctcccgagatcttgcctgtgccaccttggctgactctctcctccctacaatcctgcatacctctgtccacctgcctgtctcggcactcattttactttatttatttttcttttatatctatatttttaaagcggggtcttctacgttacccaggctggtctctaactcctgggctcaagagatttctcccacctcggcctcctaaagtgctgggattataggcatgaggcactacgcccggcctcatggtactttataacttccccaggattcattcatcgctgtctccttgactctgaggtcaaggcctggcatggcgtcagtgtcagtaaatgtttgtagaacgagtgaataaaaagggggagaggtgcaggccagaggccgggcatatcgcaggagctttgcaaggctgaatggacagtgtgggggcctgcagaaagtgtgccctggggaaggtggagggaagattctggaacgggaaccaaggaggtccgggagggtgagctgggaagaacacaacagtccgctgggtcctcagggagtggggacagcagcggtgtgcctcccccccgccggcaggtggacacggtggccgcggagcatctcacccggaagcgccctggggccgaggccaccgggaaggtgaatgtcaagacgctgcgtctgggaccgctcagcaaggctggcttctacctggccttccaggaccagggtgcc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gctgtctccacctccagggttcaagcgattctcctgcctcagtctcccaagtagctggtactataggcatgcaccaccatgctgactaatttttgtatttttagtagacacagggtttcaccatgtaggccaggctggtatcaaactcctgacctcaagtgatctccccacctcagcctcccaaagtgctggtattacaggtgtgaggcaccacgcctggccagccctctgcctttaattttccctctgggaaaggctgggctcctgggaccttcctttcccactgccccatacagctgaaggttgtcattccttctttttttttttaattttgttttaattgaattttttttttttgagatggagtttcactcttgttgcccaggccggagtgcaatggcaagatcttggctcaccgcaacctccgcctcccaggttcaagcgattctcctgccttagcctccccagtagctgggattataggcatgtgccaccacgcttgactaattttgtatttttagtagagacgggggtttctctgtgttggtcaggctggtctcgaactcccgacctcaggtgatccgcctgcctcggcctcccaaagtgctgggattacagacgtgagccaccgcgcccggccaattttttttttttttttttaagacagagtctcactctgtcctctaggctggagtgcagtggtgcattcatagctcactgtagccttgacctcctgggctcaagtgatcctcccgcctcagcctcctgagtagctggaactacactcatgtaccaccatgctcagcaaatttttaaaattttttgtagagacaggatctcgataggttgcccaggctggtctgaactcctggcctcaagcgagcctccctcctcagcctcccacagcactgggattgcaggcatgagccactgtgcctggcctgtcattccttcttttgacaaatatttactgagtgctttctacgcaccggtcatcc </li></ul>
  5. 5. <ul><li>ttccugcgcugctcugcccctgcccggcccggcccgcccggctccgcgccgcugtctccctccctcccgctccgtccccgctcgggctcccuccutccccgcccgcguggugugcuctcggcccggcggcgcgugcugugccuctccuggguggggggguguccgcgugcggccggctcugcccccgccucccggggcggguccccguggccccgguggguccccuuctccugccucgtcttgctgcgcgcccgcccggcgcggccuctgccugcucgctccgggcccgccgcccgcgcgcgcggcucugucgcggggccucucttggcgccgccgcccggtgccccgcucgctcgcutgggcccgcgctgugggccccgucguggugtcccgcgcggugtutcggcgtccucccgcccugggugugtcugucctgggggggcgugggccccccuuuctcugttcggutcctucccgugtguggcggcgccutggugctccgggtgctgctctgctgggcttcgttggccgcugctttgguuguguccctgctguucucuuuuttgguuuctgctgutctguugtgggtgucuttccctcuggtggucgggcugtgggugguuctgugcggcctggutgugguucugcucugcgtgcgcucctucguugtgtgtgucgtgcugcgtgccccgggccuggcccuctggcttcgcucuggttgggtcccucggcggggcgccgtccucgtgtucgccucgctgcgcttcuccutgctcgugtgcctgtccctgcctcgggctgggcgctcctgcuugguguccttcuccgtcttctuctutgugugcgutgcggucucggccucggccctcucgccugcctggutgguguucccctucutcuuggtggucucggtggccgcggugcutctcucccgguugcgccctggggccguggccuccggguuggtguutgtcuugucgctgcgtctggguccgctcugcuuggctggcttctucctggccttccugguccugggtgcctgcutggccctgctutccctgcucctcttctucuuuuugtgcgcccugctguctgtguucctguctcguttcccgguguctgtgcctcgggugctggttgtgcccgtggccggtugctgcgtggtggutgccgtccccgcccctggccccugccccugcctctuctgccgtguggutggccugtgggccguucugccggtcucgggctgcugctgtgctccggggttcguggcugctgugggguucuccuugtgccgugcctgtgcccugggcuccttcuugcccctgtcugguguugggtcctgccugccutgcccugccuutugccuctctuucuccuttggutcugccgtctgccugtgccgcgtcgggtucttccgggcucgcucugucccccggggtgcuccctgcuccucccctccttcggctccgcggugcgtggtttcccgcctguucggctcctccctgcucctgguutggugtgcccccctggugtctggtggccguguggucctcucctucgccctccgctgccgggugtgccgucccgguggctcctgtgcgccctgcgggggugucctgucttttguccccggcccccgggucctggtggugccctgggtggtggttcgugggctucgtcctgucttcucctutucctttguggtcuctgcuttguucggggtutcctccttugccucggggcccgtcccutttgugcctgtcuutgtcuccuctguccguguggtucctcctgcugtgtctgucutccgggtgucgcggtcctcucccugcugcttgugcctggcctgggctgttccccgggcucccugtggggctgtgctgguctucguggtcuuutuccutguguugggcgccgugggtcccugcugcgtgcggttcctguugucgtcuguuuuccgggcugugctgcgggggctguugcggggugccugctucctggtgcuggtucgggcgcgctctguggccggctucgggcccttcggccugguucutcucugccugucccuuctggutgugugcgugggctggcgggugcugctggccctguttgcgggcucggcugtcgtgggtgtggtcctggtcctggtggtcuttgtggtcgcugttctctgcctcugguugcugugcuutggguguguugcuguututtcggucuuucucggucugtutctcutcggucutggtuctuuggtctucutcguccccttcucttutguuguccctuutguggctgtguggguutttgcuuuugugutcgutgtctcctucgtcuuguttguuguggtguttggtgcuggtgugtttggcguggtgtgccgggggcggctcuuggccccuggguuguuggugugctgtgtggcuutcuuguccctguugggtggctucucggugcggcugcggcgtgugtttctgugcguggcctccutcutgggccugttcgugcuccccuututcutccgcctggugggcgtggtcuccuucugcutgcccgtcutguttctcucugugttcutgguguucggcgccctgguctccttcctgcggctuuucgucggucugttcucugtcutccugctcgtgggcutgctgcggggcutcgcctcgggcutgcggtuccttgccgugutgugctucgtccuccgugucctggctgctcgcuucutcctugtcuucugcuucctcgtctgcuuugtgtctguctttggcctttcccguttcctggugguguuctcttccgutcccucctucucgugctccctgggugguuuguttcccutccgutgguctgccccgguggccuttgccttccgguugttcucttccgccugtgutgcctggugttucggguttgtgutgtggguggtgutgtcutttgggguguggccgtuctgggucutgugcuutcuggucgtgutcuutgccuttguucugguctuccggctgcccccgcccccuguctgtcccucctccctccuccugctcutgctgguctgttggcuguuuguccgguutgcccggccccgcttcccccuggtggtcugcgccctggucuugutgutccgguuccccgccugcctcuuuutcgtggcccggguguutggcggggcctcucuccctctcctgguccugcggcugcctcuctuctcugcttttggctctgtgggcgugtggcttcgggccutcuuuutggguugutucguuguuugtttcgcugccgctggctttggctccttcgugctggtcugccugutctctgctguggucctgctccguutcggugtcuctctggcgggucuccuguuguuuutcttggccugtgtccugcucutguugtcccuggccuugccggguuccccgggtgggucuggugguccggccccgcugtuctgucctgcugguuctccccuccccugggucuccgcctccccuttttccggggcugugtgggguctcucuguggcccccugccctgtgccccgctgguttgcuctttgugcccgtggggtguggugttggcuutttggugugucuggutttgggggttctgccutuutuggugggguuuutcuccccccugccucctcgggguuctccuguccuugggtgugggcgcctttccctcugguctgggtgtguccugugguuuugguugtgcccuucutctcccugcctccccuggtgcccccctcuccttgutgggtgcgttcccgcuguccuuugugugtgtguctcccttgccugctccugugtgggggggctgtcccugggggcuuguuggggtgtcugggcccugtgucuuuutcuttggggtttgtugtcccuucttgctgctgtcuccuccuuuctcuutcutttttttcccttgtuuutgcccctcccccugctgctgccttcututtguuggtttttgugttttgtttttggtcttuutttttctccccgttccctttttgtttcttcgttttgtttttctuccgtccttgtcutuuctttgtgttgguggguucctgtttcuctutggcctcctttgcccuugttguuucuggggcccutcutcutgtctgtttccuguucugtgccttggtcutcccucutccccgguccccgcctgggucccccuugctgtgtcctutguuggggtgtggggtguggtugtguuuugggcggtugttggtggtgguucccuguuucggucgccggtgcttgguggggttcttuuuttututttuuuuuugtuuctttttgtutuuutuuuuguuuutgggucgtgtcccugctccuggggtuuuuuuuuuuuuuuuuuu </li></ul>
  6. 6. <ul><li>MELRVLLCWASLAAALEETLLNTKLETADLKWVTFPQVDGQWEELSGLDEEQHSVRTYEVCDVQRAPGQAHWLRTGWVPRRGAVHVYATLRFTMLECLSLPRAGRSCKETFTVFYYESDADTATALTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNVKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCAQLTVNLTRFPETVPRELVVPVAGSCVVDAVPAPGPSPSLYCREDGQWAEQPVTGCSCAPGFEAAEGNTKCRACAQGTFKPLSGEGSCQPCPANSHSNTIGSAVCQCRVGYFRARTDPRGAPCTTPPSAPRSVVSRLNGSSLHLEWSAPLESGGREDLTYALRCRECRPGGSCAPCGGDLTFDPGPRDLVEPWVVVRGLRPDFTYTFEVTALNGVSSLATGPVPFEPVNVTTDREVPPAVSDIRVTRSSPSSLWAVPRAPSGAVLDYEVKYHEKGAEGPSSVRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESEGWREQLALIAGTAVVGVVLVLVVIVVAVLCLRKQSNGREAEYSDKHGQYLIGHGTKVYIDPFTYEDPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVARENGGASHPLLDQRQPHYSAFGSVGEWLRAIKMGRYEESFAAAGFGSFELVSQISAEDLLRIGVTLAGHQKKILASVQHMKSQAKPGTPGGTGGPAPQY </li></ul>
  7. 8. <ul><li>Isoform A: full length </li></ul><ul><li>Isoform B: missing 52 residues near carboxy terminus (linker and SAM regions) </li></ul>
  8. 15. <ul><li>Science Primer: http://www. ncbi . nlm . nih .gov/About/primer </li></ul><ul><li>Human Protein Reference Database: http://www.hprd.org </li></ul>

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